Parkinson's Disease
October 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Comparison of efficacy and safety of complementary and alternative therapies for Parkinson's disease: A Bayesian network meta-analysis protocol.
Authors:Li C, An H, Wang J, Jiang Z, Zhang T, Huo Q
Institution:First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan. Xintai People's Hospital, Xintai.
Journal:Medicine (Baltimore). 2020 Sep 18;99(38):e22265. doi: 10.1097/MD.0000000000022265.

2:Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine.
Authors:Watanabe H, Hattori T, Kume A, Misu K, Ito T, Koike Y, Johnson TA, Kamitsuji S, Kamatani N, Sobue G
Institution:Nagoya University Graduate School of Medicine, Brain and Mind Research Center, Nagoya.
Journal:Medicine (Baltimore). 2020 Aug 28;99(35):e21576. doi: 10.1097/MD.0000000000021576.

3:Impact of Prolonged Lockdown due to COVID-19 in Patients with Parkinson's Disease.
Authors:Prasad S, Holla VV, Neeraja K, Surisetti BK, Kamble N, Yadav R, Pal PK
Institution:Department of Clinical Neurosciences; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Journal:Neurol India. 2020 Jul-Aug;68(4):792-795. doi: 10.4103/0028-3886.293472.

4:Rapid drug increase and early onset of levodopa-induced dyskinesia in Parkinson's disease.
Authors:Hong JY, Sunwoo MK, Yoon JH, Kang SY, Sohn YH, Lee PH, Kim SH
Institution:Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, South Korea.
Journal:PLoS One. 2020 Aug 20;15(8):e0237472. doi: 10.1371/journal.pone.0237472. eCollection 2020.

5:The effect on deep brain stimulation of subthalamic nucleus and dopaminergic treatment in Parkinson disease.
Authors:Lo Buono V, Palmeri R, Stroscio G, Corallo F, Di Lorenzo G, Sorbera C, Ciurleo R, Cimino V, Bramanti P, Marino S, Bonanno L
Institution:IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
Journal:Medicine (Baltimore). 2020 Aug 7;99(32):e21578. doi: 10.1097/MD.0000000000021578.

6:The efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson's disease: A systematic review and meta-analysis.
Authors:Carapellotti AM, Stevenson R, Doumas M
Institution:School of Psychology, Queen's University Belfast, Belfast, United Kingdom.
Journal:PLoS One. 2020 Aug 5;15(8):e0236820. doi: 10.1371/journal.pone.0236820. eCollection 2020.

7:Promoting Physical Activity via Telehealth in People With Parkinson Disease: The Path Forward After the COVID-19 Pandemic?
Authors:Quinn L, Macpherson C, Long K, Shah H
Institution:Department of Biobehavioral Sciences, Teachers College, Columbia University, and Department of Rehabilitation and Regenerative Medicine (Physical Therapy), Columbia University Irving Medical Center, 52 Department of Neurology, Columbia University Irving Medical Center.
Journal:Phys Ther. 2020 Sep 28;100(10):1730-1736. doi: 10.1093/ptj/pzaa128.

8:Risk factors for depression in patients with Parkinson's disease: A nationwide nested case-control study.
Authors:Chang YP, Lee MS, Wu DW, Tsai JH, Ho PS, Lin CR, Chuang HY
Institution:Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Program in Environmental and Occupation Medicine, (Taiwan) National Health Research Institutes and Kaohsiung Medical University, Kaohsiung, Taiwan.
Journal:PLoS One. 2020 Jul 27;15(7):e0236443. doi: 10.1371/journal.pone.0236443. eCollection 2020.

9:A randomized double-blind placebo-controlled multicenter trial of Bushen Yisui and Ziyin Jiangzhuo formula for constipation in Parkinson disease.
Authors:Jin Z, Liu Z, Kang L, Yang A, Zhao H, Yan X, Zhang T, Gao L, Liu A, Fang B
Institution:Parkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University.
Journal:Medicine (Baltimore). 2020 Jul 10;99(28):e21145. doi: 10.1097/MD.0000000000021145.

10:Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview.
Authors:Bove F, Fraix V, Cavallieri F, Schmitt E, Lhommée E, Bichon A, Meoni S, Pélissier P, Kistner A, Chevrier E, Ardouin C, Limousin P, Krack P, Benabid AL, Chabardès S, Seigneuret E, Castrioto A, Moro E
Institution:From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Insti
Journal:Neurology. 2020 Jul 28;95(4):e384-e392. doi: 10.1212/WNL.0000000000009822. Epub 2020 Jul 1.

