Bladder Cancer
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Bladder Cancer abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Bladder Cancer. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Bladder Cancer. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Bladder Cancer every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Bladder Cancer: Diagnosis and Treatment.
Authors:DeGeorge KC, Holt HR, Hodges SC
Institution:University of Virginia School of Medicine, Charlottesville, VA, USA.
Journal:Am Fam Physician. 2017 Oct 15;96(8):507-514.

2:Neoadjuvant Chemotherapy for Patients with Muscle-invasive Urothelial Bladder Cancer Candidates for Curative Surgery: A Prospective Clinical Trial Based on Cisplatin Feasibility.
Authors:Schinzari G, Monterisi S, Pierconti F, Nazzicone G, Marandino L, Orlandi A, Racioppi M, Cassano A, Bassi P, Barone C, Rossi E
Institution:Medical Oncology, Universita Cattolica del Sacro Cuore, Rome, Italy
Journal:Anticancer Res. 2017 Nov;37(11):6453-6458. doi: 10.21873/anticanres.12100.

3:Dose, duration and strain of bacillus Calmette-Guerin in the treatment of nonmuscle invasive bladder cancer: Meta-analysis of randomized clinical trials.
Authors:Quan Y, Jeong CW, Kwak C, Kim HH, Kim HS, Ku JH
Institution:aDepartment of Urology, Seoul National University Hospital, Seoul bDepartment of Urology, Dongguk University Ilsan Medical Center, Goyang, Korea.
Journal:Medicine (Baltimore). 2017 Oct;96(42):e8300. doi: 10.1097/MD.0000000000008300.

4:The Use of External-beam Radiotherapy for Muscle-invasive Bladder Cancer in Elderly or Medically-fragile Patients.
Authors:Aizawa R, Sakamoto M, Orito N, Kono M, Ogura M, Negoro Y, Sagoh T, Tsukahara K, Komatsu K, Noguchi M
Institution:Department of Radiology, Japanese Red Cross Fukui Hospital, Fukui, Japan Medicine, Kyoto University, Kyoto, Japan. Japan. Japan. Japan.
Journal:Anticancer Res. 2017 Oct;37(10):5761-5766. doi: 10.21873/anticanres.12016.

5:Radical Cystectomy Versus Chemoradiation for Muscle-invasive Bladder Cancer: Impact of Treatment Facility and Sociodemographics.
Authors:Haque W, Verma V, Butler EB, Teh BS
Institution:Department of Radiation Oncology, CHI St Luke's Health, The Woodlands, TX, U.S.A. NE, U.S.A.
Journal:Anticancer Res. 2017 Oct;37(10):5603-5608. doi: 10.21873/anticanres.11994.

6:Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer.
Authors:Giridhar KV, Kohli M
Institution:Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2017 Oct;92(10):1564-1582. doi: 10.1016/j.mayocp.2017.07.010.

7:Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder-preservation therapy for muscle-invasive bladder cancer.
Authors:Cahn DB, Handorf EA, Ghiraldi EM, Ristau BT, Geynisman DM, Churilla TM, Horwitz EM, Sobczak ML, Chen DYT, Viterbo R, Greenberg RE, Kutikov A, Uzzo RG, Smaldone MC
Institution:Department of Urology, Einstein Healthcare Network, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Pennsylvania. Pennsylvania. Pennsylvania. Pennsylvania. Center, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania. Center, Philadelphia, Pennsylvania.
Journal:Cancer. 2017 Nov 15;123(22):4337-4345. doi: 10.1002/cncr.30900. Epub 2017 Jul 25.

8:Neoadjuvant chemotherapy prior to radical cystectomy for muscle-invasive bladder cancer with variant histology.
Authors:Vetterlein MW, Wankowicz SAM, Seisen T, Lander R, Loppenberg B, Chun FK, Menon M, Sun M, Barletta JA, Choueiri TK, Bellmunt J, Trinh QD, Preston MA
Institution:Division of Urological Surgery, Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Urology, Pitie-Salpetriere Hospital, Pierre and Marie Curie University, Paris, France.; Department of Urology, Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany.
Journal:Cancer. 2017 Nov 15;123(22):4346-4355. doi: 10.1002/cncr.30907. Epub 2017 Jul 25.

9:Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort.
Authors:Botteri E, Ferrari P, Roswall N, Tjonneland A, Hjartaker A, Huerta JM, Fortner RT, Trichopoulou A, Karakatsani A, La Vecchia C, Pala V, Perez-Cornago A, Sonestedt E, Liedberg F, Overvad K, Sanchez MJ, Gram IT, Stepien M, Trijsburg L, Borje L, Johansson M, Kuhn T, Panico S, Tumino R, Bueno-de-Mesquita HBA, Weiderpass E
Institution:Department of Bowel Cancer Screening, Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.; National Advisory Unit for Women's Health, Women's Clinic, Oslo University Hospital, Oslo, Norway.; International Agency for Research on Cancer, Lyon, France.; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Journal:Int J Cancer. 2017 Nov 15;141(10):1963-1970. doi: 10.1002/ijc.30894. Epub 2017 Jul 31.

10:Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer.
Authors:Phillips RM, Hendriks HR, Sweeney JB, Reddy G, Peters GJ
Institution:a Department of Pharmacy , University of Huddersfield , Huddersfield , UK. Netherlands.
Journal:Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):783-791. doi: 10.1080/17425255.2017.1341490. Epub 2017 Jul 3.

11:The Role of Robotics in the Invasive Management of Bladder Cancer.
Authors:Khetrapal P, Tan WS, Lamb B, Tan M, Baker H, Thompson J, Sridhar A, Kelly JD, Briggs T
Institution:Department of Urology, University College London Hospital at Westmoreland Street, 16-18 Westmoreland St, Marylebone, London, W1G 8PH, UK.; Division of Surgical and Interventional Sciences, University College London, 4th Floor, UCL Medical School Building, 21 University Street, London, WC1E 6AU, UK.
Journal:Curr Urol Rep. 2017 Aug;18(8):57. doi: 10.1007/s11934-017-0706-7.

12:Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy.
Authors:Korpics MC, Block AM, Martin B, Hentz C, Gaynor ER, Henry E, Harkenrider MM, Solanki AA
Institution:Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.; Clinical Research Office, Health Sciences Division, Loyola University Chicago, Maywood, Illinois.; Division of Hematology/Oncology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.
Journal:Cancer. 2017 Sep 15;123(18):3524-3531. doi: 10.1002/cncr.30719. Epub 2017 Jun 5.

13:Immunotherapy in Urothelial Cancer: Recent Results and Future Perspectives.
Authors:Farina MS, Lundgren KT, Bellmunt J
Institution:Dana-Farber Cancer Institute, 450 Brookline Ave, DANA 1230, Boston, MA, 02215, USA. USA. USA. 08003, Barcelona, Spain.
Journal:Drugs. 2017 Jul;77(10):1077-1089. doi: 10.1007/s40265-017-0748-7.

14:Systematic review of the oncological and functional outcomes of pelvic organ-preserving radical cystectomy (RC) compared with standard RC in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer.
Authors:Veskimae E, Neuzillet Y, Rouanne M, MacLennan S, Lam TBL, Yuan Y, Comperat E, Cowan NC, Gakis G, van der Heijden AG, Ribal MJ, Witjes JA, Lebret T
Institution:Department of Urology, Tampere University Hospital, Tampere, Finland. Saint-Quentin-en-Yvelines, Suresnes, France. Saint-Quentin-en-Yvelines, Suresnes, France. Canada. Netherlands. Spain. Netherlands. Saint-Quentin-en-Yvelines, Suresnes, France.
Journal:BJU Int. 2017 Jul;120(1):12-24. doi: 10.1111/bju.13819. Epub 2017 Mar 24.

15:The patients' experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence.
Authors:Edmondson AJ, Birtwistle JC, Catto JWF, Twiddy M
Institution:Centre for Applied Research in Health, University of Huddersfield, Huddersfield, UK.
Journal:J Cancer Surviv. 2017 Aug;11(4):453-461. doi: 10.1007/s11764-017-0603-6. Epub 2017 Feb 17.

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