Carcinoid Tumors
March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Carcinoid Tumors abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Carcinoid Tumors. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Carcinoid Tumors. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Carcinoid Tumors every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Primary renal carcinoid tumors: Three case reports.
Authors:Chen Y, Shu Y, He L, Wu K
Institution:Department of Radiology, The First Affiliated Hospital of Nanchang University.
Journal:Medicine (Baltimore). 2021 Feb 26;100(8):e24714. doi: 10.1097/MD.0000000000024714.

2:Practical recommendations for the management of patients with gastroenteropancreatic and thoracic (carcinoid) neuroendocrine neoplasms in the COVID-19 era.
Authors:Rodriguez-Freixinos V, Capdevila J, Pavel M, Thawer A, Baudin E, O'Toole D, Herrmann K, Welin S, Grozinsky-Glasberg S, de Herder WW, Valle JW, Herman J, Kolarova T, Bouvier C, Falconi M, Ferone D, Singh S
Institution:Department of Medical Oncology and Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:
Journal:Eur J Cancer. 2021 Feb;144:200-214. doi: 10.1016/j.ejca.2020.11.037. Epub 2020 Dec 25.

3:Contributions of Adenocarcinoma and Carcinoid Tumors to Early-Onset Colorectal Cancer Incidence Rates in the United States.
Authors:Montminy EM, Zhou M, Maniscalco L, Abualkhair W, Kim MK, Siegel RL, Wu XC, Itzkowitz SH, Karlitz JJ
Institution:Tulane University School of Medicine, New Orleans, Louisiana (E.M.M., W.A.). Southeastern Louisiana Veterans Healthcare System and Tulane University School of Medicine, New Orleans, Louisiana (J.J.K.).
Journal:Ann Intern Med. 2021 Feb;174(2):157-166. doi: 10.7326/M20-0068. Epub 2020 Dec 15.

4:Chromogranin A assessment in patients with neuroendocrine neoplasm of the small bowel and carcinoid syndrome treated with somatostatin analogues.
Authors:Gut P, Czarnywojtek A, RuchaƂa M
Institution:Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.
Journal:Adv Clin Exp Med. 2020 Nov;29(11):1319-1324. doi: 10.17219/acem/126290.

5:Cancer-associated retinopathy preceding the diagnosis of a pulmonary carcinoid tumour.
Authors:Merle G, Baglivo E, Younossian AB, Vijgen S, Karenovics W, Kherad O
Institution:Internal Medicine Division, Hopital de la Tour, Geneva, Switzerland. Internal Medicine Division, Hopital de la Tour, Geneva, Switzerland
Journal:BMJ Case Rep. 2020 Nov 2;13(11):e235046. doi: 10.1136/bcr-2020-235046.

6:Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Imaging and Clinical Features of a Frequently Delayed Diagnosis.
Authors:Little BP, Junn JC, Zheng KS, Sanchez FW, Henry TS, Veeraraghavan S, Berkowitz EA
Institution:Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114. Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
Journal:AJR Am J Roentgenol. 2020 Dec;215(6):1312-1320. doi: 10.2214/AJR.19.22628. Epub 2020 Oct 6.

7:Primary ovarian carcinoid: Two cases report and review of literature.
Authors:Zhai LR, Zhang XW, Yu T, Jiang ZD, Huang DW, Jia Y, Cui MH
Institution:Department of gynecology and Obstetrics.
Journal:Medicine (Baltimore). 2020 Oct 2;99(40):e21109. doi: 10.1097/MD.0000000000021109.

8:Development and Validation of an Individualized Nomogram for Predicting Overall Survival in Patients With Typical Lung Carcinoid Tumors.
Authors:Dong S, Liang J, Zhai W, Yu Z
Institution:Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province.
Journal:Am J Clin Oncol. 2020 Sep;43(9):607-614. doi: 10.1097/COC.0000000000000715.

9:Multiple atypical thymic carcinoids with paraneoplastic giant cell arteritis.
Authors:Nakayama T, Katagiri S, Kikkawa T, Obara T, Mori T, Kiriu T
Institution:Department of General Thoracic Surgery, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8524, Japan. Department of Pathology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
Journal:Gen Thorac Cardiovasc Surg. 2020 Oct;68(10):1212-1215. doi: 10.1007/s11748-019-01230-3. Epub 2019 Oct 17.

10:Work productivity burden and indirect costs associated with carcinoid syndrome diarrhea.
Authors:Dasari A, Joish VN, Perez-Olle R, Dharba S, Balaji K, Halperin DM
Institution:Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
Journal:Expert Rev Pharmacoecon Outcomes Res. 2020 Oct;20(5):507-511. doi: 10.1080/14737167.2019.1660646. Epub 2019 Aug 26.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Carcinoid Tumors helped me prepare for my operation. It was reassuring to be able to communicate with my surgeon and the consulting doctors having knowledge about my condition."
Newcastle, England

"The Guide is detailed and written in a way that the layman can readily understand. My wife, who has just had a Carcinoid Tumor removed, is reading it as I write this. It will be helpful in her recovery and ongoing therapy."
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