Ankylosing Spondylitis
August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Insights into cardiac involvement in ankylosing spondylitis from cardiovascular magnetic resonance.
Authors:Biesbroek PS, Heslinga SC, Konings TC, van der Horst-Bruinsma IE, Hofman MBM, van de Ven PM, Kamp O, van Halm VP, Peters MJL, Smulders YM, van Rossum AC, Nurmohamed MT, Nijveldt R
Institution:Departments of Cardiology, VU University Medical Center, Amsterdam, The Netherlands. Amsterdam, The Netherlands. University Medical Center, Amsterdam, The Netherlands. Netherlands. University Medical Center, Amsterdam, The Netherlands. Amsterdam, The Netherlands. Amsterdam, The Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Amsterdam, The Netherlands. Netherlands.
Journal:Heart. 2017 May;103(10):745-752. doi: 10.1136/heartjnl-2016-310667. Epub 2016 Nov 16.

2:Secukinumab efficacy in anti-TNF-naive and anti-TNF-experienced subjects with active ankylosing spondylitis: results from the MEASURE 2 Study.
Authors:Sieper J, Deodhar A, Marzo-Ortega H, Aelion JA, Blanco R, Jui-Cheng T, Andersson M, Porter B, Richards HB
Institution:Charite University Medicine Berlin, Berlin, Germany.
Journal:Ann Rheum Dis. 2017 Mar;76(3):571-592. doi: 10.1136/annrheumdis-2016-210023. Epub 2016 Aug 31.

3:Mapping the relationship between clinical and quality-of-life outcomes in patients with ankylosing spondylitis.
Authors:Mlcoch T, Sedova L, Stolfa J, Urbanova M, Suchy D, Smrzova A, Jircikova J, Pavelka K, Dolezal T
Institution:a Institute of Health Economics and Technology Assessment , Prague , Czech Republic. , Prague , Czech Republic. Plzen , Czech Republic. Republic. Republic.
Journal:Expert Rev Pharmacoecon Outcomes Res. 2017 Apr;17(2):203-211. doi: 10.1080/14737167.2016.1200468. Epub 2016 Jun 24.

4:Efficacy of golimumab on recurrent uveitis in HLA-B27-positive ankylosing spondylitis.
Authors:Yazgan S, Celik U, Isik M, Yesil NK, Baki AE, Sahin H, Gencer E, Dogan I
Institution:Department of Ophthalmology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey. Medeniyet Universitesi Tip Fakultesi. Goztepe Egitim Ve Arastirma Hastanesi. Doktor Erkin Caddesi. Kadikoy, Istanbul, Turkey. Bulent Ecevit University, Zonguldak, Turkey. Education Hospital, Ankara, Turkey. Zonguldak, Turkey. Zonguldak, Turkey. Turkey. University, Corum, Turkey.
Journal:Int Ophthalmol. 2017 Feb;37(1):139-145. doi: 10.1007/s10792-016-0239-y. Epub 2016 May 6.

5:Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study.
Authors:Park W, Yoo DH, Miranda P, Brzosko M, Wiland P, Gutierrez-Urena S, Mikazane H, Lee YA, Smiyan S, Lim MJ, Kadinov V, Abud-Mendoza C, Kim H, Lee SJ, Bae Y, Kim S, Braun J
Institution:IN-HA University, School of Medicine, Medicine/Rheumatology, Incheon, Republic of Korea. Chile. in Szczecin, Szczecin, Poland. CUCS, Universidad de Guadalajara, Guadalajara Jalisco, Mexico. Kyung Hee University, Seoul, Republic of Korea. Ternopil Regional Council "Ternopil University Hospital", Ternopil, Ukraine. Korea. Potosi, San Luis Potosi, Mexico.
Journal:Ann Rheum Dis. 2017 Feb;76(2):346-354. doi: 10.1136/annrheumdis-2015-208783. Epub 2016 Apr 26.

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What Our Customers Are Saying...

"I'm writing to express my gratitude for the valuable information you provided in the MediFocus Guidebook on Ankylosing Spondylitis. The Guidebook was not only very well written but it also listed several newer medications for AS that my doctor had never mentioned. Without your Guidebook, I would never have known about these newer treatment options. Thanks again for helping me become better educated about this condition."
Fresno, California

"Your MediFocus Guidebook on Ankylosing Spondylitis is by far the most detailed and up-to-date publication about this condition that I have come across. Educating yourself about ankylosing spondylitis is an important aspect of controlling the symptoms and help you maintain a reasonably active lifestyle...your Guidebook certainly provides practical information that all patients with ankylosing spondylitis can put to good use."
Raleigh, North Carolina

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