Chronic Pancreatitis
October 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Pancreatitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Pancreatitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Pancreatitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Pancreatitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Risk factors for pain after Frey's procedure in chronic pancreatitis.
Authors:Li SJ, Tan CL, Tian BL
Institution:aDepartment of Pain Management, Wuhan First Hospital, Wuhan, Hubei Province bDepartment of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Journal:Medicine (Baltimore). 2017 Sep;96(36):e7675. doi: 10.1097/MD.0000000000007675.

2:Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis.
Authors:Kirkegard J, Mortensen FV, Cronin-Fenton D
Institution:Department of Surgery, HPB Section; Aarhus University Hospital, Aarhus, Denmark.
Journal:Am J Gastroenterol. 2017 Sep;112(9):1366-1372. doi: 10.1038/ajg.2017.218. Epub 2017 Aug 1.

3:Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States.
Authors:Bellin MD, Whitcomb DC, Abberbock J, Sherman S, Sandhu BS, Gardner TB, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Cote GA, Guda NM, Muniraj T, Tang G, Brand RE, Gelrud A, Amann ST, Forsmark CE, Wilcox CM, Slivka A, Yadav D
Institution:Department of Pediatrics, University of Minnesota Medical Center and Masonic Children's Hospital, Minneapolis, Minnesota, USA. Pennsylvania, USA. Pittsburgh, Pittsburgh, Pennsylvania, USA. Pittsburgh, Pittsburgh, Pennsylvania, USA. Pennsylvania, USA. Alabama, USA. Pennsylvania, USA. Pennsylvania, USA.
Journal:Am J Gastroenterol. 2017 Sep;112(9):1457-1465. doi: 10.1038/ajg.2017.181. Epub 2017 Jul 25.

4:Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group.
Authors:Conwell DL, Banks PA, Sandhu BS, Sherman S, Al-Kaade S, Gardner TB, Anderson MA, Wilcox CM, Lewis MD, Muniraj T, Forsmark CE, Cote GA, Guda NM, Tian Y, Romagnuolo J, Wisniewski SR, Brand R, Gelrud A, Slivka A, Whitcomb DC, Yadav D
Institution:Brigham and Women's Hospital, Boston, MA, USA. Wexner Medical Center, Columbus, OH, 43210, USA. Health, Pittsburgh, PA, USA. Health, Pittsburgh, PA, USA.
Journal:Dig Dis Sci. 2017 Aug;62(8):2133-2140. doi: 10.1007/s10620-017-4621-z. Epub 2017 Jun 9.

5:Novel and Experimental Therapies in Chronic Pancreatitis.
Authors:Jagannath S, Garg PK
Institution:Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India. Delhi, India.
Journal:Dig Dis Sci. 2017 Jul;62(7):1751-1761. doi: 10.1007/s10620-017-4604-0. Epub 2017 May 27.

6:Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.
Authors:Hegyi E, Sahin-Toth M
Institution:Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, 72 East Concord Street, Evans-433, Boston, MA, 02118, USA.
Journal:Dig Dis Sci. 2017 Jul;62(7):1692-1701. doi: 10.1007/s10620-017-4601-3. Epub 2017 May 23.

7:Medical Management of Pain in Chronic Pancreatitis.
Authors:Singh VK, Drewes AM
Institution:Pancreatitis Center, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Hepatology, Aalborg University Hospital, Molleparkvej, 9000, Aalborg, Denmark.
Journal:Dig Dis Sci. 2017 Jul;62(7):1721-1728. doi: 10.1007/s10620-017-4605-z. Epub 2017 May 18.

8:Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer.
Authors:Andersen DK, Korc M, Petersen GM, Eibl G, Li D, Rickels MR, Chari ST, Abbruzzese JL
Institution:Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. and Molecular Biology, Indiana University School of Medicine, and Indiana University Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN. Houston, TX. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Rochester, MN.
Journal:Diabetes. 2017 May;66(5):1103-1110. doi: 10.2337/db16-1477.

9:Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.
Authors:Lew D, Afghani E, Pandol S
Institution:Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
Journal:Dig Dis Sci. 2017 Jul;62(7):1702-1712. doi: 10.1007/s10620-017-4602-2. Epub 2017 May 13.

