Reflex Sympathetic Dystrophy
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Reflex Sympathetic Dystrophy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Reflex Sympathetic Dystrophy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Reflex Sympathetic Dystrophy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Reflex Sympathetic Dystrophy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Low-Dose Intravenous Immunoglobulin Treatment for Long-Standing Complex Regional Pain Syndrome: A Randomized Trial.
Authors:Goebel A, Bisla J, Carganillo R, Frank B, Gupta R, Kelly J, McCabe C, Murphy C, Padfield N, Phillips C, Sanders M, Serpell M, Shenker N, Shoukrey K, Wyatt L, Ambler G
Institution:From University of Liverpool and The Walton Centre National Health Service (NHS) Foundation Trust, Liverpool; Institute of Psychiatry, Psychology and Neuroscience, Guy's and St Thomas' Hospital, and University College London, London; Modepharma Limited, Beckenham; Queen Elizabeth University Hospital, Glasgow; University West of England, Bristol; Swansea University, Swansea; Norfolk and Norwich University NHS Trust, Norwich; Cambridge University Hospitals, Cambridge; and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
Journal:Ann Intern Med. 2017 Oct 3;167(7):476-483. doi: 10.7326/M17-0509. Epub 2017 Sep 12.

2:Orofacial complex regional pain syndrome: pathophysiologic mechanisms and functional MRI.
Authors:Lee YH, Lee KM, Kim HG, Kang SK, Auh QS, Hong JP, Chun YH
Institution:Department of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, Seoul, Korea.; Department of Radiology, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea. Electronic address:
Journal:Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Aug;124(2):e164-e170. doi: 10.1016/j.oooo.2017.03.006. Epub 2017 Mar 14.

3:Usefulness of bone scintigraphy for the diagnosis of Complex Regional Pain Syndrome 1: A systematic review and Bayesian meta-analysis.
Authors:Wertli MM, Brunner F, Steurer J, Held U
Institution:Horten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, Zurich, Switzerland. Freiburgstrasse 8, Bern, Switzerland. Forchstrasse 340, Zurich, Switzerland. Zurich, Pestalozzistrasse 24, Zurich, Switzerland. Zurich, Pestalozzistrasse 24, Zurich, Switzerland.
Journal:PLoS One. 2017 Mar 16;12(3):e0173688. doi: 10.1371/journal.pone.0173688. eCollection 2017.

4:Complex regional pain syndrome in children: a systematic review of clinical features and movement disorders.
Authors:Abu-Arafeh H, Abu-Arafeh I
Institution:University of Edinburgh, Edinburgh, UK.
Journal:Pain Manag. 2017 Mar;7(2):133-140. doi: 10.2217/pmt-2016-0036. Epub 2017 Feb 1.

5:Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial.
Authors:Deer TR, Levy RM, Kramer J, Poree L, Amirdelfan K, Grigsby E, Staats P, Burton AW, Burgher AH, Obray J, Scowcroft J, Golovac S, Kapural L, Paicius R, Kim C, Pope J, Yearwood T, Samuel S, McRoberts WP, Cassim H, Netherton M, Miller N, Schaufele M, Tavel E, Davis T, Davis K, Johnson L, Mekhail N
Institution:aCenter for Pain Relief, Charleston, WV, USA bMarcus Neuroscience Institute, Boca Raton, FL, USA cSt. Jude Medical, Sunnyvale, CA and Plano, TX, USA dUniversity of California, San Francisco, San Francisco, CA, USA eIPM Medical Group, Inc, Walnut Creek, CA, USA fNeurovations, Napa, CA, USA gPremier Pain Center, Shrewsbury Township, NJ, USA hHouston Pain Centers, Houston, TX, USA iHOPE Research-TPC, Phoenix, AZ, USA jHOPE Research-LVSP, Las Vegas, NV, USA kPain Management Associates, Independence, MO, USA lFlorida Pain, Merritt Island, FL, USA mCarolinas Pain Institute, Winston-Salem, NC, USA nNewport Beach Headache and Pain, Newport Beach, CA, USA oComprehensive Pain and Rehabilitation, Pascagoula, MS, USA pCleveland Clinic, Cleveland, OH, USA qHoly Cross Hospital, Ft. Lauderdale, FL, USA rEisenhower Medical Center, Rancho Mirage, CA, USA sSoutheastern Spine Institute, Mt. Pleasant, SC, USA tCoastal Pain Research, Carlsbad, CA, USA uDrug Studies America, Marietta, GA, USA vClinical Trials of South Carolina, Charleston, SC, USA wOrthopaedic Pain Specialists, Santa Monica, CA, USA.
Journal:Pain. 2017 Apr;158(4):669-681. doi: 10.1097/j.pain.0000000000000814.

6:A Comprehensive Outcome-Specific Review of the Use of Spinal Cord Stimulation for Complex Regional Pain Syndrome.
Authors:Visnjevac O, Costandi S, Patel BA, Azer G, Agarwal P, Bolash R, Mekhail NA
Institution:Pain Management Department, Cleveland Clinic, Cleveland, Ohio, U.S.A. U.S.A. U.S.A. U.S.A. U.S.A.
Journal:Pain Pract. 2017 Apr;17(4):533-545. doi: 10.1111/papr.12513. Epub 2016 Oct 14.

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