June 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review.
Authors:Thiebaut M, Launay D, Riviere S, Mahevas T, Bellakhal S, Hachulla E, Fain O, Mekinian A
Institution:Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France; Sorbonne Universites, UMPC University Paris 06, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. Electronic address:; Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France; INSERM, U995, F-59000 Lille, France; CHU Lille, Departement de Medecine Interne et Immunologie Clinique, F-59000 Lille, France; Centre National de Reference Maladies Systemiques et Auto-immunes Rares (Sclerodermie Systemique), F-59000 Lille, France.; Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.; Service de Medecine Interne-Hopital des Forces de Securite Interieure-La Marsa-Tunisie, Universite de Tunis El Manar-Faculte de medecine de Tunis, Tunisia.; Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France; INSERM, U995, F-59000 Lille, France.
Journal:Autoimmun Rev. 2018 Jun;17(6):582-587. doi: 10.1016/j.autrev.2017.12.010. Epub 2018 Apr 7.

2:Intestinal Involvement in Systemic Sclerosis: A Clinical Review.
Authors:Sakkas LI, Simopoulou T, Daoussis D, Liossis SN, Potamianos S
Institution:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110, Larissa, Greece. of Health Sciences, University of Thessaly, 41110, Larissa, Greece. Health Sciences, University of Patras, Patras, Greece. Health Sciences, University of Patras, Patras, Greece. University of Thessaly, Larissa, Greece.
Journal:Dig Dis Sci. 2018 Apr;63(4):834-844. doi: 10.1007/s10620-018-4977-8. Epub 2018 Feb 21.

3:Factors influencing early referral, early diagnosis and management in patients with diffuse cutaneous systemic sclerosis.
Authors:Distler O, Allanore Y, Denton CP, Matucci-Cerinic M, Pope JE, Hinzmann B, Davies S, de Oliveira Pena J, Khanna D
Institution:Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland. Tissue Diseases, University College London, London, UK. Department of Geriatric Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Journal:Rheumatology (Oxford). 2018 May 1;57(5):813-817. doi: 10.1093/rheumatology/kex504.

4:Mycophenolate mofetil as a therapeutic agent for interstitial lung diseases in systemic sclerosis.
Authors:Ueda T, Sakagami T, Kikuchi T, Takada T
Institution:Clinical and Translational Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan. Electronic address: Niigata University, Niigata, Japan. Electronic address: Niigata University, Niigata, Japan. Electronic address: Hospital, Niigata, Japan. Electronic address:
Journal:Respir Investig. 2018 Jan;56(1):14-20. doi: 10.1016/j.resinv.2017.11.004. Epub 2017 Dec 6.

5:Immunogenicity and safety of pneumococcal vaccination in patients with systemic sclerosis.
Authors:Hesselstrand R, Nagel J, Saxne T, Geborek P, Skattum L, Kapetanovic MC
Institution:Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University and Skane University Hospital, Lund, Sweden.; Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden.; Clinical Immunology and Transfusion Medicine University and Regional Laboratories, Region Skane, Lund, Sweden.
Journal:Rheumatology (Oxford). 2018 Apr 1;57(4):625-630. doi: 10.1093/rheumatology/kex471.

6:Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.
Authors:Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE
Institution:From the Duke University Medical Center (K.M.S., O.C., E.W.S.C.) and RTI International (D.W.), Durham, and Rho Federal Systems Division, Chapel Hill (L.K.-E., A.P., B.E., S.C.) - all in North Carolina; National Institute of Allergy and Infectious Diseases, Bethesda, MD (E.A.G., B.W., L.M.G., J.S.G.); Colorado Blood Cancer Institute, Denver (P.A.M., R.A.N.); University of Texas McGovern Medical School (M.D.M.) and M.D. Anderson Cancer Center (C.H.) - both in Houston; Vanderbilt University, Nashville (L.J.C., K.P.); University of Michigan, Ann Arbor (D.K., J.R.S.); Case Western Reserve University and University Hospitals, Cleveland (R.J.F.); University of Alabama, Birmingham (S.M.); Boston University, Boston (R.W.S.); University of Virginia, Charlottesville (K.B.); University of Washington (M.H.W., D.E.F.) and the Fred Hutchinson Cancer Research Center (G.E.G., S.H.) - both in Seattle; University of California, Los Angeles, Los Angeles (J.G., S.K., D.E.F.); City of Hope National Medical Center, Duarte, CA (S.F.); Medical University of South Carolina, Charleston (R.M.S.); Mayo Clinic, Scottsdale, AZ (L.G.); University of Calgary, Calgary, AB, Canada (J.S., S.L.); Washington University, St. Louis (R.B.); Medical College of Wisconsin, Milwaukee (M.E.C., C.K.-T.); Ottawa Hospital Research Institute, Ottawa (C.B.); University of Pittsburgh, Pittsburgh (T.M., R.T.D.); and University of Toledo Medical Center, Toledo, OH (M.B.K.).
Journal:N Engl J Med. 2018 Jan 4;378(1):35-47.

7:Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.
Authors:Peytrignet S, Denton CP, Lunt M, Hesselstrand R, Mouthon L, Silman A, Pan X, Brown E, Czirjak L, Distler JHW, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk M, Ancuta C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt O, Jordan AC, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov N, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, MacGregor AJ, McHugh N, Muller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, Inanc M, McLaren JS, van Laar JM, Pathare S, Proudman S, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Herrick AL
Institution:Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, Royal Free Campus, London, UK.; Department of Rheumatology, Lund University, Lund, Sweden.; Service de Medecine Interne, Hopital Cochin, Centre de Reference pour les Vascularites Necrosantes et la Sclerodermie Systemique, Universite Paris Descartes, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Journal:Rheumatology (Oxford). 2018 Feb 1;57(2):370-381. doi: 10.1093/rheumatology/kex410.

8:Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature.
Authors:Giuggioli D, Manfredi A, Lumetti F, Colaci M, Ferri C
Institution:Chair and Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy. Electronic address:
Journal:Autoimmun Rev. 2018 Feb;17(2):155-164. doi: 10.1016/j.autrev.2017.11.020. Epub 2017 Dec 2.

9:Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Placebo-Controlled, Phase II Study.
Authors:Denton CP, Hachulla E, Riemekasten G, Schwarting A, Frenoux JM, Frey A, Le Brun FO, Herrick AL
Institution:Royal Free Hospital, London, UK. Internal Medicine, Hopital Huriez, University of Lille, Lille, France. Kreuznach, Germany. Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Journal:Arthritis Rheumatol. 2017 Dec;69(12):2370-2379. doi: 10.1002/art.40242.

10:Patient acceptable symptom state in scleroderma: results from the tocilizumab compared with placebo trial in active diffuse cutaneous systemic sclerosis.
Authors:Arnold MB, Khanna D, Denton CP, van Laar JM, Frech TM, Anderson ME, Baron M, Chung L, Fierlbeck G, Lakshminarayanan S, Allanore Y, Riemekasten G, Steen V, Muller-Ladner U, Spotswood H, Burke L, Siegel J, Jahreis A, Furst DE, Pope JE
Institution:Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. School, London, UK. Netherlands. City, UT, USA. UK. Health Care System, Palo Alto, CA, USA. Berlin, Germany. University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany. Canada.
Journal:Rheumatology (Oxford). 2018 Jan 1;57(1):152-157. doi: 10.1093/rheumatology/kex396.

11:Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
Authors:Shibata A, Kuno M, Adachi R, Sato Y, Hattori H, Matsuda A, Okuzono Y, Igaki K, Tominari Y, Takagi T, Yabuki M, Okaniwa M
Institution:Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.; Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Journal:PLoS One. 2017 Oct 24;12(10):e0186587. doi: 10.1371/journal.pone.0186587. eCollection 2017.

12:Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients.
Authors:Virzi F, Bianca P, Giammona A, Apuzzo T, Di Franco S, Mangiapane LR, Colorito ML, Catalano D, Scavo E, Nicotra A, Benfante A, Pistone G, Caputo V, Dieli F, Pirrello R, Stassi G
Institution:Cellular and Molecular Pathophysiology Laboratory, Department of Surgical Oncological and Stomatological Sciences, University of Palermo, Via del Vespro 131, Palermo, 90127, Italy.; Division of Plastic and Reconstructive Surgery Department of Surgical and Oncological Sciences, University of Palermo, Via del Vespro 131, Palermo, 90127, Italy.; DiBiMIS, Piazza delle Cliniche, 2, University of Palermo, Palermo, 90127, Italy.; Central Laboratory of Advanced Diagnosis & Biomedical Research (CLADIBIOR), University of Palermo, Via del Vespro 131, Palermo, 90127, Italy.
Journal:Stem Cell Res Ther. 2017 Oct 23;8(1):236. doi: 10.1186/s13287-017-0690-3.

