Scleroderma
September 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Prevalence of pulmonary hypertension in patients with systemic sclerosis and mixed connective tissue disease.
Authors:Niklas K, Niklas A, Mularek-Kubzdela T, Puszczewicz M
Institution:Department of Rheumatology and Internal Diseases.
Journal:Medicine (Baltimore). 2018 Jul;97(28):e11437. doi: 10.1097/MD.0000000000011437.

2:Predictors of morbidity and mortality in early systemic sclerosis: Long-term follow-up data from a single-centre inception cohort.
Authors:Panopoulos S, Bournia VK, Konstantonis G, Fragiadaki K, Sfikakis PP, Tektonidou MG
Institution:First Department of Propaedeutic and Internal Medicine and Joint Academic Rheumatology Program, National and Kapodistrian University, Medical School of Athens, Greece. Electronic address: mtektonidou@med.uoa.gr.
Journal:Autoimmun Rev. 2018 Aug;17(8):816-820. doi: 10.1016/j.autrev.2018.02.008. Epub 2018 Jun 6.

3:The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts.
Authors:Dougherty DH, Kwakkenbos L, Carrier ME, Salazar G, Assassi S, Baron M, Bartlett SJ, Furst DE, Gottesman K, van den Hoogen F, Malcarne VL, Mouthon L, Nielson WR, Poiraudeau S, Sauve M, Boire G, Bruns A, Chung L, Denton C, Dunne JV, Fortin P, Frech T, Gill A, Gordon J, Herrick AL, Hinchcliff M, Hudson M, Johnson SR, Jones N, Kafaja S, Larche M, Manning J, Pope J, Spiera R, Steen V, Sutton E, Thorne C, Wilcox P, Thombs BD, Mayes MD
Institution:Department of Internal Medicine, Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, USA.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Behavioural Science Institute, Clinical Psychology, Radboud University, Nijmegen, the Netherlands.; Department of Medicine, McGill University, Montreal, QC, Canada.
Journal:Rheumatology (Oxford). 2018 Sep 1;57(9):1623-1631. doi: 10.1093/rheumatology/key139.

4:Mortality, length of stay and cost of hospitalization among patients with systemic sclerosis: results from the National Inpatient Sample.
Authors:Ram Poudel D, George M, Dhital R, Karmacharya P, Sandorfi N, Derk CT
Institution:Department of Medicine, Reading Hospital, Reading, USA.
Journal:Rheumatology (Oxford). 2018 Sep 1;57(9):1611-1622. doi: 10.1093/rheumatology/key150.

5:Acute and chronic effects of two different intravenous iloprost regimens in systemic sclerosis: a pragmatic non-randomized trial.
Authors:Schioppo T, Orenti A, Boracchi P, De Lucia O, Murgo A, Ingegnoli F
Institution:Division of Rheumatology, ASST Pini-CTO, Universita degli Studi di Milano, Milan, Italy. Milano, Milan, Italy. Milano, Milan, Italy. Italy. Italy. Italy. Milano, Milan, Italy.
Journal:Rheumatology (Oxford). 2018 Aug 1;57(8):1408-1416. doi: 10.1093/rheumatology/key113.

6:Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review.
Authors:Thiebaut M, Launay D, Riviere S, Mahevas T, Bellakhal S, Hachulla E, Fain O, Mekinian A
Institution:Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France; Sorbonne Universites, UMPC University Paris 06, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. Electronic address: arsene.mekinian@aphp.fr.; Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France; INSERM, U995, F-59000 Lille, France; CHU Lille, Departement de Medecine Interne et Immunologie Clinique, F-59000 Lille, France; Centre National de Reference Maladies Systemiques et Auto-immunes Rares (Sclerodermie Systemique), F-59000 Lille, France.; Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.; Service de Medecine Interne-Hopital des Forces de Securite Interieure-La Marsa-Tunisie, Universite de Tunis El Manar-Faculte de medecine de Tunis, Tunisia.; Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France; INSERM, U995, F-59000 Lille, France.
Journal:Autoimmun Rev. 2018 Jun;17(6):582-587. doi: 10.1016/j.autrev.2017.12.010. Epub 2018 Apr 7.

7:Intestinal Involvement in Systemic Sclerosis: A Clinical Review.
Authors:Sakkas LI, Simopoulou T, Daoussis D, Liossis SN, Potamianos S
Institution:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110, Larissa, Greece. lsakkas@med.uth.gr. of Health Sciences, University of Thessaly, 41110, Larissa, Greece. Health Sciences, University of Patras, Patras, Greece. Health Sciences, University of Patras, Patras, Greece. University of Thessaly, Larissa, Greece.
Journal:Dig Dis Sci. 2018 Apr;63(4):834-844. doi: 10.1007/s10620-018-4977-8. Epub 2018 Feb 21.

8:Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Authors:Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefevre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zephir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Institution:Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France; CHU Lille, Departement de medecine interne et immunologie clinique, F-59000 Lille, France; Centre national de reference maladies systemiques et auto-immunes rares, France. Electronic address: david.launay@univ-lille2.fr.; Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France.; Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France; CHU Lille, Departement de medecine interne et immunologie clinique, F-59000 Lille, France; Centre national de reference maladies systemiques et auto-immunes rares, France; CHU Lille, Institut d'immunologie, F-59000 Lille, France.; Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France; CHU Lille, Institut d'immunologie, F-59000 Lille, France.; Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France; CHU Lille, Service de neurologie, F-59000 Lille, France.
Journal:Autoimmun Rev. 2018 Mar;17(3):244-255. doi: 10.1016/j.autrev.2017.10.015. Epub 2018 Jan 16.

9:Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.
Authors:Aslani S, Sobhani S, Gharibdoost F, Jamshidi A, Mahmoudi M
Institution:Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Iran. Iran. Iran. Iran. Electronic address: mahmoudim@tums.ac.ir.
Journal:Hum Immunol. 2018 Mar;79(3):178-187. doi: 10.1016/j.humimm.2018.01.003. Epub 2018 Jan 9.

10:Mycophenolate mofetil as a therapeutic agent for interstitial lung diseases in systemic sclerosis.
Authors:Ueda T, Sakagami T, Kikuchi T, Takada T
Institution:Clinical and Translational Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan. Electronic address: uedat@med.niigata-u.ac.jp. Niigata University, Niigata, Japan. Electronic address: stakuro@med.niigata-u.ac.jp. Niigata University, Niigata, Japan. Electronic address: kikuchi@med.niigata-u.ac.jp. Hospital, Niigata, Japan. Electronic address: ttakada@med.niigata-u.ac.jp.
Journal:Respir Investig. 2018 Jan;56(1):14-20. doi: 10.1016/j.resinv.2017.11.004. Epub 2017 Dec 6.

11:Immunogenicity and safety of pneumococcal vaccination in patients with systemic sclerosis.
Authors:Hesselstrand R, Nagel J, Saxne T, Geborek P, Skattum L, Kapetanovic MC
Institution:Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University and Skane University Hospital, Lund, Sweden.; Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden.; Clinical Immunology and Transfusion Medicine University and Regional Laboratories, Region Skane, Lund, Sweden.
Journal:Rheumatology (Oxford). 2018 Apr 1;57(4):625-630. doi: 10.1093/rheumatology/kex471.

12:Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.
Authors:Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE
Institution:From the Duke University Medical Center (K.M.S., O.C., E.W.S.C.) and RTI International (D.W.), Durham, and Rho Federal Systems Division, Chapel Hill (L.K.-E., A.P., B.E., S.C.) - all in North Carolina; National Institute of Allergy and Infectious Diseases, Bethesda, MD (E.A.G., B.W., L.M.G., J.S.G.); Colorado Blood Cancer Institute, Denver (P.A.M., R.A.N.); University of Texas McGovern Medical School (M.D.M.) and M.D. Anderson Cancer Center (C.H.) - both in Houston; Vanderbilt University, Nashville (L.J.C., K.P.); University of Michigan, Ann Arbor (D.K., J.R.S.); Case Western Reserve University and University Hospitals, Cleveland (R.J.F.); University of Alabama, Birmingham (S.M.); Boston University, Boston (R.W.S.); University of Virginia, Charlottesville (K.B.); University of Washington (M.H.W., D.E.F.) and the Fred Hutchinson Cancer Research Center (G.E.G., S.H.) - both in Seattle; University of California, Los Angeles, Los Angeles (J.G., S.K., D.E.F.); City of Hope National Medical Center, Duarte, CA (S.F.); Medical University of South Carolina, Charleston (R.M.S.); Mayo Clinic, Scottsdale, AZ (L.G.); University of Calgary, Calgary, AB, Canada (J.S., S.L.); Washington University, St. Louis (R.B.); Medical College of Wisconsin, Milwaukee (M.E.C., C.K.-T.); Ottawa Hospital Research Institute, Ottawa (C.B.); University of Pittsburgh, Pittsburgh (T.M., R.T.D.); and University of Toledo Medical Center, Toledo, OH (M.B.K.).
Journal:N Engl J Med. 2018 Jan 4;378(1):35-47.

13:Systemic sclerosis.
Authors:Asano Y
Institution:Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Journal:J Dermatol. 2018 Feb;45(2):128-138. doi: 10.1111/1346-8138.14153. Epub 2017 Dec 10.

