Parkinson's Disease
October 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Progression marker of Parkinson's disease: a 4-year multi-site imaging study.
Authors:Burciu RG, Ofori E, Archer DB, Wu SS, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE
Institution:University of Florida, Department of Applied Physiology and Kinesiology, Gainesville, FL, USA. Gainesville, FL, USA. Gainesville, FL, USA. Women's Hospital, Boston, MA, USA. Gainesville, FL, USA. Gainesville, FL, USA. Gainesville, FL, USA. USA.
Journal:Brain. 2017 Aug 1;140(8):2183-2192. doi: 10.1093/brain/awx146.

2:Current approaches to the treatment of Parkinson's Disease.
Authors:Ellis JM, Fell MJ
Institution:Department of Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: Boston, MA 02115, USA.
Journal:Bioorg Med Chem Lett. 2017 Sep 15;27(18):4247-4255. doi: 10.1016/j.bmcl.2017.07.075. Epub 2017 Jul 29.

3:Botulinum Toxin in Parkinson Disease Tremor: A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach.
Authors:Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B
Institution:Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2017 Sep;92(9):1359-1367. doi: 10.1016/j.mayocp.2017.06.010. Epub 2017 Aug 5.

4:Thalamic deep brain stimulation for tremor in Parkinson disease, essential tremor, and dystonia.
Authors:Cury RG, Fraix V, Castrioto A, Perez Fernandez MA, Krack P, Chabardes S, Seigneuret E, Alho EJL, Benabid AL, Moro E
Institution:From the Service de Neurologie (R.G.C., V.F., A.C., M.A.P.F., E.M.), Service de Neurochirurgie (M.A.P.F., E.S.), Centre Hospitalier Universitaire de Grenoble, Universite Grenoble Alpes, INSERM U1216, Grenoble, France; Department of Neurology (R.G.C., M.A.P.F., E.J.L.A.), School of Medicine, University of Sao Paulo, Sao Paulo, Brazil; Hospital Dr. Dario Contreras (M.A.P.F.), Santo Domingo, Republica Dominicana; Service de Neurologie (P.K., S.C.), CHU de Geneve, Switzerland; and Clinatec (A.-L.B.), Centre Hospitalier Universitaire de Grenoble, France.
Journal:Neurology. 2017 Sep 26;89(13):1416-1423. doi: 10.1212/WNL.0000000000004295. Epub 2017 Aug 2.

5:Effectiveness of physical activity on patients with depression and Parkinson's disease: A systematic review.
Authors:Wu PL, Lee M, Huang TT
Institution:Graduate Institute of Clinical Medical Sciences, Nursing, Chang Gung University, Tao-Yuan, Taiwan. of America.
Journal:PLoS One. 2017 Jul 27;12(7):e0181515. doi: 10.1371/journal.pone.0181515. eCollection 2017.

6:Parkinson's Disease and Its Effect on the Lower Urinary Tract: Evaluation of Complications and Treatment Strategies.
Authors:Brucker BM, Kalra S
Institution:Department of Urology, New York University Langone Medical Center, 150 East 32nd street second floor, New York, NY 10016, USA; Department of Obstetrics and Gynecology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. Electronic address: street second floor, New York, NY 10016, USA.
Journal:Urol Clin North Am. 2017 Aug;44(3):415-428. doi: 10.1016/j.ucl.2017.04.008.

7:Parkinson Disease and Melanoma: Confirming and Reexamining an Association.
Authors:Dalvin LA, Damento GM, Yawn BP, Abbott BA, Hodge DO, Pulido JS
Institution:Department of Ophthalmology, Mayo Clinic, Rochester, MN. Center, Rochester, MN. Jacksonville, FL. Medicine, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2017 Jul;92(7):1070-1079. doi: 10.1016/j.mayocp.2017.03.014.

8:Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study.
Authors:Cilia R, Laguna J, Cassani E, Cereda E, Pozzi NG, Isaias IU, Contin M, Barichella M, Pezzoli G
Institution:From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Nino Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Wurzburg and Julius-Maximilians-University, Wurzburg, Germany; IRCCS-Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
Journal:Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5.

