Ankylosing Spondylitis
April 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ankylosing Spondylitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ankylosing Spondylitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ankylosing Spondylitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ankylosing Spondylitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Identification of potential target genes for ankylosing spondylitis treatment.
Authors:Ni Y, Jiang C
Institution:Department of Spine Surgery. Shandong Province, China.
Journal:Medicine (Baltimore). 2018 Feb;97(8):e9760. doi: 10.1097/MD.0000000000009760.

2:The association between ankylosing spondylitis and the risk of any, hip, or vertebral fracture: A meta-analysis.
Authors:Zhang M, Li XM, Wang GS, Tao JH, Chen Z, Ma Y, Li XP
Institution:Department of Rheumatology and Immunology, Anhui Provincial Hospital, Anhui Medical University, Hefei, PR China.
Journal:Medicine (Baltimore). 2017 Dec;96(50):e8458. doi: 10.1097/MD.0000000000008458.

3:Incident osteoarthritis and osteoarthritis-related joint replacement surgery in patients with ankylosing spondylitis: A secondary cohort analysis of a nationwide, population-based health claims database.
Authors:Lu MC, Tung CH, Yang CC, Wang CL, Huang KY, Koo M, Lai NS
Institution:Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan. Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan. Foundation, Dalin, Chiayi, Taiwan. Foundation, Dalin, Chiayi, Taiwan. Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan.
Journal:PLoS One. 2017 Nov 2;12(11):e0187594. doi: 10.1371/journal.pone.0187594. eCollection 2017.

4:The treatment strategies for spine fractures in patients with ankylosing spondylitis: A case report.
Authors:Zhu R, Song W, Hu W, Jiang Z, Yuan J, Cui Z, Wan J, Liu Y, Feng S, Zhang X
Institution:aDepartment of Spine Surgery, Tianjin Union Medicine Centre bDepartment of Orthopedics, Tianjin Medical University General Hospital, Tianjin, PR China.
Journal:Medicine (Baltimore). 2017 Nov;96(44):e8462. doi: 10.1097/MD.0000000000008462.

5:Spinal cord injury after traumatic spine fracture in patients with ankylosing spinal disorders.
Authors:Teunissen FR, Verbeek BM, Cha TD, Schwab JH
Institution:Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Journal:J Neurosurg Spine. 2017 Dec;27(6):709-716. doi: 10.3171/2017.5.SPINE1722. Epub 2017 Oct 6.

6:TNF blockers inhibit spinal radiographic progression in ankylosing spondylitis by reducing disease activity: results from the Swiss Clinical Quality Management cohort.
Authors:Molnar C, Scherer A, Baraliakos X, de Hooge M, Micheroli R, Exer P, Kissling RO, Tamborrini G, Wildi LM, Nissen MJ, Zufferey P, Bernhard J, Weber U, Landewe RBM, van der Heijde D, Ciurea A
Institution:Stastistics Group, Swiss Clinical Quality Management Foundation, Zurich, Switzerland. Switzerland.
Journal:Ann Rheum Dis. 2018 Jan;77(1):63-69. doi: 10.1136/annrheumdis-2017-211544. Epub 2017 Sep 22.

7:Comparison of drug survival and clinical outcome in patients with ankylosing spondylitis treated with etanercept or adalimumab.
Authors:Ruwaard J, l'Ami MJ, Marsman AF, Kneepkens EL, van Denderen JC, van der Horst-Bruinsma IE, Nurmohamed MT, Wolbink G
Institution:a Rheumatology , Amsterdam Rheumatology and Immunology Center, Location Reade , Amsterdam , The Netherlands.; b Rheumatology , Amsterdam Rheumatology and Immunology Center, Location VU Medical Center , Amsterdam , The Netherlands.; c Department of Immunopathology , Sanquin Research and Landsteiner Laboratory Academic Medical Centre , Amsterdam , The Netherlands.
Journal:Scand J Rheumatol. 2018 Mar;47(2):122-126. doi: 10.1080/03009742.2017.1330419. Epub 2017 Jul 26.

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What Our Customers Are Saying...

"I'm writing to express my gratitude for the valuable information you provided in the MediFocus Guidebook on Ankylosing Spondylitis. The Guidebook was not only very well written but it also listed several newer medications for AS that my doctor had never mentioned. Without your Guidebook, I would never have known about these newer treatment options. Thanks again for helping me become better educated about this condition."
Fresno, California

"Your MediFocus Guidebook on Ankylosing Spondylitis is by far the most detailed and up-to-date publication about this condition that I have come across. Educating yourself about ankylosing spondylitis is an important aspect of controlling the symptoms and help you maintain a reasonably active lifestyle...your Guidebook certainly provides practical information that all patients with ankylosing spondylitis can put to good use."
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