Parkinson's Disease
August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study.
Authors:Cilia R, Laguna J, Cassani E, Cereda E, Pozzi NG, Isaias IU, Contin M, Barichella M, Pezzoli G
Institution:From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Nino Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Wurzburg and Julius-Maximilians-University, Wurzburg, Germany; IRCCS-Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
Journal:Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5.

2:Non-motor features of Parkinson disease.
Authors:Schapira AHV, Chaudhuri KR, Jenner P
Institution:Department of Clinical Neurosciences, University College London (UCL) Institute of Neurology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Hospital, King's College London, Camberwell Road, London SE5 9RS, UK. Faculty of Life Sciences and Medicine, King's College London, Newcomen Street, London SE1 1UL, UK.
Journal:Nat Rev Neurosci. 2017 Jul;18(7):435-450. doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

3:The promise of telemedicine for chronic neurological disorders: the example of Parkinson's disease.
Authors:Schneider RB, Biglan KM
Institution:University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address:
Journal:Lancet Neurol. 2017 Jul;16(7):541-551. doi: 10.1016/S1474-4422(17)30167-9. Epub 2017 May 26.

4:Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.
Authors:Zhuo C, Xue R, Luo L, Ji F, Tian H, Qu H, Lin X, Jiang R, Tao R
Institution:aDepartment of Psychological Medicine, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang bInstitute of Mental Health, Jining Medical University, Jining, Shandong cDepartment of Psychological Medicine, Tianjin Mental Health Center dDepartment of Psychological Medicine, Tianjin Anning Hospital eDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin fDepartment of Psychological Medicine, Chinese PLA (People's Liberation Army) General Hospital gDepartment of Psychological Medicine, General Hospital of Beijing Military Region, Chinese PLA, Beijing, China.
Journal:Medicine (Baltimore). 2017 Jun;96(22):e6698. doi: 10.1097/MD.0000000000006698.

5:Pharmacokinetic drug evaluation of safinamide mesylate for the treatment of mid-to-late stage Parkinson's disease.
Authors:Muller T
Institution:a Department of Neurology , St. Joseph Hospital Berlin-Weissensee , Berlin , Germany.
Journal:Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):693-699. doi: 10.1080/17425255.2017.1329418.

6:Rotorua, hydrogen sulphide and Parkinson's disease-A possible beneficial link?
Authors:Cakmak YO
Institution:Senior Lecturer, Otago University, School of Medicine, Department of Anatomy, Dunedin.
Journal:N Z Med J. 2017 May 12;130(1455):123-125.

7:Therapeutic singing as an early intervention for swallowing in persons with Parkinson's disease.
Authors:Stegemoller EL, Hibbing P, Radig H, Wingate J
Institution:Department of Kinesiology, Iowa State University, Ames, IA, United States. Electronic address: Jacksonville, FL, United States.
Journal:Complement Ther Med. 2017 Apr;31:127-133. doi: 10.1016/j.ctim.2017.03.002. Epub 2017 Mar 7.

8:Living with Parkinson's Disease: Staying Determined.
Authors:Sorrell JM
Journal:J Psychosoc Nurs Ment Health Serv. 2017 Apr 1;55(4):15-18. doi: 10.3928/02793695-20170330-03.

9:Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative.
Authors:Ffytche DH, Pereira JB, Ballard C, Chaudhuri KR, Weintraub D, Aarsland D
Institution:KCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.; University of Exeter Medical School, University of Exeter, Exeter, Devon, UK.; Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
Journal:J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):325-331. doi: 10.1136/jnnp-2016-314832.

10:ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson's disease.
Authors:Antonini A, Barone P, Bonuccelli U, Annoni K, Asgharnejad M, Stanzione P
Institution:Parkinson and Movement Disorders Unit, IRCCS Hospital San Camillo, Venice, and Department of Neurosciences (DNS), Padova University, Padova, Italy Pisa, Pisa, Italy. Fondazione S Lucia, Rome, Italy.
Journal:J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):317-324. doi: 10.1136/jnnp-2016-315277.

11:Clinical manifestations of nonmotor symptoms in 1021 Japanese Parkinson's disease patients from 35 medical centers.
Authors:Maeda T, Shimo Y, Chiu SW, Yamaguchi T, Kashihara K, Tsuboi Y, Nomoto M, Hattori N, Watanabe H, Saiki H
Institution:Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan; Department of Neurology and Movement Disorder Research, Research Institute for Brain and Blood Vessels-Akita, 6-10 Senshukubotamachi, Akita 010-0874, Japan. Electronic address:; Department of Neurology, Juntendo University School of Medicine 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan. Electronic address:; Division of Biostatistics, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. Electronic address:; Division of Biostatistics, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. Electronic address:; Department of Neurology, Okayama Kyokuto Hospital, 567-1 Kurata, Okayama, 703-8265, Japan. Electronic address:
Journal:Parkinsonism Relat Disord. 2017 May;38:54-60. doi: 10.1016/j.parkreldis.2017.02.024. Epub 2017 Feb 21.

