December 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effectiveness of Yoga Interventions in Breast Cancer-Related lymphedema: A systematic review.
Authors:Wei CW, Wu YC, Chen PY, Chen PE, Chi CC, Tung TH
Institution:Department of Surgery, Cheng-Hsin General Hospital, Taipei, Taiwan; School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. Electronic address: Taipei, Taiwan; Maoming People's Hospital, Guangdong Province, China. Electronic address:
Journal:Complement Ther Clin Pract. 2019 Aug;36:49-55. doi: 10.1016/j.ctcp.2019.05.004. Epub 2019 May 25.

2:Comparison of Outcomes between Side-to-End and End-to-End Lymphovenous Anastomoses for Early-Grade Extremity Lymphedema.
Authors:AlJindan FK, Lin CY, Cheng MH
Institution:Taoyuan, Taiwan From the Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine.
Journal:Plast Reconstr Surg. 2019 Aug;144(2):486-496. doi: 10.1097/PRS.0000000000005870.

3:The effectiveness of lymphedema self-management in the prevention of breast cancer-related lymphedema and quality of life: A randomized controlled trial.
Authors:Temur K, Kapucu S
Institution:Hacettepe University Adult Hospital, Department of General Surgery Wards, Ankara, Turkey. Turkey. Electronic address:
Journal:Eur J Oncol Nurs. 2019 Jun;40:22-35. doi: 10.1016/j.ejon.2019.02.006. Epub 2019 Feb 25.

4:Influence of vascularized lymph node transfer (VLNT) flap positioning on the response to breast cancer-related lymphedema treatment.
Authors:Montag E, Okada AY, Arruda EGP, Fonseca AS, Bromley M, Munhoz AM, Busnardo FF, Gemperli R
Institution:Instituto do Cancer do Estado de Sao Paulo (ICESP), Servico de Cirurgia Plastica, Sao Paulo, SP, Brasil.; Universidade de Sao Paulo, Faculdade de Medicina, Disciplina de Cirurgia Plastica, Sao Paulo, SP, Brasil.
Journal:Rev Col Bras Cir. 2019 May 27;46(2):e2156. doi: 10.1590/0100-6991e-20192156.

5:What is the best method to determine excessive arm volume in patients with breast cancer-related lymphoedema in clinical practice? Reliability, time efficiency and clinical feasibility of five different methods.
Authors:De Vrieze T, Gebruers N, Tjalma WA, Nevelsteen I, Thomis S, De Groef A, Dams L, Van der Gucht E, Belgrado JP, Vandermeeren L, Devoogdt N
Institution:1 Department of Rehabilitation Sciences, KU Leuven - University of Leuven, Leuven, Belgium.; 2 MOVANT, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.; 3 Multidisciplinary Oedema Clinic, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.; 4 MIPRO, Department of Medicine, University of Antwerp, Antwerp, Belgium.; 5 Multidisciplinary Breast Clinic, Antwerp University Hospital, Antwerp, Belgium.
Journal:Clin Rehabil. 2019 Jul;33(7):1221-1232. doi: 10.1177/0269215519835907. Epub 2019 Mar 18.

6:Combined decongestive therapy and reduction of pain and heaviness in patients with breast cancer-related lymphedema.
Authors:Mobarakeh ZS, Mokhtari-Hesari P, Lotfi-Tokaldany M, Montazeri A, Heidari M, Zekri F
Institution:Quality of life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran. Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran. Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran.
Journal:Support Care Cancer. 2019 Oct;27(10):3805-3811. doi: 10.1007/s00520-019-04681-9. Epub 2019 Feb 7.

7:Efficacy of self-administered complex decongestive therapy on breast cancer-related lymphedema: a single-blind randomized controlled trial.
Authors:Ligabue MB, Campanini I, Veroni P, Cepelli A, Lusuardi M, Merlo A
Institution:Functional Rehabilitation and Recovery Service, San Sebastiano Hospital, Correggio, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Journal:Breast Cancer Res Treat. 2019 May;175(1):191-201. doi: 10.1007/s10549-019-05136-9. Epub 2019 Feb 2.

