Trigeminal Neuralgia
January 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Therapeutic efficacy and safety of Botulinum Toxin A Therapy in Trigeminal Neuralgia: a systematic review and meta-analysis of randomized controlled trials.
Authors:Morra ME, Elgebaly A, Elmaraezy A, Khalil AM, Altibi AM, Vu TL, Mostafa MR, Huy NT, Hirayama K
Institution:Faculty of Medicine, Al Azhar University, Cairo, 11884, Egypt.
Journal:J Headache Pain. 2016 Dec;17(1):63. doi: 10.1186/s10194-016-0651-8. Epub 2016 Jul 5.

Authors:ul Haq N, Ali M, Khan HM, Ishaq M, Khattak MI
Journal:J Ayub Med Coll Abbottabad. 2016 Jan-Mar;28(1):52-5.

3:Pain. Part 7: Trigeminal Neuralgia.
Authors:Jurge S
Journal:Dent Update. 2016 Mar;43(2):138-40, 143-6, 149.

4:Comparison of nerve combing and percutaneous radiofrequency thermocoagulation in the treatment for idiopathic trigeminal neuralgia.
Authors:Zhou X, Liu Y, Yue Z, Luan D, Zhang H, Han J
Institution:Shandong Provincial Hospital Affiliated to Shandong University, Department of Otorhinolaryngology Head and Neck Surgery, Jinan, China. Electronic address:; Shandong Provincial Hospital Affiliated to Shandong University, Department of Care Gastroenterology, Jinan, China.
Journal:Braz J Otorhinolaryngol. 2016 Sep-Oct;82(5):574-9. doi: 10.1016/j.bjorl.2015.11.006. Epub 2016 Jan 7.

5:Safety of microvascular decompression for elderly patients with trigeminal neuralgia.
Authors:Amagasaki K, Watanabe S, Naemura K, Shono N, Nakaguchi H
Institution:Department of Neurosurgery, Mitsui Memorial Hospital, Tokyo, Japan. Electronic address:
Journal:Clin Neurol Neurosurg. 2016 Feb;141:77-81. doi: 10.1016/j.clineuro.2015.12.019. Epub 2015 Dec 31.

6:Trigeminal Neuralgia Attributable to Intraneural Trigeminocerebellar Artery: Case Report and Review of the Literature.
Authors:Jito J, Nozaki K
Institution:Department of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Otsu, Shiga, Japan. Electronic address: Seta-Tsukinowa-Cho, Otsu, Shiga, Japan.
Journal:World Neurosurg. 2016 Apr;88:687.e7-11. doi: 10.1016/j.wneu.2015.11.059. Epub 2015 Dec 20.

7:Trigeminal Neuralgia Caused by Cerebellopontine Angle Arteriovenous Malformation Treated With Gamma Knife Radiosurgery.
Authors:Isik S, Eksi MS, Yilmaz B, Toktas ZO, Akakin A, Kilic T
Institution:*Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey daggerDepartment of Orthopaedic Surgery-Spine Center, University of California at San Francisco, San Francisco, CA double daggerDepartment of Neurosurgery, Bahcesehir University Medical School, Istanbul, Turkey.
Journal:J Craniofac Surg. 2016 Jan;27(1):e55-7. doi: 10.1097/SCS.0000000000002310.

8:Linear accelerator-based flattening-filter-free stereotactic radiosurgery for trigeminal neuralgia: Feasibility and patient-reported outcomes.
Authors:Parikh RR, Goodman RR, Rhome R, Sudentas E, Trichter F, Harrison LB, Choi W
Institution:Department of Radiation Oncology, Mount Sinai Roosevelt Hospital, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: at Mount Sinai, New York, New York. York, New York. Health System, Icahn School of Medicine at Mount Sinai, New York, New York. Health System, Icahn School of Medicine at Mount Sinai, New York, New York. Tampa, Florida. Health System, Icahn School of Medicine at Mount Sinai, New York, New York.
Journal:Pract Radiat Oncol. 2016 Jan-Feb;6(1):e1-7. doi: 10.1016/j.prro.2015.09.001. Epub 2015 Sep 10.

9:Repeat Gamma-Knife Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia with Consideration About the Optimal Second Dose.
Authors:Park SC, Kwon do H, Lee do H, Lee JK
Institution:Department of Neurosurgery, Asan Medical Center, Seoul, Korea.; Department of Neurosurgery, Asan Medical Center, Seoul, Korea; Department of Neurosurgery, College of Medicine, University of Ulsan, Seoul, Korea. Electronic address:
Journal:World Neurosurg. 2016 Feb;86:371-83. doi: 10.1016/j.wneu.2015.08.056. Epub 2015 Sep 2.

10:Long-term safety and efficacy of Gamma Knife surgery in classical trigeminal neuralgia: a 497-patient historical cohort study.
Authors:Regis J, Tuleasca C, Resseguier N, Carron R, Donnet A, Gaudart J, Levivier M
Institution:Functional and Stereotactic Neurosurgery Service and Gamma Knife Unit, Centre Hospitalier Universitaire La Timone Assistance Publique-Hopitaux de Marseille, Universite de la Mediterranee, Marseille, France;; Signal Processing Laboratory (LTS-5), Swiss Federal Institute of Technology, Lausanne, Switzerland;; Medical Image Analysis Laboratory, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;; Department of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; and.; Faculty of Biology and Medicine, University of Lausanne, Switzerland.
Journal:J Neurosurg. 2016 Apr;124(4):1079-87. doi: 10.3171/2015.2.JNS142144. Epub 2015 Sep 4.

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