Atrial Fibrillation
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Prevalence, Management, and Outcome of Atrial Fibrillation and Other Supraventricular Arrhythmias in COVID-19 Patients.
Authors:Magnocavallo M, Vetta G, Della Rocca DG, Gianni C, Mohanty S, Bassiouny M, Di Lullo L, Del Prete A, Cirone D, Lavalle C, Chimenti C, Al-Ahmad A, Burkhardt JD, Gallinghouse GJ, Sanchez JE, Horton RP, Di Biase L, Natale A
Institution:Texas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N. IH-35, Suite 720, Austin, TX 78705, USA; Department of Cardiovascular/Respiratory Diseases, Nephrology, Anesthesiology, and Geriatric Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N. IH-35, Suite 720, Austin, TX 78705, USA; Interventional Electrophysiology, Scripps Clinic, La Jolla, CA, USA; Department of Cardiology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Journal:Card Electrophysiol Clin. 2022 Mar;14(1):1-9. doi: 10.1016/j.ccep.2021.10.001. Epub 2022 Jan 22.

2:Optimal anticoagulation in elderly patients with atrial fibrillation: Which drug at which dose?
Authors:Liao JN, Chan YH, Kuo L, Tsai CT, Lim SS, Chao TF
Institution:Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal:Kardiol Pol. 2022;80(2):128-136. doi: 10.33963/KP.a2022.0046. Epub 2022 Feb 15.

3:Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration.
Authors:Rivard L, Friberg L, Conen D, Healey JS, Berge T, Boriani G, Brandes A, Calkins H, Camm AJ, Yee Chen L, Lluis Clua Espuny J, Collins R, Connolly S, Dagres N, Elkind MSV, Engdahl J, Field TS, Gersh BJ, Glotzer TV, Hankey GJ, Harbison JA, Georg Haeusler K, Hills MT, Johnson LSB, Joung B, Khairy P, Kirchhof P, Krieger D, Lip GYH, Løchen ML, Madhavan M, Mairesse GH, Montaner J, Ntaios G, Quinn TJ, Rienstra M, Rosenqvist M, Sandhu RK, Smyth B, Schnabel RB, Stavrakis S, Themistoclakis S, Van Gelder IC, Wang JG, Freedman B
Institution:Montreal Heart Institute, Universite de Montreal, Canada (L.R., P. Khairy). Charles Perkins Centre and Concord Hospital Cardiology, University of Sydney, Australia (B.F.).
Journal:Circulation. 2022 Feb;145(5):392-409. doi: 10.1161/CIRCULATIONAHA.121.055018. Epub 2022 Jan 31.

4:Efficacy and safety of same-day discharge after atrial fibrillation ablation: A systematic review and meta-analysis.
Authors:Rashedi S, Tavolinejad H, Kazemian S, Mardani M, Masoudi M, Masoudkabir F, Haghjoo M
Institution:Department of Cardiac Electrophysiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Cardiac Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Journal:Clin Cardiol. 2022 Feb;45(2):162-172. doi: 10.1002/clc.23778. Epub 2022 Jan 27.

5:Management of Atrial Fibrillation in Patients 75 Years and Older: JACC State-of-the-Art Review.
Authors:Volgman AS, Nair G, Lyubarova R, Merchant FM, Mason P, Curtis AB, Wenger NK, Aggarwal NT, Kirkpatrick JN, Benjamin EJ
Institution:Division of Cardiology, Rush University Medical Center, Chicago, Illinois, USA. Electronic address: Boston Medical Center, and Boston University School of Medicine and School of Public Health, Boston, Massachusetts, USA.
Journal:J Am Coll Cardiol. 2022 Jan 18;79(2):166-179. doi: 10.1016/j.jacc.2021.10.037.

6:Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics.
Authors:Sagris M, Vardas EP, Theofilis P, Antonopoulos AS, Oikonomou E, Tousoulis D
Institution:1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Journal:Int J Mol Sci. 2021 Dec 21;23(1):6. doi: 10.3390/ijms23010006.

7:Net clinical benefit of direct oral anticoagulants in atrial fibrillation patients with or without diabetes mellitus: A meta-analysis of outcome trials.
Authors:Drogkaris S, Thomopoulos C, Kalos T, Manta E, Tsioufis C
Institution:First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Journal:Diabetes Res Clin Pract. 2021 Dec;182:109147. doi: 10.1016/j.diabres.2021.109147. Epub 2021 Nov 15.

8:Cardioversion of recent-onset atrial fibrillation using intravenous antiarrhythmics: A European perspective.
Authors:Lévy S
Institution:Marseille School of Medicine, Aix-Marseille University, Marseille, France.
Journal:J Cardiovasc Electrophysiol. 2021 Dec;32(12):3259-3269. doi: 10.1111/jce.15264. Epub 2021 Oct 25.

