| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.
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| Authors: | Ramos F, Robledo C, Pereira A, Pedro C, Benito R, de Paz R, Del Rey M, Insunza A, Tormo M, Diez-Campelo M, Xicoy B, Salido E, Sanchez-Del-Real J, Arenillas L, Florensa L, Luno E, Del Canizo C, Sanz GF, Maria Hernandez-Rivas J |
| Institution: | Department of Hematology, Hospital Universitario de Leon, Leon, Spain.; Institute of Biomedicine (IBIOMED, Leon), Leon, Spain.; Unidad de Diagnostico Molecular y Celular del Cancer, IBSAL, IBMCC-Centro de Investigacion del Cancer (USAL-CSIC), Salamanca, Spain.; Department of Blood Transfusion, Hospital Clinic i Provincial, Barcelona, Spain.; Department of Hematology, Hospital del Mar, Barcelona, Spain. | | Journal: | Am J Hematol. 2017 Sep;92(9):E534-E541. doi: 10.1002/ajh.24813. Epub 2017 Jul 19. |
| Authors: | Heuser M, Gabdoulline R, Loffeld P, Dobbernack V, Kreimeyer H, Pankratz M, Flintrop M, Liebich A, Klesse S, Panagiota V, Stadler M, Wichmann M, Shahswar R, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Geffers R, Schlegelberger B, Gohring G, Kreipe HH, Germing U, Ganser A, Kroger N, Koenecke C, Thol F |
| Institution: | Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany. heuser.michael@mh-hannover.de.; Medizinische Klinik und Poliklinik I, Universtitatsklinikum Carl Gustav Carus, Dresden, Germany.; Klinik fur Hamatologie, Onkologie und Klinische Immunologie, Heinrich Heine University, Dusseldorf, Germany.; Helmholtz Centre for Infection Research, Braunschweig, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany. | | Journal: | Ann Hematol. 2017 Aug;96(8):1361-1372. doi: 10.1007/s00277-017-3027-5. Epub 2017 Jun 13. |
| Authors: | Musto P, Maurillo L, Simeon V, Poloni A, Finelli C, Balleari E, Ricco A, Rivellini F, Cortelezzi A, Tarantini G, Villani O, Mansueto G, Milella MR, Scapicchio D, Marziano G, Breccia M, Niscola P, Sanna A, Clissa C, Voso MT, Fenu S, Venditti A, Santini V, Angelucci E, Levis A |
| Institution: | Scientific Direction, IRCCS-CROB, 'Referral Cancer Centre of Basilicata', Rionero In Vulture (Pz), Italy.; Haematology, Department of Biomedicine and Prevention, 'Tor Vergata' University, Rome, Italy.; Laboratory of Pre-clinical and Translational Research, IRCCS-CROB, 'Referral Cancer Centre of Basilicata', Rionero In Vulture (Pz), Italy.; Haematology Clinic, Department of Clinic and Molecular Sciences, 'Universita Politecnica delle Marche', Ancona, Italy.; 'Seragnoli Institute of Haematology', University School of Medicine, Bologna, Italy. | | Journal: | Br J Haematol. 2017 Jun;177(5):741-750. doi: 10.1111/bjh.14621. Epub 2017 Apr 17. |
| Authors: | Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick ED, Fernandez HF, Alyea EP, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Le-Rademacher J, Mendizabal AM, Horowitz MM, Deeg HJ, Horwitz ME |
| Institution: | Bart L. Scott and H. Joachim Deeg, Fred Hutchinson Cancer Research Center, Seattle, WA; Marcelo C. Pasquini, Brent R. Logan, Mehdi Hamadani, and Mary M. Horowitz, Medical College of Wisconsin, Milwaukee, WI; Juan Wu and Adam M. Mendizabal, Emmes Corporation, Rockville, MD; Steven M. Devine, Ohio State University Comprehensive Cancer Center, Columbus, OH; David L. Porter, University of Pennsylvania, Philadelphia, PA; Richard T. Maziarz, Oregon Health and Science University, Portland, OR; Erica D. Warlick, University of Minnesota, Minneapolis; Jennifer Le-Rademacher, Mayo Clinic, Rochester, MN; Hugo F. Fernandez, Moffitt Cancer Center, Tampa, FL; Edwin P. Alyea, Dana Farber Cancer Institute, Boston, MA; Asad Bashey, Northside Hospital Cancer Institute, Atlanta, GA; Sergio Giralt, Memorial Sloan Kettering Cancer Center, New York, NY; Nancy L. Geller and Eric Leifer, National Heart, Lung, and Blood Institute, Bethesda, MD; and Mitchell E. Horwitz, Duke University, Durham, NC. | | Journal: | J Clin Oncol. 2017 Apr 10;35(11):1154-1161. doi: 10.1200/JCO.2016.70.7091. Epub 2017 Feb 13. |
