Atrial Fibrillation
January 2019 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Comparison of dabigatran and warfarin used in patients with non-valvular atrial fibrillation: Meta-analysis of random control trial.
Authors:Yu YB, Liu J, Fu GH, Fang RY, Gao F, Chu HM
Institution:Arrhythmia Center, Ningbo First Hospital, Ningbo, Zhejiang, China.
Journal:Medicine (Baltimore). 2018 Nov;97(46):e12841. doi: 10.1097/MD.0000000000012841.

2:Atrial fibrillation and chronic kidney disease: A review of options for therapeutic anticoagulation to reduce thromboembolism risk.
Authors:Bhatia HS, Hsu JC, Kim RJ
Institution:Department of Medicine, Weill Cornell Medicine, New York, New York. Diego, California. Diego, California. New York.
Journal:Clin Cardiol. 2018 Oct;41(10):1395-1402. doi: 10.1002/clc.23085. Epub 2018 Oct 25.

3:Triple antithrombotic therapy in patients with atrial fibrillation undergoing PCI: current evidence and practice.
Authors:Clarke A, Ibrahim A, Kiernan TJ
Institution:a University of Limerick, Graduate Entry Medical School (GEMS) , Castletroy , Ireland.
Journal:Expert Rev Cardiovasc Ther. 2018 Oct;16(10):715-723. doi: 10.1080/14779072.2018.1521721. Epub 2018 Sep 20.

4:When are the cardiovascular and stroke risks too high? Pharmacotherapy for stroke prophylaxis.
Authors:Gomez-Outes A, Suarez-Gea ML, Garcia-Pinilla JM
Institution:a Division of Pharmacology and Clinical Drug Evaluation, Medicines for Human Use , Spanish Agency for Medicines and Medical Devices (AEMPS) , Madrid , Spain. , Spanish Agency for Medicines and Medical Devices (AEMPS) , Madrid , Spain. Malaga (IBIMA), Hospital Universitario Virgen de la Victoria , Malaga , Spain. de Salud Carlos III , Madrid , Spain.
Journal:Expert Opin Pharmacother. 2018 Sep;19(13):1427-1440. doi: 10.1080/14656566.2018.1511703. Epub 2018 Sep 8.

5:Non-vitamin-K oral anticoagulants (NOACs) for the prevention of secondary stroke.
Authors:Diener HC, Ntaios G, O'Donnell M, Easton JD
Institution:a Department of Neurology , University Hospital Essen , Essen , Germany. Sciences , Galway , Ireland. Francisco , CA , USA.
Journal:Expert Opin Pharmacother. 2018 Oct;19(14):1597-1602. doi: 10.1080/14656566.2018.1515913. Epub 2018 Sep 17.

6:Catheter ablation for atrial fibrillation: current patient selection and outcomes.
Authors:Walsh K, Marchlinski F
Institution:a Cardiac Electrophysiology Section, Cardiovascular Division , Hospital of University of Pennsylvania , Philadelphia , PA , USA. University of Pennsylvania , Philadelphia , PA , USA.
Journal:Expert Rev Cardiovasc Ther. 2018 Sep;16(9):679-692. doi: 10.1080/14779072.2018.1510317. Epub 2018 Aug 28.

7:Direct oral anticoagulants for stroke prevention in atrial fibrillation: treatment outcomes and dosing in special populations.
Authors:Stacy ZA, Richter SK
Institution:Division of Acute Care Pharmacy, Pharmacy Practice Department, St Louis College of Pharmacy, 4588 Parkview Place, St Louis, MO 63110-1088, USA. of Pharmacy, St Louis, MO, USA.
Journal:Ther Adv Cardiovasc Dis. 2018 Sep;12(9):247-262. doi: 10.1177/1753944718787384.