9:Music-based interventions in neurological rehabilitation.
Authors:Sihvonen AJ, Sarkamo T, Leo V, Tervaniemi M, Altenmuller E, Soinila S
Institution:Faculty of Medicine, University of Turku, Turku, Finland; Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland. Electronic address: of Medicine, University of Helsinki, Finland. of Medicine, University of Helsinki, Finland. of Medicine, University of Helsinki, Finland; CICERO Learning, University of Helsinki, Finland. Drama Hannover, Hanover, Germany. Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Journal:Lancet Neurol. 2017 Aug;16(8):648-660. doi: 10.1016/S1474-4422(17)30168-0. Epub 2017 Jun 26.

10:Dance for Parkinson's-The effects on whole body co-ordination during turning around.
Authors:Hulbert S, Ashburn A, Roberts L, Verheyden G
Institution:University of Southampton, Health Sciences, University Hospital Southampton, Mail point 886, Tremona Road, Southampton SO16 6YD, United Kingdom. Electronic address:; University of Leuven, Department of Rehabilitation Sciences, Tervuuresevest 101-Bus 1501, 3001 Heverlee, Leuven, Belgium.
Journal:Complement Ther Med. 2017 Jun;32:91-97. doi: 10.1016/j.ctim.2017.03.012. Epub 2017 Apr 2.

11:Intake of dairy foods and risk of Parkinson disease.
Authors:Hughes KC, Gao X, Kim IY, Wang M, Weisskopf MG, Schwarzschild MA, Ascherio A
Institution:From the Departments of Epidemiology (K.C.H., I.Y.K., M.W., M.G.W., A.A.), Nutrition (K.C.H., A.A.), Biostatistics (M.W.), and Environmental Health (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), Pennsylvania State University, University Park; Channing Laboratory (M.W., A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston.
Journal:Neurology. 2017 Jul 4;89(1):46-52. doi: 10.1212/WNL.0000000000004057. Epub 2017 Jun 8.

12:Non-motor features of Parkinson disease.
Authors:Schapira AHV, Chaudhuri KR, Jenner P
Institution:Department of Clinical Neurosciences, University College London (UCL) Institute of Neurology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Hospital, King's College London, Camberwell Road, London SE5 9RS, UK. Faculty of Life Sciences and Medicine, King's College London, Newcomen Street, London SE1 1UL, UK.
Journal:Nat Rev Neurosci. 2017 Jul;18(7):435-450. doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

13:Long-term tremor therapy for Parkinson and essential tremor with sensor-guided botulinum toxin type A injections.
Authors:Samotus O, Lee J, Jog M
Institution:London Health Sciences Centre - Lawson Health Research Institute, Department of Clinical Neurological Sciences, London, Ontario, Canada.; University of Western, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Journal:PLoS One. 2017 Jun 6;12(6):e0178670. doi: 10.1371/journal.pone.0178670. eCollection 2017.

14:Remotely Programmed Deep Brain Stimulation of the Bilateral Subthalamic Nucleus for the Treatment of Primary Parkinson Disease: A Randomized Controlled Trial Investigating the Safety and Efficacy of a Novel Deep Brain Stimulation System.
Authors:Li D, Zhang C, Gault J, Wang W, Liu J, Shao M, Zhao Y, Zeljic K, Gao G, Sun B
Institution:Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal:Stereotact Funct Neurosurg. 2017;95(3):174-182. doi: 10.1159/000475765. Epub 2017 Jun 2.

15:Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.
Authors:Zhuo C, Xue R, Luo L, Ji F, Tian H, Qu H, Lin X, Jiang R, Tao R
Institution:aDepartment of Psychological Medicine, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang bInstitute of Mental Health, Jining Medical University, Jining, Shandong cDepartment of Psychological Medicine, Tianjin Mental Health Center dDepartment of Psychological Medicine, Tianjin Anning Hospital eDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin fDepartment of Psychological Medicine, Chinese PLA (People's Liberation Army) General Hospital gDepartment of Psychological Medicine, General Hospital of Beijing Military Region, Chinese PLA, Beijing, China.
Journal:Medicine (Baltimore). 2017 Jun;96(22):e6698. doi: 10.1097/MD.0000000000006698.

