Ankylosing Spondylitis
January 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Do Anti-TNF Blockers Increase the Risk of Lung Involvement in Patients with Ankylosing Spondylitis or Psoriatic Arthritis? A Systematic Review.
Authors:Atzeni F, Grillo E, Masala IF, Sarzi-Puttini P, Jones GT
Journal:Isr Med Assoc J. 2016 Mar-Apr;18(3-4):154-5.

2:Comparison on radiographic progression for 5 years between juvenile onset ankylosing spondylitis and adult onset ankylosing spondylitis: an observational study of the Korean SpondyloArthropathy Registry (OSKAR) data.
Authors:Kim TJ, Shin JH, Sung IH, Lee S, Song Y, Kim TH
Institution:Department of Rheumatology, Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea. Seoul, Republic of Korea. Seoul, Republic of Korea. Seoul, Republic of Korea. Seoul, Republic of Korea. Seoul, Republic of Korea. thkim@hanyang.ac.kr.
Journal:Clin Exp Rheumatol. 2016 Jul-Aug;34(4):668-72. Epub 2016 Apr 6.

3:Clinical experience with the European Ankylosing Spondylitis Infliximab Cohort (EASIC): long-term extension over 7 years with focus on clinical efficacy and safety.
Authors:Heldmann F, Baraliakos X, Kiltz U, Brandt J, van der Horst-Bruinsma IE, Landewe R, Sieper J, Burmester GR, van den Bosch F, de Vlam K, Gaston H, Gruenke M, Witt M, Appelboom T, Emery P, Dougados M, Leirisalo-Repo M, Breban M, Braun J
Institution:Rheumazentrum Ruhrgebiet, Herne, Germany. frank.heldmann@ediacon.de. Center/University of Amsterdam, the Netherlands. Chapel Allerton Hospital, Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal:Clin Exp Rheumatol. 2016 Mar-Apr;34(2):184-90. Epub 2016 Mar 25.

4:Low dose etanercept treatment for maintenance of clinical remission in ankylosing spondylitis.
Authors:Park JW, Yoon YI, Lee JH, Park JK, Lee EB, Song YW, Lee EY
Institution:Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. elee@snu.ac.kr.
Journal:Clin Exp Rheumatol. 2016 Jul-Aug;34(4):592-9. Epub 2016 Mar 25.

5:Patient-reported impact of spondyloarthritis on work disability and working life: the ATLANTIS survey.
Authors:Ramonda R, Marchesoni A, Carletto A, Bianchi G, Cutolo M, Ferraccioli G, Fusaro E, De Vita S, Galeazzi M, Gerli R, Matucci-Cerinic M, Minisola G, Montecucco C, Pellerito R, Salaffi F, Paolazzi G, Sarzi-Puttini P, Scarpa R, Bagnato G, Triolo G, Valesini G, Punzi L, Olivieri I
Institution:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Via Giustiniani, 2, Padova, 35128, Italy. roberta.ramonda@unipd.it.; Division of Rheumatology, Day Hospital Unit, Istituto Ortopedico G. Pini, Milano, Italy.; Rheumatology Unit, University of Verona, Verona, Italy.; Department of Locomotor System, Division of Rheumatology, ASL3-Azienda Sanitaria Genovese, Arenzano, Genova, Italy.; Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genova, Italy.
Journal:Arthritis Res Ther. 2016 Apr 1;18:78. doi: 10.1186/s13075-016-0977-2.

6:Does the reason for discontinuation of a first TNF inhibitor influence the effectiveness of a second TNF inhibitor in axial spondyloarthritis? Results from the Swiss Clinical Quality Management Cohort.
Authors:Ciurea A, Exer P, Weber U, Tamborrini G, Steininger B, Kissling RO, Bernhard J, Scherer A
Institution:Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH-8091, Zurich, Switzerland. adrian.ciurea@usz.ch. of Southern Denmark, Odense, Denmark. CH-8091, Zurich, Switzerland. Switzerland.
Journal:Arthritis Res Ther. 2016 Mar 22;18:71. doi: 10.1186/s13075-016-0969-2.

