Myelodysplastic Syndromes
November 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Glasdegib for the treatment of adult patients with newly diagnosed acute myeloid leukemia or high-grade myelodysplastic syndrome who are elderly or otherwise unfit for standard induction chemotherapy.
Authors:Goldsmith SR, Lovell AR, Schroeder MA
Institution:Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA. Missouri, USA.
Journal:Drugs Today (Barc). 2019 Sep;55(9):545-562. doi: 10.1358/dot.2019.55.9.3020160.

2:The impact of iron chelation therapy on patients with lower/intermediate IPSS MDS and the prognostic role of elevated serum ferritin in patients with MDS and AML: A meta-analysis.
Authors:Yang Y, Tang Z, An T, Zhao L
Institution:The First Clinical Medical School of Lanzhou University. Hospital, Zhejiang University School of Medicine, Hangzhou. China.
Journal:Medicine (Baltimore). 2019 Oct;98(40):e17406. doi: 10.1097/MD.0000000000017406.

3:Hematologic improvement with iron chelation therapy in myelodysplastic syndromes: Clinical data, potential mechanisms, and outstanding questions.
Authors:Leitch HA, Gattermann N
Institution:Hematology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada. Electronic address: Dusseldorf, Germany.
Journal:Crit Rev Oncol Hematol. 2019 Sep;141:54-72. doi: 10.1016/j.critrevonc.2019.06.002. Epub 2019 Jun 10.

4:Identification of predictive factors for overall survival at baseline and during azacitidine treatment in high-risk myelodysplastic syndrome patients treated in the clinical practice.
Authors:Scalzulli E, Molica M, Alunni Fegatelli D, Colafigli G, Rizzo L, Mancini M, Efficace F, Latagliata R, Foa R, Breccia M
Institution:Hematology, Department of Precision and Translational Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University, Via Benevento 6, 00161, Rome, Italy.; Department of Statistical Sciences, Sapienza University, Rome, Italy.; Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy.
Journal:Ann Hematol. 2019 Aug;98(8):1919-1925. doi: 10.1007/s00277-019-03724-9. Epub 2019 Jun 5.

5:Genetic abnormalities and pathophysiology of MDS.
Authors:Hosono N
Institution:Division of Hematology and Oncology, University of Fukui, Matsuokashimoaizuki 23-3, Eiheiji, Fukui, 910-1193, Japan.
Journal:Int J Clin Oncol. 2019 Aug;24(8):885-892. doi: 10.1007/s10147-019-01462-6. Epub 2019 May 15.

6:Transforming growth factor (TGF)-beta pathway as a therapeutic target in lower risk myelodysplastic syndromes.
Authors:Bewersdorf JP, Zeidan AM
Institution:Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT, USA. Medicine, New Haven, CT, USA.
Journal:Leukemia. 2019 Jun;33(6):1303-1312. doi: 10.1038/s41375-019-0448-2. Epub 2019 Apr 8.

7:An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study.
Authors:Savona MR, Odenike O, Amrein PC, Steensma DP, DeZern AE, Michaelis LC, Faderl S, Harb W, Kantarjian H, Lowder J, Oganesian A, Azab M, Garcia-Manero G
Institution:Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: Houston, TX, USA. Houston, TX, USA.
Journal:Lancet Haematol. 2019 Apr;6(4):e194-e203. doi: 10.1016/S2352-3026(19)30030-4.

8:Efficacy of granulocyte colony stimulating factor in combination with erythropoiesis stimulating agents for treatment of anemia in patients with lower risk myelodysplastic syndromes: A systematic review.
Authors:Affentranger L, Bohlius J, Hallal M, Bonadies N
Institution:Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland. University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. Electronic address:
Journal:Crit Rev Oncol Hematol. 2019 Apr;136:37-47. doi: 10.1016/j.critrevonc.2019.01.021. Epub 2019 Feb 15.

9:Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes.
Authors:Moncharmont P, Quittancon E, Barday G, Benamara A
Institution:Department of Vigilance, Haemovigilance, Site de Lyon Decines, Etablissement francais du Sang Auvergne Rhone-Alpes, Decines-Charpieu Cedex, France.
Journal:Vox Sang. 2019 May;114(4):349-354. doi: 10.1111/vox.12765. Epub 2019 Feb 28.

10:From cellular morphology to molecular and epigenetic anomalies of myelodysplastic syndromes.
Authors:Gadji M, Pozzo AR
Institution:Department of Physiology and Pathophysiology, University of Manitoba (UfM), Research Institute in Oncology and Hematology (RIOH), CancerCare Manitoba (CCMB), Winnipeg, Manitoba, Canada.; Faculty of Medicine, Pharmacy, and Odontology (FMPO), Service of Hematology, National Centre of Blood Transfusion (CNTS), University Cheikh Anta Diop of Dakar (UCAD), Dakar, Senegal.
Journal:Genes Chromosomes Cancer. 2019 Jul;58(7):474-483. doi: 10.1002/gcc.22689. Epub 2018 Nov 18.

11:Prognostic significance of monosomal karyotype in myelodysplastic syndrome: a meta-analysis.
Authors:Wu YC, Zhang XM, Zhu YD, Wu W
Institution:a Department of Hematology, The Third Affiliated Hospital of Suzhou University , The First People's Hospital of Changzhou , Changzhou , People's Republic of China.
Journal:Hematology. 2019 Dec;24(1):60-69. doi: 10.1080/10245332.2018.1510067. Epub 2018 Aug 21.

12:Interferon-alpha salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation.
Authors:Mo X, Zhang X, Xu L, Wang Y, Yan C, Chen H, Chen Y, Han W, Wang F, Wang J, Liu K, Huang X
Institution:Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100044, China.
Journal:Front Med. 2019 Apr;13(2):238-249. doi: 10.1007/s11684-017-0599-3. Epub 2018 Apr 14.

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