16:Randomized trial of preladenant, given as monotherapy, in patients with early Parkinson disease.
Authors:Stocchi F, Rascol O, Hauser RA, Huyck S, Tzontcheva A, Capece R, Ho TW, Sklar P, Lines C, Michelson D, Hewitt DJ
Institution:From the Institute of Neurology (F.S.), IRCCS San Raffaele, Rome, Italy; Departments of Clinical Pharmacology and Neurosciences (O.R.), Clinical Investigation Center CIC1436, NS-Park Clinical Research Network, NeuroToul Centre of Excellence in Neurodegeneration, INSERM, Toulouse University Hospital and Toulouse University, France; Parkinson's Disease and Movement Disorders Center (R.A.H.), USF Health-Byrd Institute, Tampa, FL; and Merck & Co., Inc. (S.H., A.T., R.C., T.W.H., P.S., C.L., D.M., D.J.H.), Kenilworth, NJ.
Journal:Neurology. 2017 Jun 6;88(23):2198-2206. doi: 10.1212/WNL.0000000000004003. Epub 2017 May 10.

17:Intrajejunal levodopa infusion therapy for Parkinson's disease: practical and pragmatic tips for successful maintenance of therapy.
Authors:Titova N, Ray Chaudhuri K
Institution:a Department of Neurology, Neurosurgery and Medical Genetics, Federal State Budgetary Educational Institution of Higher Education , 'N.I. Pirogov Russian National Research Medical University' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia. Excellence , Kings College and Kings College Hospital , London , UK. London , UK.
Journal:Expert Rev Neurother. 2017 Jun;17(6):529-537. doi: 10.1080/14737175.2017.1317595. Epub 2017 Apr 17.

18:Pimavanserin: A Novel Antipsychotic for Parkinson's Disease Psychosis.
Authors:Bozymski KM, Lowe DK, Pasternak KM, Gatesman TL, Crouse EL
Institution:1 Virginia Commonwealth University Health System/Medical College of Virginia Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA.
Journal:Ann Pharmacother. 2017 Jun;51(6):479-487. doi: 10.1177/1060028017693029. Epub 2017 Feb 1.

19:Uncertainty and depression in people with Parkinson's disease: A cross-sectional study.
Authors:Ahn S, Lee J, Chu SH, Sohn YH
Institution:School of Nursing, University of Minnesota, Minneapolis, Minnesota, USA. Seoul, South Korea. Seoul, South Korea.
Journal:Nurs Health Sci. 2017 Jun;19(2):220-227. doi: 10.1111/nhs.12332. Epub 2017 Mar 29.

20:Dancing for Parkinson Disease: A Randomized Trial of Irish Set Dancing Compared With Usual Care.
Authors:Shanahan J, Morris ME, Bhriain ON, Volpe D, Lynch T, Clifford AM
Institution:Department of Clinical Therapies, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. Electronic address: and Exercise Medicine Research, School Allied Health, Melbourne, VIC, Australia. Sciences, University of Limerick, Limerick, Ireland. Ireland. University of Limerick, Limerick, Ireland.
Journal:Arch Phys Med Rehabil. 2017 Sep;98(9):1744-1751. doi: 10.1016/j.apmr.2017.02.017. Epub 2017 Mar 21.

21:Deep Brain Stimulation of Pedunculopontine Nucleus for Postural Instability and Gait Disorder After Parkinson Disease: A Meta-Analysis of Individual Patient Data.
Authors:Wang JW, Zhang YQ, Zhang XH, Wang YP, Li JP, Li YJ
Institution:Beijing Institute of Functional Neurosurgery, Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:
Journal:World Neurosurg. 2017 Jun;102:72-78. doi: 10.1016/j.wneu.2017.02.110. Epub 2017 Mar 6.

22:Are non-demented patients with Parkinson's disease able to decide about their own treatment?
Authors:Eygelshoven S, van den Hout A, Tucha L, Fuermaier ABM, Bangma DF, Thome J, Lobbestael J, Tucha O, Koerts J
Institution:Department of Psychology and Psychiatry, Zuyderland Medical Center, The Netherlands. Netherlands. Groningen, The Netherlands. Groningen, The Netherlands. Groningen, The Netherlands. Department of Clinical Psychological Science, Maastricht University, The Netherlands. Groningen, The Netherlands. Groningen, The Netherlands. Electronic address:
Journal:Parkinsonism Relat Disord. 2017 May;38:48-53. doi: 10.1016/j.parkreldis.2017.02.021. Epub 2017 Feb 21.

