Hereditary Hemochromatosis
October 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Hereditary Hemochromatosis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Hereditary Hemochromatosis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Hereditary Hemochromatosis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Hereditary Hemochromatosis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature.
Authors:Zhang W, Lv T, Huang J, Ou X
Institution:aLiver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing Friendship Hospital, Capital Medical University bNational Clinical Research Center for Digestive Diseases cExperimental Center, Beijing Friendship Hospital, Capital Medical University; Beijing, China.
Journal:Medicine (Baltimore). 2017 Sep;96(38):e8064. doi: 10.1097/MD.0000000000008064.

2:Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial.
Authors:Vanclooster A, van Deursen C, Jaspers R, Cassiman D, Koek G
Institution:Department of Gastroenterology-Hepatology and Metabolic Center, University Hospital Leuven, Belgium. Zuyderland Medical Center, Heerlen, The Netherlands; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Maastricht UMC+, The Netherlands. Netherlands. Hospital Leuven, Belgium. Maastricht UMC+, The Netherlands; Nutrition and Translational Research in Metabolism (NUTRIM), University Maastricht, The Netherlands; Department of Surgery, University Hospital of the RWTH, Aachen, Germany. Electronic address:
Journal:Gastroenterology. 2017 Sep;153(3):678-680.e2. doi: 10.1053/j.gastro.2017.06.006. Epub 2017 Jun 15.

3:Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.
Authors:Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E
Institution:Molecular, Cellular, and Integrative Physiology Graduate Program and. Los Angeles (UCLA), Los Angeles, CA. for Molecular Medicine, University of Oxford, Oxford, United Kingdom. Los Angeles (UCLA), Los Angeles, CA. Los Angeles (UCLA), Los Angeles, CA. Finland; and. Los Angeles (UCLA), Los Angeles, CA. Los Angeles (UCLA), Los Angeles, CA. Los Angeles (UCLA), Los Angeles, CA. Los Angeles (UCLA), Los Angeles, CA.
Journal:Blood. 2017 Jul 20;130(3):245-257. doi: 10.1182/blood-2017-03-772715. Epub 2017 May 2.

4:HFE Gene Mutations and Iron Status in 100 Healthy Polish Children.
Authors:Kaczorowska-Hac B, Luszczyk M, Antosiewicz J, Ziolkowski W, Adamkiewicz-Drozynska E, Mysliwiec M, Milosz E, Kaczor JJ
Institution:Departments of *Occupational Therapy daggerBioenergetics and Nutrition #Physiotherapy, Gdansk University of Physical Education and Sport Departments of double daggerBioenergetics and Physiology of Exercise section signPediatrics, Hematology and Oncology parallelPediatrics, Diabetology and Endocrinology paragraph signLaboratory of Molecular Biology, Medical University of Gdansk.
Journal:J Pediatr Hematol Oncol. 2017 Jul;39(5):e240-e243. doi: 10.1097/MPH.0000000000000826.

5:Juvenile hemochromatosis and hepatocellular carcinoma in a patient with a novel mutation in the HJV gene.
Authors:Ramzan K, Imtiaz F, Al-Ashgar HI, AlSayed M, Sulaiman RA
Institution:Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Riyadh, Saudi Arabia. Riyadh, Saudi Arabia. Center, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Center, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Electronic address:
Journal:Eur J Med Genet. 2017 Jun;60(6):308-311. doi: 10.1016/j.ejmg.2017.03.011. Epub 2017 Mar 28.

6:Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis.
Authors:Unlusoy Aksu A, Caleffi A, Pietrangelo A, Sari S, Egritas Gurkan O, Demirtas Z, Yilmaz G, Dalgic B
Institution:Departments of *Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition double daggerPathology, Gazi University Faculty of Medicine, Ankara, Turkey dagger"Mario Coppo" Liver Research Center, Division of Internal Medicine 2 and Center for Hemochromatosis, University Hospital of Modena, Modena, Italy.
Journal:J Pediatr Hematol Oncol. 2017 Aug;39(6):466-469. doi: 10.1097/MPH.0000000000000752.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Hereditary Hemochromatosis was not only extremely informative and well-written but it also explained the genetic aspects of this condition in a way that can be readily understood even by people who donít have a medical or scientific background. I was pleased to learn that so much research is ongoing worldwide to try to better understand the causes of this condtion and, hopefully, come up with a way to prevent this disorder from happening in the first place."
Perth Amboy, New Jersey

"Your Guidebook on Hereditary Hemochromatosis contains a wealth of information that has helped our family answer many of the questions we had about this relatively obscure genetic disease. The Guidebook allowed us to fully understand the disease and know what to ask...and who to ask to additional information."
St. Joseph, Missouri

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