Ankylosing Spondylitis
October 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Relationship between serum adipokine levels and radiographic progression in patients with ankylosing spondylitis: A preliminary 2-year longitudinal study.
Authors:Park JH, Lee SG, Jeon YK, Park EK, Suh YS, Kim HO
Institution:aDivision of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine bBiomedical Research Institute cDivsion of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan dDivision of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Journal:Medicine (Baltimore). 2017 Aug;96(33):e7854. doi: 10.1097/MD.0000000000007854.

2:One-stage surgical treatment of cervical spine fracture-dislocation in patients with ankylosing spondylitis via the combined anterior-posterior approach.
Authors:He A, Xie D, Cai X, Qu B, Kong Q, Xu C, Yang L, Chen X, Jia L
Institution:Department of Orthopaedic Surgery, Changzheng Hospital, Shanghai, China.
Journal:Medicine (Baltimore). 2017 Jul;96(27):e7432. doi: 10.1097/MD.0000000000007432.

3:Ankylosing spondylitis patients at risk of poor radiographic outcome show diminishing spinal radiographic progression during long-term treatment with TNF-alpha inhibitors.
Authors:Maas F, Arends S, Wink FR, Bos R, Bootsma H, Brouwer E, Spoorenberg A
Institution:Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Journal:PLoS One. 2017 Jun 22;12(6):e0177231. doi: 10.1371/journal.pone.0177231. eCollection 2017.

4:Safety of tumor necrosis factor-alpha inhibitors for treatment of ankylosing spondylitis: A meta-analysis.
Authors:Ma Z, Liu X, Xu X, Jiang J, Zhou J, Wang J, Chen D, Luo S
Institution:Department of Orthopaedics, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Journal:Medicine (Baltimore). 2017 Jun;96(25):e7145. doi: 10.1097/MD.0000000000007145.

5:Pain in ankylosing spondylitis: a neuro-immune collaboration.
Authors:Bidad K, Gracey E, Hemington KS, Mapplebeck JCS, Davis KD, Inman RD
Institution:Krembil Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.; Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, 62 Dr Gharib Street, Keshavarz Boulevard, Tehran 14194, Iran.; Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Institute of Medical Science, Medical Sciences Building, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; University of Toronto Centre for the Study of Pain, 155 College Street, Toronto, Ontario M5T 1P8, Canada.
Journal:Nat Rev Rheumatol. 2017 Jul;13(7):410-420. doi: 10.1038/nrrheum.2017.92. Epub 2017 Jun 15.

6:Pathogenesis of ankylosing spondylitis - recent advances and future directions.
Authors:Ranganathan V, Gracey E, Brown MA, Inman RD, Haroon N
Institution:Krembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5S 1A8, Canada. Technology, Translational Research Institute, Brisbane, Queensland 4001, Australia. Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5S 1A8, Canada. Bathurst Street, Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5T 2S8, Canada. Bathurst Street, Toronto, Ontario M5T 2S8, Canada.
Journal:Nat Rev Rheumatol. 2017 Jun;13(6):359-367. doi: 10.1038/nrrheum.2017.56. Epub 2017 Apr 27.

7:Tumour necrosis factor inhibitor treatment and occurrence of anterior uveitis in ankylosing spondylitis: results from the Swedish biologics register.
Authors:Lie E, Lindstrom U, Zverkova-Sandstrom T, Olsen IC, Forsblad-d'Elia H, Askling J, Kapetanovic MC, Kristensen LE, Jacobsson LTH
Institution:Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. University of Gothenburg, Gothenburg, Sweden. University of Gothenburg, Gothenburg, Sweden. Umea, Sweden. Karolinska Institutet, Stockholm, Sweden. Malmo, Sweden. Malmo, Sweden. Rheumatology, Copenhagen University Hospital, Copenhagen, Denmark. University of Gothenburg, Gothenburg, Sweden.
Journal:Ann Rheum Dis. 2017 Sep;76(9):1515-1521. doi: 10.1136/annrheumdis-2016-210931. Epub 2017 Mar 2.

