Parkinson's Disease
December 2019 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Approach to Assessment of Parkinson Disease with Emphasis on Genetic Testing.
Authors:Payne K, Walls B, Wojcieszek J
Institution:Department of Neurology, Indiana University School of Medicine, 355 West 16th Street, Suite 4700, Indianapolis, IN 46202, USA. Electronic address: paynekk@iu.edu.
Journal:Med Clin North Am. 2019 Nov;103(6):1055-1075. doi: 10.1016/j.mcna.2019.08.003. Epub 2019 Aug 31.

2:The therapeutic effect of deep brain stimulation on olfactory functions and clinical scores in Parkinson's disease.
Authors:Saatci O, Yilmaz NH, Zirh A, Yulug B
Institution:Istanbul Sancaktepe, Education and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey. Turkey. Electronic address: burakyulug@gmail.com.
Journal:J Clin Neurosci. 2019 Oct;68:55-61. doi: 10.1016/j.jocn.2019.07.055. Epub 2019 Aug 2.

3:Effects of dance therapy on cognitive and mood symptoms in people with Parkinson's disease: A systematic review and meta-analysis.
Authors:Zhang Q, Hu J, Wei L, Jia Y, Jin Y
Institution:School of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Shanxi, Taiyuan, Shanxi, China. China. address: jinyi6196@163.com.
Journal:Complement Ther Clin Pract. 2019 Aug;36:12-17. doi: 10.1016/j.ctcp.2019.04.005. Epub 2019 Apr 25.

4:COGTIPS: a double-blind randomized active controlled trial protocol to study the effect of home-based, online cognitive training on cognition and brain networks in Parkinson's disease.
Authors:van Balkom TD, Berendse HW, van der Werf YD, Twisk JWR, Zijlstra I, Hagen RH, Berk T, Vriend C, van den Heuvel OA
Institution:Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, Netherlands. t.vanbalkom@amsterdamumc.nl.; Amsterdam UMC, Vrije Universiteit Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, Netherlands. t.vanbalkom@amsterdamumc.nl.; Amsterdam UMC, Vrije Universiteit Amsterdam, Neurology, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Epidemiology and Biostatistics, Amsterdam Public Health, De Boelelaan 1117, Amsterdam, Netherlands.; Dutch Parkinson's Disease Association, PO Box 46, Bunnik, 3980 CA, the Netherlands.
Journal:BMC Neurol. 2019 Jul 31;19(1):179. doi: 10.1186/s12883-019-1403-6.

5:The challenge of pain in the pharmacological management of Parkinson's disease.
Authors:Jost WH, Buhmann C
Institution:Parkinson-Klinik Ortenau , Wolfach , Germany. Center , Hamburg , Germany.
Journal:Expert Opin Pharmacother. 2019 Oct;20(15):1847-1854. doi: 10.1080/14656566.2019.1639672. Epub 2019 Jul 10.

6:Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.
Authors:Zhao Y, Dzamko N
Institution:Brain and Mind Centre, Central Clinical School, University of Sydney, Camperdown, NSW, 2050, Australia.
Journal:Drugs. 2019 Jul;79(10):1037-1051. doi: 10.1007/s40265-019-01139-4.

7:Changing the treatment paradigm for Parkinson's disease psychosis with pimavanserin.
Authors:Lyons KE, Pahwa R, Hermanowicz N, Davis T, Pagan F, Isaacson S
Institution:a Department of Neurology , University of Kansas Medical Center , Kansas City , KS , USA. KS , USA. , USA. DC , USA. FL , USA.
Journal:Expert Rev Clin Pharmacol. 2019 Jul;12(7):681-691. doi: 10.1080/17512433.2019.1623669. Epub 2019 Jun 13.

8:Systematic review of the pharmacoeconomics of Parkinson disease medications.
Authors:Wang AS, Gunzler SA
Institution:Neurological Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine , Cleveland , OH , USA.
Journal:Expert Opin Pharmacother. 2019 Sep;20(13):1659-1670. doi: 10.1080/14656566.2019.1622091. Epub 2019 May 31.

9:Drug treatment strategies for depression in Parkinson disease.
Authors:Ryan M, Eatmon CV, Slevin JT
Institution:a Department of Pharmacy Practice and Science , University of Kentucky College of Pharmacy , Lexington , KY , USA. Healthcare System , Lexington , KY , USA. of Kentucky College of Medicine , Lexington , KY , USA.
Journal:Expert Opin Pharmacother. 2019 Aug;20(11):1351-1363. doi: 10.1080/14656566.2019.1612877. Epub 2019 May 23.

10:Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson's disease: A single-arm, open-label, prospective, multicenter study.
Authors:Iijima M, Orimo S, Terashi H, Suzuki M, Hayashi A, Shimura H, Mitoma H, Kitagawa K, Okuma Y
Institution:a Department of Neurology , Tokyo Women's Medical University , Tokyo , Japan. School of Medicine , Tokyo , Japan. Japan. Japan. Japan.
Journal:Expert Opin Pharmacother. 2019 Aug;20(11):1405-1411. doi: 10.1080/14656566.2019.1614167. Epub 2019 May 28.

11:Targeting alpha-Synuclein in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapeutics.
Authors:Savitt D, Jankovic J
Institution:Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge, Suite 9A, Houston, TX, 77030-4202, USA. josephj@bcm.edu.
Journal:Drugs. 2019 Jun;79(8):797-810. doi: 10.1007/s40265-019-01104-1.

12:Parkinson's disease: Mechanisms, translational models and management strategies.
Authors:Raza C, Anjum R, Shakeel NUA
Institution:Department of Zoology, Government College University, Lahore 54000, Pakistan. Electronic address: chandraza@gcu.edu.pk.
Journal:Life Sci. 2019 Jun 1;226:77-90. doi: 10.1016/j.lfs.2019.03.057. Epub 2019 Apr 10.

13:Safety and Tolerability of Pharmacotherapies for Parkinson's Disease in Geriatric Patients.
Authors:Klietz M, Greten S, Wegner F, Hoglinger GU
Institution:Department of Neurology, Hannover Medical School, Hannover, Germany. Klietz.Martin@mh-hannover.de.
Journal:Drugs Aging. 2019 Jun;36(6):511-530. doi: 10.1007/s40266-019-00654-z.

14:Excessive daytime sleepiness and its impact on quality of life in de novo Parkinson's disease.
Authors:Yoo SW, Kim JS, Oh YS, Ryu DW, Lee KS
Institution:Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Journal:Neurol Sci. 2019 Jun;40(6):1151-1156. doi: 10.1007/s10072-019-03785-8. Epub 2019 Feb 28.

15:Compulsive eating behaviors in Parkinson's disease.
Authors:de Chazeron I, Durif F, Chereau-Boudet I, Fantini ML, Marques A, Derost P, Debilly B, Brousse G, Boirie Y, Llorca PM
Institution:Service de Psychiatrie B, CHU Clermont-Ferrand, EA7280, Universite Clermont Auvergne, Clermont-Ferrand, Rue Montalembert BP 69, 63003, Clermont-Ferrand, France. idechazeron@chu-clermontferrand.fr.; Service de neurologie A, CHU Clermont-Ferrand, EA7280, Universite Clermont Auvergne, Clermont-Ferrand, France.; Service de nutrition clinique, CHU Clermont-Ferrand, INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France.
Journal:Eat Weight Disord. 2019 Jun;24(3):421-429. doi: 10.1007/s40519-019-00648-1. Epub 2019 Feb 4.

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