Scleroderma
October 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Treatment of digital ulcers in systemic sclerosis: Case series study of thirteen patients and discussion on outcome.
Authors:Abuowda Y, Almeida RS, Oliveira AA, Pego P, Santos C, Matos-Costa J
Institution:Clinic of autoimmune diseases, Department of Internal Medicine - III, Hospital Distrital de Santarem, Santarem, Portugal.; NEDAI - Group of Systemic Autoimmune Diseases of the SPMI - Sociedade Portuguesa de Medicina Interna, Lisboa, Portugal.; DUO Registry Center - The Digital Ulcers Outcome Registry Center D0489, Santarem, Portugal.
Journal:Rev Assoc Med Bras (1992). 2017 May;63(5):422-426. doi: 10.1590/1806-9282.63.05.422.

2:Association between cigarette smoking and impaired clinical symptoms in systemic sclerosis: A review.
Authors:Zhang YJ, Zhang L, Huang XL, Duan Y, Yang LJ, Wang J
Institution:Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China. Electronic address: jwang2006@126.com.; Medical Genetics Center, Anhui Medical College, Hefei, China.
Journal:Cell Immunol. 2017 Aug;318:1-7. doi: 10.1016/j.cellimm.2017.04.002. Epub 2017 Apr 12.

3:Scleroderma Induced by Pembrolizumab: A Case Series.
Authors:Barbosa NS, Wetter DA, Wieland CN, Shenoy NK, Markovic SN, Thanarajasingam U
Institution:Department of Dermatology, Mayo Clinic, Rochester, MN. Pathology, Mayo Clinic, Rochester, MN. Mayo Clinic, Rochester, MN. Mayo Clinic, Rochester, MN; Clinical Immunology and Immunotherapeutics Program, Mayo Clinic, Rochester, MN. thanarajasingam.uma@mayo.edu.
Journal:Mayo Clin Proc. 2017 Jul;92(7):1158-1163. doi: 10.1016/j.mayocp.2017.03.016. Epub 2017 Jun 7.

4:Vitamin D deficiency and clinical correlations in systemic sclerosis patients: A retrospective analysis for possible future developments.
Authors:Trombetta AC, Smith V, Gotelli E, Ghio M, Paolino S, Pizzorni C, Vanhaecke A, Ruaro B, Sulli A, Cutolo M
Institution:Research Laboratory And Academic Division Of Clinical Rheumatology, Department Of Internal Medicine, Irccs San Martino Aou, University Of Genoa, Genoa, Italy.; Department Of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Journal:PLoS One. 2017 Jun 9;12(6):e0179062. doi: 10.1371/journal.pone.0179062. eCollection 2017.

5:Successful treatment of infliximab in a patient with scleroderma: a case report.
Authors:Li T, Liu Y, Xu H
Institution:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Journal:Medicine (Baltimore). 2017 Jun;96(22):e6737. doi: 10.1097/MD.0000000000006737.

6:Mycophenolate mofetil for scleroderma-related interstitial lung disease: A real world experience.
Authors:Baqir M, Makol A, Osborn TG, Bartholmai BJ, Ryu JH
Institution:Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America. Rochester, Minnesota, United States of America. Rochester, Minnesota, United States of America. America. Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Journal:PLoS One. 2017 May 25;12(5):e0177107. doi: 10.1371/journal.pone.0177107. eCollection 2017.

7:Mycophenolate Mofetil Versus Placebo for Systemic Sclerosis-Related Interstitial Lung Disease: An Analysis of Scleroderma Lung Studies I and II.
Authors:Volkmann ER, Tashkin DP, Li N, Roth MD, Khanna D, Hoffmann-Vold AM, Kim G, Goldin J, Clements PJ, Furst DE, Elashoff RM
Institution:University of California, Los Angeles.
Journal:Arthritis Rheumatol. 2017 Jul;69(7):1451-1460. doi: 10.1002/art.40114. Epub 2017 May 23.

8:Novel risk factors related to cancer in scleroderma.
Authors:Bernal-Bello D, de Tena JG, Guillen-Del Castillo A, Selva-O'Callaghan A, Callejas-Moraga EL, Marin-Sanchez AM, Fonollosa-Pla V, Simeon-Aznar CP
Institution:Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, C/Camino del Molino, 2, 28942, Fuenlabrada, Madrid, Spain. Electronic address: david.bernal@salud.madrid.org.; Department of Internal Medicine, Hospital Universitario de Guadalajara, Universidad de Alcala, C/Donante de Sangre, s/n, 19002 Guadalajara, Spain. Electronic address: jgtena@movistar.es.; Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Universidad Autonoma de Barcelona, Spain, P. Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Electronic address: alguille@vhebron.net.; Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Universidad Autonoma de Barcelona, Spain, P. Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Electronic address: aselva@vhebron.net.; Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Universidad Autonoma de Barcelona, Spain, P. Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Electronic address: ecallejas@vhebron.net.
Journal:Autoimmun Rev. 2017 May;16(5):461-468. doi: 10.1016/j.autrev.2017.03.012. Epub 2017 Mar 8.

9:Idiopathic and Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes.
Authors:Ramjug S, Hussain N, Hurdman J, Billings C, Charalampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ, Condliffe R
Institution:Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England. England. England. England. England. England. England. England; Department of Infection and Immunity, University of Sheffield, Sheffield, England. England. Department of Radiology, Sheffield Teaching Hospitals NHS Trust, Sheffield, England. England. Electronic address: robin.condliffe@sth.nhs.uk.
Journal:Chest. 2017 Jul;152(1):92-102. doi: 10.1016/j.chest.2017.02.010. Epub 2017 Feb 20.

10:Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).
Authors:Herrick AL, Pan X, Peytrignet S, Lunt M, Hesselstrand R, Mouthon L, Silman A, Brown E, Czirjak L, Distler JHW, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk M, Ancuta C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt O, Jordan AC, Jobanputra P, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov N, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, MacGregor AJ, McHugh N, Muller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, Inanc M, McLaren JS, van Laar JM, Pathare S, Proudman S, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Denton CP
Institution:Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.; Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Department of Rheumatology, Lund University, Lund, Sweden.; Service de Medecine Interne, Hopital Cochin, Centre de Reference pour les Vascularites Necrosantes et la Sclerodermie Systemique, Universite Paris Descartes, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
Journal:Ann Rheum Dis. 2017 Jul;76(7):1207-1218. doi: 10.1136/annrheumdis-2016-210503. Epub 2017 Feb 10.

11:Cardiopulmonary exercise testing for detecting pulmonary arterial hypertension in systemic sclerosis.
Authors:Dumitrescu D, Nagel C, Kovacs G, Bollmann T, Halank M, Winkler J, Hellmich M, Grunig E, Olschewski H, Ewert R, Rosenkranz S
Institution:Herzzentrum der Universitat zu Koln, Klinik III fur Innere Medizin, Cologne, Germany. Institute for Lung Vascular Research, and Medical University of Graz, Graz, Austria. and Infectious Diseases, University of Greifswald, Greifswald, Germany. Technical University of Dresden, Dresden, Germany. Institute for Lung Vascular Research, and Medical University of Graz, Graz, Austria. and Infectious Diseases, University of Greifswald, Greifswald, Germany. Germany.
Journal:Heart. 2017 May;103(10):774-782. doi: 10.1136/heartjnl-2016-309981. Epub 2017 Jan 6.

12:Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial.
Authors:Coghlan JG, Galie N, Barbera JA, Frost AE, Ghofrani HA, Hoeper MM, Kuwana M, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Blair C, Gillies H, Miller KL, Harris JHN, Langley J, Rubin LJ
Institution:Cardiology Department, Royal Free Hospital, London, UK. of Bologna, Bologna, Italy. Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Hannover, Germany. Medicine, Tokyo, Japan. Pneumologie, AP-HP, Centre de Reference de l'Hypertension Pulmonaire Severe, Hopital de Bicetre, Le Kremlin Bicetre, France. Therapeutique (LERMIT), UMR_S 999, INSERM, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.
Journal:Ann Rheum Dis. 2017 Jul;76(7):1219-1227. doi: 10.1136/annrheumdis-2016-210236. Epub 2016 Dec 30.

13:Early Mortality in a Multinational Systemic Sclerosis Inception Cohort.
Authors:Hao Y, Hudson M, Baron M, Carreira P, Stevens W, Rabusa C, Tatibouet S, Carmona L, Joven BE, Huq M, Proudman S, Nikpour M
Institution:St. Vincent's Hospital Melbourne, Melbourne, Victoria, Australia, and Peking University First Hospital, Beijing, China. Canada. Canada.
Journal:Arthritis Rheumatol. 2017 May;69(5):1067-1077. doi: 10.1002/art.40027. Epub 2017 Apr 6.

14:Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate.
Authors:Hughes M, Moore T, Manning J, Wilkinson J, Dinsdale G, Roberts C, Murray A, Herrick AL
Institution:Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address: Michael.Hughes-6@postgrad.manchester.ac.uk.; Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, United Kingdom.; Research and Development, Salford Royal NHS Foundation Trust, Salford, United Kingdom.; Centre for Biostatistics, Institute of Population Health, School of Medicine, The University of Manchester, Manchester, United Kingdom.; Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Photon Science Institute, The University of Manchester, United Kingdom.
Journal:Microvasc Res. 2017 May;111:32-36. doi: 10.1016/j.mvr.2016.12.008. Epub 2016 Dec 24.

15:Update of EULAR recommendations for the treatment of systemic sclerosis.
Authors:Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Muller-Ladner U
Institution:Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.; Radboud University Medical Center, Nijmegen, The Netherlands.; Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France.; University Hospital Charite, Berlin, Germany.; University Hospital Zurich, Zurich, Switzerland.
Journal:Ann Rheum Dis. 2017 Aug;76(8):1327-1339. doi: 10.1136/annrheumdis-2016-209909. Epub 2016 Nov 9.

16:Primary myocardial disease in scleroderma-a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group.
Authors:Bissell LA, Md Yusof MY, Buch MH
Institution:Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital.; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal:Rheumatology (Oxford). 2017 Jun 1;56(6):882-895. doi: 10.1093/rheumatology/kew364.

17:Personalized Physical Therapy Versus Usual Care for Patients With Systemic Sclerosis: A Randomized Controlled Trial.
Authors:Rannou F, Boutron I, Mouthon L, Sanchez K, Tiffreau V, Hachulla E, Thoumie P, Cabane J, Chatelus E, Sibilia J, Roren A, Berezne A, Baron G, Porcher R, Guillevin L, Ravaud P, Poiraudeau S
Institution:AP-HP Cochin Hospital, Universite Paris Descartes Sorbonne Paris Cite, and INSERM U1153, Paris, France.; AP-HP Hotel Dieu Hospital, Universite Paris Descartes Sorbonne Paris Cite, and INSERM U1153, Paris, France.; Reference Center for Rare Diseases, AP-HP Cochin Hospital, and Universite Paris Descartes Sorbonne Paris Cite, Paris, France.; Reference Center for Rare Diseases, Lille University Medical Center, University of Lille 2, Lille, France.; AP-HP Rothschild Hospital and Pierre and Marie Curie University, Paris, France.
Journal:Arthritis Care Res (Hoboken). 2017 Jul;69(7):1050-1059. doi: 10.1002/acr.23098. Epub 2017 Jun 7.

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