Polycystic Kidney Disease
April 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Kidney Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Kidney Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Kidney Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Kidney Disease every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The prevalence of autosomal dominant polycystic kidney disease (ADPKD): A meta-analysis of European literature and prevalence evaluation in the Italian province of Modena suggest that ADPKD is a rare and underdiagnosed condition.
Authors:Solazzo A, Testa F, Giovanella S, Busutti M, Furci L, Carrera P, Ferrari M, Ligabue G, Mori G, Leonelli M, Cappelli G, Magistroni R
Institution:Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy.; UO Nefrologia, Dialisi e Trapianto, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Ospedale Sant'Orsola-Malpighi, Alma Mater Studiorum Universita di Bologna, Bologna, Italy.; Divisione di Nefrologia Dialisi e Trapianto Renale, Dipartimento interaziendale ad attivita integrata Malattie Nefrologiche, Cardiache e Vascolari, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.; Division of Genetics and Cell Biology, Unit of Genomics for human disease diagnosis, and Laboratory of Clinical Molecular Genetics, San Raffaele Scientific Institute, Milan, Italy.; Universita Vita e Salute San Raffaele, Milan, Italy.
Journal:PLoS One. 2018 Jan 16;13(1):e0190430. doi: 10.1371/journal.pone.0190430. eCollection 2018.

2:Autosomal dominant polycystic kidney disease combined with hypertrophic cardiomyopathy: A case report.
Authors:Shen Y, Xu C
Institution:Department of Nephrology, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.
Journal:Medicine (Baltimore). 2017 Nov;96(46):e8625. doi: 10.1097/MD.0000000000008625.

3:Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
Authors:Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O
Institution:From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universite Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston (R.D.P.); the Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill (G.K.); and Otsuka Pharmaceutical Development and Commercialization, Rockville, MD (J.O., R.D.M., J.D.B., F.S.C., O.S.).
Journal:N Engl J Med. 2017 Nov 16;377(20):1930-1942. doi: 10.1056/NEJMoa1710030. Epub 2017 Nov 4.

4:New treatment paradigms for ADPKD: moving towards precision medicine.
Authors:Lanktree MB, Chapman AB
Institution:Nephrology Division, Department of Medicine, McMaster University, St Joseph's Healthcare Hamilton, 50 Charlton Avenue E, Hamilton, Ontario L8N 4A6, Canada. Maryland Avenue, W503, Chicago, Illinois 60637, USA.
Journal:Nat Rev Nephrol. 2017 Dec;13(12):750-768. doi: 10.1038/nrneph.2017.127. Epub 2017 Oct 9.

5:Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease.
Authors:Tesar V, Ciechanowski K, Pei Y, Barash I, Shannon M, Li R, Williams JH, Levisetti M, Arkin S, Serra A
Institution:Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Vladimir.Tesar@vfn.cz. York. Zurich, Switzerland.
Journal:J Am Soc Nephrol. 2017 Nov;28(11):3404-3413. doi: 10.1681/ASN.2016111232. Epub 2017 Aug 24.

6:PKD2-Related Autosomal Dominant Polycystic Kidney Disease: Prevalence, Clinical Presentation, Mutation Spectrum, and Prognosis.
Authors:Cornec-Le Gall E, Audrezet MP, Renaudineau E, Hourmant M, Charasse C, Michez E, Frouget T, Vigneau C, Dantal J, Siohan P, Longuet H, Gatault P, Ecotiere L, Bridoux F, Mandart L, Hanrotel-Saliou C, Stanescu C, Depraetre P, Gie S, Massad M, Kersale A, Seret G, Augusto JF, Saliou P, Maestri S, Chen JM, Harris PC, Ferec C, Le Meur Y
Institution:Service de Nephrologie, Centre Hospitalier Regional Universitaire de Brest, Brest, France; Universite europeenne de Bretagne, Universite de Bretagne Occidentale, Brest, France; Institut National de la Sante et de la Recherche Medicale, Unite 1078, Brest, France; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address: emilie.cornec-legall@chu-brest.fr.; Institut National de la Sante et de la Recherche Medicale, Unite 1078, Brest, France; Laboratoire de Genetique et Genomique Fonctionnelle et Biotechnologies, Centre Hospitalier Regional Universitaire de Brest, Brest, France.; Service de Nephrologie, Centre Hospitalier Broussais, Saint Malo, France.; Service de Nephrologie-Immunologie Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France.; Service de Nephrologie, Centre Hospitalier Yves Le Foll, Saint Brieuc, France.
Journal:Am J Kidney Dis. 2017 Oct;70(4):476-485. doi: 10.1053/j.ajkd.2017.01.046. Epub 2017 Mar 27.

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"Last year my brother and his daughter were diagnosed with PKD. We had no idea what this disease was, if there was a cure, or how it would affect my family. There seemed to be very little information about PKD. Then I found the MediFocus Guidebook on Polycystic Kidney Disease. What a tremendous help! It has answered many questions and has given us some hope. Thank you."
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