Atrial Fibrillation
December 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Is ablation to atrial fibrillation termination of persistent atrial fibrillation the end point?: A systematic review and meta-analysis.
Authors:Li F, Tu X, Li D, Jiang Y, Cheng Y, Jia Y, Zhang X, Fu H, Hu H, Jiang J, Zeng R
Institution:Department of Cardiology. Cardiology, West China Hospital. Cardiology, West China Hospital.
Journal:Medicine (Baltimore). 2019 Nov;98(47):e18045. doi: 10.1097/MD.0000000000018045.

2:Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.
Authors:Valembois L, Audureau E, Takeda A, Jarzebowski W, Belmin J, Lafuente-Lafuente C
Institution:Service de Geriatrie a Orientation Cardiologique et Neurologique, Groupe Hospitalier Pitie-Salpetriere-Charles Foix, AP-HP, Universite Pierre et Marie Curie, 7 avenue de la Republique, Ivry-sur-Seine, France, 94200.
Journal:Cochrane Database Syst Rev. 2019 Sep 4;9:CD005049. doi: 10.1002/14651858.CD005049.pub5.

3:Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease.
Authors:Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H
Institution:From the National Cerebral and Cardiovascular Center, Suita (S.Y., H.O.), the Department of Cardiology, Osaka Police Hospital, Osaka (A.H.), the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (K. Kaikita), and the Department of General Medicine, Kumamoto University Hospital (K. Matsui), Kumamoto, the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M.A.), the Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara (J.A.), the Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka (T.M.), the Division of Cardiovascular Medicine, Toho University Ohashi Medical Center (M.N.), the Department of Cardiology, Juntendo University School of Medicine (K. Miyauchi), and the Department of Cardiology, Tokyo Women's Medical University (N.H.), Tokyo, and the Cardiovascular Center, Yokohama City University Medical Center, Yokohama (K. Kimura) - all in Japan.
Journal:N Engl J Med. 2019 Sep 19;381(12):1103-1113. doi: 10.1056/NEJMoa1904143. Epub 2019 Sep 2.

4:Recent advances in cryoballoon ablation for atrial fibrillation.
Authors:Osorio TG, Coutino HE, Brugada P, Chierchia GB, De Asmundis C
Institution:Heart Rhythm Management Centre, Postgraduate course in Cardiac Electrophysiology and Pacing, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel , Brussels , Belgium.
Journal:Expert Rev Med Devices. 2019 Sep;16(9):799-808. doi: 10.1080/17434440.2019.1653181. Epub 2019 Aug 16.

5:Stroke Prevention in Atrial Fibrillation: The Role of Oral Anticoagulation.
Authors:Mtwesi V, Amit G
Institution:Division of Cardiology, Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada. Electronic address:
Journal:Med Clin North Am. 2019 Sep;103(5):847-862. doi: 10.1016/j.mcna.2019.05.006.

6:Pharmacologic and Nonpharmacologic Management of Atrial Fibrillation.
Authors:Dahya V, Taigen TL
Institution:Cardiovascular Disease, Summa Health System, NEOMED University, Akron City Hospital, 95 Arch Street, Suite 300, Akron, OH 44304, USA. Heart and Vascular Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue/J2, Cleveland, OH 44195, USA. Electronic address:
Journal:Med Clin North Am. 2019 Sep;103(5):835-846. doi: 10.1016/j.mcna.2019.04.004. Epub 2019 Jul 1.

7:Edoxaban Versus Warfarin Stratified by Average Blood Pressure in 19 679 Patients With Atrial Fibrillation and a History of Hypertension in the ENGAGE AF-TIMI 48 Trial.
Authors:Park S, Bergmark BA, Shi M, Lanz HJ, Chung N, Ruff CT, Antman EM, Braunwald E, Giugliano RP
Institution:From the Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea (S.P., N.C.).; Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (B.A.B., C.T.R., E.M.A., E.B., R.P.G.).; Daiichi Sankyo, Inc., Basking Ridge, NJ (M.S.).; Daiichi Sankyo Europe GmbH, Munich, Germany (H.J.L.).
Journal:Hypertension. 2019 Sep;74(3):597-605. doi: 10.1161/HYPERTENSIONAHA.119.13138. Epub 2019 Jul 29.

8:Resting Heart Rate and the Risk of Atrial Fibrillation.
Authors:Liu X, Guo N, Zhu W, Zhou Q, Liu M, Chen C, Yuan P, Wan R, Hong K
Institution:Department of Cardiology, The Second Affiliated Hospital of Nanchang University.
Journal:Int Heart J. 2019 Jul 27;60(4):805-811. doi: 10.1536/ihj.18-470. Epub 2019 Jun 14.

9:Pharmacotherapeutic strategies for atrial fibrillation in pregnancy.
Authors:Georgiopoulos G, Tsiachris D, Kordalis A, Kontogiannis C, Spartalis M, Pietri P, Magkas N, Stefanadis C
Institution:Department of Cardiology, Athens Medical Center , Athens , Greece. Kapodistrian University of Athens , Athens , Greece. Kapodistrian University of Athens , Athens , Greece. University of Athens , Athens , Greece.
Journal:Expert Opin Pharmacother. 2019 Sep;20(13):1625-1636. doi: 10.1080/14656566.2019.1621290. Epub 2019 May 28.

10:Pharmacotherapy for Patients with Atrial Fibrillation and Cerebral Microbleeds.
Authors:Badi MK, Vilanilam GK, Gupta V, Barrett KM, Lesser ER, Cochuyt JJ, Hodge DO, Brott TG, Meschia JF
Institution:Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida. Florida. Florida. Florida. address:
Journal:J Stroke Cerebrovasc Dis. 2019 Aug;28(8):2159-2167. doi: 10.1016/j.jstrokecerebrovasdis.2019.04.027. Epub 2019 May 15.

11:Atrial Fibrillation: An Underestimated Cause of Ischemic Monocular Visual Loss?
Authors:Zarkali A, Cheng SF, Dados A, Simister R, Chandratheva A
Institution:Hyperacute Stroke Unit, University College London Hospital, United Kingdom. Electronic address: Kingdom.
Journal:J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1495-1499. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.017. Epub 2019 Mar 29.

12:Cardiovascular outcome in type 2 diabetes and atrial fibrillation.
Authors:Costard-Jackle A, Tschope D, Meinertz T
Institution:Diabetes Center at Heart and Diabetes Center NRW, Ruhr University Bochum, Georg Str. 5, 32549, Bad Oeynhausen, Germany. Str. 5, 32549, Bad Oeynhausen, Germany. Frankfurt/Main, Germany.
Journal:Herz. 2019 Sep;44(6):522-525. doi: 10.1007/s00059-018-4704-4. Epub 2018 May 2.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Atrial Fibrillation has enhanced and clearly explained this condition for me. It has also enabled me to make choices with confidence regarding my treatment. The references in the medical literature section has put me in touch with the research base in this country. Many thanks."
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