Atrial Fibrillation
May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Non-Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients with Atrial Fibrillation with Coronary or Peripheral Artery Disease.
Authors:Zhang H, Xue Z, Yi D, Li X, Tan Y, Li J
Institution:Department of Cardiovascular Medicine, Xiangdong Hospital Hunan normal University.
Journal:Int Heart J. 2020 Mar 28;61(2):231-238. doi: 10.1536/ihj.19-202. Epub 2020 Mar 14.

2:Oral anticoagulant therapy in atrial fibrillation older patients with previous bleeding.
Authors:Bo M, Giannecchini F, Papurello M, Brunetti E
Institution:Section of Geriatrics, Departement of Medical Sciences, University of Turin, Citta della Salute e della Scienza, Molinette Hospital, Turin.
Journal:Monaldi Arch Chest Dis. 2020 Mar 9;90(1). doi: 10.4081/monaldi.2020.1252.

3:The influence of atrial fibrillation on the mortality of incident ESRD patients undergoing maintenance hemodialysis.
Authors:Hsieh HL, Hsu SC, Cheng HS, Chen CY, Huang WC, Sue YM, Lin FY, Shih CM, Chen JW, Lin SJ, Huang PH, Liu CT
Institution:Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Journal:PLoS One. 2020 Jan 30;15(1):e0228405. doi: 10.1371/journal.pone.0228405. eCollection 2020.

4:Statins reduce new-onset atrial fibrillation after acute myocardial infarction: A nationwide study.
Authors:Tseng CH, Chung WJ, Li CY, Tsai TH, Lee CH, Hsueh SK, Wu CC, Cheng CI
Institution:Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung.
Journal:Medicine (Baltimore). 2020 Jan;99(2):e18517. doi: 10.1097/MD.0000000000018517.

5:Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.
Authors:Garcia DA, Fisher DA, Mulder H, Wruck L, De Caterina R, Halvorsen S, Granger CB, Held C, Wallentin L, Alexander JH, Lopes RD
Institution:Division of Hematology, University of Washington School of Medicine, Seattle, WA. Duke Clinical Research Institute, Durham, NC; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC. Electronic address:
Journal:Am Heart J. 2020 Mar;221:1-8. doi: 10.1016/j.ahj.2019.10.013. Epub 2019 Oct 31.

6:Alcohol Abstinence in Drinkers with Atrial Fibrillation.
Authors:Voskoboinik A, Kalman JM, De Silva A, Nicholls T, Costello B, Nanayakkara S, Prabhu S, Stub D, Azzopardi S, Vizi D, Wong G, Nalliah C, Sugumar H, Wong M, Kotschet E, Kaye D, Taylor AJ, Kistler PM
Institution:From the Heart Center, Alfred Hospital (A.V., T.N., B.C., S.N., S.P., D.S., S.A., D.V., H.S., D.K., A.J.T., P.M.K.), the Baker Heart and Diabetes Institute (A.V., B.C., S.P., D.S., H.S., A.J.T., P.M.K.
Journal:N Engl J Med. 2020 Jan 2;382(1):20-28. doi: 10.1056/NEJMoa1817591.

7:Rhythm monitoring strategies in patients at high risk for atrial fibrillation and stroke: A comparative analysis from the REVEAL AF study.
Authors:Reiffel JA, Verma A, Kowey PR, Halperin JL, Gersh BJ, Elkind MSV, Ziegler PD, Kaplon RE, Sherfesee L, Wachter R
Institution:Department of Medicine, Division of Cardiology, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY. Electronic address: Clinic and Policlinic for Cardiology, University Hospital Leipzig, LiebigstraŖe 20, Leipzig, Germany. Electronic address:
Journal:Am Heart J. 2020 Jan;219:128-136. doi: 10.1016/j.ahj.2019.07.016.

8:Percutaneous left atrial appendage closure versus non-vitamin K oral anticoagulants in patients with non-valvular atrial fibrillation and high bleeding risk.
Authors:Godino C, Melillo F, Bellini B, Mazzucca M, Pivato CA, Rubino F, Figini F, Mazzone P, Della Bella P, Margonato A, Colombo A, Montorfano M
Institution:Cardiology Unit, San Raffaele Hospital, Milan, Italy.
Journal:EuroIntervention. 2020 Apr 17;15(17):1548-1554. doi: 10.4244/EIJ-D-19-00507.

