| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Tang Y, Miao M, Han S, Qi J, Wang H, Ruan C, Wu D, Han Y |
| Institution: | Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Collaborative Innovation Center of Hematology of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. Electronic address: wudepei@medmail.com.cn.; Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Collaborative Innovation Center of Hematology of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. Electronic address: hanyue@suda.edu.cn. | | Journal: | Crit Rev Oncol Hematol. 2019 Jan;133:74-83. doi: 10.1016/j.critrevonc.2018.07.013. Epub 2018 Aug 3. |
| Authors: | Fozza C |
| Institution: | Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy. | | Journal: | Crit Rev Oncol Hematol. 2019 Jan;133:112-119. doi: 10.1016/j.critrevonc.2018.11.001. Epub 2018 Nov 16. |
| Authors: | Ko BS, Chang MC, Chiou TJ, Chang TK, Chen YC, Lin SF, Chang CS, Lu YC, Yeh SP, Chen TY, Hwang WS |
| Institution: | a Department of Internal Medicine , National Taiwan University Hospital , Taipei , Taiwan. Taiwan. General Hospital , Taipei , Taiwan. Taiwan. Taiwan. University Hospital , Kaohsiung , Taiwan. Taiwan. Tainan , Taiwan. Taichung , Taiwan. | | Journal: | Hematology. 2019 Dec;24(1):247-254. doi: 10.1080/16078454.2018.1557860. |
| Authors: | Taher AT, Origa R, Perrotta S, Kouraklis A, Ruffo GB, Kattamis A, Goh AS, Huang V, Zia A, Herranz RM, Porter JB |
| Institution: | Department of Internal Medicine, Director - Fellowship and Residents Research Program, Faculty of Medicine American University of Beirut Medical Center, Beirut, Lebanon. ataher@aub.edu.lb. Medical School, Patras, Greece. Italy. | | Journal: | Health Qual Life Outcomes. 2018 Nov 19;16(1):216. doi: 10.1186/s12955-018-1041-5. |
| Authors: | Zeidan AM, Giri S, DeVeaux M, Ballas SK, Duong VH |
| Institution: | Yale University School of Medicine and Yale Cancer Center, Smilow Cancer Hospital at Yale New Haven, New Haven, CT, USA. amer.zeidan@yale.edu. at Yale New Haven, New Haven, CT, USA. Philadelphia, PA, USA. | | Journal: | Ann Hematol. 2019 Feb;98(2):339-350. doi: 10.1007/s00277-018-3539-7. Epub 2018 Nov 9. |
| Authors: | Seguier J, Gelsi-Boyer V, Ebbo M, Hamidou Z, Charbonnier A, Bernit E, Durand JM, Harle JR, Vey N, Schleinitz N |
| Institution: | Aix-Marseille Univ, APHM, Medecine Interne Hopital de la Timone, Marseille, France. France. France. France. France. France. France. France. France. Electronic address: nicolas.schleinitz@ap-hm.fr. | | Journal: | Autoimmun Rev. 2019 Jan;18(1):36-42. doi: 10.1016/j.autrev.2018.07.009. Epub 2018 Nov 5. |
| Authors: | Konuma T, Shimomura Y, Ozawa Y, Ueda Y, Uchida N, Onizuka M, Akiyama M, Mori T, Nakamae H, Ohno Y, Shiratori S, Onishi Y, Kanda Y, Fukuda T, Atsuta Y, Ishiyama K |
| Institution: | Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Center General Hospital, Kobe, Japan. Japan. Japan. Aid Associations Toranomon Hospital, Tokyo, Japan. Isehara, Japan. Medicine, Tokyo, Japan. Japan. Japan. Japan. Hospital, Tokyo, Japan. Medicine, Nagoya, Japan. | | Journal: | Hematol Oncol. 2019 Feb;37(1):85-95. doi: 10.1002/hon.2566. Epub 2018 Nov 19. |
| Authors: | Alkharabsheh OA, Saadeh SS, Zblewski DL, Gangat N, Begna KH, Elliott MA, Alkhateeb HB, Patnaik MS, Hogan WJ, Litzow MR, Al-Kali A |
| Institution: | Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. alkali.aref@mayo.edu. | | Journal: | Ann Hematol. 2019 Feb;98(2):331-337. doi: 10.1007/s00277-018-3509-0. Epub 2018 Oct 18. |
| Authors: | Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ |
| Institution: | From the Department of Pathology and Immunology (E.J.D.), the Department of Medicine, Division of Oncology (M.A.J., C.A.M., N.E., J.S., K.E., J.R., S.E.H., K.B., L.D.W., M.J.C., I.P., J.S.W., G.L.U., D.C.L., J.F.D., P.W., T.J.L., M.J.W.), the McDonnell Genome Institute (G.S.C., C.A.M., H.A., R.S.F., C.C.F., M.O.), the Department of Medicine, Division of Hospital Medicine (R.S.), and Siteman Biostatistics Shared Resource, Siteman Cancer Center (K.T.), Washington University School of Medicine in St. Louis, St. Louis; and Massachusetts General Hospital Cancer Center, Boston (T.A.G.). | | Journal: | N Engl J Med. 2018 Sep 13;379(11):1028-1041. doi: 10.1056/NEJMoa1804714. |