23:Land Plus Aquatic Therapy Versus Land-Based Rehabilitation Alone for the Treatment of Balance Dysfunction in Parkinson Disease: A Randomized Controlled Study With 6-Month Follow-Up.
Authors:Palamara G, Gotti F, Maestri R, Bera R, Gargantini R, Bossio F, Zivi I, Volpe D, Ferrazzoli D, Frazzitta G
Institution:Department of Parkinson Disease and Brain Injury Rehabilitation, 'Moriggia-Pelascini' Hospital, Gravedona ed Uniti, Italy. Electronic address:; Department of Biomedical Engineering, Scientific Institute of Montescano, S. Maugeri Foundation IRCCS, Montescano, Italy.; Department of Physical Medicine and Rehabilitation, S. Raffaele Arcangelo Fatebenefratelli Hospital, Venice, Italy.
Journal:Arch Phys Med Rehabil. 2017 Jun;98(6):1077-1085. doi: 10.1016/j.apmr.2017.01.025. Epub 2017 Feb 27.

24:Olfactory dysfunction and dementia in newly diagnosed patients with Parkinson's disease.
Authors:Domellof ME, Lundin KF, Edstrom M, Forsgren L
Institution:Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden. Electronic address:
Journal:Parkinsonism Relat Disord. 2017 May;38:41-47. doi: 10.1016/j.parkreldis.2017.02.017. Epub 2017 Feb 21.

25:Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up.
Authors:Sensi M, Cossu G, Mancini F, Pilleri M, Zibetti M, Modugno N, Quatrale R, Tamma F, Antonini A
Institution:Department of Neurology, Azienda Ospedaliera Universitaria Arcispedale S.Anna, Ferrara, Italy. Arcugnano, Vicenza, Italy. Turin, Italy.
Journal:Parkinsonism Relat Disord. 2017 May;38:90-92. doi: 10.1016/j.parkreldis.2017.02.020. Epub 2017 Feb 21.

26:Walking on four limbs: A systematic review of Nordic Walking in Parkinson disease.
Authors:Bombieri F, Schena F, Pellegrini B, Barone P, Tinazzi M, Erro R
Institution:Department of Neuroscience, Biomedicine and Movement Sciences, Universita di Verona, Verona, Italy. Verona, Verona, Italy. Verona, Verona, Italy; CeRiSM (Research Centre of Mountain Sport and Health), University of Verona, Rovereto, Italy. Surgery, Neuroscience Section, University of Salerno, Salerno, Italy. Verona, Verona, Italy. Electronic address: Surgery, Neuroscience Section, University of Salerno, Salerno, Italy; Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL) Institute of Neurology, London, United Kingdom.
Journal:Parkinsonism Relat Disord. 2017 May;38:8-12. doi: 10.1016/j.parkreldis.2017.02.004. Epub 2017 Feb 6.

27:Preclinical and Potential Applications of Common Western Herbal Supplements as Complementary Treatment in Parkinson's Disease.
Authors:Morgan LA, Grundmann O
Institution:a Department of Medicinal Chemistry , College of Pharmacy, University of Florida , Gainesville , FL , USA. , Gainesville , FL , USA.
Journal:J Diet Suppl. 2017 Jul 4;14(4):453-466. doi: 10.1080/19390211.2016.1263710. Epub 2017 Jan 17.

28:Benefits of Exercise on the Executive Functions in People with Parkinson Disease: A Controlled Clinical Trial.
Authors:de Oliveira RT, Felippe LA, Bucken Gobbi LT, Barbieri FA, Christofoletti G
Institution:From the Graduate Program in Health and Development, Universidade Federal de Mato Grosso do Sul, UFMS, Campo Grande, Mato Grosso do Sul (RTO, LAF, GC); Universidade Estadual Paulista, UNESP, Rio Claro (LTBG, FAB); and Universidade Estadual Paulista, UNESP, Bauru, Sao Paulo, Brazil (FAB).
Journal:Am J Phys Med Rehabil. 2017 May;96(5):301-306. doi: 10.1097/PHM.0000000000000612.

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"I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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