Parkinson's Disease
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:The significance of uric acid in the diagnosis and treatment of Parkinson disease: An updated systemic review.
Authors:Yu Z, Zhang S, Wang D, Fan M, Gao F, Sun W, Li Z, Li S
Institution:aDepartment of Acupuncture, China-Japan Friendship Hospital, Beijing bDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu Province cDepartment of Orthopedics, Tumd Right Banner Hospital, Baotou City dDepartment of Orthopedics, China-Japan Friendship Hospital, Beijing, China.
Journal:Medicine (Baltimore). 2017 Nov;96(45):e8502. doi: 10.1097/MD.0000000000008502.

2:Longitudinal decline of driving safety in Parkinson disease.
Authors:Uc EY, Rizzo M, O'Shea AMJ, Anderson SW, Dawson JD
Institution:From the Departments of Neurology (E.Y.U., M.R., S.W.A.) and Biostatistics (A.M.J.O., J.D.D.), University of Iowa; Neurology Service (E.Y.U.) and Comprehensive Access and Delivery Research & Evaluation (A.M.J.O.), Veterans Affairs Medical Center, Iowa City, IA; and Department of Neurology (M.R.), University of Nebraska, Omaha.
Journal:Neurology. 2017 Nov 7;89(19):1951-1958. doi: 10.1212/WNL.0000000000004629. Epub 2017 Oct 11.

3:Clinical outcomes of asleep vs awake deep brain stimulation for Parkinson disease.
Authors:Brodsky MA, Anderson S, Murchison C, Seier M, Wilhelm J, Vederman A, Burchiel KJ
Institution:From the Departments of Neurology (M.A.B., S.A., C.M., M.S., J.W.) and Neurosurgery (A.V., K.J.B.), Oregon Health & Science University, Portland.
Journal:Neurology. 2017 Nov 7;89(19):1944-1950. doi: 10.1212/WNL.0000000000004630. Epub 2017 Oct 6.

4:Caffeine as symptomatic treatment for Parkinson disease (Cafe-PD): A randomized trial.
Authors:Postuma RB, Anang J, Pelletier A, Joseph L, Moscovich M, Grimes D, Furtado S, Munhoz RP, Appel-Cresswell S, Moro A, Borys A, Hobson D, Lang AE
Institution:From the Department of Neurology, Montreal General Hospital (R.B.P., A.P.), and Department of Epidemiology and Biostatistics (L.J.), McGill University, Montreal; Department of Neurology (J.A., A.B., D.H.), University of Manitoba, Winnipeg, Canada; Pontifical Catholic University of Parana (M.M., A.M.), Curitiba, Brazil; Department of Neurology (D.G.), Ottawa Hospital, University of Ottawa Brain and Mind Research Institute; Department of Neurology (S.F.), University of Calgary; Division of Neurology (R.P.M., A.E.L.), Toronto Western Hospital; and Department of Medicine, Division of Neurology, Djavad Mowafaghian Centre for Brain Health, and Pacific Parkinson's Research Centre (S.A.-C.), University of British Columbia, Vancouver, Canada.
Journal:Neurology. 2017 Oct 24;89(17):1795-1803. doi: 10.1212/WNL.0000000000004568. Epub 2017 Sep 27.

5:Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms.
Authors:Rodriguez-Violante M, Zeron-Martinez R, Cervantes-Arriaga A, Corona T
Institution:Unidad de Investigacion de Enfermedades Neurodegenerativas Clinicas, Instituto Nacional de Neurologia y Neurocirugia, Ciudad de Mexico, Mexico; Clinica de Trastornos del Movimiento, Instituto Nacional de Neurologia y Neurocirugia, Ciudad de Mexico, Mexico.; Unidad de Investigacion de Enfermedades Neurodegenerativas Clinicas, Instituto Nacional de Neurologia y Neurocirugia, Ciudad de Mexico, Mexico. Electronic address:
Journal:Arch Med Res. 2017 Apr;48(3):221-227. doi: 10.1016/j.arcmed.2017.08.005. Epub 2017 Sep 4.

6:Current approaches to the treatment of Parkinson's Disease.
Authors:Ellis JM, Fell MJ
Institution:Department of Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: Boston, MA 02115, USA.
Journal:Bioorg Med Chem Lett. 2017 Sep 15;27(18):4247-4255. doi: 10.1016/j.bmcl.2017.07.075. Epub 2017 Jul 29.

7:Pimavanserin, a novel antipsychotic for management of Parkinson's disease psychosis.
Authors:Kianirad Y, Simuni T
Institution:a Department of Neurology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA. , Chicago , IL , USA.
Journal:Expert Rev Clin Pharmacol. 2017 Nov;10(11):1161-1168. doi: 10.1080/17512433.2017.1369405. Epub 2017 Oct 17.

8:Botulinum Toxin in Parkinson Disease Tremor: A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach.
Authors:Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B
Institution:Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2017 Sep;92(9):1359-1367. doi: 10.1016/j.mayocp.2017.06.010. Epub 2017 Aug 5.