13:Cardiac complications of systemic sclerosis and management: recent progress.
Authors:Rangarajan V, Matiasz R, Freed BH
Institution:Division of Cardiology, Department of Medicine, Northwestern University Feinberg, School of Medicine, Chicago, Illinois, USA.
Journal:Curr Opin Rheumatol. 2017 Nov;29(6):574-584. doi: 10.1097/BOR.0000000000000439.

14:Epigenetics: The Future Direction in Systemic Sclerosis.
Authors:Walczyk M, Paradowska-Gorycka A, Olesinska M
Institution:Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. Rheumatology and Rehabilitation, Warsaw, Poland.
Journal:Scand J Immunol. 2017 Dec;86(6):427-435. doi: 10.1111/sji.12595. Epub 2017 Sep 19.

15:Humanistic and cost burden of systemic sclerosis: A review of the literature.
Authors:Fischer A, Zimovetz E, Ling C, Esser D, Schoof N
Institution:University of Colorado School of Medicine, Denver, CO, USA. Electronic address:
Journal:Autoimmun Rev. 2017 Nov;16(11):1147-1154. doi: 10.1016/j.autrev.2017.09.010. Epub 2017 Sep 9.

16:New insights into the recognition, classification and management of systemic sclerosis-associated pulmonary hypertension.
Authors:Mullin CJ, Mathai SC
Institution:Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal:Curr Opin Rheumatol. 2017 Nov;29(6):561-567. doi: 10.1097/BOR.0000000000000440.

17:Raynaud's phenomenon and its impact on activities in daily life during one year of follow-up in early systemic sclerosis.
Authors:Sandqvist G, Wollmer P, Scheja A, Wildt M, Hesselstrand R
Institution:a Department of Clinical Sciences Lund, Section of Rheumatology , Lund University, Skane University Hospital , Lund , Sweden.; b Department of Translational Medicine , Lund University , Lund , Sweden.
Journal:Scand J Rheumatol. 2018 May;47(3):206-209. doi: 10.1080/03009742.2017.1350745. Epub 2017 Aug 13.

18:European Dermatology Forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes.
Authors:Knobler R, Moinzadeh P, Hunzelmann N, Kreuter A, Cozzio A, Mouthon L, Cutolo M, Rongioletti F, Denton CP, Rudnicka L, Frasin LA, Smith V, Gabrielli A, Aberer E, Bagot M, Bali G, Bouaziz J, Braae Olesen A, Foeldvari I, Frances C, Jalili A, Just U, Kahari V, Karpati S, Kofoed K, Krasowska D, Olszewska M, Orteu C, Panelius J, Parodi A, Petit A, Quaglino P, Ranki A, Sanchez Schmidt JM, Seneschal J, Skrok A, Sticherling M, Sunderkotter C, Taieb A, Tanew A, Wolf P, Worm M, Wutte NJ, Krieg T
Institution:Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.; Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Klinik Oberhausen, University Witten-Herdecke, Oberhausen, Germany.; Department of Dermatology, Venereology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Service de Medecine Interne, Centre de reference maladies rares: vascularites et sclerodermie systemique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France.
Journal:J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1401-1424. doi: 10.1111/jdv.14458. Epub 2017 Aug 9.

19:How I treat patients with systemic sclerosis in clinical practice.
Authors:Rossi D, Zanatta E, Marson P, Sciascia S, Polito P, Roccatello D, Cozzi F
Institution:Center of Research of Immunopathology and Rare Diseases - Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences and University of Turin, Italy; SCU Nephrology and Dialysis Unit, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address:; Rheumatology Unit, University Hospital, Padua, Italy. Electronic address:; Apheresis Unit, University Hospital, Padua, Italy.
Journal:Autoimmun Rev. 2017 Oct;16(10):1024-1028. doi: 10.1016/j.autrev.2017.07.018. Epub 2017 Aug 1.

20:Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model.
Authors:Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE Jr, Collard HR, Lee JS
Institution:Department of Medicine, University of California, San Francisco, San Francisco, CA. Electronic address: Francisco, San Francisco, CA. CA. CA. CA. Francisco, CA. CA. CA. CA. CA. CA. CA. CA; Department of Medicine, University of Colorado Denver, Denver, CO.
Journal:Chest. 2017 Nov;152(5):999-1007. doi: 10.1016/j.chest.2017.06.009. Epub 2017 Jun 16.