8:Atrial fibrillation in young patients.
Authors:Gourraud JB, Khairy P, Abadir S, Tadros R, Cadrin-Tourigny J, Macle L, Dyrda K, Mondesert B, Dubuc M, Guerra PG, Thibault B, Roy D, Talajic M, Rivard L
Institution:a Electrophysiology Service , Montreal Heart Institute, Universite de Montreal , Montreal , Canada.; b Department of Pediatric Cardiology , Sainte-Justine Hospital, Universite de Montreal , Montreal Canada.
Journal:Expert Rev Cardiovasc Ther. 2018 Jul;16(7):489-500. doi: 10.1080/14779072.2018.1490644. Epub 2018 Jul 2.

9:Biatrial versus Isolated Left Atrial Ablation in Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Authors:Li H, Lin X, Ma X, Tao J, Zou R, Yang S, Liu H, Hua P
Institution:Department of Cardiovascular Surgery, Quanzhou First Hospital of Fujian Medical University, Quanzhou 362000, China. University, Guangzhou 510120, China. University, Guangzhou 510120, China. University, Guangzhou 510120, China.
Journal:Biomed Res Int. 2018 Apr 29;2018:3651212. doi: 10.1155/2018/3651212. eCollection 2018.

10:Current Evidence-Based Understanding of the Epidemiology, Prevention, and Treatment of Atrial Fibrillation.
Authors:Rogers PA, Bernard ML, Madias C, Thihalolipavan S, Mark Estes NA 3rd, Morin DP
Journal:Curr Probl Cardiol. 2018 Jun;43(6):241-283. doi: 10.1016/j.cpcardiol.2017.06.001. Epub 2017 Jun 7.

11:Antithrombotic Therapy in Nonvalvular Atrial Fibrillation: Consensus and Challenges.
Authors:Khattak F, Alam MB, Paul TK, Rijal S, Wazir S, Lavie CJ, Saba S
Institution:Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: fhk2@pitt.edu. Virginia. Illinois. Pittsburgh, Pennsylvania. Queensland School of Medicine, New Orleans, Louisiana, Louisiana. Pittsburgh, Pennsylvania.
Journal:Am J Med Sci. 2018 May;355(5):467-476. doi: 10.1016/j.amjms.2018.01.013. Epub 2018 Jan 31.

12:Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study.
Authors:Staerk L, Wang B, Preis SR, Larson MG, Lubitz SA, Ellinor PT, McManus DD, Ko D, Weng LC, Lunetta KL, Frost L, Benjamin EJ, Trinquart L
Institution:National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, USA.; Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark.; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA.
Journal:BMJ. 2018 Apr 26;361:k1453. doi: 10.1136/bmj.k1453.

13:Clinical Characteristics and Efficacy of Radiofrequency Catheter Ablation in the Treatment of Elderly Patients with Atrial Fibrillation.
Authors:Zhang XY, Yu RH, Dong JZ
Institution:Emergency Center, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing, China. Electronic address: xinyongzhangdoc@163.com. Hospital, Beijing, China. Hospital, Beijing, China.
Journal:Am J Med Sci. 2018 Apr;355(4):357-361. doi: 10.1016/j.amjms.2017.12.002. Epub 2017 Dec 9.

14:Risk factors for new-onset atrial fibrillation: A focus on Asian populations.
Authors:Li Y, Pastori D, Guo Y, Wang Y, Lip GYH
Institution:Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom; Chinese PLA General Hospital, Chinese PLA Medical School, Department of Cardiology, Beijing, China. United Kingdom; I Clinica Medica, Atherothrombosis Center, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Cardiology, Beijing, China. Cardiology, Beijing, China. United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address: g.y.h.lip@bham.ac.uk.
Journal:Int J Cardiol. 2018 Jun 15;261:92-98. doi: 10.1016/j.ijcard.2018.02.051.

15:Atrial Fibrillation in Patients with Heart Failure: Current State and Future Directions.
Authors:Mene-Afejuku TO, Lopez PD, Akinlonu A, Dumancas C, Visco F, Mushiyev S, Pekler G
Institution:Department of Medicine, Health + Hospitals/Metropolitan, New York, NY, USA. persiod.lopez@gmail.com. New York, NY, USA. New York, NY, USA. New York, NY, USA.
Journal:Am J Cardiovasc Drugs. 2018 Oct;18(5):347-360. doi: 10.1007/s40256-018-0276-1.

