Parkinson's Disease
April 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:The launch of opicapone for Parkinson's disease: negatives versus positives.
Authors:Castro Caldas A, Teodoro T, Ferreira JJ
Institution:a Neurology Service, Department of Neurosciences , Hospital de Santa Maria , Lisbon , Portugal. Portugal. University Hospitals NHS Foundation Trust , London , United Kingdom.
Journal:Expert Opin Drug Saf. 2018 Mar;17(3):331-337. doi: 10.1080/14740338.2018.1433659.

2:Depression in Parkinson's disease: A case-control study.
Authors:Wu YH, Chen YH, Chang MH, Lin CH
Institution:Section of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan. Taichung, Taiwan.
Journal:PLoS One. 2018 Feb 1;13(2):e0192050. doi: 10.1371/journal.pone.0192050. eCollection 2018.

3:The effects of anxiety and external attentional focus on postural control in patients with Parkinson's disease.
Authors:Jazaeri SZ, Azad A, Mehdizadeh H, Habibi SA, Mandehgary Najafabadi M, Saberi ZS, Rahimzadegan H, Moradi S, Behzadipour S, Parnianpour M, Taghizadeh G, Khalaf K
Institution:Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran. Iran. Iran.
Journal:PLoS One. 2018 Feb 1;13(2):e0192168. doi: 10.1371/journal.pone.0192168. eCollection 2018.

4:Pharmacokinetic drug evaluation of opicapone for the treatment of Parkinson's disease.
Authors:Svetel M, Tomic A, Kresojevic N, Kostic V
Institution:a Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.; b Clinic of Neurology , Clinical Center of Serbia , Belgrade , Serbia.
Journal:Expert Opin Drug Metab Toxicol. 2018 Mar;14(3):353-360. doi: 10.1080/17425255.2018.1430138. Epub 2018 Jan 24.

5:Comparison of the Efficacy of Different Drugs on Non-Motor Symptoms of Parkinson's Disease: a Network Meta-Analysis.
Authors:Li BD, Cui JJ, Song J, Qi C, Ma PF, Wang YR, Bai J
Institution:Department of Neurology, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou, China.; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Journal:Cell Physiol Biochem. 2018;45(1):119-130. doi: 10.1159/000486252. Epub 2018 Jan 15.

6:Towards stem cell based therapies for Parkinson's disease.
Authors:Parmar M
Institution:Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, BMC A11, S-221 84 Lund, Sweden
Journal:Development. 2018 Jan 8;145(1). pii: 145/1/dev156117. doi: 10.1242/dev.156117.

7:Handwriting training in Parkinson's disease: A trade-off between size, speed and fluency.
Authors:Nackaerts E, Broeder S, Pereira MP, Swinnen SP, Vandenberghe W, Nieuwboer A, Heremans E
Institution:Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Journal:PLoS One. 2017 Dec 22;12(12):e0190223. doi: 10.1371/journal.pone.0190223. eCollection 2017.

8:Factors influencing psychological well-being in patients with Parkinson's disease.
Authors:Nicoletti A, Mostile G, Stocchi F, Abbruzzese G, Ceravolo R, Cortelli P, D'Amelio M, De Pandis MF, Fabbrini G, Pacchetti C, Pezzoli G, Tessitore A, Canesi M, Zappia M
Institution:Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy. Catania, Italy. Genoa, Genoa, Italy. Italy. Palermo, Palermo, Italy. Institute, Cassino (FR), Italy. University of Rome, Rome, Italy. Institute C. Mondino, Pavia, Italy. Second University of Naples, Naples, Italy.
Journal:PLoS One. 2017 Dec 15;12(12):e0189682. doi: 10.1371/journal.pone.0189682. eCollection 2017.

9:Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinson Disease.
Authors:Marshall T, Pugh A, Fairchild A, Hass S
Institution:AbbVie, Inc., North Chicago, IL, USA. Electronic address:
Journal:Value Health. 2017 Dec;20(10):1383-1393. doi: 10.1016/j.jval.2017.06.001. Epub 2017 Jul 20.

10:Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease: A Randomized Clinical Trial.
Authors:Bond AE, Shah BB, Huss DS, Dallapiazza RF, Warren A, Harrison MB, Sperling SA, Wang XQ, Gwinn R, Witt J, Ro S, Elias WJ
Institution:Department of Neurosurgery, University of Virginia Health Science Center, Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Center, Charlottesville. Charlottesville.
Journal:JAMA Neurol. 2017 Dec 1;74(12):1412-1418. doi: 10.1001/jamaneurol.2017.3098.