11:Deep brain stimulation in early-stage Parkinson disease: Five-year outcomes.
Authors:Hacker ML, Turchan M, Heusinkveld LE, Currie AD, Millan SH, Molinari AL, Konrad PE, Davis TL, Phibbs FT, Hedera P, Cannard KR, Wang L, Charles D
Institution:From the Departments of Neurology (M.L.H., M.T., L.E.H., A.D.C., S.H.M., A.L.M., T.L.D., F.T.P., P.H., D.C.), Neurosurgery (P.E.K.), and Biostatistics (L.W.), Vanderbilt University Medical Center, Nash
Journal:Neurology. 2020 Jul 28;95(4):e393-e401. doi: 10.1212/WNL.0000000000009946. Epub 2020 Jun 29.

12:Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial.
Authors:Volc D, Poewe W, Kutzelnigg A, Lührs P, Thun-Hohenstein C, Schneeberger A, Galabova G, Majbour N, Vaikath N, El-Agnaf O, Winter D, Mihailovska E, Mairhofer A, Schwenke C, Staffler G, Medori R
Institution:Confraternitaet-Privatklinik Josefstadt, Vienna, Austria. AFFiRiS, Vienna, Austria.
Journal:Lancet Neurol. 2020 Jul;19(7):591-600. doi: 10.1016/S1474-4422(20)30136-8.

13:Treatment of Dysphagia in Parkinson's Disease: A Systematic Review.
Authors:López-Liria R, Parra-Egeda J, Vega-Ramírez FA, Aguilar-Parra JM, Trigueros-Ramos R, Morales-Gázquez MJ, Rocamora-Pérez P
Institution:Health Research Centre, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera del Sacramento s/n, La Canada de San Urbano, 04120 Almeria, Spain.
Journal:Int J Environ Res Public Health. 2020 Jun 9;17(11):4104. doi: 10.3390/ijerph17114104.

14:COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy.
Authors:Fasano A, Cereda E, Barichella M, Cassani E, Ferri V, Zecchinelli AL, Pezzoli G
Institution:Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario Fondazione Grigioni per il Morbo di Parkinson, Italy.
Journal:Mov Disord. 2020 Jul;35(7):1089-1093. doi: 10.1002/mds.28176. Epub 2020 Jun 26.

15:Effects of COVID-19 on Parkinson's Disease Clinical Features: A Community-Based Case-Control Study.
Authors:Cilia R, Bonvegna S, Straccia G, Andreasi NG, Elia AE, Romito LM, Devigili G, Cereda E, Eleopra R
Institution:Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Parkinson and Movement Disorders Unit, Milan, Italy.
Journal:Mov Disord. 2020 Aug;35(8):1287-1292. doi: 10.1002/mds.28170. Epub 2020 Jun 11.

16:Cognitive behavioral therapy for depression and anxiety of Parkinson's disease: A systematic review and meta-analysis.
Authors:Zhang Q, Yang X, Song H, Jin Y
Institution:Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address: Department of Nursing, Tianjin Huanhu Hospital, Tianjin, China. Electronic address:
Journal:Complement Ther Clin Pract. 2020 May;39:101111. doi: 10.1016/j.ctcp.2020.101111. Epub 2020 Jan 30.

17:Tobacco smoking and the risk of Parkinson disease: A 65-year follow-up of 30,000 male British doctors.
Authors:Mappin-Kasirer B, Pan H, Lewington S, Kizza J, Gray R, Clarke R, Peto R
Institution:From the Clinical Trial Service Unit and Epidemiological Studies Unit (B.M.-K., H.P., S.L., J.K., R.G., R.C., R.P.), Nuffield Department of Population Health, University of Oxford; and Medical Research
Journal:Neurology. 2020 May 19;94(20):e2132-e2138. doi: 10.1212/WNL.0000000000009437. Epub 2020 May 5.

18:Medical cannabis as an alternative therapeutics for Parkinsons' disease: Systematic review.
Authors:Bougea A, Koros C, Simitsi AM, Chrysovitsanou C, Leonardos A, Stefanis L
Institution:1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:
Journal:Complement Ther Clin Pract. 2020 May;39:101154. doi: 10.1016/j.ctcp.2020.101154. Epub 2020 Mar 31.

19:Cognitive decline profiles differ in Parkinson disease dementia and dementia with Lewy bodies.
Authors:Smirnov DS, Galasko D, Edland SD, Filoteo JV, Hansen LA, Salmon DP
Institution:From the Department of Neurosciences (D.S.S., D.G., D.P.S.), Department of Family Medicine and Public Health (S.D.E.), Departments of Psychiatry and Neurosciences (J.V.F.), and Departments of Pathology
Journal:Neurology. 2020 May 19;94(20):e2076-e2087. doi: 10.1212/WNL.0000000000009434. Epub 2020 Apr 24.

20:Sensory focused exercise improves anxiety in Parkinson's disease: A randomized controlled trial.
Authors:Beck EN, Wang MTY, Intzandt BN, Almeida QJ, Ehgoetz Martens KA
Institution:School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland. Department of Kinesiology and Physical Education, Movement Disorders Research & Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Journal:PLoS One. 2020 Apr 16;15(4):e0230803. doi: 10.1371/journal.pone.0230803. eCollection 2020.