| Authors: | Benton CB, Chien KS, Tefferi A, Rodriguez J, Ravandi F, Daver N, Jabbour E, Jain N, Alvarado Y, Kwari M, Pierce S, Maiti A, Hornbaker M, Santos MA, Martinez S, Siguero M, Zblewski D, Al-Kali A, Hogan WJ, Kantarjian H, Pardanani A, Garcia-Manero G |
| Institution: | Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. | | Journal: | Hematol Oncol. 2019 Feb;37(1):96-102. doi: 10.1002/hon.2557. Epub 2018 Dec 5. |
| Authors: | Grignano E, Jachiet V, Fenaux P, Ades L, Fain O, Mekinian A |
| Institution: | Department of Hematology, Assistance Publique-Hopitaux de Paris, Hopital Cochin, 75014, Paris, France.; Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France. arsene.mekinian@aphp.fr.; UPMC University Paris 06, Paris, France. arsene.mekinian@aphp.fr.; Department of Hematology, Assistance Publique-Hopitaux de Paris, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.; Sorbonne Universites, UMPC University Paris 06, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. arsene.mekinian@aphp.fr. | | Journal: | Ann Hematol. 2018 Nov;97(11):2015-2023. doi: 10.1007/s00277-018-3472-9. Epub 2018 Aug 8. |
| Authors: | Wang H, Li Y, Lv N, Li Y, Wang L, Yu L |
| Institution: | Department of Hematology and BMT Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. Road, Beijing, 100853, China. 572013, Hainan Province, China. Road, Beijing, 100853, China. Shenzhen University, 1098 Xueyuan Ave, Shenzhen, 518060, China. Road, Beijing, 100853, China. Road, Beijing, 100853, China. | | Journal: | Ann Hematol. 2018 Nov;97(11):2025-2038. doi: 10.1007/s00277-018-3464-9. Epub 2018 Aug 6. |
| Authors: | Schuler E, Zadrozny N, Blum S, Schroeder T, Strupp C, Hildebrandt B, Kundgen A, Gattermann N, Aul C, Kondakci M, Kobbe G, Haas R, Germing U |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, University Hospital, Heinrich Heine-University, Moorenstr. 5, 40225, Dusseldorf, Germany. Esther.Schuler@med.uni-duesseldorf.de.; Department of Oncology, University Hospital, Lausanne, Switzerland.; Institute of Human Genetics and Anthropology, Heinrich Heine-University, Duesseldorf, Germany.; Department of Hematology and Oncology, Johannes Hospital Duisburg, Duisburg, Germany. | | Journal: | Ann Hematol. 2018 Dec;97(12):2325-2332. doi: 10.1007/s00277-018-3466-7. Epub 2018 Aug 4. |
| Authors: | Baek DW, Lee YJ, Kim H, Ahn SY, Ahn JS, Shin HJ, Lee WS, Lee SM, Song IC, Lee HS, Park SW, Choi Y, Cho YY, Bae SH, Kim HJ, Sohn SK, Moon JH |
| Institution: | Department of Hematology/Oncology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. South Korea. Hwasun, South Korea. Hwasun, South Korea. Hwasun, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. jhmoon@knu.ac.kr. jhmoon@knu.ac.kr. | | Journal: | Ann Hematol. 2018 Dec;97(12):2309-2317. doi: 10.1007/s00277-018-3458-7. Epub 2018 Aug 2. |
| Authors: | Laribi K, Bolle D, Alani M, Ghnaya H, Le Bourdelles S, Besancon A, Farhi J, Denizon N, Baugier de Materre A |
| Institution: | Department of Hematology, Centre Hospitalier Le Mans, Le Mans, France. Electronic address: klaribi@ch-lemans.fr. | | Journal: | Exp Hematol. 2018 Sep;65:34-37. doi: 10.1016/j.exphem.2018.05.006. Epub 2018 Jun 5. |
| Authors: | Gayoso J, Balsalobre P, Kwon M, Herrera P, Bermudez A, Sampol A, Jimenez S, Lopez-Corral L, Serrano D, Pinana JL, Pascual MJ, Heras I, Bento L, Varela R, Humala K, Zabalza A, Laiglesia A, Bastos-Oreiro M, Perez-Corral A, Martinez-Laperche C, Buno I, Diez-Martin JL |
| Institution: | Facultad de Medicina Universidad Complutense, HGU Gregorio Maranon, Madrid, Spain. Spain. Spain. Spain. Spain. Spain. Spain. Spain. Spain. | | Journal: | Eur J Haematol. 2018 Sep;101(3):332-339. doi: 10.1111/ejh.13103. Epub 2018 Aug 3. |
| Authors: | Shallis RM, Ahmad R, Zeidan AM |
| Institution: | Division of Hematology/Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. School of Medicine, New Haven, CT, USA. School of Medicine, New Haven, CT, USA. University, New Haven, CT, USA. | | Journal: | Eur J Haematol. 2018 Sep;101(3):260-271. doi: 10.1111/ejh.13092. Epub 2018 Jul 12. |
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