10:Operative management of chronic pancreatitis: A review.
Authors:Tillou JD, Tatum JA, Jolissaint JS, Strand DS, Wang AY, Zaydfudim V, Adams RB, Brayman KL
Institution:Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. VA, USA. VA, USA. System, Charlottesville, VA, USA. System, Charlottesville, VA, USA. VA, USA. VA, USA. VA, USA. Electronic address:
Journal:Am J Surg. 2017 Aug;214(2):347-357. doi: 10.1016/j.amjsurg.2017.03.004. Epub 2017 Mar 14.

11:Complications of Chronic Pancreatitis.
Authors:Ramsey ML, Conwell DL, Hart PA
Institution:Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 3210, USA.
Journal:Dig Dis Sci. 2017 Jul;62(7):1745-1750. doi: 10.1007/s10620-017-4518-x. Epub 2017 Mar 9.

12:Surgical Approaches to Chronic Pancreatitis: Indications and Techniques.
Authors:Dua MM, Visser BC
Institution:Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Journal:Dig Dis Sci. 2017 Jul;62(7):1738-1744. doi: 10.1007/s10620-017-4526-x. Epub 2017 Mar 9.

13:Endoscopic Therapies for Chronic Pancreatitis.
Authors:Adler JM, Gardner TB
Institution:Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA.
Journal:Dig Dis Sci. 2017 Jul;62(7):1729-1737. doi: 10.1007/s10620-017-4502-5. Epub 2017 Mar 3.

14:Laparoscopic Total Pancreatectomy With Islet Autotransplantation and Intraoperative Islet Separation as a Treatment for Patients With Chronic Pancreatitis.
Authors:Fan CJ, Hirose K, Walsh CM, Quartuccio M, Desai NM, Singh VK, Kalyani RR, Warren DS, Sun Z, Hanna MN, Makary MA
Institution:School of Medicine, Johns Hopkins University, Baltimore, Maryland. of Surgery, University of California, San Francisco. University, Baltimore, Maryland.
Journal:JAMA Surg. 2017 Jun 1;152(6):550-556. doi: 10.1001/jamasurg.2016.5707.

15:Early Experience with Laparoscopic Frey Procedure for Chronic Pancreatitis: a Case Series and Review of Literature.
Authors:Kilburn DJ, Chiow AKH, Leung U, Siriwardhane M, Cavallucci DJ, Bryant R, O'Rourke NA
Institution:Hepatopancreatobiliary Unit, Department of Surgery, Royal Brisbane Hospital, Brisbane, Queensland, 4029, Australia. Singapore, Singapore. Brisbane, Queensland, 4029, Australia. Brisbane, Queensland, 4029, Australia. Brisbane, Queensland, 4029, Australia. Brisbane, Queensland, 4029, Australia. Brisbane, Queensland, 4029, Australia. Queensland, 4066, Australia.
Journal:J Gastrointest Surg. 2017 May;21(5):904-909. doi: 10.1007/s11605-016-3343-4. Epub 2016 Dec 26.

16:Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis.
Authors:de la Iglesia-Garcia D, Huang W, Szatmary P, Baston-Rey I, Gonzalez-Lopez J, Prada-Ramallal G, Mukherjee R, Nunes QM, Dominguez-Munoz JE, Sutton R
Institution:NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK. Compostela, Compostela, Spain. Hospital, University of Liverpool, Liverpool, UK. Provincial Pancreatitis Centre, West China Hospital, Sichuan University, Chengdu, China. Hospital, University of Liverpool, Liverpool, UK. Compostela, Compostela, Spain. Compostela, Spain. Compostela, Compostela, Spain. Hospital, University of Liverpool, Liverpool, UK. Hospital, University of Liverpool, Liverpool, UK. Compostela, Compostela, Spain.
Journal:Gut. 2017 Aug;66(8):1354-1355. doi: 10.1136/gutjnl-2016-312529. Epub 2016 Dec 9.

17:Clinical effectiveness of a pylorus-preserving procedure on total pancreatectomy with islet autotransplantation.
Authors:Shahbazov R, Yoshimatsu G, Haque WZ, Khan OS, Saracino G, Lawrence MC, Kim PT, Onaca N, Naziruddin B, Levy MF
Institution:Department of Surgery, University of Virginia, Charlottesville, VA, USA. Center, Dallas, TX, USA. Center, Dallas, TX, USA. Center, Dallas, TX, USA. Center, Dallas, TX, USA. Electronic address: Medical Center, Richmond, VA, USA.
Journal:Am J Surg. 2017 Jun;213(6):1065-1071. doi: 10.1016/j.amjsurg.2016.09.051. Epub 2016 Oct 8.

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