Atrial Fibrillation
June 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Early Recurrence after Longstanding Persistent Atrial Fibrillation Ablation.
Authors:Takayama K, Hachiya H, Iesaka Y, Hirao K, Isobe M
Institution:Department of Cardiovascular Medicine, Tokyo Medical and Dental University.
Journal:Int Heart J. 2018 Mar 30;59(2):321-327. doi: 10.1536/ihj.16-652. Epub 2018 Mar 20.

2:Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation.
Authors:Bruins Slot KM, Berge E
Institution:Department of Internal Medicine, Oslo University Hospital, Oslo, Norway, NO-0407.
Journal:Cochrane Database Syst Rev. 2018 Mar 6;3:CD008980. doi: 10.1002/14651858.CD008980.pub3.

3:A new clinical decision support tool for improving the adequacy of anticoagulant therapy and reducing the incidence of stroke in nonvalvular atrial fibrillation: A randomized clinical trial in primary care.
Authors:Dalmau Llorca MR, Goncalves AQ, Forcadell Drago E, Fernandez-Saez J, Hernandez Rojas Z, Pepio Vilaubi JM, Rodriguez Cumplido D, Morral Parente RM, Aguilar Martin C
Institution:Equip d'Atencio Primaria Tortosa Oest, Institut Catala de la Salut. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. Institut Catala de la Salut, Tortosa. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. de la Salut, Tortosa, Tarragona, Spain.
Journal:Medicine (Baltimore). 2018 Jan;97(3):e9578. doi: 10.1097/MD.0000000000009578.

4:Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care.
Authors:Kumar S, de Lusignan S, McGovern A, Correa A, Hriskova M, Gatenby P, Jones S, Goldsmith D, Camm AJ
Institution:Centre for Medical Imaging, University College London, London, UK. Guildford, UK. Guildford, UK. Guildford, UK. UK. Guildford, UK. UK. Guildford, UK. Guildford, UK. School of Medicine, New York, USA. London, UK. Foundation Trust, London, UK. London, UK
Journal:BMJ. 2018 Feb 14;360:k342.

5:Comparison of Rhythm and Rate Control Strategies for Stroke Occurrence in a Prospective Cohort of Atrial Fibrillation Patients.
Authors:Choi YJ, Kang KW, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Shim J, Uhm JS, Kim J, Park HW, Choi EK, Kim JB, Kim C, Lee YS, Joung B
Institution:Division of Cardiology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Korea.; Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea.; Department of Cardiology, School of Medicine, Ewha Womans University, Seoul, Korea.
Journal:Yonsei Med J. 2018 Mar;59(2):258-264. doi: 10.3349/ymj.2018.59.2.258.

6:Gender specific considerations in atrial fibrillation treatment: a review.
Authors:Mohanty S, Trivedi C, Gianni C, Natale A
Institution:a Texas Cardiac Arrhythmia Institute , St. David's Medical Center , Austin , TX , USA. USA. USA. USA. San Francisco , CA , USA. Medicine , Cleveland , OH , USA.
Journal:Expert Opin Pharmacother. 2018 Mar;19(4):365-374. doi: 10.1080/14656566.2018.1434144. Epub 2018 Feb 9.

7:Catheter Ablation for Atrial Fibrillation with Heart Failure.
Authors:Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bansch D
Institution:From the Comprehensive Arrhythmia Research and Management Center, Division of Cardiovascular Medicine, School of Medicine, University of Utah Health, Salt Lake City (N.F.M.); Klinikum Coburg, Coburg (J.B.), Kardiologie an den Ev. Elisabeth-Kliniken (D.A.) and Biotronik (J.P., H.S.), Berlin, Klinik Rotes Kreuz, Frankfurt/Main (J.S.), Klinikum Links der Weser, Bremen (L.B.), Deutsches Herzzentrum Munchen, Munich (H.C.), Institute of Medical Statistics and Computational Biology, Cologne (D.B.), and KMG Klinikum, Gustrow (J.V.) - all in Germany; Antonius Ziekenhuis Nieuwegein, Nieuwegein (L.J.), and the Erasmus University Medical Center, Rotterdam (B.M.) - both in the Netherlands; Semmelweis Medical University, Budapest, Hungary (E.P.); and the State Research Institute of Circulation Pathology, Novosibirsk, Russia (P.S.).
Journal:N Engl J Med. 2018 Feb 1;378(5):417-427. doi: 10.1056/NEJMoa1707855.

8:Anticoagulant and antiplatelet therapy choices for patients with atrial fibrillation one year after coronary stenting or acute coronary syndrome.
Authors:Olivier CB, Turakhia MP, Mahaffey KW
Institution:a Stanford Center for Clinical Research (SCCR), Department of Medicine , Stanford University School of Medicine , Stanford , CA , USA. of Medicine , Stanford , CA , USA. of Medicine , Stanford , CA , USA. University School of Medicine , Stanford , CA , USA.
Journal:Expert Opin Drug Saf. 2018 Mar;17(3):251-258. doi: 10.1080/14740338.2018.1424827. Epub 2018 Jan 24.