16:Association between Sleep Apnea Hypopnea Syndrome and the Risk of Atrial Fibrillation: A Meta-Analysis of Cohort Study.
Authors:Zhao E, Chen S, Du Y, Zhang Y
Institution:Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Journal:Biomed Res Int. 2018 Jan 18;2018:5215868. doi: 10.1155/2018/5215868. eCollection 2018.

17:Restarting oral anticoagulant therapy after major bleeding in atrial fibrillation: A systematic review and meta-analysis.
Authors:Proietti M, Romiti GF, Romanazzi I, Farcomeni A, Staerk L, Nielsen PB, Lip GYH
Institution:Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom; IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, Milan, Italy. Rome, Italy. Hellerup, Denmark. Health, Aalborg University, Aalborg, Denmark. Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark. Electronic address: g.y.h.lip@bham.ac.uk.
Journal:Int J Cardiol. 2018 Jun 15;261:84-91. doi: 10.1016/j.ijcard.2018.03.053. Epub 2018 Mar 14.

18:Cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation: a meta-analysis of randomized controlled trials.
Authors:Murray MI, Arnold A, Younis M, Varghese S, Zeiher AM
Institution:Department of Cardiology, University Hospital Frankfurt, Frankfurt-am Main, Germany. marieisabel.murray@gmail.com. London, UK. marieisabel.murray@gmail.com. London, UK. College London, London, UK. London, UK. London, UK. Germany.
Journal:Clin Res Cardiol. 2018 Aug;107(8):658-669. doi: 10.1007/s00392-018-1232-4. Epub 2018 Mar 21.

19:Catheter ablation versus medical therapy for patients with persistent atrial fibrillation: a systematic review and meta-analysis of evidence from randomized controlled trials.
Authors:Chen C, Zhou X, Zhu M, Chen S, Chen J, Cai H, Dai J, Xu X, Mao W
Institution:Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. maoweilw@163.com.; The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Journal:J Interv Card Electrophysiol. 2018 Jun;52(1):9-18. doi: 10.1007/s10840-018-0349-8. Epub 2018 Mar 16.

20:Emerging pharmacotherapies for the treatment of atrial fibrillation.
Authors:Capucci A, Cipolletta L, Guerra F, Giannini I
Institution:a Department of Scienze Cardiovascolari , Clinica di Cardiologia Universita' Politecnica delle Marche - Scienze Cardiovascolari , Ancona , Italy.
Journal:Expert Opin Emerg Drugs. 2018 Mar;23(1):25-36. doi: 10.1080/14728214.2018.1446941. Epub 2018 Mar 13.

21:A new clinical decision support tool for improving the adequacy of anticoagulant therapy and reducing the incidence of stroke in nonvalvular atrial fibrillation: A randomized clinical trial in primary care.
Authors:Dalmau Llorca MR, Goncalves AQ, Forcadell Drago E, Fernandez-Saez J, Hernandez Rojas Z, Pepio Vilaubi JM, Rodriguez Cumplido D, Morral Parente RM, Aguilar Martin C
Institution:Equip d'Atencio Primaria Tortosa Oest, Institut Catala de la Salut. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. Institut Catala de la Salut, Tortosa. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. de la Salut, Tortosa, Tarragona, Spain.
Journal:Medicine (Baltimore). 2018 Jan;97(3):e9578. doi: 10.1097/MD.0000000000009578.

22:Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care.
Authors:Kumar S, de Lusignan S, McGovern A, Correa A, Hriskova M, Gatenby P, Jones S, Goldsmith D, Camm AJ
Institution:Centre for Medical Imaging, University College London, London, UK. Guildford, UK. Guildford, UK. Guildford, UK. UK. Guildford, UK. UK. Guildford, UK. Guildford, UK. School of Medicine, New York, USA. London, UK. Foundation Trust, London, UK. London, UK jcamm@sgul.ac.uk.
Journal:BMJ. 2018 Feb 14;360:k342. doi: 10.1136/bmj.k342.

