Reflex Sympathetic Dystrophy
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Reflex Sympathetic Dystrophy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Reflex Sympathetic Dystrophy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Reflex Sympathetic Dystrophy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Reflex Sympathetic Dystrophy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effectiveness of perampanel in managing chronic pain caused by the complex regional pain syndrome: A case report.
Authors:Chang MC, Park D
Institution:Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea. Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Journal:Medicine (Baltimore). 2021 Dec 3;100(48):e27791. doi: 10.1097/MD.0000000000027791.

2:Hypnotherapy for complex regional pain syndrome.
Authors:Thomson L
Institution:Ludlow, VT, USA.
Journal:Am J Clin Hypn. 2022 Jan;64(3):195-205. doi: 10.1080/00029157.2021.1943298.

3:Pain, disability, and lifestyle: Patients with complex regional pain syndrome compared to chronic musculoskeletal pain-A retrospective analysis.
Authors:Kindl G, Teichmüller K, Escolano-Lozano F, Birklein F, Rittner HL
Institution:Center for Interdisciplinary Pain Medicine, Department of Anesthesiology, University Hospital of Wurzburg, Wurzburg, Germany.
Journal:Eur J Pain. 2022 Mar;26(3):719-728. doi: 10.1002/ejp.1900. Epub 2022 Jan 5.

4:Acute worsening of clinical presentation in CRPS after SARS-CoV-2 (COVID-19) vaccination: a case series.
Authors:Zhang J, Gungor S
Institution:Research Assistant, Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, New York, NY 10021, USA. Attending Physician, Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, New York, NY 10021, USA.
Journal:Pain Manag. 2022 Apr;12(3):249-254. doi: 10.2217/pmt-2021-0089. Epub 2021 Nov 23.

5:Improved symptoms of complex regional pain syndrome after novel lymphatic treatment and interdisciplinary pain management.
Authors:Zafereo J, Jones S, Jarrett RB, Frost S, Noe C
Institution:Department of Physical Therapy, UT Southwestern Medical Center, USA. Electronic address: Department of Anesthesiology & Pain Management, UT Southwestern Medical Center, USA.
Journal:Complement Ther Clin Pract. 2022 Feb;46:101512. doi: 10.1016/j.ctcp.2021.101512. Epub 2021 Nov 10.

6:Intravenous treatment with biphosphates in Complex Regional Pain Syndrome.
Authors:Faggiani M, Piccato A, Baroni C, Risitano S, Conforti LG
Institution:Department of Orthopaedic Surgery and Traumatology. 'Maggiore' Hospital of Chieri. Turin. Italy.
Journal:Acta Biomed. 2021 Sep 2;92(4):e2021190. doi: 10.23750/abm.v92i4.11194.

7:Complex Regional Pain Syndrome: The Importance of Early Diagnosis.
Authors:Nirenberg M
Institution:Michael Nirenberg, DPM, Clinical and Forensic Podiatrist, Friendly Foot Care, PC, Crown Point, IN.
Journal:Orthop Nurs. 2021 Jul-Aug 01;40(4):204-208. doi: 10.1097/NOR.0000000000000769.

8:Long-Term Outcome of Spinal Cord Stimulation in Complex Regional Pain Syndrome.
Authors:Hoikkanen T, Nissen M, Ikäheimo TM, Jyrkkänen HK, Huttunen J, von Und Zu Fraunberg M
Institution:Neurosurgery of KUH NeuroCenter, Kuopio University Hospital, Kuopio, Finland.
Journal:Neurosurgery. 2021 Sep 15;89(4):597-609. doi: 10.1093/neuros/nyab239.

9:Effect of intravenous low-dose S-ketamine on pain in patients with Complex Regional Pain Syndrome: A retrospective cohort study.
Authors:Mangnus TJP, Dirckx M, Bharwani KD, de Vos CC, Frankema SPG, Stronks DL, Huygen FJPM
Institution:Center for Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Netherlands.
Journal:Pain Pract. 2021 Nov;21(8):890-897. doi: 10.1111/papr.13056. Epub 2021 Jul 24.

10:Spinal cord stimulation in severe cases of complex regional pain syndrome: A retrospective cohort study with long-term follow-up.
Authors:Eriksen LE, Terkelsen AJ, Blichfeldt-Eckhardt MR, Sørensen JCH, Meier K
Institution:Department of Neurology and Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark. Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Journal:Eur J Pain. 2021 Nov;25(10):2212-2225. doi: 10.1002/ejp.1834. Epub 2021 Jul 17.

11:Patients Describe their Lived Experiences of Battling to Live with Complex Regional Pain Syndrome.
Authors:Johnston-Devin C, Oprescu F, Gray M, Wallis M
Institution:School of Health and Sport Science, University of the Sunshine Coast, Sippy Downs, QLD, Australia; School of Nursing, Midwifery and Social Sciences, CQUniversity Australia, Brisbane, QLD, Australia. Electronic address: QLD, Australia. QLD, Australia; School of Health and Wellbeing, University of Southern Queensland, Ipswich, QLD, Australia. Sippy Downs, QLD, Australia; School of Health and Human Sciences, Southern Cross University, Bilinga, QLD, Australia.
Journal:J Pain. 2021 Sep;22(9):1111-1128. doi: 10.1016/j.jpain.2021.03.151. Epub 2021 Apr 20.

12:"I Don't Identify with It": A Qualitative Analysis of People's Experiences of Living with Complex Regional Pain Styndrome.
Authors:Antunovich D, Tuck N, Reynolds LM, Bean D
Institution:Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand. Auckland, New Zealand. Zealand. Waitemata District Health Board, Auckland, New Zealand. Zealand. Auckland, New Zealand. Waitemata District Health Board, Auckland, New Zealand.
Journal:Pain Med. 2021 Dec 11;22(12):3008-3020. doi: 10.1093/pm/pnab094.

13:Effect of Patient Characteristics on Clinical Outcomes More Than 12 Months Following Dorsal Root Ganglion Stimulation Implantation: A Retrospective Review.
Authors:Hagedorn JM, McArdle I, D'Souza RS, Yadav A, Engle AM, Deer TR
Institution:Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA. Mayo Clinic, Rochester, MN, USA.
Journal:Neuromodulation. 2021 Jun;24(4):695-699. doi: 10.1111/ner.13326. Epub 2021 Jan 28.

14:Referral and treatment patterns for complex regional pain syndrome in the Netherlands.
Authors:DE Mos M, Huygen FJ, VAN DER Hoeven-Borgman M, Dieleman JP, Stricker BH, Sturkenboom MC
Institution:Department of Medical Informatics and Epidemiology & Biostatistics, Erasmus University Medical Center, Rottedam, The Netherlands.
Journal:Acta Anaesthesiol Scand. 2009 Jul;53(6):816-25. Epub 2009 Apr 15.

15:Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups.
Authors:Schinkel C, Scherens A, Koller M, Roellecke G, Muhr G, Maier C
Institution:Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of Surgery, Ruhr University, Bochum, Germany.
Journal:Eur J Med Res. 2009 Mar 17;14(3):130-5.

16:Spinal cord stimulation in the treatment of complex regional pain syndrome (CRPS) of the lower extremity: a case report.
Authors:Saranita J, Childs D, Saranita AD
Institution:American Board of Anesthesiology, Director of South Lake Pain Institute, PA, Clermont, FL 34711, USA.
Journal:J Foot Ankle Surg. 2009 Jan-Feb;48(1):52-5.

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