Chronic Pancreatitis
January 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Pancreatitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Pancreatitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Pancreatitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Pancreatitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Chronic Pancreatitis Correlates With Increased Risk of Cerebrovascular Disease: A Retrospective Population-Based Cohort Study in Taiwan.
Authors:Wong TS, Liao KF, Lin CM, Lin CL, Chen WC, Lai SW
Institution:From the Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung (T-SW, K-FL, C-ML); College of Medicine, Tzu Chi University, Hualien (K-FL); Graduate Institute of Integrated Medicine (K-FL, W-CC); College of Medicine, China Medical University (C-LL, S-WL); Management Office for Health Data (C-LL); Department of Urology (W-CC); and Department of Family Medicine, China Medical University Hospital (S-WL), Taichung, Taiwan.
Journal:Medicine (Baltimore). 2016 Apr;95(15):e3266. doi: 10.1097/MD.0000000000003266.

2:Risk Factors for Diabetes Mellitus in Chronic Pancreatitis: A Cohort of 2,011 Patients.
Authors:Pan J, Xin L, Wang D, Liao Z, Lin JH, Li BR, Du TT, Ye B, Zou WB, Chen H, Ji JT, Zheng ZH, Hu LH, Li ZS
Institution:From the Department of Gastroenterology and Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University, Shanghai (JP, LX, DW, ZL, J-HL, B-RL, T-TD, BY, W-BZ, HC, J-TJ, Z-HZ, L-HH, Z-SL); Department of Gastroenterology, Air Force General Hospital, Beijing (B-RL); and Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China (BY).
Journal:Medicine (Baltimore). 2016 Apr;95(14):e3251. doi: 10.1097/MD.0000000000003251.

3:Chronic pancreatitis.
Authors:Majumder S, Chari ST
Institution:Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Journal:Lancet. 2016 May 7;387(10031):1957-66. doi: 10.1016/S0140-6736(16)00097-0. Epub 2016 Mar 2.

4:Bilateral Thoracoscopic Splanchnotomy to Alleviate Pain in Chronic Pancreatic Disease.
Authors:Bosanquet DC, Wilcox CR, Rasheed A
Institution:Department of Surgery, Royal Gwent Hospital, Newport, United Kingdom. Electronic address: of South Wales, Newport, United Kingdom.
Journal:Ann Thorac Surg. 2016 Mar;101(3):e91-3. doi: 10.1016/j.athoracsur.2015.10.019.

5:Hereditary Pancreatitis.
Authors:Rivera Rivera ED, Chugh A, Cordova J, Young S
Journal:Pediatr Ann. 2016 Feb;45(2):e50-3. doi: 10.3928/00904481-20160115-01.

6:Duodenum-preserving pancreatic resection versus pancreaticoduodenectomy for chronic pancreatitis.
Authors:Gurusamy KS, Lusuku C, Halkias C, Davidson BR
Institution:Department of Surgery, Royal Free Campus, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK, NW3 2PF.
Journal:Cochrane Database Syst Rev. 2016 Feb 3;2:CD011521. doi: 10.1002/14651858.CD011521.pub2.

7:Pregabalin for decreasing pancreatic pain in chronic pancreatitis.
Authors:Gurusamy KS, Lusuku C, Davidson BR
Institution:Department of Surgery, Royal Free Campus, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK, NW3 2PF.
Journal:Cochrane Database Syst Rev. 2016 Feb 2;2:CD011522. doi: 10.1002/14651858.CD011522.pub2.

8:Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis.
Authors:Giri AK, Midha S, Banerjee P, Agrawal A, Mehdi SJ, Dhingra R, Kaur I, G RK, Lakhotia R, Ghosh S, Das K, Mohindra S, Rana S, Bhasin DK, Garg PK, Bharadwaj D
Institution:Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.; Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.; Human Genetics Unit, Indian Statistical Institute, Kolkata, India.; Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Journal:PLoS One. 2016 Jan 28;11(1):e0147345. doi: 10.1371/journal.pone.0147345. eCollection 2016.

