Atrial Fibrillation
October 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Stroke prevention and guideline adherent antithrombotic treatment in elderly patients with atrial fibrillation: A real-world experience.
Authors:Gorczyca I, Jelonek O, Michalska A, Chrapek M, Wałek P, Wożakowska-Kapłon B
Institution:a1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre bCollegium Medicum, The Jan Kochanowski University cFaculty of Mathematics and Natural Sciences, The Jan Kochanowski Unive
Journal:Medicine (Baltimore). 2020 Jul 17;99(29):e21209. doi: 10.1097/MD.0000000000021209.

2:Usefulness of Long-Term Anticoagulation After Catheter Ablation of Atrial Fibrillation.
Authors:Arias R, Leef G, Daimee U, Sivasambu B, Akhtar T, Marine JE, Berger R, Calkins H, Spragg D
Institution:Johns Hopkins Hospital Division of Cardiology, Baltimore, Maryland.
Journal:Am J Cardiol. 2020 Aug 1;128:12-15. doi: 10.1016/j.amjcard.2020.04.036. Epub 2020 May 13.

3:Objectively Measured Physical Activity and the Risk of Atrial Fibrillation (from the REGARDS Study).
Authors:O'Neal WT, Bennett A, Singleton MJ, Judd SE, Howard G, Howard VJ, Hooker SP, Soliman EZ
Institution:Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. Electronic address: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE), Wake Fo
Journal:Am J Cardiol. 2020 Aug 1;128:107-112. doi: 10.1016/j.amjcard.2020.05.004. Epub 2020 May 15.

4:Dual anti-thrombotic treatment with direct anticoagulants improves clinical outcomes in patients with Atrial Fibrillation with ACS or undergoing PCI. A systematic review and meta-analysis.
Authors:De Rosa S, Sabatino J, Polimeni A, Sorrentino S, Indolfi C
Institution:Division of Cardiology, Department of Medical and Surgical Sciences, 'Magna Graecia' University, Catanzaro, Italy.
Journal:PLoS One. 2020 Jul 9;15(7):e0235511. doi: 10.1371/journal.pone.0235511. eCollection 2020.

5:Guidance on Short-Term Management of Atrial Fibrillation in Coronavirus Disease 2019.
Authors:Rattanawong P, Shen W, El Masry H, Sorajja D, Srivathsan K, Valverde A, Scott LR
Institution:Division of Heart Rhythm Services Department of Cardiovascular Diseases Mayo Clinic Arizona Phoenix AZ.
Journal:J Am Heart Assoc. 2020 Jul 21;9(14):e017529. doi: 10.1161/JAHA.120.017529. Epub 2020 Jun 9.

6:Atrial Fibrillation in COVID-19: From Epidemiological Association to Pharmacological Implications.
Authors:Russo V, Rago A, Carbone A, Bottino R, Ammendola E, Della Cioppa N, Galante D, Golino P, Nigro G
Institution:Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli,' Monaldi Hospital, Naples, Italy.
Journal:J Cardiovasc Pharmacol. 2020 Aug;76(2):138-145. doi: 10.1097/FJC.0000000000000854.

7:Non-Vitamin K Antagonist Oral Anticoagulant for Atrial Fibrillation in Obese Patients.
Authors:Wang SY, Giugliano RP
Institution:Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
Journal:Am J Cardiol. 2020 Jul 15;127:176-183. doi: 10.1016/j.amjcard.2020.04.016. Epub 2020 Apr 23.

8:Clinicians' views and experiences of prescribing oral anticoagulants for stroke prevention in atrial fibrillation: A qualitative meta-synthesis.
Authors:Pritchett RV, Clarke JL, Jolly K, Clarkesmith D, Bem D, Turner GM, Thomas GN, Lane DA
Institution:Institute of Applied Health Research, University of Birmingham, Birmingham, England, United Kingdom. Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom.
Journal:PLoS One. 2020 May 7;15(5):e0232484. doi: 10.1371/journal.pone.0232484. eCollection 2020.

9:Effectiveness and Safety of Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Diabetes Mellitus.
Authors:Lip GYH, Keshishian AV, Kang AL, Li X, Dhamane AD, Luo X, Balachander N, Rosenblatt L, Mardekian J, Nadkarni A, Pan X, Di Fusco M, Garcia Reeves AB, Yuce H, Deitelzweig SB
Institution:Liverpool Centre for Cardiovascular Science, at the Liverpool Heart & Chest Hospital, University of Liverpool, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medici Department of Hospital Medicine, Ochsner Clinic Foundation, New Orleans, LA; Queensland School of Medicine, University of Queensland School of Medicine, New Orleans, LA.
Journal:Mayo Clin Proc. 2020 May;95(5):929-943. doi: 10.1016/j.mayocp.2019.05.032.

10:Real-World Direct Comparison of the Effectiveness and Safety of Apixaban, Dabigatran, Rivaroxaban, and Warfarin in Medicare Beneficiaries With Atrial Fibrillation.
Authors:Yang L, Brooks MM, Glynn NW, Zhang Y, Saba S, Hernandez I
Institution:Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:
Journal:Am J Cardiol. 2020 Jul 1;126:29-36. doi: 10.1016/j.amjcard.2020.03.034. Epub 2020 Apr 10.

