January 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Fractional carbon dioxide laser versus low-dose UVA-1 phototherapy for treatment of localized scleroderma: a clinical and immunohistochemical randomized controlled study.
Authors:Shalaby SM, Bosseila M, Fawzy MM, Abdel Halim DM, Sayed SS, Allam RS
Institution:Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Journal:Lasers Med Sci. 2016 Nov;31(8):1707-1715. Epub 2016 Aug 10.

2:Pulmonary involvement in systemic sclerosis.
Authors:Morales-Cardenas A, Perez-Madrid C, Arias L, Ojeda P, Mahecha MP, Rojas-Villarraga A, Carrillo-Bayona JA, Anaya JM
Institution:Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogota, Colombia. Electronic address:; Mederi, Hospital Universitario Mayor, Calle 24 No. 29-45, Bogota, Colombia.; Hospital Santa Clara ESE, CRA 14 B No. 1-45 Sur, Bogota, Colombia.
Journal:Autoimmun Rev. 2016 Nov;15(11):1094-1108. doi: 10.1016/j.autrev.2016.07.025. Epub 2016 Aug 4.

3:Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial.
Authors:Khanna D, Denton CP, Jahreis A, van Laar JM, Frech TM, Anderson ME, Baron M, Chung L, Fierlbeck G, Lakshminarayanan S, Allanore Y, Pope JE, Riemekasten G, Steen V, Muller-Ladner U, Lafyatis R, Stifano G, Spotswood H, Chen-Harris H, Dziadek S, Morimoto A, Sornasse T, Siegel J, Furst DE
Institution:University of Michigan Scleroderma Program, Ann Arbor, MI, USA. Electronic address: Alto, CA, USA. ON, Canada.
Journal:Lancet. 2016 Jun 25;387(10038):2630-40. doi: 10.1016/S0140-6736(16)00232-4. Epub 2016 May 5.

4:Exploring Sources of Emotional Distress among People Living with Scleroderma: A Focus Group Study.
Authors:Gumuchian ST, Pelaez S, Delisle VC, Carrier ME, Jewett LR, El-Baalbaki G, Fortune C, Hudson M, Impens A, Korner A, Persmann J, Kwakkenbos L, Bartlett SJ, Thombs BD
Institution:Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Centre de recherche du Centre hospitalier universitaire Sainte-Justine, Montreal, Quebec, Canada.; Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada.; Department of Psychology, Universite du Quebec a Montreal, Montreal, Quebec, Canada.
Journal:PLoS One. 2016 Mar 23;11(3):e0152419. doi: 10.1371/journal.pone.0152419. eCollection 2016.

5:Cellular Therapies in Systemic Sclerosis: Recent Progress.
Authors:van Rhijn-Brouwer FC, Gremmels H, Fledderus JO, Radstake TR, Verhaar MC, van Laar JM
Institution:Department of Nephrology and Hypertension, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.; Department of Rheumatology & Clinical Immunology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Journal:Curr Rheumatol Rep. 2016 Feb;18(2):12. doi: 10.1007/s11926-015-0555-7.

6:Wenyang Huazhuo Tongluo formula, a Chinese herbal decoction, improves skin fibrosis by promoting apoptosis and inhibiting proliferation through down-regulation of survivin and cyclin D1 in systemic sclerosis.
Authors:Han L, Bian H, Ouyang J, Bi Y, Yang L, Ye S
Institution:Zhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Changjiang Road 80, Nanyang, 473004, Henan, China. Changjiang Road 80, Nanyang, 473004, Henan, China. China. Changjiang Road 80, Nanyang, 473004, Henan, China. Changjiang Road 80, Nanyang, 473004, Henan, China.
Journal:BMC Complement Altern Med. 2016 Feb 20;16:69. doi: 10.1186/s12906-016-1056-6.

7:Current Approaches to the Treatment of Systemic-Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH).
Authors:Sobanski V, Launay D, Hachulla E, Humbert M
Institution:U995 Lille Inflammation Research International Center, University Lille, Lille, France. France. (Sclerodermie Systemique), Lille, France. Lille, France. France. France. (Sclerodermie Systemique), Lille, France. Lille, France. France. France. (Sclerodermie Systemique), Lille, France. Lille, France. Bicetre, France.
Journal:Curr Rheumatol Rep. 2016 Feb;18(2):10. doi: 10.1007/s11926-015-0560-x.

