Atrial Fibrillation
April 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:A new clinical decision support tool for improving the adequacy of anticoagulant therapy and reducing the incidence of stroke in nonvalvular atrial fibrillation: A randomized clinical trial in primary care.
Authors:Dalmau Llorca MR, Goncalves AQ, Forcadell Drago E, Fernandez-Saez J, Hernandez Rojas Z, Pepio Vilaubi JM, Rodriguez Cumplido D, Morral Parente RM, Aguilar Martin C
Institution:Equip d'Atencio Primaria Tortosa Oest, Institut Catala de la Salut. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. Institut Catala de la Salut, Tortosa. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. d'Investigacio en Atencio Primaria (IDIAP) Jordi Gol. de la Salut, Tortosa, Tarragona, Spain.
Journal:Medicine (Baltimore). 2018 Jan;97(3):e9578. doi: 10.1097/MD.0000000000009578.

2:Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care.
Authors:Kumar S, de Lusignan S, McGovern A, Correa A, Hriskova M, Gatenby P, Jones S, Goldsmith D, Camm AJ
Institution:Centre for Medical Imaging, University College London, London, UK. Guildford, UK. Guildford, UK. Guildford, UK. UK. Guildford, UK. UK. Guildford, UK. Guildford, UK. School of Medicine, New York, USA. London, UK. Foundation Trust, London, UK. London, UK
Journal:BMJ. 2018 Feb 14;360:k342.

3:Risk factors for heart failure hospitalizations among patients with atrial fibrillation.
Authors:Eggimann L, Blum S, Aeschbacher S, Reusser A, Ammann P, Erne P, Moschovitis G, Di Valentino M, Shah D, Schlapfer J, Mondet N, Kuhne M, Sticherling C, Osswald S, Conen D
Institution:Division of Cardiology, Department of Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. Basel, Basel, Switzerland. University of Basel, Basel, Switzerland. Basel, Basel, Switzerland. University of Basel, Basel, Switzerland.
Journal:PLoS One. 2018 Feb 2;13(2):e0191736. doi: 10.1371/journal.pone.0191736. eCollection 2018.

4:Chinese herbal medicine for patients with atrial fibrillation: protocol for a systematic review and meta-analysis.
Authors:Cai X, Wang Y, Li Z, Zhang Y, Wang D, Yan X
Institution:Guangzhou University of Chinese Medicine. Guangdong Provincial Hospital of Chinese Medicine. China. Guangdong Provincial Hospital of Chinese Medicine.
Journal:Medicine (Baltimore). 2017 Dec;96(50):e9228. doi: 10.1097/MD.0000000000009228.

5:Catheter Ablation for Atrial Fibrillation with Heart Failure.
Authors:Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bansch D
Institution:From the Comprehensive Arrhythmia Research and Management Center, Division of Cardiovascular Medicine, School of Medicine, University of Utah Health, Salt Lake City (N.F.M.); Klinikum Coburg, Coburg (J.B.), Kardiologie an den Ev. Elisabeth-Kliniken (D.A.) and Biotronik (J.P., H.S.), Berlin, Klinik Rotes Kreuz, Frankfurt/Main (J.S.), Klinikum Links der Weser, Bremen (L.B.), Deutsches Herzzentrum Munchen, Munich (H.C.), Institute of Medical Statistics and Computational Biology, Cologne (D.B.), and KMG Klinikum, Gustrow (J.V.) - all in Germany; Antonius Ziekenhuis Nieuwegein, Nieuwegein (L.J.), and the Erasmus University Medical Center, Rotterdam (B.M.) - both in the Netherlands; Semmelweis Medical University, Budapest, Hungary (E.P.); and the State Research Institute of Circulation Pathology, Novosibirsk, Russia (P.S.).
Journal:N Engl J Med. 2018 Feb 1;378(5):417-427. doi: 10.1056/NEJMoa1707855.

