Hereditary Hemochromatosis
August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Hereditary Hemochromatosis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Hereditary Hemochromatosis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Hereditary Hemochromatosis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Hereditary Hemochromatosis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Haemochromatosis: evaluating the effectiveness of a novel patient self-management approach to venesection as blood donation.
Authors:Mishra S, Sim D, Flanagan P
Institution:Haematology Department, Wellington Regional Hospital, Wellington.
Journal:N Z Med J. 2017 Jun 16;130(1457):26-33.

2:Interventions for hereditary haemochromatosis: an attempted network meta-analysis.
Authors:Buzzetti E, Kalafateli M, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Institution:Sheila Sherlock Liver Centre, Royal Free Hospital and the UCL Institute of Liver and Digestive Health, London, UK.; Department of Surgery, Royal Free Campus, UCL Medical School, Pond Street, London, UK, NW3 2QG.
Journal:Cochrane Database Syst Rev. 2017 Mar 8;3:CD011647. doi: 10.1002/14651858.CD011647.pub2.

3:Course of iron parameters in HFE-hemochromatosis patients during initial treatment with erythrocytapheresis compared to phlebotomy.
Authors:Rombout-Sestrienkova E, Koek GH, Neslo R, van Kraaij M, Menheere PP, Masclee A, Swinkels DW
Institution:Blood Bank Division, Department of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, The Netherlands. The Netherlands. The Netherlands. Sciences and Primary Care, Transfusion Technology Assessment Department, Utrecht, The Netherlands. Amsterdam, The Netherlands. Netherlands. Maastricht, The Netherlands. The Netherlands. The Netherlands.
Journal:J Clin Apher. 2016 Dec;31(6):564-570. doi: 10.1002/jca.21451. Epub 2016 Feb 16.

4:Identification of novel mutations in hemochromatosis genes by targeted next generation sequencing in Italian patients with unexplained iron overload.
Authors:Badar S, Busti F, Ferrarini A, Xumerle L, Bozzini P, Capelli P, Pozzi-Mucelli R, Campostrini N, De Matteis G, Marin Vargas S, Giorgetti A, Delledonne M, Olivieri O, Girelli D
Institution:Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy. Verona, Italy. Verona, Italy. Italy. Verona, Verona, Italy. Verona, Italy. Verona, Italy. Verona, Italy. Verona, Italy. Interdisciplinare Sulle Malattie Del Ferro), Azienda Ospedaliera Uiversitaria Integrata Verona, Verona, Italy.
Journal:Am J Hematol. 2016 Jun;91(4):420-5. doi: 10.1002/ajh.24304.

5:Erythrocytapheresis versus phlebotomy in the maintenance treatment of HFE hemochromatosis patients: results from a randomized crossover trial.
Authors:Rombout-Sestrienkova E, Winkens B, Essers BA, Nieman FH, Noord PA, Janssen MC, van Deursen CT, Boonen A, Reuser-Kaasenbrood EP, Heeremans J, van Kraaij M, Masclee A, Koek GH
Institution:Department of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, the Netherlands. University Medical Centre, Maastricht, the Netherlands. Care (CAPHRI), Maastricht University. Nijmegen, the Netherlands. Heerlen/Brunssum/Sittard, the Netherlands. Netherlands. Netherlands. Netherlands. University Medical Centre, Maastricht, the Netherlands. University Medical Centre, Maastricht, the Netherlands.
Journal:Transfusion. 2016 Jan;56(1):261-70. doi: 10.1111/trf.13328. Epub 2015 Sep 10.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Hereditary Hemochromatosis was not only extremely informative and well-written but it also explained the genetic aspects of this condition in a way that can be readily understood even by people who donít have a medical or scientific background. I was pleased to learn that so much research is ongoing worldwide to try to better understand the causes of this condtion and, hopefully, come up with a way to prevent this disorder from happening in the first place."
Perth Amboy, New Jersey

"Your Guidebook on Hereditary Hemochromatosis contains a wealth of information that has helped our family answer many of the questions we had about this relatively obscure genetic disease. The Guidebook allowed us to fully understand the disease and know what to ask...and who to ask to additional information."
St. Joseph, Missouri

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