7:Comparative Effectiveness of Biologic Therapy Regimens for Ankylosing Spondylitis: A Systematic Review and a Network Meta-Analysis.
Authors:Chen C, Zhang X, Xiao L, Zhang X, Ma X
Institution:From the Department of Spinal Surgery (CC, XLZ, XLM), Tianjin Hospital, Tianjin; Air Force Centre of Aviation Medical Evaluation and Training (LX), Hangzhou, Zhejiang; and Department of Orthopedics (XSZ), Chinese PLA General Hospital, Beijing, China.
Journal:Medicine (Baltimore). 2016 Mar;95(11):e3060. doi: 10.1097/MD.0000000000003060.

8:Secukinumab (AIN457) in the treatment of ankylosing spondylitis.
Authors:Braun J, Baraliakos X, Kiltz U
Institution:a Rheumazentrum Ruhrgebiet, Herne and Ruhr-Universitat , Bochum , Germany.
Journal:Expert Opin Biol Ther. 2016;16(5):711-22. doi: 10.1517/14712598.2016.1167183.

9:Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-alpha blocking therapy.
Authors:Maas F, Spoorenberg A, Brouwer E, Schilder AM, Chaudhry RN, Wink F, Bootsma H, van der Veer E, Arends S
Institution:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands. f.maas@umcg.nl.; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; and Department of Rheumatology, Medical Center Leeuwarden, The Netherlands.; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.
Journal:Clin Exp Rheumatol. 2016 Mar-Apr;34(2):191-9. Epub 2016 Feb 9.

10:Investigating the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis.
Authors:Kisacik P, Unal E, Akman U, Yapali G, Karabulut E, Akdogan A
Institution:Hacettepe University, Faculty of Health Science, Physiotehrapy and Rehabilitation Department, Ankara, Turkey. Electronic address: pinar_dizmek@hotmail.com. Department, Ankara, Turkey. Electronic address: eyakut@hacettepe.edu.tr. Ankara, Turkey. Electronic address: uakman@hacettepe.edu.tr. Electronic address: gyapali@yahoo.com. Turkey. Electronic address: ekarabul@hacettepe.edu.tr. Turkey. Electronic address: aakdogan@hacettepe.edu.tr.
Journal:Complement Ther Clin Pract. 2016 Feb;22:38-43. doi: 10.1016/j.ctcp.2015.11.002. Epub 2015 Dec 2.

11:Tumour necrosis factor-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation.
Authors:Corbett M, Soares M, Jhuti G, Rice S, Spackman E, Sideris E, Moe-Byrne T, Fox D, Marzo-Ortega H, Kay L, Woolacott N, Palmer S
Institution:Centre for Reviews and Dissemination, University of York, York, UK. Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, UK. Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, UK.
Journal:Health Technol Assess. 2016 Feb;20(9):1-334, v-vi. doi: 10.3310/hta20090.

12:Etoricoxib in ankylosing spondylitis: is there a role for active patients refractory to traditional NSAIDs?
Authors:Gratacos J, Moreno Martinez-Losa M, Font P, Montilla C, Fernandez-Espartero C, Linares LF, Brito E, Oliva JC, Collantes-Estevez E
Institution:Rheumatology Unit, Hospital Universitario Parc Tauli, Sabadell, Spain. jgratacosmas@gmail.com.
Journal:Clin Exp Rheumatol. 2016 Jan-Feb;34(1):94-9. Epub 2016 Jan 20.

13:Golimumab for treatment of axial spondyloarthritis.
Authors:Rios Rodriguez V, Poddubnyy D
Institution:Rheumatology, Medical Department I, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany. Universitatsmedizin Berlin, 10117 Berlin, Germany.
Journal:Immunotherapy. 2016 Feb;8(2):107-15. doi: 10.2217/imt.15.112. Epub 2016 Jan 22.

14:LLLT for the management of patients with ankylosing spondylitis.
Authors:Stasinopoulos D, Papadopoulos K, Lamnisos D, Stergioulas A
Institution:Physiotherapy Program, Department of Health Sciences, School of Sciences, European University Cyprus, Laureate International Universities, 6 Diogenes Street, 2044, Engomi, Nicosia, Cyprus. kostpap@yahoo.com.; Lab of Health, Fitness and Disability Management, Faculty of Human Movement and Quality of Life, University of Peloponnese, Efstathiou & Stamatikis Balioti & Plateon, 231 00, Sparta, Laconia, Greece.
Journal:Lasers Med Sci. 2016 Apr;31(3):459-69. doi: 10.1007/s10103-016-1874-2. Epub 2016 Jan 21.

15:Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis: 54-week results from the randomized, parallel-group PLANETAS study.
Authors:Park W, Yoo DH, Jaworski J, Brzezicki J, Gnylorybov A, Kadinov V, Sariego IG, Abud-Mendoza C, Escalante WJ, Kang SW, Andersone D, Blanco F, Hong SS, Lee SH, Braun J
Institution:Inha University Hospital, Incheon, Republic of Korea. parkwon@inha.ac.kr. c_abud@hotmail.com. kangsw@cnuh.co.kr. daina.andersone@stradini.lv. francisco.blanco.garcia@sergas.es.
Journal:Arthritis Res Ther. 2016 Jan 20;18:25. doi: 10.1186/s13075-016-0930-4.

16:Impact of tobacco smoking on response to tumour necrosis factor-alpha inhibitor treatment in patients with ankylosing spondylitis: results from the Danish nationwide DANBIO registry.
Authors:Glintborg B, Hojgaard P, Lund Hetland M, Steen Krogh N, Kollerup G, Jensen J, Chrysidis S, Jensen Hansen IM, Holland-Fischer M, Hojland Hansen T, Nilsson C, Espesen J, Nordin H, Rasmussen Loft AG, Pelck R, Lorenzen T, Flejsborg Oeftiger S, Unger B, Jaeger F, Mosborg Petersen P, Rasmussen C, Dreyer L
Institution:Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark, The Danish Rheumatologic Database, Rigshospitalet, Glostrup Hospital, Glostrup, Denmark, glintborg@dadlnet.dk. Denmark, Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup Hospital, Glostrup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark'
Journal:Rheumatology (Oxford). 2016 Apr;55(4):659-68. doi: 10.1093/rheumatology/kev392. Epub 2015 Nov 30.

17:An overview of investigational new drugs for treating ankylosing spondylitis.
Authors:Wendling D
Institution:a Rheumatology , Universite de Franche-Comte , Besancon , France. Besancon , F-25030 Besancon , France.
Journal:Expert Opin Investig Drugs. 2016;25(1):95-104. doi: 10.1517/13543784.2016.1116519. Epub 2015 Nov 25.

18:Golimumab for the treatment of axial spondyloarthritis.
Authors:Gelfer G, Perry L, Deodhar A
Institution:a Division of Arthritis & Rheumatic Diseases (OP09) , Oregon Health & Science University , Portland , OR 97239 , USA. University , Portland , OR 97239 , USA. University , Portland , OR 97239 , USA.
Journal:Expert Rev Clin Immunol. 2016;12(1):9-18. doi: 10.1586/1744666X.2016.1106941. Epub 2015 Nov 2.

19:Work Outcome in Patients With Ankylosing Spondylitis: Results From a 12-Year Followup of an International Study.
Authors:Castillo-Ortiz JD, Ramiro S, Landewe R, van der Heijde D, Dougados M, van den Bosch F, Boonen A
Institution:Maastricht University, Maastricht, The Netherlands, and Unidad de Investigacion en Enfermedades Cronico Degenerativas, Guadalajara, Jalisco, Mexico. Orta, Almada, Portugal. The Netherlands.
Journal:Arthritis Care Res (Hoboken). 2016 Apr;68(4):544-52. doi: 10.1002/acr.22730.

20:American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Authors:Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, Smith JA, Borenstein D, Hiratzka J, Weiss PF, Inman RD, Majithia V, Haroon N, Maksymowych WP, Joyce J, Clark BM, Colbert RA, Figgie MP, Hallegua DS, Prete PE, Rosenbaum JT, Stebulis JA, van den Bosch F, Yu DT, Miller AS, Reveille JD, Caplan L
Institution:National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland. Hamilton, Ontario, Canada. Bethesda, Maryland. California, Irvine.
Journal:Arthritis Rheumatol. 2016 Feb;68(2):282-98. doi: 10.1002/art.39298. Epub 2015 Sep 24.

