Chronic Lymphocytic Leukemia
June 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:BCL-2 as a therapeutic target in chronic lymphocytic leukemia.
Authors:Daniel C, Mato AR
Institution:Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania.
Journal:Clin Adv Hematol Oncol. 2017 Mar;15(3):210-218.

2:Duvelisib: a phosphoinositide-3 kinase delta/gamma inhibitor for chronic lymphocytic leukemia.
Authors:Vangapandu HV, Jain N, Gandhi V
Institution:a Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA. Houston , TX , USA. Cancer Center , Houston , TX , USA.
Journal:Expert Opin Investig Drugs. 2017 May;26(5):625-632. doi: 10.1080/13543784.2017.1312338. Epub 2017 Apr 13.

3:Lenalidomide in the treatment of chronic lymphocytic leukemia.
Authors:Itchaki G, Brown JR
Institution:a Department of Medical Oncology , Dana Farber Cancer Institute , Boston , MA , USA. USA.
Journal:Expert Opin Investig Drugs. 2017 May;26(5):633-650. doi: 10.1080/13543784.2017.1313230. Epub 2017 Apr 17.

4:Targeted therapy in the treatment of chronic lymphocytic leukemia: facts, shortcomings and hopes for the future.
Authors:Molica S
Institution:a Department of Hematology-Oncology , Azienda Ospedaliera Pugliese-Ciaccio , Catanzaro , Italy.
Journal:Expert Rev Hematol. 2017 May;10(5):425-432. doi: 10.1080/17474086.2017.1313108. Epub 2017 Apr 12.

5:Magic pills: new oral drugs to treat chronic lymphocytic leukemia.
Authors:Vitale C, Griggio V, Todaro M, Salvetti C, Boccadoro M, Coscia M
Institution:a Division of Hematology , University of Torino, AOU Citta della Salute e della Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy.
Journal:Expert Opin Pharmacother. 2017 Mar;18(4):411-425. doi: 10.1080/14656566.2017.1293655. Epub 2017 Feb 22.

6:A phase 1/2 trial of ublituximab, a novel anti-CD20 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukaemia previously exposed to rituximab.
Authors:Sawas A, Farber CM, Schreeder MT, Khalil MY, Mahadevan D, Deng C, Amengual JE, Nikolinakos PG, Kolesar JM, Kuhn JG, Sportelli P, Miskin HP, O'Connor OA
Institution:Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY, USA. NY, USA. NY, USA. NY, USA.
Journal:Br J Haematol. 2017 Apr;177(2):243-253. doi: 10.1111/bjh.14534. Epub 2017 Feb 21.

7:Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy.
Authors:Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V
Institution:German CLL Study Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany.
Journal:Drug Des Devel Ther. 2017 Jan 25;11:295-304. doi: 10.2147/DDDT.S104869. eCollection 2017.

8:Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia.
Authors:Aghebati-Maleki L, Shabani M, Baradaran B, Motallebnezhad M, Majidi J, Yousefi M
Institution:Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Medical Sciences, Tehran, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: jmajidiz@yahoo.com. Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefime@tbzmed.ac.ir.
Journal:Biomed Pharmacother. 2017 Apr;88:814-822. doi: 10.1016/j.biopha.2017.01.070. Epub 2017 Feb 1.

9:A multicenter, single-arm, Phase II clinical trial of bendamustine monotherapy in patients with chronic lymphocytic leukemia in Japan.
Authors:Ogawa Y, Izutsu K, Kiguchi T, Choi I, Takatsuka Y, Ando K, Suzumiya J
Institution:Department of Hematology and Oncology, Tokai University Hospital, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. yoshioga@is.icc.u-tokai.ac.jp. of Public School Teachers, Fukuyama, Japan. Fukuoka, Japan. Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. Japan.
Journal:Int J Hematol. 2017 May;105(5):631-637. doi: 10.1007/s12185-016-2178-9. Epub 2017 Feb 3.

10:Development of acute myeloid leukemia in patients with untreated chronic lymphocytic leukemia.
Authors:Ito S, Fujiwara SI, Mashima K, Umino K, Minakata D, Nakano H, Yamasaki R, Kawasaki Y, Sugimoto M, Ashizawa M, Yamamoto C, Hatano K, Okazuka K, Sato K, Oh I, Ohmine K, Suzuki T, Muroi K, Kanda Y
Institution:Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. ycanda-tky@umin.ac.jp.
Journal:Ann Hematol. 2017 May;96(5):719-724. doi: 10.1007/s00277-017-2933-x. Epub 2017 Feb 1.