8:Advances in pathogenesis and treatment of systemic sclerosis.
Authors:Denton CP
Institution:Royal Free Hospital and UCL Division of Medicine, London, UK
Journal:Clin Med (Lond). 2016 Feb;16(1):55-60. doi: 10.7861/clinmedicine.16-1-55.

9:Genetic factors and systemic sclerosis.
Authors:Murdaca G, Contatore M, Gulli R, Mandich P, Puppo F
Institution:Departments of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit, University of Genova, Genova, Italy. Electronic address:; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, Section of Medical Genetics, University of Genova, Genova, Italy.
Journal:Autoimmun Rev. 2016 May;15(5):427-32. doi: 10.1016/j.autrev.2016.01.016. Epub 2016 Jan 28.

10:Systemic sclerosis: An update in 2016.
Authors:Desbois AC, Cacoub P
Institution:Sorbonne Universites, UPMC Universite Paris 06, UMR 7211, Paris, France; Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005 Paris, France; INSERM, UMR_S 959, F-75013 Paris, France; CNRS, FRE3632, F-75005 Paris, France. Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005 Paris, France; AP-HP, Groupe Hospitalier Pitie-Salpetriere, Department of Internal Medicine and Clinical Immunology, 83 boulevard de l'hopital, F-75013 Paris, France. Electronic address:
Journal:Autoimmun Rev. 2016 May;15(5):417-26. doi: 10.1016/j.autrev.2016.01.007. Epub 2016 Jan 20.

11:Systemic sclerosis and calcinosis cutis: response to rituximab.
Authors:Poormoghim H, Andalib E, Almasi AR, Hadibigi E
Institution:Scleroderma Study Group, Department of Rheumatology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.; Department of Radiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Journal:J Clin Pharm Ther. 2016 Feb;41(1):94-6. doi: 10.1111/jcpt.12340. Epub 2015 Dec 15.

12:Difficulty with daily activities involving the lower extremities in people with systemic sclerosis.
Authors:Poole JL, Brandenstein J
Institution:Occupational Therapy Graduate Program, University of New Mexico, MSC09 5240, Albuquerque, NM, 87131-0001, USA.
Journal:Clin Rheumatol. 2016 Feb;35(2):483-8. doi: 10.1007/s10067-015-3137-1. Epub 2015 Dec 10.

13:Diagnosis and Management of Systemic Sclerosis: A Practical Approach.
Authors:Lee JJ, Pope JE
Institution:Division of Rheumatology, Department of Medicine, Schulich School of Medicine, Western University, London, ON, Canada. Western University, London, ON, Canada. ON, N6A 4V2, Canada.
Journal:Drugs. 2016 Feb;76(2):203-13. doi: 10.1007/s40265-015-0491-x.

14:Combination therapy with Bosentan and Sildenafil improves Raynaud's phenomenon and fosters the recovery of microvascular involvement in systemic sclerosis.
Authors:Bellando-Randone S, Lepri G, Bruni C, Blagojevic J, Radicati A, Cometi L, De Paulis A, Matucci-Cerinic M, Guiducci S
Institution:Department of Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy.; Department of Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy.; Department of Translational Medical Sciences, Centre for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.
Journal:Clin Rheumatol. 2016 Jan;35(1):127-32. doi: 10.1007/s10067-015-3119-3. Epub 2015 Dec 3.

15:Corticosteroids in Myositis and Scleroderma.
Authors:Postolova A, Chen JK, Chung L
Institution:Division of Rheumatology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Pavilion C, Suite 242, Redwood City, CA 94063, USA. 300 Pasteur Drive, Stanford, CA 94305, USA; Division of Rheumatology, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA. Electronic address:
Journal:Rheum Dis Clin North Am. 2016 Feb;42(1):103-18, ix. doi: 10.1016/j.rdc.2015.08.011. Epub 2015 Oct 26.