8:Fatigue contributes to work productivity impairment in patients with axial spondyloarthritis: a cross-sectional UK study.
Authors:Espahbodi S, Bassett P, Cavill C, Freeth M, Hole J, Sengupta R
Institution:Royal National Hospital for Rheumatic Diseases (RNHRD), Bath, UK. Bath, UK.
Journal:Clin Exp Rheumatol. 2017 Jul-Aug;35(4):571-578. Epub 2017 Feb 24.

9:Secukinumab and Sustained Improvement in Signs and Symptoms of Patients With Active Ankylosing Spondylitis Through Two Years: Results From a Phase III Study.
Authors:Marzo-Ortega H, Sieper J, Kivitz A, Blanco R, Cohen M, Martin R, Readie A, Richards HB, Porter B
Institution:Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. de Valdecilla-IDIVAL, Santander, Spain.
Journal:Arthritis Care Res (Hoboken). 2017 Jul;69(7):1020-1029. doi: 10.1002/acr.23233. Epub 2017 Jun 7.

10:Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study.
Authors:van der Heijde D, Deodhar A, Wei JC, Drescher E, Fleishaker D, Hendrikx T, Li D, Menon S, Kanik KS
Institution:Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Portland, Oregon, USA. Hospital, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Journal:Ann Rheum Dis. 2017 Aug;76(8):1340-1347. doi: 10.1136/annrheumdis-2016-210322. Epub 2017 Jan 27.

11:Axial spondyloarthritis.
Authors:Sieper J, Poddubnyy D
Institution:Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany. Electronic address:
Journal:Lancet. 2017 Jul 1;390(10089):73-84. doi: 10.1016/S0140-6736(16)31591-4. Epub 2017 Jan 20.

12:Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial.
Authors:Coates L, Packham JC, Creamer P, Hailwood S, Bhalla AS, Chakravarty K, Mulherin D, Taylor G, Mattey DL, Bhalla AK
Institution:Department of Rheumatology, Tameside Hospital, Ashton-Under-Lyne, Lancashire, UK. Hospital, Cannock, UK.
Journal:Clin Exp Rheumatol. 2017 May-Jun;35(3):445-451. Epub 2017 Jan 4.

13:Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study.
Authors:Braun J, Baraliakos X, Deodhar A, Baeten D, Sieper J, Emery P, Readie A, Martin R, Mpofu S, Richards HB
Institution:Department of Rheumatology, Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany. Herne, Germany.
Journal:Ann Rheum Dis. 2017 Jun;76(6):1070-1077. doi: 10.1136/annrheumdis-2016-209730. Epub 2016 Dec 13.

14:Reasons for Discontinuation and Adverse Effects of TNFalpha Inhibitors in a Cohort of Patients With Rheumatoid Arthritis and Ankylosing Spondylitis.
Authors:Garcia-Lagunar MH, Gutierrez-Civicos MR, Garcia-Simon MS, Conesa-Zamora P, Jimenez-Santos E, Cano-Vivar P, Garcia-Marquez A, Munoz-Garcia I, Viney AC
Institution:1 Department of Hospital Pharmacy, Santa Lucia General University Hospital (HGUSL), Cartagena, Spain.; 2 Department of Clinical Analysis, HGUSL, Cartagena, Spain.; 3 Department of Cardiology, HGUSL, Cartagena, Spain.
Journal:Ann Pharmacother. 2017 May;51(5):388-393. doi: 10.1177/1060028016682330. Epub 2016 Dec 5.

15:Effects of cold mist shower on patients with inflammatory arthritis: a crossover controlled clinical trial.
Authors:Hinkka H, Vaattanen S, Ala-Peijari S, Nummi T
Institution:a Research Unit , Rehabilitation Centre Apila , Kangasala , Finland.
Journal:Scand J Rheumatol. 2017 May;46(3):206-209. doi: 10.1080/03009742.2016.1199733. Epub 2016 Aug 30.

16:Clinical Risk Factors for the Presence and Development of Vertebral Fractures in Patients With Ankylosing Spondylitis.
Authors:Maas F, Spoorenberg A, van der Slik BPG, van der Veer E, Brouwer E, Bootsma H, Bos R, Wink FR, Arends S
Institution:University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen, and Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Journal:Arthritis Care Res (Hoboken). 2017 May;69(5):694-702. doi: 10.1002/acr.22980.

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