11:Idelalisib or placebo in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukaemia: interim results from a phase 3, randomised, double-blind, placebo-controlled trial.
Authors:Zelenetz AD, Barrientos JC, Brown JR, Coiffier B, Delgado J, Egyed M, Ghia P, Illes A, Jurczak W, Marlton P, Montillo M, Morschhauser F, Pristupa AS, Robak T, Sharman JP, Simpson D, Smolej L, Tausch E, Adewoye AH, Dreiling LK, Kim Y, Stilgenbauer S, Hillmen P
Institution:Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA. Electronic address: zeleneta@mskcc.org. School, Boston, MA, USA. Ospedale San Raffaele and Universita Vita-Salute San Raffaele, Milan, Italy. School of Medicine, Brisbane, Australia. Italy. France. Hospital, Lodz, Poland. Eugene, OR, USA. University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Journal:Lancet Oncol. 2017 Mar;18(3):297-311. doi: 10.1016/S1470-2045(16)30671-4. Epub 2017 Jan 28.

12:Safety, efficacy and pharmacokinetics of humanized anti-CD52 monoclonal antibody alemtuzumab in Japanese patients with relapsed or refractory B-cell chronic lymphocytic leukemia.
Authors:Ishizawa K, Fukuhara N, Nakaseko C, Chiba S, Ogura M, Okamoto A, Sunaga Y, Tobinai K
Institution:Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi kishizaw@med.id.yamagata-u.ac.jp. Medicine, Sendai, Miyagi. Ibaraki. Aichi.
Journal:Jpn J Clin Oncol. 2017 Jan;47(1):54-60. doi: 10.1093/jjco/hyw146. Epub 2016 Oct 7.

13:Ibrutinib: A Review in Chronic Lymphocytic Leukaemia.
Authors:Deeks ED
Institution:Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. demail@springer.com.
Journal:Drugs. 2017 Feb;77(2):225-236. doi: 10.1007/s40265-017-0695-3.

14:Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study.
Authors:Seymour JF, Ma S, Brander DM, Choi MY, Barrientos J, Davids MS, Anderson MA, Beaven AW, Rosen ST, Tam CS, Prine B, Agarwal SK, Munasinghe W, Zhu M, Lash LL, Desai M, Cerri E, Verdugo M, Kim SY, Humerickhouse RA, Gordon GB, Kipps TJ, Roberts AW
Institution:Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, Parkville, Melbourne, VIC, Australia; Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia. Electronic address: john.seymour@petermac.org. School of Medicine, Chicago, IL, USA. Parkville, Melbourne, VIC, Australia; Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia. Cancer Centre, Parkville, Melbourne, VIC, Australia; Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia. Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia; Department of Clinical Haematology and BMT, The Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia; Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.
Journal:Lancet Oncol. 2017 Feb;18(2):230-240. doi: 10.1016/S1470-2045(17)30012-8. Epub 2017 Jan 13.

15:Front-line treatment of CLL in the era of novel agents.
Authors:Robak T, Stilgenbauer S, Tedeschi A
Institution:Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-510 Lodz, ul. Ciolkowskiego 2, Poland. Electronic address: robaktad@csk.umed.lodz.pl. Ulm 89081, Germany. Electronic address: Stephan.Stilgenbauer@uniklinik-ulm.de. Ospedale Maggiore 3, 20162 Milano, Italy. Electronic address: alessandra.tedeschi@ospedaleniguarda.it.
Journal:Cancer Treat Rev. 2017 Feb;53:70-78. doi: 10.1016/j.ctrv.2016.12.007. Epub 2016 Dec 30.

16:Eradication of minimal residual disease improves overall and progression-free survival in patients with chronic lymphocytic leukaemia, evidence from NCRN CLL207: a phase II trial assessing alemtuzumab consolidation.
Authors:Varghese AM, Howard DR, Pocock C, Rawstron AC, Follows G, McCarthy H, Dearden C, Fegan C, Milligan D, Smith AF, Gregory W, Hillmen P
Institution:Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal:Br J Haematol. 2017 Feb;176(4):573-582. doi: 10.1111/bjh.14342. Epub 2016 Dec 29.

17:Ublituximab (TG-1101), a novel glycoengineered anti-CD20 antibody, in combination with ibrutinib is safe and highly active in patients with relapsed and/or refractory chronic lymphocytic leukaemia: results of a phase 2 trial.
Authors:Sharman JP, Farber CM, Mahadevan D, Schreeder MT, Brooks HD, Kolibaba KS, Fanning S, Klein L, Greenwald DR, Sportelli P, Miskin HP, Weiss MS, Burke JM
Institution:Willamette Valley Cancer Institute, Springfield, OR, USA. USA.
Journal:Br J Haematol. 2017 Feb;176(3):412-420. doi: 10.1111/bjh.14447. Epub 2016 Dec 16.