9:Parkinson's Disease and Its Effect on the Lower Urinary Tract: Evaluation of Complications and Treatment Strategies.
Authors:Brucker BM, Kalra S
Institution:Department of Urology, New York University Langone Medical Center, 150 East 32nd street second floor, New York, NY 10016, USA; Department of Obstetrics and Gynecology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. Electronic address: street second floor, New York, NY 10016, USA.
Journal:Urol Clin North Am. 2017 Aug;44(3):415-428. doi: 10.1016/j.ucl.2017.04.008.

10:Music-based interventions in neurological rehabilitation.
Authors:Sihvonen AJ, Sarkamo T, Leo V, Tervaniemi M, Altenmuller E, Soinila S
Institution:Faculty of Medicine, University of Turku, Turku, Finland; Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland. Electronic address: of Medicine, University of Helsinki, Finland. of Medicine, University of Helsinki, Finland. of Medicine, University of Helsinki, Finland; CICERO Learning, University of Helsinki, Finland. Drama Hannover, Hanover, Germany. Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Journal:Lancet Neurol. 2017 Aug;16(8):648-660. doi: 10.1016/S1474-4422(17)30168-0. Epub 2017 Jun 26.

11:REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson's Disease.
Authors:Jozwiak N, Postuma RB, Montplaisir J, Latreille V, Panisset M, Chouinard S, Bourgouin PA, Gagnon JF
Institution:Department of Psychology, Universite du Quebec a Montreal, Montreal, QC, Canada. Montreal, Montreal, QC, Canada. Montreal, Montreal, QC, Canada. de Montreal, Montreal, QC, Canada. de Montreal, Montreal, QC, Canada. Montreal, Montreal, QC, Canada. Montreal, Montreal, QC, Canada.
Journal:Sleep. 2017 Aug 1;40(8). pii: 3884498. doi: 10.1093/sleep/zsx101.

12:Non-motor features of Parkinson disease.
Authors:Schapira AHV, Chaudhuri KR, Jenner P
Institution:Department of Clinical Neurosciences, University College London (UCL) Institute of Neurology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Hospital, King's College London, Camberwell Road, London SE5 9RS, UK. Faculty of Life Sciences and Medicine, King's College London, Newcomen Street, London SE1 1UL, UK.
Journal:Nat Rev Neurosci. 2017 Jul;18(7):435-450. doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

13:Long-term tremor therapy for Parkinson and essential tremor with sensor-guided botulinum toxin type A injections.
Authors:Samotus O, Lee J, Jog M
Institution:London Health Sciences Centre - Lawson Health Research Institute, Department of Clinical Neurological Sciences, London, Ontario, Canada.; University of Western, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Journal:PLoS One. 2017 Jun 6;12(6):e0178670. doi: 10.1371/journal.pone.0178670. eCollection 2017.

14:Remotely Programmed Deep Brain Stimulation of the Bilateral Subthalamic Nucleus for the Treatment of Primary Parkinson Disease: A Randomized Controlled Trial Investigating the Safety and Efficacy of a Novel Deep Brain Stimulation System.
Authors:Li D, Zhang C, Gault J, Wang W, Liu J, Shao M, Zhao Y, Zeljic K, Gao G, Sun B
Institution:Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal:Stereotact Funct Neurosurg. 2017;95(3):174-182. doi: 10.1159/000475765. Epub 2017 Jun 2.

15:Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.
Authors:Zhuo C, Xue R, Luo L, Ji F, Tian H, Qu H, Lin X, Jiang R, Tao R
Institution:aDepartment of Psychological Medicine, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang bInstitute of Mental Health, Jining Medical University, Jining, Shandong cDepartment of Psychological Medicine, Tianjin Mental Health Center dDepartment of Psychological Medicine, Tianjin Anning Hospital eDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin fDepartment of Psychological Medicine, Chinese PLA (People's Liberation Army) General Hospital gDepartment of Psychological Medicine, General Hospital of Beijing Military Region, Chinese PLA, Beijing, China.
Journal:Medicine (Baltimore). 2017 Jun;96(22):e6698. doi: 10.1097/MD.0000000000006698.

16:Safinamide for the treatment of Parkinson's disease.
Authors:deSouza RM, Schapira A
Institution:a Department of Clinical Neurosciences , Institute of Neurology, University College London , London , UK. College London , London , UK.
Journal:Expert Opin Pharmacother. 2017 Jun;18(9):937-943. doi: 10.1080/14656566.2017.1329819. Epub 2017 May 23.

17:Randomized trial of preladenant, given as monotherapy, in patients with early Parkinson disease.
Authors:Stocchi F, Rascol O, Hauser RA, Huyck S, Tzontcheva A, Capece R, Ho TW, Sklar P, Lines C, Michelson D, Hewitt DJ
Institution:From the Institute of Neurology (F.S.), IRCCS San Raffaele, Rome, Italy; Departments of Clinical Pharmacology and Neurosciences (O.R.), Clinical Investigation Center CIC1436, NS-Park Clinical Research Network, NeuroToul Centre of Excellence in Neurodegeneration, INSERM, Toulouse University Hospital and Toulouse University, France; Parkinson's Disease and Movement Disorders Center (R.A.H.), USF Health-Byrd Institute, Tampa, FL; and Merck & Co., Inc. (S.H., A.T., R.C., T.W.H., P.S., C.L., D.M., D.J.H.), Kenilworth, NJ.
Journal:Neurology. 2017 Jun 6;88(23):2198-2206. doi: 10.1212/WNL.0000000000004003. Epub 2017 May 10.