| Authors: | Daher M, Hidalgo Lopez JE, Randhawa JK, Jabbar KJ, Wei Y, Pemmaraju N, Borthakur G, Kadia T, Konopleva M, Kantarjian HM, Hearn K, Estrov Z, Reyes S, Bueso-Ramos CE, Garcia-Manero G |
| Institution: | Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Texas, USA.; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Texas, USA.; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Texas, USA. | | Journal: | Am J Hematol. 2017 Jul;92(7):674-682. doi: 10.1002/ajh.24746. Epub 2017 Jun 9. |
| Authors: | Park S, Hamel JF, Toma A, Kelaidi C, Thepot S, Campelo MD, Santini V, Sekeres MA, Balleari E, Kaivers J, Sapena R, Gotze K, Muller-Thomas C, Beyne-Rauzy O, Stamatoullas A, Kotsianidis I, Komrokji R, Steensma DP, Fensterl J, Roboz GJ, Bernal T, Ramos F, Calabuig M, Guerci-Bresler A, Bordessoule D, Cony-Makhoul P, Cheze S, Wattel E, Rose C, Vey N, Gioia D, Ferrero D, Gaidano G, Cametti G, Pane F, Sanna A, Germing U, Sanz GF, Dreyfus F, Fenaux P |
| Institution: | Sophie Park, Centre Hospitalier Universitaire (CHU) Grenoble Alpes, Universite Grenoble Alpes, Grenoble; Jean-Francois Hamel and Sylvain Thepot, CHU d'Angers; Sylvain Thepot, Universite d'Angers, Institut National de la Sante et de la Recherche Medicale, Unite 1232, and LabEx IGO, Angers; Andrea Toma, CHU Henri Mondor, Assistance Publique Hopitaux de Paris (AP-HP), Universite Paris-Est Creteil; Rosa Sapena and Pierre Fenaux, CHU Saint Louis, AP-HP, Universite Paris X; Francois Dreyfus, CHU Cochin, AP-HP, Universite Paris V, Paris; Charikleia Kelaidi, CHU Avicenne, Avicenne; Odile Beyne-Rauzy, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Agnes Guerci-Bresler, CHU Nancy, Nancy; Dominique Bordessoule, CHU Dupuytren, Limoges; Pascale Cony-Makhoul, Centre Hospitalier Annecy Genevois, Epagny Metz-Tessy; Stephane Cheze, CHU de Caen, Caen; Eric Wattel, Centre Hospitalier Lyon-Sud, Pierre Benite, Lyon; Christian Rose, Universite Catholique de Lille, Lille; Norbert Vey, Institut Paoli-Calmettes Marseille, Marseille, France; Maria Diez Campelo, Hospital Universitario de Salamanca, Salamanca; Teresa Bernal, Hospital Central de Asturias, Oviedo; Fernando Ramos, Hospital de Leon, Leon; Marisa Calabuig, Hospital Clinico de Valencia; Guillermo F. Sanz, Hospital Universitario y Politecnico La Fe, Valencia, Spain; Valeria Santini and Alessandro Sanna, Azienda Ospedaliero Universitaria (AOU) Careggi and University of Florence, Florence; Enrico Balleari, Istituto di Ricovero e Cura a Carattere Scientifico AOU San Martino di Genova, Genova; Daniela Gioia, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria; Dario Ferrero, Universita degli Studi di Torino; Gianluca Gaidano, Amedeo Avogadro University of Eastern Piedmont, Torino; Giovanni Cametti, Ospedale Maggiore di Chieri, Chieri; Fabrizio Pane, Universita Federico II, Napoli, Italy; Mikkael A. Sekeres and Jaime Fensterl, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; Rami Komrokji, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; David P. Steensma, Dana-Farber Cancer Institute, Boston, MA; Gail J. Roboz, Weill Medical College of Cornell University, New York, NY; Jennifer Kaivers and Ulrich Germing, University of Dusseldorf, Dusseldorf; Katharina Gotze and Catharina Muller-Thomas, Universitat Munchen, Munchen, Germany; and Ioannis Kotsianidis, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece. | | Journal: | J Clin Oncol. 2017 May 10;35(14):1591-1597. doi: 10.1200/JCO.2016.71.3271. Epub 2017 Mar 28. |
| Authors: | Killick SB |
| Institution: | Department of Haematology, Royal Bournemouth Hospital NHS Foundation Trust, Bournemouth, UK. | | Journal: | Br J Haematol. 2017 May;177(3):375-387. doi: 10.1111/bjh.14602. Epub 2017 Mar 16. |
| Authors: | Stahl M, Zeidan AM |