9:Laser balloon in pulmonary vein isolation for atrial fibrillation: current status and future prospects.
Authors:Tohoku S, Bordignon S, Bologna F, Chen S, Urbanek L, Operhalski F, Chun KJ, Schmidt B
Institution:Academy for Arrhythmias (FAFA), Abteilung fur Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Cardioangiologisches Centrum Bethanien, Frankfurt, Germany.
Journal:Expert Rev Med Devices. 2021 Nov;18(11):1083-1091. doi: 10.1080/17434440.2021.1990754. Epub 2021 Oct 20.

10:Recent clinical trials in atrial fibrillation.
Authors:Flautt T, Valderrábano M
Institution:Division of Electrophysiology, Department of Cardiology, Department of Medicine, Houston Methodist Debakey, Houston, Texas, USA.
Journal:Curr Opin Cardiol. 2021 Nov 1;36(6):798-802. doi: 10.1097/HCO.0000000000000914.

11:Ischaemic stroke in anticoagulated patients with atrial fibrillation.
Authors:Stretz C, Wu TY, Wilson D, Seiffge DJ, Smith EE, Gurol ME, Yaghi S
Institution:Department of Neurology, Brown University, Providence, Rhode Island, USA. Bern, Switzerland. Canada.
Journal:J Neurol Neurosurg Psychiatry. 2021 Nov;92(11):1164-1172. doi: 10.1136/jnnp-2020-323963. Epub 2021 Aug 26.

12:Rate control strategies for atrial fibrillation.
Authors:Alobaida M, Alrumayh A
Institution:Department of Basic Sciences, Prince Sultan bin Abdulaziz College for Emergency Medical Services, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Journal:Ann Med. 2021 Dec;53(1):682-692. doi: 10.1080/07853890.2021.1930137.

13:Pre-existing atrial fibrillation is associated with increased mortality in COVID-19 Patients.
Authors:Zuin M, Rigatelli G, Bilato C, Zanon F, Zuliani G, Roncon L
Institution:Department of Translational Medicine, University of Ferrara, Ferrara, Italy. Misericordia Hospital, Viale Tre Martiri, 45100, Rovigo, Italy. Hospital, Rovigo, Italy. Misericordia Hospital, Viale Tre Martiri, 45100, Rovigo, Italy.
Journal:J Interv Card Electrophysiol. 2021 Nov;62(2):231-238. doi: 10.1007/s10840-021-00992-2. Epub 2021 Apr 15.

14:Catheter ablation superiority over the pharmacological treatments in atrial fibrillation: a dedicated review.
Authors:Alrumayh A, Alobaida M
Institution:Department of Basic Sciences, King Saud University, Riyadh, Saudi Arabia.
Journal:Ann Med. 2021 Dec;53(1):551-557. doi: 10.1080/07853890.2021.1905873.

15:Mortality in atrial fibrillation. Is it changing?
Authors:Alonso A, Almuwaqqat Z, Chamberlain A
Institution:Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, CNR 3051, Atlanta, GA 30322, United States. Electronic address: Atlanta, GA, United States.
Journal:Trends Cardiovasc Med. 2021 Nov;31(8):469-473. doi: 10.1016/j.tcm.2020.10.010. Epub 2020 Oct 27.

16:The management of atrial fibrillation in heart failure: an expert panel consensus.
Authors:Farmakis D, Chrysohoou C, Giamouzis G, Giannakoulas G, Hamilos M, Naka K, Tzeis S, Xydonas S, Karavidas A, Parissis J
Institution:Shakolas Educational Center for Clinical Medicine, University of Cyprus Medical School, Palaios dromos Lefkosias Lemesou No.215/6, Aglantzia, 2029, Nicosia, Cyprus. Heart Failure Unit, Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Journal:Heart Fail Rev. 2021 Nov;26(6):1345-1358. doi: 10.1007/s10741-020-09978-0.

17:Effect of non-vitamin K antagonist oral anticoagulants versus warfarin in heart failure patients with atrial fibrillation.
Authors:Chen F, Zhou Y, Wan Q, Yu P, Ma J, Hu J
Institution:Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, 330006, Jiangxi, China. The Affiliated Children's Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. Nanchang University, Nanchang, 330006, Jiangxi, China. Nanchang University, Nanchang, 330006, Jiangxi, China. of Medicine, Cincinnati, OH, 45267, USA. Nanchang University, Nanchang, 330006, Jiangxi, China.
Journal:Heart Fail Rev. 2021 Nov;26(6):1391-1397. doi: 10.1007/s10741-020-09946-8.

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