6:Apixaban 5 and 2.5 mg twice-daily versus warfarin for stroke prevention in nonvalvular atrial fibrillation patients: Comparative effectiveness and safety evaluated using a propensity-score-matched approach.
Authors:Li X, Keshishian A, Hamilton M, Horblyuk R, Gupta K, Luo X, Mardekian J, Friend K, Nadkarni A, Pan X, Lip GYH, Deitelzweig S
Institution:Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb Company, Lawrenceville, NJ, United States of America.; STATinMED Research, Ann Arbor, MI, United States of America.; Formerly of Pfizer, New York, NY, United States of America.; US Health Economics and Outcomes Research, Bristol-Myers Squibb Company, Lawrenceville, NJ, United States of America.; Pfizer, Inc., Groton, CT, United States of America.
Journal:PLoS One. 2018 Jan 26;13(1):e0191722. doi: 10.1371/journal.pone.0191722. eCollection 2018.

7:Risk factors for death, stroke, and bleeding in 28,628 patients from the GARFIELD-AF registry: Rationale for comprehensive management of atrial fibrillation.
Authors:Bassand JP, Accetta G, Al Mahmeed W, Corbalan R, Eikelboom J, Fitzmaurice DA, Fox KAA, Gao H, Goldhaber SZ, Goto S, Haas S, Kayani G, Pieper K, Turpie AGG, van Eickels M, Verheugt FWA, Kakkar AK
Institution:Department of Cardiology-EA 3920, University of Besancon, Besancon, France. United Arab Emirates. Chile. Kingdom. Medical School, Boston, Massachusetts, United States of America. Kanagawa, Japan. Germany. America.
Journal:PLoS One. 2018 Jan 25;13(1):e0191592. doi: 10.1371/journal.pone.0191592. eCollection 2018.

8:Oral anticoagulant re-initiation following intracerebral hemorrhage in non-valvular atrial fibrillation: Global survey of the practices of neurologists, neurosurgeons and thrombosis experts.
Authors:Xu Y, Shoamanesh A, Schulman S, Dowlatshahi D, Salman RA, Moldovan ID, Wells PS, AlKherayf F
Institution:Department of Medicine, University of Toronto, Toronto, Canada. Institute, McMaster University, Hamilton, Canada. Canada. Canada. Kingdom. Canada. Canada.
Journal:PLoS One. 2018 Jan 25;13(1):e0191137. doi: 10.1371/journal.pone.0191137. eCollection 2018.

9:Anticoagulant and antiplatelet therapy choices for patients with atrial fibrillation one year after coronary stenting or acute coronary syndrome.
Authors:Olivier CB, Turakhia MP, Mahaffey KW
Institution:a Stanford Center for Clinical Research (SCCR), Department of Medicine , Stanford University School of Medicine , Stanford , CA , USA. of Medicine , Stanford , CA , USA. of Medicine , Stanford , CA , USA. University School of Medicine , Stanford , CA , USA.
Journal:Expert Opin Drug Saf. 2018 Mar;17(3):251-258. doi: 10.1080/14740338.2018.1424827. Epub 2018 Jan 24.

10:Left atrial concomitant surgical ablation for treatment of atrial fibrillation in cardiac surgery: A meta-analysis of randomized controlled trials.
Authors:Wang X, Wang C, Ye M, Lin J, Jin J, Hu Q, Zhu C, Chen B
Institution:Department of Thoracic and Cardiovascular Surgery, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, China.
Journal:PLoS One. 2018 Jan 23;13(1):e0191354. doi: 10.1371/journal.pone.0191354. eCollection 2018.

11:Catheter ablation versus rate control in patients with atrial fibrillation and heart failure: A multicenter study.
Authors:Geng J, Zhang Y, Wang Y, Cao L, Song J, Wang B, Song W, Li J, Xu W
Institution:aDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical UniversitybDepartment of Cardiology, Huai'an Second People's Hospital, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, JiangsucDepartment of Cardiology, Nanjing Jiangning HospitaldDepartment of Cardiology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Journal:Medicine (Baltimore). 2017 Dec;96(49):e9179. doi: 10.1097/MD.0000000000009179.

