June 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Long term effects of manual lymphatic drainage and active exercises on physical morbidities, lymphoscintigraphy parameters and lymphedema formation in patients operated due to breast cancer: A clinical trial.
Authors:Oliveira MMF, Gurgel MSC, Amorim BJ, Ramos CD, Derchain S, Furlan-Santos N, Dos Santos CC, Sarian LO
Institution:Department of Obstetrics and Gynecology- University of Campinas, School of Medicine, Campinas, Sao Paulo, Brazil.; Department of Nuclear Medicine and Radiology, University of Campinas, School of Medicine, Campinas, Sao Paulo, Brazil.
Journal:PLoS One. 2018 Jan 5;13(1):e0189176. doi: 10.1371/journal.pone.0189176. eCollection 2018.

2:The effect of relaxation techniques on edema, anxiety and depression in post-mastectomy lymphedema patients undergoing comprehensive decongestive therapy: A clinical trial.
Authors:Abbasi B, Mirzakhany N, Angooti Oshnari L, Irani A, Hosseinzadeh S, Tabatabaei SM, Haghighat S
Institution:School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sciences, Tehran, Iran. Sciences, Tehran, Iran. Sciences, Tehran, Iran. University of Medical Sciences, Tehran, Iran.
Journal:PLoS One. 2018 Jan 5;13(1):e0190231. doi: 10.1371/journal.pone.0190231. eCollection 2018.

3:Stress Lymphoscintigraphy for Early Detection and Management of Secondary Limb Lymphedema.
Authors:Tartaglione G, Visconti G, Bartoletti R, Gentileschi S, Salgarello M, Rubello D, Colletti PM
Journal:Clin Nucl Med. 2018 Mar;43(3):155-161. doi: 10.1097/RLU.0000000000001963.

4:Liposuction as an effective treatment for lower extremity lymphoedema: A single surgeon's experience over nine years.
Authors:Stewart CJ, Munnoch DA
Institution:Department of Plastic and Reconstructive Surgery, Ninewells Hospital, Dundee, United Kingdom. Electronic address: United Kingdom.
Journal:J Plast Reconstr Aesthet Surg. 2018 Feb;71(2):239-245. doi: 10.1016/j.bjps.2017.11.003. Epub 2017 Dec 2.

5:The effectiveness of a clinical and home-based physical activity program and simple lymphatic drainage in the prevention of breast cancer-related lymphedema: A prospective randomized controlled study.
Authors:Donmez AA, Kapucu S
Institution:Department of Internal Medicine Nursing, Faculty of Nursing, Hacettepe University, Ankara, Turkey. Electronic address: University, Ankara, Turkey.
Journal:Eur J Oncol Nurs. 2017 Dec;31:12-21. doi: 10.1016/j.ejon.2017.09.004. Epub 2017 Oct 9.

6:Lymphedema: Diagnostic workup and management.
Authors:Grada AA, Phillips TJ
Institution:Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address: Massachusetts.
Journal:J Am Acad Dermatol. 2017 Dec;77(6):995-1006. doi: 10.1016/j.jaad.2017.03.021.

7:Lymphedema: Pathophysiology and clinical manifestations.
Authors:Grada AA, Phillips TJ
Institution:Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address: Massachusetts.
Journal:J Am Acad Dermatol. 2017 Dec;77(6):1009-1020. doi: 10.1016/j.jaad.2017.03.022.

8:Incidence and risk factors of lymphedema after breast cancer treatment: 10 years of follow-up.
Authors:Ribeiro Pereira ACP, Koifman RJ, Bergmann A
Institution:National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. Electronic address: Brazil. Electronic address:
Journal:Breast. 2017 Dec;36:67-73. doi: 10.1016/j.breast.2017.09.006. Epub 2017 Oct 6.

9:Advances in understanding and management of lymphoedema (cancer, primary).
Authors:Keeley V
Institution:aLymphoedema Clinic, Royal Derby Hospital, Derby Teaching Hospitals NHS Foundation Trust, Derby bMedical School, University of Nottingham, Nottingham, United Kingdom.
Journal:Curr Opin Support Palliat Care. 2017 Dec;11(4):355-360. doi: 10.1097/SPC.0000000000000311.

10:Effects of a complex rehabilitation program on edema status, physical function, and quality of life in lower-limb lymphedema after gynecological cancer surgery.
Authors:Do JH, Choi KH, Ahn JS, Jeon JY
Institution:Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. Electronic address:
Journal:Gynecol Oncol. 2017 Nov;147(2):450-455. doi: 10.1016/j.ygyno.2017.09.003. Epub 2017 Sep 20.

11:Preventing Early Postoperative Arm Swelling and Lymphedema Manifestation by Compression Sleeves After Axillary Lymph Node Interventions in Breast Cancer Patients: A Randomized Controlled Trial.
Authors:Ochalek K, Gradalski T, Partsch H
Institution:Department of Clinical Rehabilitation, Faculty of Motor Rehabilitation, University of Physical Education, Krakow, Poland; St. Lazarus Hospice, Krakow, Poland.
Journal:J Pain Symptom Manage. 2017 Sep;54(3):346-354. doi: 10.1016/j.jpainsymman.2017.04.014. Epub 2017 Aug 8.

12:The efficacy of lymphaticovenular anastomosis in breast cancer-related lymphedema.
Authors:Winters H, Tielemans HJP, Hameeteman M, Paulus VAA, Beurskens CH, Slater NJ, Ulrich DJO
Institution:Department of Plastic and Reconstructive Surgery, Radboud University Medical Center, 9101, 6500 HB, Nijmegen, The Netherlands.; Department of Orthopaedics, Section of Physical Therapy, Radboud University Medical Center, 9101, 6500 HB, Nijmegen, The Netherlands.
Journal:Breast Cancer Res Treat. 2017 Sep;165(2):321-327. doi: 10.1007/s10549-017-4335-0. Epub 2017 Jun 12.

13:Yoga, breast cancer-related lymphoedema and well-being: A descriptive report of women's participation in a clinical trial.
Authors:Loudon A, Barnett T, Williams A
Institution:Forest Yoga Massage and Pilates, Forestville, NSW, Australia.
Journal:J Clin Nurs. 2017 Dec;26(23-24):4685-4695. doi: 10.1111/jocn.13819. Epub 2017 Jun 22.

14:A meta-analysis of the effectiveness and safety of kinesiology taping in the management of cancer-related lymphoedema.
Authors:Gatt M, Willis S, Leuschner S
Institution:Sir Paul Boffa Hospital, Floriana, Malta.
Journal:Eur J Cancer Care (Engl). 2017 Sep;26(5). doi: 10.1111/ecc.12510. Epub 2016 May 11.

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