9:Pancreatic Duct Changes in Patients With Chronic Pancreatitis Treated With Polyethylene and Sof-Flex Material Stents: A Blinded Comparison.
Authors:Samuelson A, Zeligman B, Russ P, Austin GL, Yen R, Shah RJ
Institution:From the *Division of Gastroenterology and Hepatology, Department of Internal Medicine, and daggerDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Journal:Pancreas. 2016 Feb;45(2):281-5. doi: 10.1097/MPA.0000000000000471.

10:Evidence-based clinical practice guidelines for chronic pancreatitis 2015.
Authors:Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T
Institution:Guidelines Committee for creating and evaluating the 'Evidence-based clinical practice guidelines for chronic pancreatitis', The Japanese Society of Gastroenterology (JSGE), K-18 Building 8F, 8-9-13. Ginza, Chuo, Tokyo, 104-0061, Japan.
Journal:J Gastroenterol. 2016 Feb;51(2):85-92. doi: 10.1007/s00535-015-1149-x. Epub 2016 Jan 4.

11:Laparoscopic Longitudinal Pancreaticojejunostomy Using Barbed Sutures: an Efficient and Secure Solution for Pancreatic Duct Obstructions in Patients with Chronic Pancreatitis.
Authors:Kim EY, Hong TH
Institution:Department of Hepato-biliary and Pancreas Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 137-701, Republic of Korea.
Journal:J Gastrointest Surg. 2016 Apr;20(4):861-6. doi: 10.1007/s11605-015-3053-3. Epub 2015 Dec 21.

12:Subclinical Inflammation and Endothelial Dysfunction in Patients with Chronic Pancreatitis and Newly Diagnosed Pancreatic Cancer.
Authors:Gasiorowska A, Talar-Wojnarowska R, Kaczka A, Borkowska A, Czupryniak L, Malecka-Panas E
Institution:Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90-153, Lodz, Poland.; Department of Internal Medicine and Diabetology, Medical University of Lodz, Pomorska 251, 92-213, Lodz, Poland.
Journal:Dig Dis Sci. 2016 Apr;61(4):1121-9. doi: 10.1007/s10620-015-3972-6. Epub 2015 Nov 23.

13:Successful Application of Closed-Loop Artificial Pancreas Therapy After Islet Autotransplantation.
Authors:Forlenza GP, Nathan BM, Moran AM, Dunn TB, Beilman GJ, Pruett TL, Bellin MD
Institution:Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN. Denver, CO. MN. MN. MN.
Journal:Am J Transplant. 2016 Feb;16(2):527-34. doi: 10.1111/ajt.13539. Epub 2015 Nov 20.

14:Follicular pancreatitis: a distinct form of chronic pancreatitis-an additional mimic of pancreatic neoplasms.
Authors:Gupta RK, Xie BH, Patton KT, Lisovsky M, Burks E, Behrman SW, Klimstra D, Deshpande V
Institution:Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163. Electronic address:; Pathology Group of Midsouth (Trumbull Laboratories), Germantown, TN, 38138; Department of Pathology, Baptist Memorial Hospital, Memphis, TN, 38120. Electronic address:; Pathology Group of Midsouth (Trumbull Laboratories), Germantown, TN, 38138; Department of Pathology, Baptist Memorial Hospital, Memphis, TN, 38120. Electronic address:; Department of Pathology, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH. Electronic address:; Department of Pathology, Lahey Hospital, Burlington, MA, 01805. Electronic address:
Journal:Hum Pathol. 2016 Feb;48:154-62. doi: 10.1016/j.humpath.2015.09.017. Epub 2015 Oct 3.

15:Pancreaticojejunostomy Stricture After Pancreatoduodenectomy: Outcomes After Operative Revision.
Authors:Cioffi JL, McDuffie LA, Roch AM, Zyromski NJ, Ceppa EP, Schmidt CM, Nakeeb A, House MG
Institution:Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, EH 513, Indianapolis, IN, 46202, USA.
Journal:J Gastrointest Surg. 2016 Feb;20(2):293-9. doi: 10.1007/s11605-015-3012-z. Epub 2015 Nov 9.

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