Peripheral Neuropathy
June 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Unsteady walking as a symptom in type 2 diabetes mellitus: independent association with depression and sedentary lifestyle and no association with diabetic neuropathy.
Authors:Dias LS, Nienov OH, Goelzer Neto CF, Schmid H
Institution:Programa de Pos-Graduacao em Ciencias da Saude, Ginecologia e Obstetricia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.; Programa de Pos-Graduacao em Ciencias da Saude, Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS, Brasil.; Servico de Endocrinologia, Hospital Santa Casa de Misericordia de Porto Alegre, Porto Alegre, RS, Brasil.; Departamento de Medicina Interna, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brasil.
Journal:Braz J Med Biol Res. 2018 Mar 26;51(5):e6605. doi: 10.1590/1414-431X20186605.

2:Clinical correlates of sudomotor dysfunction in patients with type 2 diabetes and peripheral neuropathy.
Authors:Shivaprasad C, Amit G, Anish K, Rakesh B, Anupam B, Aiswarya Y
Institution:Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India. Electronic address:
Journal:Diabetes Res Clin Pract. 2018 May;139:188-194. doi: 10.1016/j.diabres.2018.03.004. Epub 2018 Mar 8.

3:Gabapentin for Chronic Neuropathic Pain.
Authors:Moore A, Derry S, Wiffen P
Institution:Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England. Oxford, Oxford, England. Oxford, Oxford, England.
Journal:JAMA. 2018 Feb 27;319(8):818-819. doi: 10.1001/jama.2017.21547.

4:Goshajinkigan for reducing chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis.
Authors:Hoshino N, Ganeko R, Hida K, Sakai Y
Institution:Department of Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Journal:Int J Clin Oncol. 2018 Jun;23(3):434-442. doi: 10.1007/s10147-017-1229-4. Epub 2017 Dec 21.

5:Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: A systematic review.
Authors:Duregon F, Vendramin B, Bullo V, Gobbo S, Cugusi L, Di Blasio A, Neunhaeuserer D, Zaccaria M, Bergamin M, Ermolao A
Institution:Sport and Exercise Medicine Division, Department of Medicine, University of Padova, Italy. Padova, Italy. Padova, Italy. Padova, Italy. Italy. Chieti-Pescara, Italy. Padova, Italy. Padova, Italy. Padova, Italy. Electronic address: Padova, Italy.
Journal:Crit Rev Oncol Hematol. 2018 Jan;121:90-100. doi: 10.1016/j.critrevonc.2017.11.002. Epub 2017 Nov 7.

6:Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial.
Authors:van Schaik IN, Bril V, van Geloven N, Hartung HP, Lewis RA, Sobue G, Lawo JP, Praus M, Mielke O, Durn BL, Cornblath DR, Merkies ISJ
Institution:Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands. Electronic address: Toronto, Toronto, ON, Canada. Leiden, Netherlands. Germany. Japan. MD, USA. Netherlands.
Journal:Lancet Neurol. 2018 Jan;17(1):35-46. doi: 10.1016/S1474-4422(17)30378-2. Epub 2017 Nov 6.

7:Dose-response of pregabalin for diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia.
Authors:Arnold LM, McCarberg BH, Clair AG, Whalen E, Thomas N, Jorga A, Pauer L, Vissing R, Park PW
Institution:a Department of Psychiatry and Behavioral Neuroscience, Women's Health Research Program , University of Cincinnati College of Medicine , Cincinnati , OH , USA. Medicine , San Diego , CA , USA. CT , USA.
Journal:Postgrad Med. 2017 Nov;129(8):921-933. doi: 10.1080/00325481.2017.1384691. Epub 2017 Oct 16.

8:Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review.
Authors:Rivera DR, Ganz PA, Weyrich MS, Bandos H, Melnikow J
Institution:Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD; Schools of Medicine and Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA; Center for Healthcare Policy and Research, University of California Davis, Sacramento, CA; NRG Oncology and the University of Pittsburgh, Pittsburgh, PA.
Journal:J Natl Cancer Inst. 2018 Feb 1;110(2). pii: 4093778. doi: 10.1093/jnci/djx140.

9:Risk-reduction and treatment of chemotherapy-induced peripheral neuropathy.
Authors:Bakogeorgos M, Georgoulias V
Institution:a Department of Medical Oncology , Athens , Greece.
Journal:Expert Rev Anticancer Ther. 2017 Nov;17(11):1045-1060. doi: 10.1080/14737140.2017.1374856. Epub 2017 Sep 11.

10:Anxiety affects disability and quality of life in patients with painful diabetic neuropathy.
Authors:Geelen CC, Smeets RJEM, Schmitz S, van den Bergh JP, Goossens MEJB, Verbunt JA
Institution:Adelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands. University, Maastricht, The Netherlands. University, Maastricht, The Netherlands. University, Maastricht, The Netherlands. The Netherlands. University, Maastricht, The Netherlands. Netherlands. University, Maastricht, The Netherlands.
Journal:Eur J Pain. 2017 Nov;21(10):1632-1641. doi: 10.1002/ejp.1067. Epub 2017 Jun 27.

11:Factors associated with the development and severity of oxaliplatin-induced peripheral neuropathy: a systematic review.
Authors:Pulvers JN, Marx G
Institution:Sydney Medical School, University of Sydney, NSW, Australia.
Journal:Asia Pac J Clin Oncol. 2017 Dec;13(6):345-355. doi: 10.1111/ajco.12694. Epub 2017 Jun 27.

12:Optimal clinical assessment strategies for chemotherapy-induced peripheral neuropathy (CIPN): a systematic review and Delphi survey.
Authors:McCrary JM, Goldstein D, Boyle F, Cox K, Grimison P, Kiernan MC, Krishnan AV, Lewis CR, Webber K, Baron-Hay S, Horvath L, Park SB
Institution:Prince of Wales Clinical School, UNSW Medicine, The University of New South Wales, Randwick, NSW, 2031, Australia. Wales, Randwick, NSW, 2031, Australia. Sydney, NSW, 2050, Australia. Wales, Randwick, NSW, 2031, Australia. Wales, Randwick, NSW, 2031, Australia. Wales, Randwick, NSW, 2031, Australia. 2065, Australia. Wales, Randwick, NSW, 2031, Australia. Sydney, NSW, 2050, Australia.
Journal:Support Care Cancer. 2017 Nov;25(11):3485-3493. doi: 10.1007/s00520-017-3772-y. Epub 2017 Jun 7.

13:The Impact of Serum Drug Concentration on the Efficacy of Imipramine, Pregabalin, and their Combination in Painful Polyneuropathy.
Authors:Sindrup SH, Holbech JV, Bach FW, Finnerup NB, Brosen K, Jensen TS
Institution:*Department of Neurology, Odense University Hospital section signClinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense Departments of daggerNeurology double daggerDepartment of Neurology and Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.
Journal:Clin J Pain. 2017 Dec;33(12):1047-1052. doi: 10.1097/AJP.0000000000000497.

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What Our Customers Are Saying...

"This is the BEST informational and reference book pertaining to my long-time ailment 'Peripheral Neuropathy'. I have researched this relatively obscure subject for seven years. The MediFocus Guidebook on Peripheral Neuropathy is easy reading, concise, and contains great references."
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