Ankylosing Spondylitis
June 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).
Authors:Chen B, Li J, He C, Li D, Tong W, Zou Y, Xu W
Institution:Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China. Military Medical University, Shanghai 200433, P.R. China.
Journal:Mol Med Rep. 2017 Apr;15(4):1943-1951. doi: 10.3892/mmr.2017.6248. Epub 2017 Feb 24.

2:The immune dysfunction in ankylosing spondylitis patients.
Authors:Duan Z, Gui Y, Li C, Lin J, Gober HJ, Qin J, Li D, Wang L
Institution:Obstetrics and Gynecology Hospital, Fudan University.
Journal:Biosci Trends. 2017 Mar 22;11(1):69-76. doi: 10.5582/bst.2016.01171. Epub 2017 Feb 7.

3:Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis-A National Population-Based Study.
Authors:Yen JC, Hsu CA, Hsiao SH, Hsu MH
Institution:Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. m701061@gmail.com. Taiwan. m701061@gmail.com. johnhsu129@gmail.com. Taiwan. ns27111512@yahoo.com.tw. ns27111512@yahoo.com.tw. Technology, Taipei Medical University, Taipei 11031, Taiwan. 701056@gmail.com.
Journal:Int J Environ Res Public Health. 2017 Jan 23;14(1). pii: E107. doi: 10.3390/ijerph14010107.

4:Progression rate of ankylosing spondylitis in patients with undifferentiated spondyloarthritis: A systematic review and meta-analysis.
Authors:Xia Q, Fan D, Yang X, Li X, Zhang X, Wang M, Xu S, Pan F
Institution:aDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui bDepartment of Obstetrics, South Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong cDepartment of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Journal:Medicine (Baltimore). 2017 Jan;96(4):e5960. doi: 10.1097/MD.0000000000005960.

5:Cementless total hip arthroplasty in patients with ankylosing spondylitis: A retrospective observational study.
Authors:Xu J, Zeng M, Xie J, Wen T, Hu Y
Institution:aDepartment of Orthopedics, Seventh People's Hospital of Shenzhen, Shenzhen, Guangdong bDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Journal:Medicine (Baltimore). 2017 Jan;96(4):e5813. doi: 10.1097/MD.0000000000005813.

6:Secukinumab efficacy in anti-TNF-naive and anti-TNF-experienced subjects with active ankylosing spondylitis: results from the MEASURE 2 Study.
Authors:Sieper J, Deodhar A, Marzo-Ortega H, Aelion JA, Blanco R, Jui-Cheng T, Andersson M, Porter B, Richards HB
Institution:Charite University Medicine Berlin, Berlin, Germany.
Journal:Ann Rheum Dis. 2017 Mar;76(3):571-592. doi: 10.1136/annrheumdis-2016-210023. Epub 2016 Aug 31.

7:An update on the use of tumor necrosis factor alpha inhibitors in the treatment of ankylosing spondylitis.
Authors:Osman MS, Maksymowych WP
Institution:a Division of Rheumatology, Department of Medicine , University of Alberta , Edmonton , AB , USA. Edmonton , AB , USA.
Journal:Expert Rev Clin Immunol. 2017 Feb;13(2):125-131. doi: 10.1080/1744666X.2016.1218761. Epub 2016 Aug 10.

8:A multicenter, open-label, long-term study of three-year infliximab administration in Japanese patients with ankylosing spondylitis.
Authors:Kobayashi S, Yoshinari T
Institution:a Division of Rheumatology, Department of Internal Medicine , Juntendo University Koshigaya Hospital , Koshigaya , Japan and. Tokyo , Japan.
Journal:Mod Rheumatol. 2017 Jan;27(1):142-149. doi: 10.1080/14397595.2016.1176635. Epub 2016 Jun 14.

9:Is ankylosing spondylitis a risk factor for cardiovascular disease, and how do these risks compare with those in rheumatoid arthritis?
Authors:Eriksson JK, Jacobsson L, Bengtsson K, Askling J
Institution:Clinical Epidemiology Unit and Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. University of Gothenburg, Gothenburg, Sweden. University of Gothenburg, Gothenburg, Sweden. Institutet, Stockholm, Sweden. Stockholm, Sweden.
Journal:Ann Rheum Dis. 2017 Feb;76(2):364-370. doi: 10.1136/annrheumdis-2016-209315. Epub 2016 Jun 9.

10:Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers.
Authors:Hellgren K, Dreyer L, Arkema EV, Glintborg B, Jacobsson LT, Kristensen LE, Feltelius N, Hetland ML, Askling J
Institution:Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden. Stockholm, Sweden. Denmark. Copenhagen, Denmark. Stockholm, Sweden. Denmark. Copenhagen, Denmark. University of Gothenburg, Gothenburg, Sweden. Copenhagen, Denmark. Karolinska University Hospital, Stockholm, Sweden. Orthopaedics, Rigshospitalet, Glostrup, Denmark. University of Copenhagen, Copenhagen, Denmark. Karolinska University Hospital, Stockholm, Sweden. Stockholm, Sweden.
Journal:Ann Rheum Dis. 2017 Jan;76(1):105-111. doi: 10.1136/annrheumdis-2016-209270. Epub 2016 May 4.

11:Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study.
Authors:Park W, Yoo DH, Miranda P, Brzosko M, Wiland P, Gutierrez-Urena S, Mikazane H, Lee YA, Smiyan S, Lim MJ, Kadinov V, Abud-Mendoza C, Kim H, Lee SJ, Bae Y, Kim S, Braun J
Institution:IN-HA University, School of Medicine, Medicine/Rheumatology, Incheon, Republic of Korea. Chile. in Szczecin, Szczecin, Poland. CUCS, Universidad de Guadalajara, Guadalajara Jalisco, Mexico. Kyung Hee University, Seoul, Republic of Korea. Ternopil Regional Council "Ternopil University Hospital", Ternopil, Ukraine. Korea. Potosi, San Luis Potosi, Mexico.
Journal:Ann Rheum Dis. 2017 Feb;76(2):346-354. doi: 10.1136/annrheumdis-2015-208783. Epub 2016 Apr 26.

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What Our Customers Are Saying...

"I'm writing to express my gratitude for the valuable information you provided in the MediFocus Guidebook on Ankylosing Spondylitis. The Guidebook was not only very well written but it also listed several newer medications for AS that my doctor had never mentioned. Without your Guidebook, I would never have known about these newer treatment options. Thanks again for helping me become better educated about this condition."
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"Your MediFocus Guidebook on Ankylosing Spondylitis is by far the most detailed and up-to-date publication about this condition that I have come across. Educating yourself about ankylosing spondylitis is an important aspect of controlling the symptoms and help you maintain a reasonably active lifestyle...your Guidebook certainly provides practical information that all patients with ankylosing spondylitis can put to good use."
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