December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effects of a complex rehabilitation program on edema status, physical function, and quality of life in lower-limb lymphedema after gynecological cancer surgery.
Authors:Do JH, Choi KH, Ahn JS, Jeon JY
Institution:Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. Electronic address:
Journal:Gynecol Oncol. 2017 Nov;147(2):450-455. doi: 10.1016/j.ygyno.2017.09.003. Epub 2017 Sep 20.

2:Health-related quality of life in melanoma patients: Impact of melanoma-related limb lymphoedema.
Authors:Gjorup CA, Groenvold M, Hendel HW, Dahlstroem K, Drzewiecki KT, Klausen TW, Holmich LR
Institution:Department of Plastic Surgery, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address: Department of Palliative Medicine, Bispebjerg University Hospital, Copenhagen, Denmark. Gentofte Hospital, University of Copenhagen, Denmark. Copenhagen, Denmark. Rigshospitalet, University of Copenhagen, Denmark. Denmark. Copenhagen, Denmark.
Journal:Eur J Cancer. 2017 Nov;85:122-132. doi: 10.1016/j.ejca.2017.07.052. Epub 2017 Sep 15.

3:Diagnosis of Upper Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline From the Oncology Section of the American Physical Therapy Association.
Authors:Levenhagen K, Davies C, Perdomo M, Ryans K, Gilchrist L
Institution:Saint Louis University, Doisy College of Health Sciences, Department of Physical Therapy & Athletic Training, St Louis, Missouri. Therapy, Los Angeles, California. South, Minneapolis, MN 55454.
Journal:Phys Ther. 2017 Jul 1;97(7):729-745. doi: 10.1093/ptj/pzx050.

4:Lower Body Lymphedema in Patients with Gynecologic Cancer.
Authors:Biglia N, Zanfagnin V, Daniele A, Robba E, Bounous VE
Institution:Obstetrics and Gynaecology Unit, Umberto I Hospital, Department of Surgical Sciences, School of Medicine, University of Turin, Turin, Italy; Obstetrics and Gynaecology Unit, Umberto I Hospital, Department of Surgical Sciences, School of Medicine, University of Turin, Turin, Italy.
Journal:Anticancer Res. 2017 Aug;37(8):4005-4015. doi: 10.21873/anticanres.11785.

5:Comparison of long-term clinical outcomes among different vascularized lymph node transfers: 6-year experience of a single center's approach to the treatment of lymphedema.
Authors:Ciudad P, Agko M, Perez Coca JJ, Manrique OJ, Chang WL, Nicoli F, Chen SH, Chen HC
Institution:Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan. Taichung, Taiwan. Hospital, Taichung, Taiwan. Hospital, Taichung, Taiwan. Hospital, Taichung, Taiwan. Hospital, Taichung, Taiwan. Hospital, Taichung, Taiwan. Chang-Gung University, Linkou, Taiwan. Hospital, Taichung, Taiwan.
Journal:J Surg Oncol. 2017 Nov;116(6):671-682. doi: 10.1002/jso.24730. Epub 2017 Jul 10.

6:Immediate effects of active exercise with compression therapy on lower-limb lymphedema.
Authors:Fukushima T, Tsuji T, Sano Y, Miyata C, Kamisako M, Hohri H, Yoshimura C, Asakura M, Okitsu T, Muraoka K, Liu M
Institution:Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, Japan. Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Journal:Support Care Cancer. 2017 Aug;25(8):2603-2610. doi: 10.1007/s00520-017-3671-2. Epub 2017 Apr 6.

7:Real-Time Direct Evidence of the Superficial Lymphatic Drainage Effect of Intermittent Pneumatic Compression Treatment for Lower Limb Lymphedema.
Authors:Kitayama S, Maegawa J, Matsubara S, Kobayashi S, Mikami T, Hirotomi K, Kagimoto S
Institution:1 Department of Plastic and Reconstructive Surgery, Yokohama City University School of Medicine , Yokohama, Japan .; 2 Department of Plastic and Reconstructive Surgery, Kanagawa Children's Medical Center , Yokohama, Japan .
Journal:Lymphat Res Biol. 2017 Mar;15(1):77-86. doi: 10.1089/lrb.2016.0031.