23:Gender specific considerations in atrial fibrillation treatment: a review.
Authors:Mohanty S, Trivedi C, Gianni C, Natale A
Institution:a Texas Cardiac Arrhythmia Institute , St. David's Medical Center , Austin , TX , USA. USA. USA. USA. San Francisco , CA , USA. Medicine , Cleveland , OH , USA.
Journal:Expert Opin Pharmacother. 2018 Mar;19(4):365-374. doi: 10.1080/14656566.2018.1434144. Epub 2018 Feb 9.

24:Catheter Ablation for Atrial Fibrillation with Heart Failure.
Authors:Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bansch D
Institution:From the Comprehensive Arrhythmia Research and Management Center, Division of Cardiovascular Medicine, School of Medicine, University of Utah Health, Salt Lake City (N.F.M.); Klinikum Coburg, Coburg (J.B.), Kardiologie an den Ev. Elisabeth-Kliniken (D.A.) and Biotronik (J.P., H.S.), Berlin, Klinik Rotes Kreuz, Frankfurt/Main (J.S.), Klinikum Links der Weser, Bremen (L.B.), Deutsches Herzzentrum Munchen, Munich (H.C.), Institute of Medical Statistics and Computational Biology, Cologne (D.B.), and KMG Klinikum, Gustrow (J.V.) - all in Germany; Antonius Ziekenhuis Nieuwegein, Nieuwegein (L.J.), and the Erasmus University Medical Center, Rotterdam (B.M.) - both in the Netherlands; Semmelweis Medical University, Budapest, Hungary (E.P.); and the State Research Institute of Circulation Pathology, Novosibirsk, Russia (P.S.).
Journal:N Engl J Med. 2018 Feb 1;378(5):417-427. doi: 10.1056/NEJMoa1707855.

25:Dual (Anticoagulant Plus Single Antiplatelet) vs Triple (Anticoagulant Plus Dual Antiplatelet) Antithrombotic Therapy - "Real World" Experience.
Authors:Effron MB, Gibson CM
Institution:Division of Consultative Cardiology, John Ochsner Heart and Vascular Institute, New Orleans, LA, United States. Electronic address: mark.effron@ochsner.org. Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Journal:Prog Cardiovasc Dis. 2018 Jan - Feb;60(4-5):531-536. doi: 10.1016/j.pcad.2018.01.010. Epub 2018 Jan 31.

26:Comparison of Anticoagulant Therapy for Atrial Fibrillation - Novel Oral Anticoagulants Versus Vitamin K Antagonists.
Authors:Chen ST, Patel MR
Institution:Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, United States. Medicine, Durham, NC, United States; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States. Electronic address: manesh.patel@duke.edu.
Journal:Prog Cardiovasc Dis. 2018 Jan - Feb;60(4-5):514-523. doi: 10.1016/j.pcad.2018.01.005. Epub 2018 Jan 13.

27:Safety and Efficacy of Transcatheter Left Atrial Appendage Closure for Stroke Prevention in Patients with Atrial Fibrillation.
Authors:Price MJ
Institution:Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA, United States. Electronic address: price.matthew@scrippshealth.org.
Journal:Prog Cardiovasc Dis. 2018 Jan - Feb;60(4-5):542-549. doi: 10.1016/j.pcad.2018.01.002. Epub 2018 Jan 12.

28:Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.
Authors:Larsson SC, Drca N, Jensen-Urstad M, Wolk A
Institution:Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: susanna.larsson@ki.se. Stockholm, Sweden. Stockholm, Sweden. Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Journal:Am Heart J. 2018 Jan;195:86-90. doi: 10.1016/j.ahj.2017.09.013. Epub 2017 Sep 21.