14:First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study.
Authors:Rubio-Rivas M, Corbella X, Pestana-Fernandez M, Tolosa-Vilella C, Guillen-Del Castillo A, Colunga-Arguelles D, Trapiella-Martinez L, Iniesta-Arandia N, Castillo-Palma MJ, Saez-Comet L, Egurbide-Arberas MV, Ortego-Centeno N, Freire M, Vargas-Hitos JA, Rios-Blanco JJ, Todoli-Parra JA, Rodriguez-Carballeira M, Marin-Ballve A, Segovia-Alonso P, Pla-Salas X, Madronero-Vuelta AB, Ruiz-Munoz M, Fonollosa-Pla V, Simeon-Aznar CP, Callejas Moraga E, Calvo E, Carbonell C, Castillo MJ, Chamorro AJ, Colunga D, Corbella X, Egurbide MV, Espinosa G, Fonollosa V, Freire M, Garcia Hernandez FJ, Gonzalez Leon R, Guillen Del Castillo A, Iniesta N, Lorenzo R, Madronero AB, Mari B, Marin A, Ortego-Centeno N, Perez Conesa M, Pestana M, Pla X, Rios Blanco JJ, Rodriguez Carballeira M, Rubio Rivas M, Ruiz Munoz M, Saez Comet L, Segovia P, Simeon CP, Soto A, Tari E, Todoli JA, Tolosa C, Trapiella L, Vargas Hitos JA, Verdejo G
Institution:Department of Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. mrubio@bellvitgehospital.cat.; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.; Department of Internal Medicine, Corporacion Sanitaria Universitaria Parc Tauli, Sabadell, Barcelona, Spain.; Autoimmune Unit, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
Journal:Clin Rheumatol. 2018 Apr;37(4):999-1009. doi: 10.1007/s10067-017-3936-7. Epub 2017 Dec 7.

15:Malnutrition and sarcopenia in a large cohort of patients with systemic sclerosis.
Authors:Caimmi C, Caramaschi P, Venturini A, Bertoldo E, Vantaggiato E, Viapiana O, Ferrari M, Lippi G, Frulloni L, Rossini M
Institution:Rheumatology Unit, University of Verona, Verona, Italy. cristian.caimmi@gmail.com.
Journal:Clin Rheumatol. 2018 Apr;37(4):987-997. doi: 10.1007/s10067-017-3932-y. Epub 2017 Dec 1.

16:Gastrointestinal and Hepatic Disease in Systemic Sclerosis.
Authors:Frech TM, Mar D
Institution:Department of Internal Medicine, Division of Rheumatology, University of Utah, Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, USA. Electronic address: tracy.frech@hsc.utah.edu. Avenue, Aurora, CO 80045, USA.
Journal:Rheum Dis Clin North Am. 2018 Feb;44(1):15-28. doi: 10.1016/j.rdc.2017.09.002.

17:Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study.
Authors:Hesselvig JH, Kofoed K, Wu JJ, Dreyer L, Gislason G, Ahlehoff O
Institution:Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
Journal:Acta Derm Venereol. 2018 Mar 13;98(3):361-365. doi: 10.2340/00015555-2842.

18:Potential biomarkers in patients with systemic sclerosis.
Authors:Delle Sedie A, Riente L, Maggiorini L, Pratesi F, Tavoni A, Migliorini P, Puxeddu I
Institution:Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Immunology and Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Journal:Int J Rheum Dis. 2018 Jan;21(1):261-265. doi: 10.1111/1756-185X.13196. Epub 2017 Oct 11.

19:Are there risk factors for scleroderma-related calcinosis?
Authors:Pai S, Hsu V
Institution:a Institute for Rheumatic and Autoimmune Diseases, Overlook Hospital and Medical Center , Summit , NJ , USA. , Rutgers-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.
Journal:Mod Rheumatol. 2018 May;28(3):518-522. doi: 10.1080/14397595.2017.1349594. Epub 2017 Jul 19.

20:Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group.
Authors:Jaeger VK, Distler O, Maurer B, Czirjak L, Lorand V, Valentini G, Vettori S, Del Galdo F, Abignano G, Denton C, Nihtyanova S, Allanore Y, Avouac J, Riemekasten G, Siegert E, Huscher D, Matucci-Cerinic M, Guiducci S, Frerix M, Tarner IH, Garay Toth B, Fankhauser B, Umbricht J, Zakharova A, Mihai C, Cozzi F, Yavuz S, Hunzelmann N, Rednic S, Vacca A, Schmeiser T, Riccieri V, Garcia de la Pena Lefebvre P, Gabrielli A, Krummel-Lorenz B, Martinovic D, Ancuta C, Smith V, Muller-Ladner U, Walker UA
Institution:Department of Rheumatology, University Hospital Basel, Basel.; Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.; Department of Rheumatology and Immunology, Medical Center, University of Pecs, Pecs, Hungary.; Department of Rheumatology, Second University of Naples, Naples, Italy.; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds.
Journal:Rheumatology (Oxford). 2018 Mar 1;57(3):441-450. doi: 10.1093/rheumatology/kex182.

21:Serological and clinical profile of systemic sclerosis: analysis in a cohort of patients from a single center in Northern Italy.
Authors:Priora M, Manetta T, Scarati M, Parisi S, Lagana A, Peroni CL, Bruzzone M, Borrelli R, Rende M, Mengozzi G, Fusaro E
Institution:Department of Rheumatology, A.O.U. Citta della Salute e della Scienza, Turin, Italy - mpriora@cittadellasalute.to.it. Scienza, Turin, Italy. Italy. Italy. Italy. Italy. Italy. Italy. Scienza, Turin, Italy. Scienza, Turin, Italy. Italy.
Journal:G Ital Dermatol Venereol. 2018 Feb;153(1):33-38. doi: 10.23736/S0392-0488.16.05319-0. Epub 2016 Apr 7.

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