12:Comparison of Oral Anticoagulants for Stroke Prevention in Nonvalvular Atrial Fibrillation: A Multicriteria Decision Analysis.
Authors:Tervonen T, Ustyugova A, Sri Bhashyam S, Lip GYH, Verdecchia P, Kwan R, Gropper S, Heinrich-Nols J, Marsh K
Institution:Evidera, London, UK. Electronic address: Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Value Health. 2017 Dec;20(10):1394-1402. doi: 10.1016/j.jval.2017.06.006. Epub 2017 Jul 15.

13:Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.
Authors:Larsson SC, Drca N, Jensen-Urstad M, Wolk A
Institution:Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: Stockholm, Sweden. Stockholm, Sweden. Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Journal:Am Heart J. 2018 Jan;195:86-90. doi: 10.1016/j.ahj.2017.09.013. Epub 2017 Sep 21.

14:Atrial fibrillation decision support tool: Population perspective.
Authors:Eckman MH, Costea A, Attari M, Munjal J, Wise RE, Knochelmann C, Flaherty ML, Baker P, Ireton R, Harnett BM, Leonard AC, Steen D, Rose A, Kues J
Institution:Division of General Internal Medicine and Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH; Center for Health Informatics, University of Cincinnati, Cincinnati, OH. Electronic address: University of Cincinnati, Cincinnati, OH. Cincinnati, OH. University of Cincinnati, Cincinnati, OH. Cincinnati, OH.
Journal:Am Heart J. 2017 Dec;194:49-60. doi: 10.1016/j.ahj.2017.08.016. Epub 2017 Aug 23.

15:Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
Authors:Dewland TA, Soliman EZ, Yamal JM, Davis BR, Alonso A, Albert CM, Simpson LM, Haywood LJ, Marcus GM
Institution:From the Knight Cardiovascular Institute, Oregon Health & Science University, Portland (T.A.D.); Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); University of Texas School of Public Health, Houston (J.-M.Y., B.R.D., L.M.S.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.); Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.M.A.); Keck School of Medicine, University of Southern California, Los Angeles (L.J.H.); and Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.).
Journal:Circ Arrhythm Electrophysiol. 2017 Dec;10(12). pii: CIRCEP.117.005463. doi: 10.1161/CIRCEP.117.005463.

16:Combined Cryoballoon and Radiofrequency Ablation Versus Radiofrequency Ablation Alone for Long-Standing Persistent Atrial Fibrillation.
Authors:Guler TE, Aksu T, Yalin K, Golcuk SE, Mutluer FO, Bozyel S
Institution:Department of Cardiology, Kocaeli Derince Education and Research Hospital, University of Health Sciences, Kocaeli, Turkey. University of Health Sciences, Kocaeli, Turkey. Electronic address: Turkey. Turkey. University of Health Sciences, Kocaeli, Turkey.
Journal:Am J Med Sci. 2017 Dec;354(6):586-596. doi: 10.1016/j.amjms.2017.08.010. Epub 2017 Aug 19.

17:Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation.
Authors:Rivard L, Khairy P
Institution:Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada. Electronic address: Montreal, Quebec, Canada.
Journal:Can J Cardiol. 2017 Dec;33(12):1556-1564. doi: 10.1016/j.cjca.2017.09.024. Epub 2017 Oct 6.

18:Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Authors:Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH
Institution:From the Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom (M.P., I.R., G.F.R., G.Y.H.L.); Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy (M.P.); Department of Public Health and Infectious Disease, Sapienza-University of Rome, Italy (A.F.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark (G.Y.H.L.).
Journal:Stroke. 2018 Jan;49(1):98-106. doi: 10.1161/STROKEAHA.117.018395. Epub 2017 Nov 22.