29:Impact of Cardiorespiratory Fitness on Frequency of Atrial Fibrillation, Stroke, and All-Cause Mortality.
Authors:Hussain N, Gersh BJ, Gonzalez Carta K, Sydo N, Lopez-Jimenez F, Kopecky SL, Thomas RJ, Asirvatham SJ, Allison TG
Institution:Mayo Clinic, Rochester, Minnesota. University, Budapest, Hungary.
Journal:Am J Cardiol. 2018 Jan 1;121(1):41-49. doi: 10.1016/j.amjcard.2017.09.021. Epub 2017 Nov 13.

30:Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Authors:Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH
Institution:From the Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom (M.P., I.R., G.F.R., G.Y.H.L.); Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy (M.P.); Department of Public Health and Infectious Disease, Sapienza-University of Rome, Italy (A.F.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark (G.Y.H.L.). g.y.h.lip@bham.ac.uk.
Journal:Stroke. 2018 Jan;49(1):98-106. doi: 10.1161/STROKEAHA.117.018395. Epub 2017 Nov 22.

31:The impact of lifestyle intervention on atrial fibrillation.
Authors:Hong KL, Glover BM
Institution:Department of Cardiology, Queen's University, Kingston, Ontario, Canada.
Journal:Curr Opin Cardiol. 2018 Jan;33(1):14-19. doi: 10.1097/HCO.0000000000000470.

32:Atrial fibrillation and cardiac resynchronization therapy.
Authors:Gasparini M, Galimberti P
Institution:Electrophysiology and Pacing Unit, Humanitas Research Hospital, Rozzano, Milano, Italy.
Journal:Curr Opin Cardiol. 2018 Jan;33(1):1-6. doi: 10.1097/HCO.0000000000000472.

33:Sleep, sleep apnea and atrial fibrillation: Questions and answers.
Authors:Kwon Y, Koene RJ, Johnson AR, Lin GM, Ferguson JD
Institution:Division of Cardiovascular Medicine, Department of Medicine and Department of Sleep Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address: yk2j@hscmail.mcc.virginia.edu. Clinic Foundation, Cleveland, OH, USA. Sleep Medicine, University of Virginia, Charlottesville, VA, USA. Taiwan; Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; College of Science and Engineering, National Dong Hwa University, Hualien 974, Taiwan. Sleep Medicine, University of Virginia, Charlottesville, VA, USA.
Journal:Sleep Med Rev. 2018 Jun;39:134-142. doi: 10.1016/j.smrv.2017.08.005. Epub 2017 Sep 4.

34:Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis.
Authors:Bai Y, Guo SD, Deng H, Shantsila A, Fauchier L, Ma CS, Lip GYH
Institution:Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B18 7QH, UK. Beijing 100730, China. Hepingli, Chaoyang District, Beijing100029, China. of Medical Science, Guangzhou, China. 7QH, UK. Universitaire Trousseau et Faculte de Medecine, Universite Franis Rabelais, Tours, France. Beijing 100730, China. National Clinical Research Center for Cardiovascular Diseases, Beijing Shi, China. 7QH, UK. University, Aalborg, Denmark.
Journal:Age Ageing. 2018 Jan 1;47(1):9-17. doi: 10.1093/ageing/afx103.

35:Patients with atrial fibrillation and coronary artery disease - Double trouble.
Authors:Michniewicz E, Mlodawska E, Lopatowska P, Tomaszuk-Kazberuk A, Malyszko J
Institution:Department of Cardiology, Medical University in Bialystok, Bialystok, Poland. University, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland. Electronic address: jolmal@poczta.onet.pl.
Journal:Adv Med Sci. 2018 Mar;63(1):30-35. doi: 10.1016/j.advms.2017.06.005. Epub 2017 Aug 14.

36:Does atrial fibrillation cause cognitive decline and dementia?
Authors:Dietzel J, Haeusler KG, Endres M
Institution:Center for Stroke Research Berlin, Charite - Universitatsmedizin Berlin, Germany.
Journal:Europace. 2018 Mar 1;20(3):408-419. doi: 10.1093/europace/eux031.

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