8:Clinical and diagnostic aspects of lymphedema.
Authors:Keo HH, Gretener SB, Staub D
Institution:1 Vascular Institute Central Switzerland, and Hirslanden Clinic, Aarau, Aarau, Switzerland. Basel, Basel, Switzerland.
Journal:Vasa. 2017 Jul;46(4):255-261. doi: 10.1024/0301-1526/a000622. Epub 2017 Mar 10.

9:Lymphedema after treatment for endometrial cancer - A review of prevalence and risk factors.
Authors:Lindqvist E, Wedin M, Fredrikson M, Kjolhede P
Institution:Department of Obstetrics and Gynecology, The Highland Hospital, Eksjo, Sweden. Medicine, Linkoping University, Linkoping, Sweden. University, Linkoping, Sweden; Occupational and Environmental Medicine, Department of Experimental and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden. Medicine, Linkoping University, Linkoping, Sweden. Electronic address:
Journal:Eur J Obstet Gynecol Reprod Biol. 2017 Apr;211:112-121. doi: 10.1016/j.ejogrb.2017.02.021. Epub 2017 Feb 22.

10:Systematic Review of Occupational Therapy and Adult Cancer Rehabilitation: Part 1. Impact of Physical Activity and Symptom Management Interventions.
Authors:Hunter EG, Gibson RW, Arbesman M, D'Amico M
Institution:Elizabeth G. Hunter, PhD, OTR/L, is Assistant Professor, Graduate Center for Gerontology, University of Kentucky, Lexington; Department of Emergency Medicine, Medical College of Georgia, Augusta University, Augusta, GA. Project, American Occupational Therapy Association, Bethesda, MD; President, ArbesIdeas, Inc., Williamsville, NY; and Adjunct Associate Professor, Department of Clinical Research and Leadership, School of Medicine and Health Sciences, George Washington University, Washington, DC. Occupational Therapy, Nova Southeastern University, Fort Lauderdale, FL.
Journal:Am J Occup Ther. 2017 Mar/Apr;71(2):7102100030p1-7102100030p11. doi: 10.5014/ajot.2017.023564.

11:Comparisons Between Cancer-Related and Noncancer-Related Lymphedema: An Overview of New Patients Referred to a Specialized Hospital-Based Center in Canada.
Authors:Shallwani SM, Hodgson P, Towers A
Institution:1 Lymphedema Program, McGill University Health Centre , Montreal, Canada .
Journal:Lymphat Res Biol. 2017 Mar;15(1):64-69. doi: 10.1089/lrb.2016.0023. Epub 2017 Jan 30.

12:Efficacy and safety of far infrared radiation in lymphedema treatment: clinical evaluation and laboratory analysis.
Authors:Li K, Zhang Z, Liu NF, Feng SQ, Tong Y, Zhang JF, Constantinides J, Lazzeri D, Grassetti L, Nicoli F, Zhang YX
Institution:Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.; Department of Medical Cosmetology Surgery, Jinhua People's Hospital, Jinhua, China.; Department of Medical Cosmetology Surgery, Hangzhou First People's Hospital, Hangzhou, China.; Department of Plastic and Reconstructive Surgery, Guy's and Saint Thomas' NHS Foundation Trust, London, UK.; Plastic Reconstructive and Aesthetic Surgery, Villa Salaria Clinic, Rome, Italy.
Journal:Lasers Med Sci. 2017 Apr;32(3):485-494. doi: 10.1007/s10103-016-2135-0. Epub 2017 Jan 26.

13:Association between adjuvant docetaxel-based chemotherapy and breast cancer-related lymphedema.
Authors:Zhu W, Li D, Li X, Ren J, Chen W, Gu H, Shu Y, Wang D
Institution:aDepartment of Medical Oncology, The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang bDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Journal:Anticancer Drugs. 2017 Mar;28(3):350-355. doi: 10.1097/CAD.0000000000000468.

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