12:The impact of motor symptoms on self-reported anxiety in Parkinson's disease.
Authors:Salazar RD, Le AM, Neargarder S, Cronin-Golomb A
Institution:Department of Psychological and Brain Sciences, Boston University, USA. Department of Psychology, Bridgewater State University, USA. Electronic address:
Journal:Parkinsonism Relat Disord. 2017 May;38:26-30. doi: 10.1016/j.parkreldis.2017.01.011. Epub 2017 Jan 24.

13:Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up.
Authors:Sensi M, Cossu G, Mancini F, Pilleri M, Zibetti M, Modugno N, Quatrale R, Tamma F, Antonini A
Institution:Department of Neurology, Azienda Ospedaliera Universitaria Arcispedale S.Anna, Ferrara, Italy. Arcugnano, Vicenza, Italy. Turin, Italy.
Journal:Parkinsonism Relat Disord. 2017 May;38:90-92. doi: 10.1016/j.parkreldis.2017.02.020. Epub 2017 Feb 21.

14:Subthalamic nucleus deep brain stimulation on motor-symptoms of Parkinson's disease: Focus on neurochemistry.
Authors:Stefani A, Trendafilov V, Liguori C, Fedele E, Galati S
Institution:Department of System Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy. Switzerland (NSI), Lugano, Switzerland. 1, 00133 Rome, Italy. for Biomedical Research, University of Genoa, 16148 Genoa, Italy. Switzerland (NSI), Lugano, Switzerland. Electronic address:
Journal:Prog Neurobiol. 2017 Apr;151:157-174. doi: 10.1016/j.pneurobio.2017.01.003. Epub 2017 Jan 31.

15:The diagnosis, clinical findings and treatment options for Parkinson's disease patients attending a tertiary referral voice clinic.
Authors:Gibbins N, Awad R, Harris S, Aymat A
Institution:Department of Otolaryngology,University Hospital Lewisham,London,UK.
Journal:J Laryngol Otol. 2017 Apr;131(4):357-362. doi: 10.1017/S0022215117000159. Epub 2017 Jan 31.

16:Levodopa/carbidopa microtablets in Parkinson's disease: a study of pharmacokinetics and blinded motor assessment.
Authors:Senek M, Aquilonius SM, Askmark H, Bergquist F, Constantinescu R, Ericsson A, Lycke S, Medvedev A, Memedi M, Ohlsson F, Spira J, Westin J, Nyholm D
Institution:Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden. Sweden.
Journal:Eur J Clin Pharmacol. 2017 May;73(5):563-571. doi: 10.1007/s00228-017-2196-4. Epub 2017 Jan 18.

17:Aquatic Exercise Therapy for People With Parkinson Disease: A Randomized Controlled Trial.
Authors:Carroll LM, Volpe D, Morris ME, Saunders J, Clifford AM
Institution:St. Gabriel's Center, Dooradoyle, Limerick, Ireland. Electronic address: Institute Italy - NYU Langone, Casa di Cura Villa Margherita via Costacolonna n 1 Arcugnano, Vicenza, Italy. and Exercise Medicine Research, School of Allied Health, La Trobe University, Melbourne, VIC, Australia. University of Limerick, Limerick, Ireland. Limerick, Ireland.
Journal:Arch Phys Med Rehabil. 2017 Apr;98(4):631-638. doi: 10.1016/j.apmr.2016.12.006. Epub 2017 Jan 12.

18:Benefits of Exercise on the Executive Functions in People with Parkinson Disease: A Controlled Clinical Trial.
Authors:de Oliveira RT, Felippe LA, Bucken Gobbi LT, Barbieri FA, Christofoletti G
Institution:From the Graduate Program in Health and Development, Universidade Federal de Mato Grosso do Sul, UFMS, Campo Grande, Mato Grosso do Sul (RTO, LAF, GC); Universidade Estadual Paulista, UNESP, Rio Claro (LTBG, FAB); and Universidade Estadual Paulista, UNESP, Bauru, Sao Paulo, Brazil (FAB).
Journal:Am J Phys Med Rehabil. 2017 May;96(5):301-306. doi: 10.1097/PHM.0000000000000612.

19:Sleeping difficulties and health-related quality of life in Parkinson's disease.
Authors:Ylikoski A, Martikainen K, Sieminski M, Partinen M
Institution:Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland. of Helsinki, Helsinki, Finland.
Journal:Acta Neurol Scand. 2017 Apr;135(4):459-468. doi: 10.1111/ane.12620. Epub 2016 Jun 10.

20:Outpatient titration of carbidopa/levodopa enteral suspension (Duopa).
Authors:Pahwa R, Lyons KE
Institution:a Parkinson's Disease and Movement Disorder Center , University of Kansas Medical Center , Kansas City , KS , USA - A National Parkinson Foundation Center of Excellence.
Journal:Int J Neurosci. 2017 May;127(5):459-465. doi: 10.1080/00207454.2016.1193862. Epub 2016 Jun 21.

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