19:5-Year Outcomes After Left Atrial Appendage Closure: From the PREVAIL and PROTECT AF Trials.
Authors:Reddy VY, Doshi SK, Kar S, Gibson DN, Price MJ, Huber K, Horton RP, Buchbinder M, Neuzil P, Gordon NT, Holmes DR Jr.
Institution:Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Cardiology, Homolka Hospital, Prague, Czech Republic. Electronic address: Missouri.
Journal:J Am Coll Cardiol. 2017 Dec 19;70(24):2964-2975. doi: 10.1016/j.jacc.2017.10.021. Epub 2017 Nov 4.

20:Achieving ventricular rate control in patients taking chronic beta-blocker therapy.
Authors:Feeney ME, Rowe SLB, Mah ND, Barton CA, Ran R
Institution:Department of Pharmacy, Boston Medical Center, United States. Electronic address: States.
Journal:Am J Emerg Med. 2018 Jan;36(1):110-113. doi: 10.1016/j.ajem.2017.09.013. Epub 2017 Sep 11.

21:New onset postoperative atrial fibrillation and early anticoagulation after cardiac surgery.
Authors:Maaroos M, Pohjantahti-Maaroos H, Halonen J, Vahametsa J, Turtiainen J, Rantonen J, Hakala T, Mennander AA, Hartikainen J
Institution:a Heart Centre Kuopio University Hospital, University of Eastern Finland , Kuopio , Finland. , Finland. , Finland. , Finland. Finland. , Finland.
Journal:Scand Cardiovasc J. 2017 Dec;51(6):323-326. doi: 10.1080/14017431.2017.1385836. Epub 2017 Oct 9.

22:Efficacy and safety of dronedarone in the treatment of patients with atrial fibrillation.
Authors:Khan MH, Rochlani Y, Aronow WS
Institution:a The Cardiology Division, Department of Medicine , Westchester Medical Center and New York Medical College , Valhalla , NY , USA.
Journal:Expert Opin Drug Saf. 2017 Dec;16(12):1407-1412. doi: 10.1080/14740338.2017.1387246. Epub 2017 Oct 6.

23:Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study.
Authors:Zuo H, Nygard O, Vollset SE, Ueland PM, Ulvik A, Midttun O, Meyer K, Igland J, Sulo G, Tell GS
Institution:Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Bergen, Norway. Norway. Bergen, Norway. Bergen, Norway. Bergen, Norway. Bergen, Norway.
Journal:J Intern Med. 2018 Jan;283(1):73-82. doi: 10.1111/joim.12689. Epub 2017 Oct 4.

24:Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study.
Authors:Staerk L, Gerds TA, Lip GYH, Ozenne B, Bonde AN, Lamberts M, Fosbol EL, Torp-Pedersen C, Gislason GH, Olesen JB
Institution:Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Hellerup, Denmark. Copenhagen K, Denmark. University, Aalborg, Denmark. Copenhagen K, Denmark. Hellerup, Denmark. Hellerup, Denmark. Copenhagen O, Denmark. Denmark. Hospital, Aalborg, Denmark. Hellerup, Denmark. Denmark. Copenhagen K, Denmark. Hellerup, Denmark.
Journal:J Intern Med. 2018 Jan;283(1):45-55. doi: 10.1111/joim.12683. Epub 2017 Sep 21.

25:Integrated care in atrial fibrillation: a systematic review and meta-analysis.
Authors:Gallagher C, Elliott AD, Wong CX, Rangnekar G, Middeldorp ME, Mahajan R, Lau DH, Sanders P, Hendriks JML
Institution:Centre for Heart Rhythm Disorders, University of Adelaide, South Australian Health and Medical Research Institute and Royal Adelaide Hospital, Adelaide, Australia.
Journal:Heart. 2017 Dec;103(24):1947-1953. doi: 10.1136/heartjnl-2016-310952. Epub 2017 May 10.

26:Systematic review and meta-analysis on the impact of preoperative atrial fibrillation on short- and long-term outcomes after aortic valve replacement.
Authors:Saxena A, Virk SA, Bowman S, Bannon PG
Institution:Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia. Australia -
Journal:J Cardiovasc Surg (Torino). 2017 Dec;58(6):943-950. doi: 10.23736/S0021-9509.17.09814-7. Epub 2017 Mar 20.

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