21:Surgical Treatment of Parkinson Disease.
Authors:Mitchell KT, Ostrem JL
Institution:Duke University Movement Disorders Center, DUMC 3333, 932 Morreene Road, Durham, NC 27705, USA. Electronic address: UCSF Movement Disorders and Neuromodulation Center, 1635 Divisadero Street Suite 520, Box 1838, San Francisco, CA 94115, USA.
Journal:Neurol Clin. 2020 May;38(2):293-307. doi: 10.1016/j.ncl.2020.01.001. Epub 2020 Feb 22.

22:Treatment of Nonmotor Symptoms Associated with Parkinson Disease.
Authors:Goldman JG, Guerra CM
Institution:Parkinson's Disease and Movement Disorders, Shirley Ryan AbilityLab, 355 East Erie Street, Chicago, IL 60611, USA; Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern Univer PRISMA Advanced Care Center for Parkinson's, movement disorders and Dementia, San Luis Potosi, Mexico; Facutly of Psychology, Autonomous University of San Luis Potosi Sierra de las Cascadas 117, Lomas
Journal:Neurol Clin. 2020 May;38(2):269-292. doi: 10.1016/j.ncl.2019.12.003. Epub 2020 Feb 12.

23:Pharmacologic Treatment of Motor Symptoms Associated with Parkinson Disease.
Authors:Poewe W, Mahlknecht P
Institution:Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria. Electronic address: WERNER.POEWE@I-MED.AC.AT.
Journal:Neurol Clin. 2020 May;38(2):255-267. doi: 10.1016/j.ncl.2019.12.002. Epub 2020 Feb 20.

24:A review of possible therapies for Parkinson's disease.
Authors:Chakraborty A, Brauer S, Diwan A
Institution:Allexcel, Inc., 1 Controls Drive, Shelton, CT 06484, United States. Electronic address:
Journal:J Clin Neurosci. 2020 Jun;76:1-4. doi: 10.1016/j.jocn.2020.03.047. Epub 2020 Apr 9.

25:Possible therapies of Parkinson's disease: A review.
Authors:Chakraborty A, Brauer S, Diwan A
Institution:Allexcel, Inc., 1 Controls Drive, Shelton 06484, CT, United States. Electronic address:
Journal:J Clin Neurosci. 2020 May;75:1-4. doi: 10.1016/j.jocn.2020.03.024. Epub 2020 Apr 1.

26:Initiation of pharmacological therapy in Parkinson's disease: when, why, and how.
Authors:de Bie RMA, Clarke CE, Espay AJ, Fox SH, Lang AE
Institution:Amsterdam University Medical Centers, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON, Cana
Journal:Lancet Neurol. 2020 May;19(5):452-461. doi: 10.1016/S1474-4422(20)30036-3. Epub 2020 Mar 12.

27:Combined deep brain stimulation and thalamotomy for tremor-dominant Parkinson's disease.
Authors:Kojoh A, Enatsu R, Kitagawa M, Mikami T, Sasagawa A, Kuribara T, Hirano T, Arihara M, Mikuni N
Institution:Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Journal:J Clin Neurosci. 2020 Apr;74:244-247. doi: 10.1016/j.jocn.2020.02.014. Epub 2020 Feb 15.

28:The pharmacological management of constipation in patients with Parkinson's disease: a much-needed relief.
Authors:Mozaffari S, Nikfar S, Daniali M, Abdollahi M
Institution:Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), the Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences , Tehran, Iran.
Journal:Expert Opin Pharmacother. 2020 Apr;21(6):701-707. doi: 10.1080/14656566.2020.1726319. Epub 2020 Feb 8.

29:Safinamide as an adjunct therapy in older patients with Parkinson's disease: a retrospective study.
Authors:Lo Monaco MR, Petracca M, Vetrano DL, Di Stasio E, Fusco D, Ricciardi D, Laudisio A, Zuccalà G, Onder G, Bentivoglio AR
Institution:Institute of Internal Medicine and Geriatrics, Universita Cattolica del Sacro Cuore, 00168, Rome, Italy. Fondazione Policlinico Universitario 'Agostino Gemelli'-IRCSS, Largo A Gemelli, 8, 00168, Rome, Italy.
Journal:Aging Clin Exp Res. 2020 Jul;32(7):1369-1373. doi: 10.1007/s40520-020-01469-4. Epub 2020 Jan 24.

30:Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson's disease: a meta-analysis.
Authors:Jiang DQ, Li MX, Jiang LL, Chen XB, Zhou XW
Institution:Department of Biology and Pharmacy, Yulin Normal University, Jiaoyudong Road No.1303, Yuzhou District, Yulin, 537000, Guangxi, China.
Journal:Aging Clin Exp Res. 2020 May;32(5):769-779. doi: 10.1007/s40520-019-01232-4. Epub 2019 Jun 7.

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