18:Randomized phase 2 study of otlertuzumab and bendamustine versus bendamustine in patients with relapsed chronic lymphocytic leukaemia.
Authors:Robak T, Hellmann A, Kloczko J, Loscertales J, Lech-Maranda E, Pagel JM, Mato A, Byrd JC, Awan FT, Hebart H, Garcia-Marco JA, Hill BT, Hallek M, Eisenfeld AJ, Stromatt SC, Jaeger U
Institution:Department of Haematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. Warsaw, Poland. Medical Education, Warsaw, Poland. USA. Philadelphia, PA, USA. Mutlangen, Germany. Cleveland Clinic, Cleveland, OH, USA. of Excellence on Cellular Stress Responses in Aging (CECAD) University of Cologne, Cologne, Germany. University of Vienna, Vienna, Austria.
Journal:Br J Haematol. 2017 Feb;176(4):618-628. doi: 10.1111/bjh.14464. Epub 2016 Dec 15.

19:Flow cytometry minimal residual disease after allogeneic transplant for chronic lymphocytic leukemia.
Authors:Algrin C, Golmard JL, Michallet M, Reman O, Huynh A, Perrot A, Sirvent A, Plesa A, Salaun V, Bene MC, Bories D, Tournilhac O, Merle-Beral H, Leblond V, Le Garff-Tavernier M, Dhedin N
Institution:Hematologie, Groupe Hospitalier Pitie-Salpetriere, Paris, France. France. France. France.
Journal:Eur J Haematol. 2017 Apr;98(4):363-370. doi: 10.1111/ejh.12836. Epub 2017 Jan 30.

20:Chronic lymphocytic leukemia and small lymphocytic lymphoma: two faces of the same disease.
Authors:Tees MT, Flinn IW
Institution:a Colorado Blood Cancer Institute , Denver , CO , USA.
Journal:Expert Rev Hematol. 2017 Feb;10(2):137-146. doi: 10.1080/17474086.2017.1270203. Epub 2016 Dec 26.

21:The safety profile of monoclonal antibodies for chronic lymphocytic leukemia.
Authors:Korycka-Wolowiec A, Wolowiec D, Robak T
Institution:a Department of Hematology Medical , University of Lodz , Lodz , Poland.
Journal:Expert Opin Drug Saf. 2017 Feb;16(2):185-201. doi: 10.1080/14740338.2017.1264387. Epub 2016 Dec 4.

22:Alemtuzumab consolidation in chronic lymphocytic leukaemia: a phase I/II multicentre trial.
Authors:Al-Sawaf O, Fischer K, Herling CD, Ritgen M, Bottcher S, Bahlo J, Elter T, Stilgenbauer S, Eichhorst BF, Busch R, Elberskirch U, Abenhardt W, Kneba M, Hallek M, Wendtner CM
Institution:Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Diseases and Tropical Medicine, Klinikum Schwabing, Munich, Germany.
Journal:Eur J Haematol. 2017 Mar;98(3):254-262. doi: 10.1111/ejh.12825. Epub 2016 Dec 1.

23:Management of central nervous system involvement in chronic lymphocytic leukaemia: a retrospective cohort of 30 patients.
Authors:Wanquet A, Birsen R, Bonnet C, Boubaya M, Choquet S, Dupuis J, Lepretre S, Re D, Fahri J, Michallet AS, Ysebaert L, Lemal R, Lamy T, Delarue R, Troussard X, Cymbalista F, Levy V, Dietrich PY, Leblond V, Aurran-Schleinitz T
Institution:Department of Haematology, Institut Paoli-Calmettes, Marseille, France. France. Clermont-Ferrand, Clermont-Ferrand, France.
Journal:Br J Haematol. 2017 Jan;176(1):37-49. doi: 10.1111/bjh.14387. Epub 2016 Nov 11.

24:Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies.
Authors:Roberts AW, Huang D
Institution:Integrated Department of Clinical Hematology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Australia. Research, Parkville, Australia. Parkville, Australia. Research, Parkville, Australia. Parkville, Australia.
Journal:Clin Pharmacol Ther. 2017 Jan;101(1):89-98. doi: 10.1002/cpt.553. Epub 2016 Nov 26.

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