21:Long-term effects of secukinumab on MRI findings in relation to clinical efficacy in subjects with active ankylosing spondylitis: an observational study.
Authors:Baraliakos X, Borah B, Braun J, Baeten D, Laurent D, Sieper J, Emery P, McInnes IB, van Laar JM, Wordsworth P, Wollenhaupt J, Kellner H, Colin L, Vandenhende F, Radford K, Hueber W
Institution:Rheumazentrum Ruhrgebiet, Herne, Germany. and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Centre, Oxford, UK.
Journal:Ann Rheum Dis. 2016 Feb;75(2):408-12. doi: 10.1136/annrheumdis-2015-207544. Epub 2015 Aug 6.

22:Impaired response to treatment with tumour necrosis factor alpha inhibitors in smokers with axial spondyloarthritis.
Authors:Ciurea A, Scherer A, Weber U, Exer P, Bernhard J, Tamborrini G, Riek M, Muller RB, Weiss B, Nissen MJ, Kissling R, Michel BA, Finckh A
Institution:Department of Rheumatology, University Hospital, Zurich, Switzerland. Switzerland.
Journal:Ann Rheum Dis. 2016 Mar;75(3):532-9. doi: 10.1136/annrheumdis-2013-205133. Epub 2015 Feb 9.

23:Ankylosing spondylitis and risk of ischaemic heart disease: a population-based cohort study.
Authors:Essers I, Stolwijk C, Boonen A, De Bruin ML, Bazelier MT, de Vries F, van Tubergen A
Institution:Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands Department of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK.
Journal:Ann Rheum Dis. 2016 Jan;75(1):203-9. doi: 10.1136/annrheumdis-2014-206147. Epub 2014 Oct 31.

For a FREE PREVIEW of the Medifocus Guidebook on Ankylosing Spondylitis click here

To purchase a copy of the COMPLETE Medifocus Guidebook on Ankylosing Spondylitis click here

To subscribe to additional FREE Medifocus Digest Alert on other disease/condition areas click here

  
Get the Medifocus Guidebook on Ankylosing Spondylitis...
at a Special 20% Discount


Medifocus Guidebook on Ankylosing Spondylitis

Updated: January 19, 2017
149 Pages

This one of a kind Guidebook offers:

  • Answers to your critical health questions including the latest treatments, clinical trials, and expert research.
     
  • High Quality, Professional level information you can trust and understand culled from the latest peer-reviewed journals.
     
  • Timely, up to date content with free guidebook updates for 1 year.
     
  • A unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks.
     
  • Over 130,000 Guidebooks Sold
     
  • 100% Risk Free Money Back Guarantee



ORDER THE GUIDEBOOK

The Medifocus Guidebook on Ankylosing Spondylitis is available in the following two convenient formats:

PRINTED GUIDEBOOK

Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $36.95
  • Less 20% Discount = - $7.40
  • Discounted Price = $29.55(excluding shipping & handling)

Order the Printed Guidebook

DIGITAL GUIDEBOOK

Available for immediate download as a PDF document.

  • Regular List Price = $27.95
  • Less 20% Discount = - $5.60
  • Discounted Price = $22.35

Order the Digital Guidebook



Order by Phone

Call Toll Free in the U.S.
1-800-965-3002

From Outside the U.S.
1-301-649-9300

You can also receive a 20% discount when you order your Guidebook by phone.

To receive your 20% discount, simply mention the Discount Coupon Code below to the customer service representative taking your order.

Discount Coupon Code for
Phone Orders

AS62357822

Coupon Expires: April 25, 2017



What Our Customers Are Saying...

"I'm writing to express my gratitude for the valuable information you provided in the MediFocus Guidebook on Ankylosing Spondylitis. The Guidebook was not only very well written but it also listed several newer medications for AS that my doctor had never mentioned. Without your Guidebook, I would never have known about these newer treatment options. Thanks again for helping me become better educated about this condition."
P.D.F.
Fresno, California


"Your MediFocus Guidebook on Ankylosing Spondylitis is by far the most detailed and up-to-date publication about this condition that I have come across. Educating yourself about ankylosing spondylitis is an important aspect of controlling the symptoms and help you maintain a reasonably active lifestyle...your Guidebook certainly provides practical information that all patients with ankylosing spondylitis can put to good use."
J.P.
Raleigh, North Carolina



  
Medifocus Digest Alert is published monthly by Medifocus, Inc.
6810 Park Heights Avenue, Suite C5, Baltimore, MD 21215 USA
Copyright © 2013 Medifocus, Inc. All rights reserved.