16:Early Cardiovascular Disease After the Diagnosis of Systemic Sclerosis.
Authors:Avina-Zubieta JA, Man A, Yurkovich M, Huang K, Sayre EC, Choi HK
Institution:Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada; Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: Canada. Vancouver, Canada. Vancouver, Canada. Department of Rheumatology, Division of Rheumatology, Allergy and Immunology, Harvard Medical School, Boston, Mass.
Journal:Am J Med. 2016 Mar;129(3):324-31. doi: 10.1016/j.amjmed.2015.10.037. Epub 2015 Nov 19.

17:Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy.
Authors:Distler O, Cozzio A
Institution:Division of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091, Zurich, Switzerland.
Journal:Semin Immunopathol. 2016 Jan;38(1):87-95. doi: 10.1007/s00281-015-0551-z. Epub 2015 Nov 17.

18:Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients.
Authors:Moinzadeh P, Riemekasten G, Siegert E, Fierlbeck G, Henes J, Blank N, Melchers I, Mueller-Ladner U, Frerix M, Kreuter A, Tigges C, Lahner N, Susok L, Guenther C, Zeidler G, Pfeiffer C, Worm M, Karrer S, Aberer E, Bretterklieber A, Genth E, Simon JC, Distler JH, Hein R, Schneider M, Seitz CS, Herink C, Steinbrink K, Sardy M, Varga R, Mensing H, Mensing C, Lehmann P, Neeck G, Fiehn C, Weber M, Goebeler M, Burkhardt H, Buslau M, Ahmadi-Simab K, Himsel A, Juche A, Koetter I, Kuhn A, Sticherling M, Hellmich M, Kuhr K, Krieg T, Ehrchen J, Sunderkoetter C, Hunzelmann N
Journal:J Rheumatol. 2016 Jan;43(1):66-74. doi: 10.3899/jrheum.150382. Epub 2015 Nov 15.

19:Risk factors for severity and manifestations in systemic sclerosis and prediction of disease course.
Authors:Becker MO, Riemekasten G
Institution:a Department of Rheumatology and Clinical Immunology , University Hospital Charite Berlin , Berlin , Germany.
Journal:Expert Rev Clin Immunol. 2016;12(2):115-35. doi: 10.1586/1744666X.2016.1115717. Epub 2015 Dec 2.

20:Risk of ischemic stroke in patients with systemic sclerosis: A systematic review and meta-analysis.
Authors:Ungprasert P, Sanguankeo A, Upala S
Institution:a Division of Rheumatology, Department of Internal Medicine , Mayo Clinic , Rochester , MN , USA. University , Bangkok , Thailand. hospital, Mahidol University , Bangkok , Thailand. hospital, Mahidol University , Bangkok , Thailand.
Journal:Mod Rheumatol. 2016;26(1):128-31. doi: 10.3109/14397595.2015.1056931. Epub 2015 Sep 16.

21:Digital ulcers predict a worse disease course in patients with systemic sclerosis.
Authors:Mihai C, Landewe R, van der Heijde D, Walker UA, Constantin PI, Gherghe AM, Ionescu R, Rednic S, Allanore Y, Avouac J, Czirjak L, Hachulla E, Riemekasten G, Cozzi F, Airo P, Cutolo M, Mueller-Ladner U, Matucci-Cerinic M
Institution:Department of Internal Medicine and Rheumatology, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Heerlen, The Netherlands.
Journal:Ann Rheum Dis. 2016 Apr;75(4):681-6. doi: 10.1136/annrheumdis-2014-205897. Epub 2015 Feb 16.

22:Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study.
Authors:Avouac J, Walker UA, Hachulla E, Riemekasten G, Cuomo G, Carreira PE, Caramaschi P, Ananieva LP, Matucci-Cerinic M, Czirjak L, Denton C, Ladner UM, Allanore Y
Institution:Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France. Hopital Claude-Huriez, and Centre Hospitalier Regional Universitaire de Lille, Lille, France. Centre, a Leibniz institute, Charite-University Medicine, Berlin, Germany. University of Naples, Naples, Italy. Florence, Italy. London, UK. Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany. France.
Journal:Ann Rheum Dis. 2016 Jan;75(1):103-9. doi: 10.1136/annrheumdis-2014-205295. Epub 2014 Aug 27.

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