11:Meta-Analysis Comparing Direct Oral Anticoagulants Versus Warfarin in Morbidly Obese Patients With Atrial Fibrillation.
Authors:Kido K, Shimizu M, Shiga T, Hashiguchi M
Institution:Department of Clinical Pharmacy, West Virginia University School of Pharmacy, Morgantown, West Virginia. Electronic address: Division for Evaluation and Analysis of Drug Information, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Journal:Am J Cardiol. 2020 Jul 1;126:23-28. doi: 10.1016/j.amjcard.2020.03.048. Epub 2020 Apr 8.

12:Effect of Combined Pulmonary Vein and Superior Vena Cava Isolation on the Outcome of Second Catheter Ablation for Paroxysmal Atrial Fibrillation.
Authors:Zhang T, Wang Y, Liang Z, Zhao H, Han Z, Wang Y, Wu Y, Ren X
Institution:Department of Cardiology, Beijing Anzhen Hospital Affliated to Capital Medical University, Beijing, China. Electronic address:
Journal:Am J Cardiol. 2020 Jun 15;125(12):1845-1850. doi: 10.1016/j.amjcard.2020.03.030. Epub 2020 Apr 3.

13:History of Lyme Disease as a Predictor of Atrial Fibrillation.
Authors:Szymanska A, Platek AE, Dluzniewski M, Szymanski FM
Institution:Department of Heart Diseases, The Medial Centre of Postgraduate Education, Warsaw, Poland. 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Journal:Am J Cardiol. 2020 Jun 1;125(11):1651-1654. doi: 10.1016/j.amjcard.2020.03.003. Epub 2020 Mar 13.

14:Atrial Fibrillation and Cognitive Impairment: An Associated Burden or Burden by Association?
Authors:Manolis TA, Manolis AA, Apostolopoulos EJ, Melita H, Manolis AS
Institution:Red Cross Hospital, Athens, Greece. First and Third Department of Cardiology, Athens University School of Medicine, Athens, Greece.
Journal:Angiology. 2020 Jul;71(6):498-519. doi: 10.1177/0003319720910669. Epub 2020 Apr 1.

15:Risk of major cardiovascular and neurologic events with obstructive sleep apnea among patients with atrial fibrillation.
Authors:Dalgaard F, North R, Pieper K, Fonarow GC, Kowey PR, Gersh BJ, Mahaffey KW, Pokorney S, Steinberg BA, Naccarrelli G, Allen LA, Reiffel JA, Ezekowitz M, Singer DE, Chan PS, Peterson ED, Piccini JP
Institution:Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark; Duke Clinical Research Institute, Duke University, Durham, NC. Duke Clinical Research Institute, Duke University, Durham, NC. Electronic address:
Journal:Am Heart J. 2020 May;223:65-71. doi: 10.1016/j.ahj.2020.01.001. Epub 2020 Jan 7.

16:Rivaroxaban versus warfarin in patients with nonvalvular atrial fibrillation and stage IV-V chronic kidney disease.
Authors:Weir MR, Ashton V, Moore KT, Shrivastava S, Peterson ED, Ammann EM
Institution:University of Maryland School of Medicine, Baltimore, MD. Electronic address: Janssen Scientific Affairs, Titusville, NJ.
Journal:Am Heart J. 2020 May;223:3-11. doi: 10.1016/j.ahj.2020.01.010. Epub 2020 Jan 22.

17:Atrial fibrillation in patients with heart failure with preserved ejection fraction.
Authors:Aldaas OM, Malladi CL, Hsu JC
Institution:Division of Cardiac Electrophysiology at the University of California San Diego Health System, La Jolla, California, USA.
Journal:Curr Opin Cardiol. 2020 May;35(3):260-270. doi: 10.1097/HCO.0000000000000732.

18:Atrial Fibrillation After Cardiac Surgery: Electrophysiological Mechanism and Outcome.
Authors:Ehrlich MP, Osorio-Jaramillo E, Aref T, Coti I, Andreas M, Laufer G, Ad N
Institution:Division of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. Electronic address: Division of Cardiothoracic Surgery, Washington Adventist Hospital and University of Maryland, Tacoma Park, Maryland.
Journal:Ann Thorac Surg. 2020 Jun;109(6):1765-1772. doi: 10.1016/j.athoracsur.2019.12.069. Epub 2020 Feb 12.

19:Impact of atrial fibrillation on frailty and functionality in older adults.
Authors:Koca M, Yavuz BB, Tuna Doğrul R, Çalışkan H, Şengül Ayçiçek G, Özsürekçi C, Balcı C, Eşme M, Ünsal P, Halil M, Cankurtaran M
Institution:Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Department of Internal Medicine, Faculty of Medicine, Division of Geriatric Medicine, Hacettepe University, Ankara, Turkey.
Journal:Ir J Med Sci. 2020 Aug;189(3):917-924. doi: 10.1007/s11845-020-02190-x. Epub 2020 Jan 29.

20:Association of Erectile Dysfunction with Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA).
Authors:Tanaka Y, Bundy JD, Allen NB, Uddin SMI, Feldman DI, Michos ED, Heckbert SR, Greenland P
Institution:Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill. Electronic address:
Journal:Am J Med. 2020 May;133(5):613-620.e1. doi: 10.1016/j.amjmed.2019.08.052. Epub 2019 Nov 16.

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