Polycystic Kidney Disease
October 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Kidney Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Kidney Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Kidney Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Kidney Disease every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Use of targeted sequence capture and high-throughput sequencing identifies a novel PKD1 mutation involved in adult polycystic kidney disease.
Authors:Sha YK, Sha YW, Mei LB, Huang XJ, Wang X, Lin SB, Li L, Li P
Institution:Department of Nephrology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 361003, China. Xiamen 361005, China. Xiamen 361005, China. Xiamen 361005, China. Xiamen 361005, China. Xiamen 361005, China. University, Beijing 100026, China. Electronic address: linlithu@163.com. Xiamen 361005, China. Electronic address: saarc2001@sina.com.
Journal:Gene. 2017 Nov 15;634:1-4. doi: 10.1016/j.gene.2017.08.040. Epub 2017 Sep 1.

2:Kidney volume measurement methods for clinical studies on autosomal dominant polycystic kidney disease.
Authors:Sharma K, Caroli A, Quach LV, Petzold K, Bozzetto M, Serra AL, Remuzzi G, Remuzzi A
Institution:Bioengineering Department, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy. Bergamo, Italy. Bergamo, Italy. Switzerland. Bergamo, Italy. Zurich, Switzerland. Bergamo, Italy. Italy. Bergamo, Italy. Bergamo, Bergamo, Italy.
Journal:PLoS One. 2017 May 30;12(5):e0178488. doi: 10.1371/journal.pone.0178488. eCollection 2017.

3:Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease.
Authors:Kugita M, Nishii K, Yamaguchi T, Suzuki A, Yuzawa Y, Horie S, Higashihara E, Nagao S
Institution:Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, Japan. Toyoake, Aichi, Japan. Medical Science, Suzuka, Mie, Japan. Health University, Toyoake, Aichi, Japan. Aichi, Japan. Japan. Japan. University, Toyoake, Aichi, Japan.
Journal:PLoS One. 2017 May 18;12(5):e0177934. doi: 10.1371/journal.pone.0177934. eCollection 2017.

4:On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.
Authors:Venugopal J, Blanco G
Institution:Department of Molecular and Integrative Physiology, and The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. jessica.venugopal@gmail.com. University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. gblanco@kumc.edu.
Journal:Molecules. 2017 May 3;22(5). pii: E729. doi: 10.3390/molecules22050729.

5:Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. A systematic review.
Authors:Cagnazzo F, Gambacciani C, Morganti R, Perrini P
Institution:Department of Neurosurgery, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy. f.cagnazzo86@gmail.com. Italy. University of Pisa, Pisa, Italy. Italy.
Journal:Acta Neurochir (Wien). 2017 May;159(5):811-821. doi: 10.1007/s00701-017-3142-z. Epub 2017 Mar 10.

6:Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial.
Authors:Devuyst O, Chapman AB, Gansevoort RT, Higashihara E, Perrone RD, Torres VE, Blais JD, Zhou W, Ouyang J, Czerwiec FS
Institution:Institute of Physiology, University of Zurich, Zurich, Switzerland; olivier.devuyst@uzh.ch. Center Groningen, University of Groningen, Groningen, The Netherlands. University School of Medicine, Boston, Massachusetts. Clinic, Rochester, Minnesota; and.
Journal:J Am Soc Nephrol. 2017 May;28(5):1592-1602. doi: 10.1681/ASN.2016040448. Epub 2016 Dec 5.

7:Tolvaptan and Kidney Pain in Patients With Autosomal Dominant Polycystic Kidney Disease: Secondary Analysis From a Randomized Controlled Trial.
Authors:Casteleijn NF, Blais JD, Chapman AB, Czerwiec FS, Devuyst O, Higashihara E, Leliveld AM, Ouyang J, Perrone RD, Torres VE, Gansevoort RT
Institution:Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. University of Zurich, Zurich, Switzerland. Groningen, Groningen, the Netherlands. Medicine, Boston, MA. Clinic, Rochester, MN. Groningen, Groningen, the Netherlands. Electronic address: r.t.gansevoort@umcg.nl.
Journal:Am J Kidney Dis. 2017 Feb;69(2):210-219. doi: 10.1053/j.ajkd.2016.08.028. Epub 2016 Nov 14.

8:Predictors of rapid disease progression in autosomal dominant polycystic kidney disease.
Authors:Corradi V, Gastaldon F, Caprara C, Giuliani A, Martino F, Ferrari F, Ronco C
Institution:Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy - valentina.corradi@ulssvicenza.it. Italy - valentina.corradi@ulssvicenza.it. Vicenza, Italy. Italy. Vicenza, Italy. Vicenza, Italy. Italy. Vicenza, Italy. Italy.
Journal:Minerva Med. 2017 Feb;108(1):43-56. doi: 10.23736/S0026-4806.16.04830-8. Epub 2016 Oct 4.

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What Our Customers Are Saying...

"Last year my brother and his daughter were diagnosed with PKD. We had no idea what this disease was, if there was a cure, or how it would affect my family. There seemed to be very little information about PKD. Then I found the MediFocus Guidebook on Polycystic Kidney Disease. What a tremendous help! It has answered many questions and has given us some hope. Thank you."
J.R.
Muskegon, Michigan


"I found the MediFocus Guidebook on Polycystic Kidney Disease to be very informative with links to loads of information. It has been extremely helpful learning about my inherited PKD disease which is very common yet not heard of by the general public."
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Flint, Michigan


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Denver, Colorado



  
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