Parkinson's Disease
January 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Parkinson's disease: Autoimmunity and neuroinflammation.
Authors:De Virgilio A, Greco A, Fabbrini G, Inghilleri M, Rizzo MI, Gallo A, Conte M, Rosato C, Ciniglio Appiani M, de Vincentiis M
Institution:Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100, Rome, Italy; Department of Surgical Science, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100, Rome, Italy. Electronic address: mariaidarizzo@gmail.com.; Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.; Department of Neurology and Psychiatry, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.; Department of Medico-Surgical Sciences and Biotechnologies, Otorhinolaryngology Section, 'Sapienza' University of Rome, Corso della Repubblica, 79, 04100 Latina, Italy.
Journal:Autoimmun Rev. 2016 Oct;15(10):1005-11. doi: 10.1016/j.autrev.2016.07.022. Epub 2016 Aug 4.

2:Continuous dopaminergic stimulation therapy for Parkinson's disease - recent advances.
Authors:Timpka J, Mundt-Petersen U, Odin P
Institution:aDepartment of Clinical Sciences Lund, Faculty of Medicine, Lund University bDepartment of Neurology, Skane University Hospital, Lund, Sweden cDepartment of Neurology, Central Hospital, Bremerhaven, Germany.
Journal:Curr Opin Neurol. 2016 Aug;29(4):474-9. doi: 10.1097/WCO.0000000000000354.

3:Treatment of Fatigue in Parkinson Disease.
Authors:Elbers RG, Berendse HW, Kwakkel G
Institution:Department of Physiotherapy, University of Applied Sciences, Leiden, the Netherlands2Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, the Netherlands. Netherlands. the Netherlands.
Journal:JAMA. 2016 Jun 7;315(21):2340-1. doi: 10.1001/jama.2016.5260.

4:Evaluation of rotigotine transdermal patch for the treatment of apathy and motor symptoms in Parkinson's disease.
Authors:Hauser RA, Slawek J, Barone P, Dohin E, Surmann E, Asgharnejad M, Bauer L
Institution:Parkinson's Disease and Movement Disorders Center, USF Health - Byrd Institute, National Parkinson Foundation Center of Excellence, Tampa, FL, USA. rhauser@health.usf.edu. Department of Neurology, St Adalbert Hospital, Gdansk, Poland.
Journal:BMC Neurol. 2016 Jun 7;16:90. doi: 10.1186/s12883-016-0610-7.

5:The nonmotor features of Parkinson's disease: pathophysiology and management advances.
Authors:Reichmann H, Brandt MD, Klingelhoefer L
Institution:Department of Neurology, Technical University Dresden, Dresden, Germany.
Journal:Curr Opin Neurol. 2016 Aug;29(4):467-73. doi: 10.1097/WCO.0000000000000348.

6:No Effect of Subthalamic Deep Brain Stimulation on Intertemporal Decision-Making in Parkinson Patients.
Authors:Seinstra M, Wojtecki L, Storzer L, Schnitzler A, Kalenscher T
Institution:Comparative Psychology, Institute of Experimental Psychology, Heinrich-Heine University Dusseldorf , 40225 Dusseldorf, Germany.; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Dusseldorf , 40225 Dusseldorf, Germany.
Journal:eNeuro. 2016 May 23;3(2). pii: ENEURO.0019-16.2016. doi: 10.1523/ENEURO.0019-16.2016. eCollection 2016 Mar-Apr.

7:Fall-related activity avoidance in relation to a history of falls or near falls, fear of falling and disease severity in people with Parkinson's disease.
Authors:Kader M, Iwarsson S, Odin P, Nilsson MH
Institution:Department of Health Sciences, Lund University, PO Box 157, SE-221 00, Lund, Sweden. manzur.kader@med.lu.se. Sweden. Hospital, Lund, Sweden. Sweden.
Journal:BMC Neurol. 2016 Jun 2;16:84. doi: 10.1186/s12883-016-0612-5.

8:Apathy in patients with Parkinson's disease following deep brain stimulation of the subthalamic nucleus.
Authors:Hindle Fisher I, Pall HS, Mitchell RD, Kausar J, Cavanna AE
Institution:1University of Birmingham Medical School,Birmingham,UK. Birmingham,Birmingham,UK. Birmingham,Birmingham,UK.
Journal:CNS Spectr. 2016 Jun;21(3):258-64. doi: 10.1017/S1092852916000171. Epub 2016 May 6.

9:What daily activities increase the risk of falling in Parkinson patients? An analysis of the utility of the ABC-16 scale.
Authors:Foongsathaporn C, Panyakaew P, Jitkritsadakul O, Bhidayasiri R
Institution:Chulalongkorn Center of Excellence for Parkinson Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand.; Chulalongkorn Center of Excellence for Parkinson Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand; Department of Rehabilitation Medicine, Juntendo University, Tokyo, Japan. Electronic address: rbh@chulapd.org.
Journal:J Neurol Sci. 2016 May 15;364:183-7. doi: 10.1016/j.jns.2016.03.037. Epub 2016 Mar 25.