18:Intrajejunal levodopa infusion therapy for Parkinson's disease: practical and pragmatic tips for successful maintenance of therapy.
Authors:Titova N, Ray Chaudhuri K
Institution:a Department of Neurology, Neurosurgery and Medical Genetics, Federal State Budgetary Educational Institution of Higher Education , 'N.I. Pirogov Russian National Research Medical University' of the Ministry of Healthcare of the Russian Federation , Moscow , Russia. Excellence , Kings College and Kings College Hospital , London , UK. London , UK.
Journal:Expert Rev Neurother. 2017 Jun;17(6):529-537. doi: 10.1080/14737175.2017.1317595. Epub 2017 Apr 17.

19:Evidence-Based Review of Pharmacotherapy Used for Parkinson's Disease Psychosis.
Authors:Wilby KJ, Johnson EG, Johnson HE, Ensom MHH
Institution:1 Qatar University, Doha, Qatar. Canada.
Journal:Ann Pharmacother. 2017 Aug;51(8):682-695. doi: 10.1177/1060028017703992. Epub 2017 Apr 6.

20:Pimavanserin: A Novel Antipsychotic for Parkinson's Disease Psychosis.
Authors:Bozymski KM, Lowe DK, Pasternak KM, Gatesman TL, Crouse EL
Institution:1 Virginia Commonwealth University Health System/Medical College of Virginia Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA. Hospitals, Richmond, VA, USA.
Journal:Ann Pharmacother. 2017 Jun;51(6):479-487. doi: 10.1177/1060028017693029. Epub 2017 Feb 1.

21:Dancing for Parkinson Disease: A Randomized Trial of Irish Set Dancing Compared With Usual Care.
Authors:Shanahan J, Morris ME, Bhriain ON, Volpe D, Lynch T, Clifford AM
Institution:Department of Clinical Therapies, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. Electronic address: and Exercise Medicine Research, School Allied Health, Melbourne, VIC, Australia. Sciences, University of Limerick, Limerick, Ireland. Ireland. University of Limerick, Limerick, Ireland.
Journal:Arch Phys Med Rehabil. 2017 Sep;98(9):1744-1751. doi: 10.1016/j.apmr.2017.02.017. Epub 2017 Mar 21.

22:Land Plus Aquatic Therapy Versus Land-Based Rehabilitation Alone for the Treatment of Balance Dysfunction in Parkinson Disease: A Randomized Controlled Study With 6-Month Follow-Up.
Authors:Palamara G, Gotti F, Maestri R, Bera R, Gargantini R, Bossio F, Zivi I, Volpe D, Ferrazzoli D, Frazzitta G
Institution:Department of Parkinson Disease and Brain Injury Rehabilitation, 'Moriggia-Pelascini' Hospital, Gravedona ed Uniti, Italy. Electronic address:; Department of Biomedical Engineering, Scientific Institute of Montescano, S. Maugeri Foundation IRCCS, Montescano, Italy.; Department of Physical Medicine and Rehabilitation, S. Raffaele Arcangelo Fatebenefratelli Hospital, Venice, Italy.
Journal:Arch Phys Med Rehabil. 2017 Jun;98(6):1077-1085. doi: 10.1016/j.apmr.2017.01.025. Epub 2017 Feb 27.

23:Preclinical and Potential Applications of Common Western Herbal Supplements as Complementary Treatment in Parkinson's Disease.
Authors:Morgan LA, Grundmann O
Institution:a Department of Medicinal Chemistry , College of Pharmacy, University of Florida , Gainesville , FL , USA. , Gainesville , FL , USA.
Journal:J Diet Suppl. 2017 Jul 4;14(4):453-466. doi: 10.1080/19390211.2016.1263710. Epub 2017 Jan 17.

24:A Meta-Analysis of Nonpharmacological Interventions for People With Parkinson's Disease.
Authors:Lee J, Choi M, Yoo Y
Institution:1 Yonsei University, Seodaemun-gu, Seoul, Korea.
Journal:Clin Nurs Res. 2017 Oct;26(5):608-631. doi: 10.1177/1054773816655091. Epub 2016 Jun 17.

25:More than just dancing: experiences of people with Parkinson's disease in a therapeutic dance program.
Authors:Bognar S, DeFaria AM, O'Dwyer C, Pankiw E, Simic Bogler J, Teixeira S, Nyhof-Young J, Evans C
Institution:a Department of Physical Therapy , University of Toronto , Toronto , Canada. , Canada.
Journal:Disabil Rehabil. 2017 Jun;39(11):1073-1078. doi: 10.1080/09638288.2016.1175037. Epub 2016 May 23.

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