8:Head and Neck Lymphedema: Treatment Response to Single and Multiple Sessions of Advanced Pneumatic Compression Therapy.
Authors:Gutierrez C, Karni RJ, Naqvi S, Aldrich MB, Zhu B, Morrow JR, Sevick-Muraca EM, Rasmussen JC
Institution:1 Department of Physical Medicine & Rehabilitation, University of Texas Health Science Center at Houston, Houston, Texas, USA.; 2 Department of Otorhinolaryngology - Head and Neck Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA.; 3 Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine at the University of Texas Head Science Center at Houston, Houston, Texas, USA.
Journal:Otolaryngol Head Neck Surg. 2019 Apr;160(4):622-626. doi: 10.1177/0194599818823180. Epub 2019 Jan 29.

9:Effectiveness of a precast adjustable compression system compared to multilayered compression bandages in the treatment of breast cancer-related lymphoedema: a randomized, single-blind clinical trial.
Authors:Pujol-Blaya V, Salinas-Huertas S, Catasus ML, Pascual T, Belmonte R
Institution:1 Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Journal:Clin Rehabil. 2019 Apr;33(4):631-641. doi: 10.1177/0269215518821785. Epub 2019 Jan 4.

10:Tackling the diversity of breast cancer related lymphedema: Perspectives on diagnosis, risk assessment, and clinical management.
Authors:Michelotti A, Invernizzi M, Lopez G, Lorenzini D, Nesa F, De Sire A, Fusco N
Institution:Division of Medical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.; Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.; Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; School of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.; Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. Electronic address:
Journal:Breast. 2019 Apr;44:15-23. doi: 10.1016/j.breast.2018.12.009. Epub 2018 Dec 17.

11:Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren(R)) in addition to complex decongestive therapy on management of breast cancer-related lymphedema.
Authors:Cacchio A, Prencipe R, Bertone M, De Benedictis L, Taglieri L, D'Elia E, Centoletti C, Di Carlo G
Institution:Department of Life, Health & Environmental Sciences, School of Medicine, University of L'Aquila, L'Aquila, Italy.; Universita dell'Aquila, P.le San Salvatore 1 - Edificio Delta 6 Medicina, 67100, L'Aquila, Italy.; Rehabilitation Service, 'Serafino Rinaldi' Territorial Assistance Hospital of Pescina, ASL 01 Avezzano-Sulmona, L'Aquila, Pescina, Italy.; Rehabilitation Service ex Polio Centre, ASL 01 Avezzano-Sulmona, L'Aquila, Avezzano, Italy.
Journal:Support Care Cancer. 2019 Apr;27(4):1471-1480. doi: 10.1007/s00520-018-4514-5. Epub 2018 Oct 20.

For a FREE PREVIEW of the Medifocus Guidebook on Lymphedema click here

To purchase a copy of the COMPLETE Medifocus Guidebook on Lymphedema click here

To subscribe to additional FREE Medifocus Digest Alert on other disease/condition areas click here

Get the Medifocus Guidebook on Lymphedema...
at a Special 20% Discount

Medifocus Guidebook on Lymphedema

Updated: January 6, 2020
164 Pages

This one of a kind Guidebook offers:

  • Answers to your critical health questions including the latest treatments, clinical trials, and expert research.
  • High Quality, Professional level information you can trust and understand culled from the latest peer-reviewed journals.
  • Timely, up to date content with free guidebook updates for 1 year.
  • A unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks.
  • Over 130,000 Guidebooks Sold
  • 100% Risk Free Money Back Guarantee


The Medifocus Guidebook on Lymphedema is available in the following two convenient formats:


Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $36.95
  • Less 20% Discount = - $7.40
  • Discounted Price = $29.55(excluding shipping & handling)

Order the Printed Guidebook


Available for immediate download as a PDF document.

  • Regular List Price = $27.95
  • Less 20% Discount = - $5.60
  • Discounted Price = $22.35

Order the Digital Guidebook

Order by Phone

Call Toll Free in the U.S.

From Outside the U.S.

You can also receive a 20% discount when you order your Guidebook by phone.

To receive your 20% discount, simply mention the Discount Coupon Code below to the customer service representative taking your order.

Discount Coupon Code for
Phone Orders


Coupon Expires: May 2, 2020

What Our Customers Are Saying...

"Lymphedema is a rare condition... and my specific type of lymphedema (congenital lymphedema) is even more rare. Your Guidebook covered the recommendations for treatment with a thoroughness I've seen nowhere else. Thank you for taking the time to offer current information about Lymphedema that empowers me to take control of my health care."
Grand Rapids, Michigan

Medifocus Digest Alert is published by Medifocus, Inc.
3809 Clarks Lane, Suite 100, Baltimore, MD 21215 USA
Copyright © 2020 Medifocus, Inc. All rights reserved.