10:Levodopa therapy for Parkinson disease: A look backward and forward.
Authors:LeWitt PA, Fahn S
Institution:From the Department of Neurology (P.A.L.), Henry Ford Hospital; Department of Neurology (P.A.L.), Wayne State University School of Medicine, Detroit, MI; and Department of Neurology (S.F.), Columbia University Medical Center, New York, NY. plewitt1@hfhs.org.
Journal:Neurology. 2016 Apr 5;86(14 Suppl 1):S3-12. doi: 10.1212/WNL.0000000000002509. Epub 2016 Apr 4.

11:Physicians' experience with RYTARY (carbidopa and levodopa) extended-release capsules in patients who have Parkinson disease.
Authors:Silver DE, Trosch RM
Institution:From the Coastal Neurological Medical Group, Inc. (D.E.S.), La Jolla, CA; and the Parkinson's and Movement Disorders Center (R.M.T.), Farmington Hills, MI. richardtrosch@comcast.net.
Journal:Neurology. 2016 Apr 5;86(14 Suppl 1):S25-35. doi: 10.1212/WNL.0000000000002511. Epub 2016 Apr 4.

12:Advances in levodopa therapy for Parkinson disease: Review of RYTARY (carbidopa and levodopa) clinical efficacy and safety.
Authors:Dhall R, Kreitzman DL
Institution:From the Parkinson's Institute and Clinical Center (R.D.), Sunnyvale, CA; and Parkinson's Disease and Movement Disorder Center of Long Island (D.L.K.), Commack, NY. drdhall@gmail.com.
Journal:Neurology. 2016 Apr 5;86(14 Suppl 1):S13-24. doi: 10.1212/WNL.0000000000002510. Epub 2016 Apr 4.

13:Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia.
Authors:Gomperts SN
Journal:Continuum (Minneap Minn). 2016 Apr;22(2 Dementia):435-63. doi: 10.1212/CON.0000000000000309.

14:Emerging targets and new small molecule therapies in Parkinson's disease treatment.
Authors:Zhang H, Tong R, Bai L, Shi J, Ouyang L
Institution:Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.; Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China; State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address: shijianyoude@126.com.; State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address: ouyangliang@scu.edu.cn.
Journal:Bioorg Med Chem. 2016 Apr 1;24(7):1419-30. doi: 10.1016/j.bmc.2016.02.030. Epub 2016 Feb 24.

15:Novel Approaches to Optimization of Levodopa Therapy for Parkinson's Disease.
Authors:Kianirad Y, Simuni T
Institution:Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Yasaman.Kianirad@northwestern.edu. Feinberg School of Medicine, Northwestern University, Abbott Hall 11th Floor, 710 North Lake Shore Drive, Chicago, IL, 60611, USA. TSimuni@nm.org.
Journal:Curr Neurol Neurosci Rep. 2016 Apr;16(4):34. doi: 10.1007/s11910-016-0635-8.

16:Integrated Approach for Pain Management in Parkinson Disease.
Authors:Geroin C, Gandolfi M, Bruno V, Smania N, Tinazzi M
Institution:Neuromotor and Cognitive Rehabilitation Research Center (CRRNC), Department of Neurological, Biomedical and Movement Sciences, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy. christian.geroin@univr.it. Neurological, Biomedical and Movement Sciences, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy. marialuisa.gandolfi@univr.it. 10, 37134, Verona, Italy. marialuisa.gandolfi@univr.it. Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. veubru@gmail.com. Neurological, Biomedical and Movement Sciences, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy. nicola.smania@univr.it. 10, 37134, Verona, Italy. nicola.smania@univr.it. Biomedical and Movement Sciences, University of Verona, P.le Scuro 10, 37134, Verona, Italy. michele.tinazzi@univr.it.
Journal:Curr Neurol Neurosci Rep. 2016 Apr;16(4):28. doi: 10.1007/s11910-016-0628-7.

17:What to do when people with Parkinson's disease cannot take their usual oral medications.
Authors:Alty J, Robson J, Duggan-Carter P, Jamieson S
Institution:Department of Neurosciences, Leeds Teaching Hospitals NHS Trust, Leeds, West Yorkshire, UK University of Leeds Hull York Medical School, University of York. Yorkshire, UK. Yorkshire, UK. Yorkshire, UK University of Leeds Hull York Medical School, University of York.
Journal:Pract Neurol. 2016 Apr;16(2):122-8. doi: 10.1136/practneurol-2015-001267. Epub 2015 Dec 30.

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"I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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