9:Predictors of the need for pacemaker implantation after the Cox maze IV procedure for atrial fibrillation.
Authors:Masaki N, Kawamoto S, Motoyoshi N, Adachi O, Kumagai K, Kawatsu S, Hayatsu Y, Katahira S, Hosoyama K, Akiyama M, Saiki Y
Institution:Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Seiryocho, Aoba-ku, Sendai, 980-8574, Japan.
Journal:Surg Today. 2018 May;48(5):495-501. doi: 10.1007/s00595-017-1614-7. Epub 2017 Dec 16.

10:Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.
Authors:Larsson SC, Drca N, Jensen-Urstad M, Wolk A
Institution:Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: Stockholm, Sweden. Stockholm, Sweden. Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Journal:Am Heart J. 2018 Jan;195:86-90. doi: 10.1016/j.ahj.2017.09.013. Epub 2017 Sep 21.

11:Predictors of perioperative major bleeding in patients who interrupt warfarin for an elective surgery or procedure: Analysis of the BRIDGE trial.
Authors:Clark NP, Douketis JD, Hasselblad V, Schulman S, Kindzelski AL, Ortel TL
Institution:Kaiser Permanente Colorado, Aurora, CO. Electronic address: Rockville, MD.
Journal:Am Heart J. 2018 Jan;195:108-114. doi: 10.1016/j.ahj.2017.09.015. Epub 2017 Sep 21.

12:Oral anticoagulation therapy upon discharge in hospitalized patients with nonvalvular atrial fibrillation: a retrospective cohort study.
Authors:Singh-Franco D, Hale G, Jacobs RJ
Institution:a Department of Pharmacy Practice , Nova Southeastern University College of Pharmacy , Fort Lauderdale , FL , USA.
Journal:Hosp Pract (1995). 2018 Feb;46(1):22-29. doi: 10.1080/21548331.2018.1415621. Epub 2017 Dec 18.

13:New anticoagulants for venous thromboembolism and atrial fibrillation: what the future holds.
Authors:Dimitropoulos G, Rahim SMZ, Moss AS, Lip GYH
Institution:a Institute of Cardiovascular Sciences , University of Birmingham , Birmingham , UK. UK. UK. UK. University , Aalborg , Denmark.
Journal:Expert Opin Investig Drugs. 2018 Jan;27(1):71-86. doi: 10.1080/13543784.2018.1416090. Epub 2017 Dec 14.

14:Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Authors:Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH
Institution:From the Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom (M.P., I.R., G.F.R., G.Y.H.L.); Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy (M.P.); Department of Public Health and Infectious Disease, Sapienza-University of Rome, Italy (A.F.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark (G.Y.H.L.).
Journal:Stroke. 2018 Jan;49(1):98-106. doi: 10.1161/STROKEAHA.117.018395. Epub 2017 Nov 22.

15:Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and End-Stage Renal Disease.
Authors:Nishimura M, Hsu JC
Institution:Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, California. Electronic address:
Journal:Am J Cardiol. 2018 Jan 1;121(1):131-140. doi: 10.1016/j.amjcard.2017.09.030. Epub 2017 Oct 12.

16:Efficacy and safety of rivaroxaban in extreme elderly patients with atrial fibrillation: Analysis of the Shikoku Rivaroxaban Registry Trial (SRRT).
Authors:Bando S, Nishikado A, Hiura N, Ikeda S, Kakutani A, Yamamoto K, Kaname N, Fukatani M, Takagi Y, Yukiiri K, Fukuda Y, Nakaya Y
Institution:Department of Arrhythmia, Kagawa Prefectural Shirotori Hospital, Kagawa, Japan. Electronic address:
Journal:J Cardiol. 2018 Feb;71(2):197-201. doi: 10.1016/j.jjcc.2017.08.005. Epub 2017 Sep 29.

17:Smoking and risk of atrial fibrillation.
Authors:Watanabe I
Institution:Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. Electronic address:
Journal:J Cardiol. 2018 Feb;71(2):111-112. doi: 10.1016/j.jjcc.2017.08.001. Epub 2017 Sep 14.

18:Smoking and risk of atrial fibrillation in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Authors:Imtiaz Ahmad M, Mosley CD, O'Neal WT, Judd SE, McClure LA, Howard VJ, Howard G, Soliman EZ
Institution:Department of Medicine, Section on Hospital Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Birmingham, Birmingham, AL, USA. Medicine, Atlanta, GA, USA. Birmingham, Birmingham, AL, USA. Drexel University, Philadelphia, PA, USA. Birmingham, Birmingham, AL, USA. Birmingham, Birmingham, AL, USA. and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:
Journal:J Cardiol. 2018 Feb;71(2):113-117. doi: 10.1016/j.jjcc.2017.07.014. Epub 2017 Sep 5.

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