| Institution: | a Section of Hematology, Department of Internal Medicine, Section of Hematology, Yale University and the Yale Comprehensive Cancer Center , Yale University School of Medicine , New Haven , CT , USA. | | Journal: | Expert Rev Hematol. 2017 Apr;10(4):345-364. doi: 10.1080/17474086.2017.1297704. Epub 2017 Mar 9. |
| Authors: | Luskin MR, Cronin AM, Owens RL, DeAngelo DJ, Stone RM, Wadleigh M, Steensma DP, Abel GA |
| Institution: | Dana-Farber Cancer Institute, Boston, MA, USA. | | Journal: | Br J Haematol. 2017 May;177(4):562-566. doi: 10.1111/bjh.14573. Epub 2017 Mar 8. |
| Authors: | Lyons RM, Marek BJ, Paley C, Esposito J, McNamara K, Richards PD, DiBella N, Garcia-Manero G |
| Institution: | Texas Oncology and US Oncology Research, 4411 Medical Drive, San Antonio, TX 78229, United States. Electronic address: roger.lyons@usoncology.com. 78503, United States. Electronic address: billie.marek@usoncology.com. United States. Electronic address: carole.paley@novartis.com. United States. Electronic address: jason.esposito@novartis.com. United States. Electronic address: katie.mcnamara@novartis.com. 24153, United States. Electronic address: paul.richards@usoncology.com. Street, Aurora, CO 80012, United States. Electronic address: nick.dibella@usoncology.com. TX 77030, United States. Electronic address: ggarciam@mdanderson.org. | | Journal: | Leuk Res. 2017 May;56:88-95. doi: 10.1016/j.leukres.2017.01.033. Epub 2017 Jan 31. |
| Authors: | Taher AT, Origa R, Perrotta S, Kourakli A, Ruffo GB, Kattamis A, Goh AS, Cortoos A, Huang V, Weill M, Merino Herranz R, Porter JB |
| Institution: | American University of Beirut Medical Center, Beirut, Lebanon. Italy. Medical School, Patras, Greece. Italy. | | Journal: | Am J Hematol. 2017 May;92(5):420-428. doi: 10.1002/ajh.24668. Epub 2017 Feb 18. |
| Authors: | Garcia-Manero G, Montalban-Bravo G, Berdeja JG, Abaza Y, Jabbour E, Essell J, Lyons RM, Ravandi F, Maris M, Heller B, DeZern AE, Babu S, Wright D, Anz B, Boccia R, Komrokji RS, Kuriakose P, Reeves J, Sekeres MA, Kantarjian HM, Ghalie R, Roboz GJ |
| Institution: | Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. Houston, Texas. Houston, Texas. Houston, Texas. Houston, Texas. Maryland. Hospital, Detroit, Michigan. Houston, Texas. | | Journal: | Cancer. 2017 May 15;123(6):994-1002. doi: 10.1002/cncr.30533. Epub 2017 Jan 17. |
| Authors: | Ades L, Prebet T, Stamatoullas A, Recher C, Guieze R, Raffoux E, Bouabdallah K, Hunault M, Wattel E, Stalnikiewicz L, Toma A, Dombret H, Vey N, Sebert M, Gardin C, Chaffaut C, Chevret S, Fenaux P |
| Institution: | Hopital St Louis, Assistance Publique-Hopitaux de Paris and Paris 7 University, Paris, France. du Haut-Leveque, Pessac, France. Paris, France. Paris, France pierre.fenaux@aphp.fr. | | Journal: | Haematologica. 2017 Apr;102(4):728-735. doi: 10.3324/haematol.2016.151894. Epub 2016 Dec 29. |
| Authors: | Orti G, Barba P, Fox L, Salamero O, Bosch F, Valcarcel D |
| Institution: | Hematopoietic Cell Transplant Program, Department of Hematology, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: gorti@vebron.net. | | Journal: | Exp Hematol. 2017 Apr;48:1-11. doi: 10.1016/j.exphem.2016.12.004. Epub 2016 Dec 24. |
| Authors: | Del Corso L, Biale L, Parodi EL, Russo R, Filiberti R, Arboscello E |
| Institution: | Internal Medicine, Department of Hematology and Oncology, IRCCS AOU San Martino-IST, Largo R. Benzi, 10, 16132, Genoa, Italy. Corso Bramante 88, 10126, Turin, Italy. San Martino-IST, Largo R. Benzi, 10, 16132, Genoa, Italy. San Martino-IST, Largo R. Benzi, 10, 16132, Genoa, Italy. Genoa, Italy. Martino-IST, Largo R. Benzi, 10, 16132, Genoa, Italy. eleonora.arboscello@alice.it. | | Journal: | Int J Clin Oncol. 2017 Apr;22(2):380-386. doi: 10.1007/s10147-016-1042-5. Epub 2016 Oct 22. |
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