11:Pimavanserin: novel pharmacotherapy for Parkinson's disease psychosis.
Authors:Sahli ZT, Tarazi FI
Institution:a Department of Psychiatry and Neuroscience Program , Harvard Medical School, McLean Hospital , Belmont , MA , USA. McLean Hospital , Belmont , MA , USA.
Journal:Expert Opin Drug Discov. 2018 Jan;13(1):103-110. doi: 10.1080/17460441.2018.1394838. Epub 2017 Oct 31.

12:Dopamine dysregulation syndrome in Parkinson's disease: a systematic review of published cases.
Authors:Warren N, O'Gorman C, Lehn A, Siskind D
Institution:School of Medicine, University of Queensland, Brisbane, Queensland, Australia. Brisbane, Queensland, Australia. Australia. Australia. Brisbane, Queensland, Australia.
Journal:J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1060-1064. doi: 10.1136/jnnp-2017-315985. Epub 2017 Oct 10.

13:Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification.
Authors:Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA
Institution:HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address:; HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address:
Journal:Exp Neurol. 2017 Dec;298(Pt B):148-161. doi: 10.1016/j.expneurol.2017.10.002. Epub 2017 Oct 4.

14:Vaccination strategies in tauopathies and synucleinopathies.
Authors:Braczynski AK, Schulz JB, Bach JP
Institution:Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany. and Neuroimaging, FZ Julich and RWTH University, Aachen, Germany.
Journal:J Neurochem. 2017 Dec;143(5):467-488. doi: 10.1111/jnc.14207. Epub 2017 Oct 16.

15:Efficacy of Combined Treatment with Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment for Parkinson's Disease.
Authors:Cho SY, Lee YE, Doo KH, Lee JH, Jung WS, Moon SK, Park JM, Ko CN, Kim H, Rhee HY, Park HJ, Park SU
Institution:1 Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.; 2 Stroke and Neurological Disorders Center, Kyung Hee University Hospital at Gangdong , Seoul, Republic of Korea.; 3 Department of Epidemiology and Biostatistics, Graduate School of Public Health and Institute of Health and Environment, Seoul University , Seoul, Republic of Korea.; 4 Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University , Seoul, Republic of Korea.; 5 Integrative Parkinson's Disease Research Group, Acupuncture and Meridian Science Research Center, Kyung Hee University , Seoul, Republic of Korea.
Journal:J Altern Complement Med. 2018 Jan;24(1):25-32. doi: 10.1089/acm.2016.0250. Epub 2017 Jul 28.

16:Gender differences in Parkinson's disease: A clinical perspective.
Authors:Georgiev D, Hamberg K, Hariz M, Forsgren L, Hariz GM
Institution:Department of Neurology, University Clinical Centre Ljubljana, Ljubljana, Slovenia. Neurology, University College London, London, UK. Sweden. University, Umea, Sweden. Neurology, University College London, London, UK. Sweden. Sweden. Sweden.
Journal:Acta Neurol Scand. 2017 Dec;136(6):570-584. doi: 10.1111/ane.12796. Epub 2017 Jul 2.

17:Effects of Transcranial Direct Current Stimulation Plus Physical Therapy on Gait in Patients With Parkinson Disease: A Randomized Controlled Trial.
Authors:Yotnuengnit P, Bhidayasiri R, Donkhan R, Chaluaysrimuang J, Piravej K
Institution:From the Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand (PY, RD, KP); Chulalongkorn Center of Excellence for Parkinson's Disease and Related Disorders, King Chulalongkorn Memorial Hospital, Thailand (RB); and Department of Rehabilitation Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand (JC).
Journal:Am J Phys Med Rehabil. 2018 Jan;97(1):7-15. doi: 10.1097/PHM.0000000000000783.

18:Clinical approaches to the development of a neuroprotective therapy for PD.
Authors:Olanow CW, Kieburtz K, Katz R
Institution:Clintrex LLC, United States; Dept of Neurology, Dept of Neuroscience, Mount Sinai School of Medicine, New York, NY, United States. Electronic address: States. States.
Journal:Exp Neurol. 2017 Dec;298(Pt B):246-251. doi: 10.1016/j.expneurol.2017.06.018. Epub 2017 Jun 13.

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