9:Meta-Analysis Comparing Double Versus Triple Antithrombotic Therapy in Patients With Atrial Fibrillation and Coronary Artery Disease.
Authors:Ravi V, Pulipati P, Vij A, Kodumuri V
Institution:Division of Cardiology, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois. Division of Cardiology, Department of Internal Medicine, Ascension All Saints Hospital, Racine, Wisconsin. Electronic address:
Journal:Am J Cardiol. 2020 Jan 1;125(1):19-28. doi: 10.1016/j.amjcard.2019.09.045. Epub 2019 Oct 11.

10:Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation.
Authors:Pokorney SD, Holmes DN, Shrader P, Thomas L, Fonarow GC, Mahaffey KW, Gersh BJ, Kowey PR, Naccarelli GV, Freeman JV, Singer DE, Washam JB, Peterson ED, Piccini JP, Reiffel JA
Institution:Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: Columbia University Medical Center, New York, NY.
Journal:Am Heart J. 2020 Feb;220:145-154. doi: 10.1016/j.ahj.2019.09.017. Epub 2019 Oct 23.

11:Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.
Authors:Sutter JS, Lokhnygina Y, Daubert JP, Bahnson T, Jackson K, Koontz JI, Sun AY, Hegland DD, Thomas KL, Jackson L, Lewis R, Granger C, Piccini JP, Atwater BD
Institution:Duke University Medical Center, Durham, NC. Electronic address: Duke University Medical Center, Durham, NC; Duke Center for Atrial Fibrillation, Durham, NC.
Journal:Am Heart J. 2020 Feb;220:89-96. doi: 10.1016/j.ahj.2019.11.010. Epub 2019 Nov 22.

12:Effect of Heart Rate on Stroke Recurrence and Mortality in Acute Ischemic Stroke With Atrial Fibrillation.
Authors:Lee KJ, Kim BJ, Han MK, Kim JT, Choi KH, Shin DI, Yeo MJ, Cha JK, Kim DH, Nah HW, Kim DE, Ryu WS, Park JM, Kang K, Lee SJ, Kim JG, Oh MS, Yu KH, Lee BC, Hong KS, Cho YJ, Choi JC, Park TH, Park SS, Kwon JH, Kim WJ, Lee J, Lee JS, Lee J, Gorelick PB, Bae HJ
Institution:From the Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea (K.-J.L., B.J.K., M.-K.H., H.-J.B.).
Journal:Stroke. 2020 Jan;51(1):162-169. doi: 10.1161/STROKEAHA.119.026847. Epub 2019 Dec 4.

13:Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin in Patients With Chronic Kidney Disease and Atrial Fibrillation.
Authors:Makani A, Saba S, Jain SK, Bhonsale A, Sharbaugh MS, Thoma F, Wang Y, Marroquin OC, Lee JS, Estes NAM, Mulukutla SR
Institution:Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:
Journal:Am J Cardiol. 2020 Jan 15;125(2):210-214. doi: 10.1016/j.amjcard.2019.10.033. Epub 2019 Nov 1.

14:Impact of Lifestyle Modification on Atrial Fibrillation.
Authors:Wingerter R, Steiger N, Burrows A, Estes NAM 3rd
Institution:College of Medicine at University of Central Florida, Orlando, Florida. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Journal:Am J Cardiol. 2020 Jan 15;125(2):289-297. doi: 10.1016/j.amjcard.2019.10.018. Epub 2019 Oct 26.

15:Atrial Fibrillation in Heart Failure: Focus on Antithrombotic Management.
Authors:Obeidat M, Burgess M, Lip GYH
Institution:Department of Cardiology, Aintree Hospital, Liverpool, UK. Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg Un
Journal:Heart Fail Clin. 2020 Jan;16(1):107-120. doi: 10.1016/j.hfc.2019.08.007.

16:Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation.
Authors:Loring Z, Shrader P, Allen LA, Blanco R, Chan PS, Ezekowitz MD, Fonarow GC, Freeman JV, Gersh BJ, Mahaffey KW, Naccarelli GV, Pieper K, Reiffel JA, Singer DE, Steinberg BA, Thomas LE, Peterson ED, Piccini JP
Institution:Division of Cardiology, Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address:
Journal:Am Heart J. 2020 Jan;219:21-30. doi: 10.1016/j.ahj.2019.10.008. Epub 2019 Nov 8.

17:Incidence and predictors of atrial fibrillation episodes as detected by implantable loop recorder in patients at risk: From the LOOP study.
Authors:Diederichsen SZ, Haugan KJ, Brandes A, Graff C, Krieger D, Kronborg C, Holst AG, Nielsen JB, K√łber L, H√łjberg S, Svendsen JH
Institution:Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark. Electronic address: Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, Copenhagen U
Journal:Am Heart J. 2020 Jan;219:117-127. doi: 10.1016/j.ahj.2019.09.009. Epub 2019 Oct 20.

18:Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period.
Authors:Karamchandani K, Khanna AK, Bose S, Fernando RJ, Walkey AJ
Institution:From the Department of Anesthesiology & Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania. Evans Center for Implementation and Improvement Sciences, Department of Medicine and the Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts.
Journal:Anesth Analg. 2020 Jan;130(1):2-13. doi: 10.1213/ANE.0000000000004474.

19:Long-term Outcomes of Stand-Alone Maze IV for Persistent or Long-standing Persistent Atrial Fibrillation.
Authors:Lapenna E, De Bonis M, Giambuzzi I, Del Forno B, Ruggeri S, Cireddu M, Gulletta S, Castiglioni A, Alfieri O, Della Bella P, Benussi S
Institution:Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: Department of Cardiac Surgery, Spedali Civili di Brescia, University Hospital, Brescia, Italy.
Journal:Ann Thorac Surg. 2020 Jan;109(1):124-131. doi: 10.1016/j.athoracsur.2019.05.061. Epub 2019 Jul 17.

20:Triple, dual, and single antithrombotic therapy for patients with atrial fibrillation undergoing percutaneous coronary intervention.
Authors:Saito Y, Kobayashi Y
Institution:Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
Journal:Cardiovasc Interv Ther. 2020 Jan;35(1):44-51. doi: 10.1007/s12928-019-00600-1. Epub 2019 Jul 8.

21:Direct oral anticoagulants versus vitamin K antagonists in real-world patients with nonvalvular atrial fibrillation. The FANTASIIA study.
Authors:Anguita S√°nchez M, Bertomeu Mart√≠nez V, Ruiz Ortiz M, Cequier Fillat √Ā, Rold√°n Rabad√°n I, Mu√Īiz Garc√≠a J, Badim√≥n Maestro L, Esteve Pastor MA, Mar√≠n Ortu√Īo F
Institution:Servicio de Cardiologia, Hospital Universitario Reina Sofia, Cordoba, Spain. Electronic address: Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, CIBERCV, EL Palmar, Murcia, Spain.
Journal:Rev Esp Cardiol (Engl Ed). 2020 Jan;73(1):14-20. doi: 10.1016/j.rec.2019.02.021. Epub 2019 May 31.

22:Left atrial appendage occlusion in patients older than 85 years. Safety and efficacy in the EWOLUTION registry.
Authors:Cruz-Gonz√°lez I, Ince H, Kische S, Schmitz T, Schmidt B, Gori T, Foley D, de Potter T, Tschishow W, Vireca E, Stein K, Boersma LV
Institution:Servicio de Cardiologia, Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares (CIBER-CV Cardiologie, St Antonius Hospital, Nieuwegein, The Netherlands.
Journal:Rev Esp Cardiol (Engl Ed). 2020 Jan;73(1):21-27. doi: 10.1016/j.rec.2019.02.008. Epub 2019 Apr 5.

23:Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation.
Authors:Ojo A, Yandrapalli S, Veseli G, Karim M, Aronow WS, Sharma M, Frishman WH, Naidu SS, Jacobson JT, Iwai S
Institution:From the Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.
Journal:Cardiol Rev. 2020 Jan/Feb;28(1):42-51. doi: 10.1097/CRD.0000000000000240.

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