21:The efficacy of methotrexate in the treatment of en coup de sabre (linear morphea subtype).
Authors:Rattanakaemakorn P, Jorizzo JL
Institution:a Division of Dermatology, Department of Medicine, Ramathibodi Hospital , Mahidol University , Ratchathewi , Bangkok , Thailand. , USA. , USA.
Journal:J Dermatolog Treat. 2018 Mar;29(2):197-199. doi: 10.1080/09546634.2017.1341615. Epub 2017 Jun 29.

22:Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic stem cell transplantation: recommendations from the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party and collaborating partners.
Authors:Farge D, Burt RK, Oliveira MC, Mousseaux E, Rovira M, Marjanovic Z, de Vries-Bouwstra J, Del Papa N, Saccardi R, Shah SJ, Lee DC, Denton C, Alexander T, Kiely DG, Snowden JA
Institution:Department of Internal Medicine, Unite Clinique de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hopital Saint-Louis, AP-HP Assistance Publique des Hopitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University, Paris, France. Chicago, IL, USA. Center of Ribeirao Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. Paris, INSERM UMR 970, Universite Paris Descartes, Paris, France. Hopitaux de Paris, APHP, Paris, France. Italy. Chicago, IL, USA. Chicago, IL, USA. Berlin, Berlin, Germany. Sheffield, UK. University of Sheffield, Sheffield, UK.
Journal:Bone Marrow Transplant. 2017 Nov;52(11):1495-1503. doi: 10.1038/bmt.2017.56. Epub 2017 May 22.

23:Clinical characteristics and survival of systemic sclerosis patients with pulmonary hypertension and elevated wedge pressure: Observations from the PHAROS cohort.
Authors:Lammi MR, Saketkoo LA, Gordon JK, Lauto P, Fagan K, Steen VD
Institution:Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. University School of Medicine, New Orleans, Louisiana, USA. USA. Sciences Center, New Orleans, Louisiana, USA.
Journal:Respirology. 2017 Oct;22(7):1386-1392. doi: 10.1111/resp.13067. Epub 2017 May 12.

24:Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group.
Authors:Jaeger VK, Distler O, Maurer B, Czirjak L, Lorand V, Valentini G, Vettori S, Del Galdo F, Abignano G, Denton C, Nihtyanova S, Allanore Y, Avouac J, Riemekasten G, Siegert E, Huscher D, Matucci-Cerinic M, Guiducci S, Frerix M, Tarner IH, Garay Toth B, Fankhauser B, Umbricht J, Zakharova A, Mihai C, Cozzi F, Yavuz S, Hunzelmann N, Rednic S, Vacca A, Schmeiser T, Riccieri V, Garcia de la Pena Lefebvre P, Gabrielli A, Krummel-Lorenz B, Martinovic D, Ancuta C, Smith V, Muller-Ladner U, Walker UA
Institution:Department of Rheumatology, University Hospital Basel, Basel.; Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.; Department of Rheumatology and Immunology, Medical Center, University of Pecs, Pecs, Hungary.; Department of Rheumatology, Second University of Naples, Naples, Italy.; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds.
Journal:Rheumatology (Oxford). 2018 Mar 1;57(3):441-450. doi: 10.1093/rheumatology/kex182.

25:Clinical algorithms for the diagnosis and prognosis of interstitial lung disease in systemic sclerosis.
Authors:Hax V, Bredemeier M, Didonet Moro AL, Pavan TR, Vieira MV, Pitrez EH, da Silva Chakr RM, Xavier RM
Institution:Department of Internal Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Division of Rheumatology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. Electronic address:; Division of Rheumatology, Hospital Nossa Senhora da Conceicao, Grupo Hospitalar Conceicao, Porto Alegre, Brazil.; Department of Internal Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Division of Radiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Journal:Semin Arthritis Rheum. 2017 Oct;47(2):228-234. doi: 10.1016/j.semarthrit.2017.03.019. Epub 2017 Apr 1.

26:Localized scleroderma: clinical and epidemiological features with emphasis on adulthood- versus childhood-onset disease differences.
Authors:Lis-Swiety A, Skrzypek-Salamon A, Ranosz-Janicka I, Brzezinska-Wcislo L
Institution:Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. Silesia, Katowice, Poland. Silesia, Katowice, Poland. Silesia, Katowice, Poland.
Journal:J Eur Acad Dermatol Venereol. 2017 Oct;31(10):1595-1603. doi: 10.1111/jdv.14197. Epub 2017 Apr 3.

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