Ankylosing Spondylitis
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Survival benefit of statin use in ankylosing spondylitis: a general population-based cohort study.
Authors:Oza A, Lu N, Schoenfeld SR, Fisher MC, Dubreuil M, Rai SK, Zhang Y, Choi HK
Institution:Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA.
Journal:Ann Rheum Dis. 2017 Oct;76(10):1737-1742. doi: 10.1136/annrheumdis-2017-211253. Epub 2017 Jul 11.

2:Safety of tumor necrosis factor-alpha inhibitors for treatment of ankylosing spondylitis: A meta-analysis.
Authors:Ma Z, Liu X, Xu X, Jiang J, Zhou J, Wang J, Chen D, Luo S
Institution:Department of Orthopaedics, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Journal:Medicine (Baltimore). 2017 Jun;96(25):e7145. doi: 10.1097/MD.0000000000007145.

3:Pain in ankylosing spondylitis: a neuro-immune collaboration.
Authors:Bidad K, Gracey E, Hemington KS, Mapplebeck JCS, Davis KD, Inman RD
Institution:Krembil Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.; Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, 62 Dr Gharib Street, Keshavarz Boulevard, Tehran 14194, Iran.; Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Institute of Medical Science, Medical Sciences Building, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; University of Toronto Centre for the Study of Pain, 155 College Street, Toronto, Ontario M5T 1P8, Canada.
Journal:Nat Rev Rheumatol. 2017 Jul;13(7):410-420. doi: 10.1038/nrrheum.2017.92. Epub 2017 Jun 15.

4:Pathogenesis of ankylosing spondylitis - recent advances and future directions.
Authors:Ranganathan V, Gracey E, Brown MA, Inman RD, Haroon N
Institution:Krembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5S 1A8, Canada. Technology, Translational Research Institute, Brisbane, Queensland 4001, Australia. Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5S 1A8, Canada. Bathurst Street, Toronto, Ontario M5T 2S8, Canada. Toronto, Ontario M5T 2S8, Canada. Bathurst Street, Toronto, Ontario M5T 2S8, Canada.
Journal:Nat Rev Rheumatol. 2017 Jun;13(6):359-367. doi: 10.1038/nrrheum.2017.56. Epub 2017 Apr 27.

5:Ankylosing Spondylitis: HLA-B*27-Positive Versus HLA-B*27-Negative Disease.
Authors:Akkoc N, Yarkan H, Kenar G, Khan MA
Institution:, Izmir, Turkey. 35340, Izmir, Turkey. 35340, Izmir, Turkey. Drive, Cleveland, OH, 44109, USA.
Journal:Curr Rheumatol Rep. 2017 May;19(5):26. doi: 10.1007/s11926-017-0654-8.

6:Erectile dysfunction in ankylosing spondylitis patients.
Authors:Santana T, Skare T, Delboni VS, Simione J, Campos APB, Nisihara R
Institution:Unidade de Reumatologia, Hospital Evangelico, Padre Anchieta, Curitiba, PR, Brasil. Brasil. Brasil. Brasil. Brasil. Brasil.
Journal:Int Braz J Urol. 2017 Jul-Aug;43(4):730-735. doi: 10.1590/S1677-5538.IBJU.2016.0378.

7:Secukinumab and Sustained Improvement in Signs and Symptoms of Patients With Active Ankylosing Spondylitis Through Two Years: Results From a Phase III Study.
Authors:Marzo-Ortega H, Sieper J, Kivitz A, Blanco R, Cohen M, Martin R, Readie A, Richards HB, Porter B
Institution:Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. de Valdecilla-IDIVAL, Santander, Spain.
Journal:Arthritis Care Res (Hoboken). 2017 Jul;69(7):1020-1029. doi: 10.1002/acr.23233. Epub 2017 Jun 7.

8:Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study.
Authors:van der Heijde D, Deodhar A, Wei JC, Drescher E, Fleishaker D, Hendrikx T, Li D, Menon S, Kanik KS
Institution:Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Portland, Oregon, USA. Hospital, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Journal:Ann Rheum Dis. 2017 Aug;76(8):1340-1347. doi: 10.1136/annrheumdis-2016-210322. Epub 2017 Jan 27.

9:Axial spondyloarthritis.
Authors:Sieper J, Poddubnyy D
Institution:Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany. Electronic address:
Journal:Lancet. 2017 Jul 1;390(10089):73-84. doi: 10.1016/S0140-6736(16)31591-4. Epub 2017 Jan 20.

10:Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo-controlled trial.
Authors:Coates L, Packham JC, Creamer P, Hailwood S, Bhalla AS, Chakravarty K, Mulherin D, Taylor G, Mattey DL, Bhalla AK
Institution:Department of Rheumatology, Tameside Hospital, Ashton-Under-Lyne, Lancashire, UK. Hospital, Cannock, UK.
Journal:Clin Exp Rheumatol. 2017 May-Jun;35(3):445-451. Epub 2017 Jan 4.

11:Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study.
Authors:Braun J, Baraliakos X, Deodhar A, Baeten D, Sieper J, Emery P, Readie A, Martin R, Mpofu S, Richards HB
Institution:Department of Rheumatology, Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany. Herne, Germany.
Journal:Ann Rheum Dis. 2017 Jun;76(6):1070-1077. doi: 10.1136/annrheumdis-2016-209730. Epub 2016 Dec 13.

12:Reduction in Spinal Radiographic Progression in Ankylosing Spondylitis Patients Receiving Prolonged Treatment With Tumor Necrosis Factor Inhibitors.
Authors:Maas F, Arends S, Brouwer E, Essers I, van der Veer E, Efde M, van Ooijen PMA, Wolf R, Veeger NJGM, Bootsma H, Wink FR, Spoorenberg A
Institution:University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Medical Center Leeuwarden, Leeuwarden, The Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Netherlands. Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Journal:Arthritis Care Res (Hoboken). 2017 Jul;69(7):1011-1019. doi: 10.1002/acr.23097. Epub 2017 Jun 9.

13:Effects of cold mist shower on patients with inflammatory arthritis: a crossover controlled clinical trial.
Authors:Hinkka H, Vaattanen S, Ala-Peijari S, Nummi T
Institution:a Research Unit , Rehabilitation Centre Apila , Kangasala , Finland.
Journal:Scand J Rheumatol. 2017 May;46(3):206-209. doi: 10.1080/03009742.2016.1199733. Epub 2016 Aug 30.

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What Our Customers Are Saying...

"I'm writing to express my gratitude for the valuable information you provided in the MediFocus Guidebook on Ankylosing Spondylitis. The Guidebook was not only very well written but it also listed several newer medications for AS that my doctor had never mentioned. Without your Guidebook, I would never have known about these newer treatment options. Thanks again for helping me become better educated about this condition."
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