Sjogren's Syndrome
August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Characterization and risk estimate of cancer in patients with primary Sjogren syndrome.
Authors:Brito-Zeron P, Kostov B, Fraile G, Caravia-Duran D, Maure B, Rascon FJ, Zamora M, Casanovas A, Lopez-Dupla M, Ripoll M, Pinilla B, Fonseca E, Akasbi M, de la Red G, Duarte-Millan MA, Fanlo P, Guisado-Vasco P, Perez-Alvarez R, Chamorro AJ, Morcillo C, Jimenez-Heredia I, Sanchez-Berna I, Lopez-Guillermo A, Ramos-Casals M
Institution:Autoimmune Diseases Unit, Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Spain. Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Primaria de Salut Barcelona Esquerre (CAPSBE), Barcelona, Spain. Oviedo, Spain. Spain. Spain. Spain. Barcelona, Spain. Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Diseases, ICMiD, Hospital Clinic, Barcelona, Spain.
Journal:J Hematol Oncol. 2017 Apr 17;10(1):90. doi: 10.1186/s13045-017-0464-5.

2:Incidence and Mortality of Physician-Diagnosed Primary Sjogren Syndrome: Time Trends Over a 40-Year Period in a Population-Based US Cohort.
Authors:Maciel G, Crowson CS, Matteson EL, Cornec D
Institution:Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN; Hospital Maciel, Montevideo, Uruguay. MN; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN. MN; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN. Electronic address: and Science, Rochester, MN; Rheumatology Department, Brest Teaching Hospital, Brest, France.
Journal:Mayo Clin Proc. 2017 May;92(5):734-743. doi: 10.1016/j.mayocp.2017.01.020.

3:Reviewing primary Sjogren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment.
Authors:Both T, Dalm VA, van Hagen PM, van Daele PL
Institution:Department of Internal Medicine, Division of Clinical Immunology.; Department of Internal Medicine, Division of Clinical Immunology;; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Journal:Int J Med Sci. 2017 Feb 23;14(3):191-200. doi: 10.7150/ijms.17718. eCollection 2017.

4:One year in review 2017: primary Sjogren's syndrome.
Authors:Ferro F, Marcucci E, Orlandi M, Baldini C, Bartoloni-Bocci E
Institution:Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy. of Florence, Italy. of Pisa, Italy.
Journal:Clin Exp Rheumatol. 2017 Mar-Apr;35(2):179-191. Epub 2017 Mar 15.

5:Acupuncture for Primary Sjogren Syndrome (pSS) on symptomatic improvements: study protocol for a randomized controlled trial.
Authors:Jiang Q, Zhang H, Pang R, Chen J, Liu Z, Zhou X
Institution:Rheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Sciences, Beijing, China. Sciences, Beijing, China. (BUCM), Beijing, China. Sciences, Beijing, China. Sciences, Beijing, China.
Journal:BMC Complement Altern Med. 2017 Jan 19;17(1):61. doi: 10.1186/s12906-017-1559-9.

6:Sjogren Syndrome and Pregnancy: A Literature Review.
Authors:Gupta S, Gupta N
Institution:Medical Officer in the Department of Obstetrics and Gynecology at the Vardhman Mahavir Medical College and Safdarjung Hospital in Delhi, New Delhi, India. Vellore, India.
Journal:Perm J. 2017;21. pii: 16-047. doi: 10.7812/TPP/16-047. Epub 2016 Nov 9.

7:An investigation into the prevalence of sleep disturbances in primary Sjogren's syndrome: a systematic review of the literature.
Authors:Hackett KL, Gotts ZM, Ellis J, Deary V, Rapley T, Ng WF, Newton JL, Deane KHO
Institution:Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases. Northumbria University. Research Centre for Ageing and Chronic Diseases. Chronic Diseases, Newcastle upon Tyne.
Journal:Rheumatology (Oxford). 2017 Apr 1;56(4):570-580. doi: 10.1093/rheumatology/kew443.

8:A multicentre study of 95 biopsy-proven cases of renal disease in primary Sjogren's syndrome.
Authors:Jasiek M, Karras A, Le Guern V, Krastinova E, Mesbah R, Faguer S, Jourde-Chiche N, Fauchais AL, Chiche L, Dernis E, Moulis G, Fraison JB, Lazaro E, Jullien P, Hachulla E, Le Quellec A, Remy P, Hummel A, Costedoat-Chalumeau N, Ronco P, Vanhille P, Meas-Yedid V, Cordonnier C, Ferlicot S, Daniel L, Seror R, Mariette X, Thervet E, Francois H, Terrier B
Institution:Department of Nephrology, Hopital Bicetre, Assistance Publique-Hopitaux de Paris, Universite Paris-Sud, Le Kremlin-Bicetre.; Department of Nephrology, Hopital Europeen Georges Pompidou, AP-HP.; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hopital Cochin, AP-HP, Universite Paris Descartes, Paris.; Department of Epidemiology and Statistics, Hopital Bicetre, AP-HP, Universite Paris-Sud, Le Kremlin-Bicetre.; Department of Nephrology, Centre Hospitalier, Boulogne-Sur-Mer.
Journal:Rheumatology (Oxford). 2017 Mar 1;56(3):362-370. doi: 10.1093/rheumatology/kew376.

9:2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjogren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts.
Authors:Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X
Institution:University of California, San Francisco. Paris, France. Paris, France. Center, and Department of Veterans Affairs Medical Center, Oklahoma City. Italy. Paris, France.
Journal:Arthritis Rheumatol. 2017 Jan;69(1):35-45. doi: 10.1002/art.39859. Epub 2016 Oct 26.

10:Sjogren's syndrome: managed care data from a large United States population highlight real-world health care burden and lack of treatment options.
Authors:Birt JA, Tan Y, Mozaffarian N
Institution:Lilly Corporate Center, Indianapolis, IN, USA.
Journal:Clin Exp Rheumatol. 2017 Jan-Feb;35(1):98-107. Epub 2016 Oct 7.

11:Interstitial lung disease in primary Sjogren's syndrome.
Authors:Roca F, Dominique S, Schmidt J, Smail A, Duhaut P, Levesque H, Marie I
Institution:Department of Internal Medicine, Rouen University Hospital, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address:; Department of Pneumology, Rouen University Hospital, Rouen, France.; Department of Internal Medicine, Amiens University Hospital, Amiens, France.
Journal:Autoimmun Rev. 2017 Jan;16(1):48-54. doi: 10.1016/j.autrev.2016.09.017. Epub 2016 Sep 25.

12:Present and future of biologic drugs in primary Sjogren's syndrome.
Authors:Sambataro D, Sambataro G, Dal Bosco Y, Polosa R
Institution:a Department of Clinical and Experimental Medicine, Teaching Hospital Policlinico 'G. Rodolico' , University of Catania , Catania , Italy.; b Outpatient Clinic of Rheumatology accredited to National Health System , 'Artroreuma srl' , Mascalucia , Italy.
Journal:Expert Opin Biol Ther. 2017 Jan;17(1):63-75. Epub 2016 Sep 20.

13:Comorbidities in Patients With Primary Sjogren's Syndrome and Systemic Lupus Erythematosus: A Comparative Registries-Based Study.
Authors:Rua-Figueroa I, Fernandez Castro M, Andreu JL, Sanchez-Piedra C, Martinez-Taboada V, Olive A, Lopez-Longo J, Rosas J, Galindo M, Calvo-Alen J, Fernandez-Nebro A, Alonso F, Rodriguez-Lozano B, Alberto Garcia Vadillo J, Menor R, Narvaez FJ, Erausquin C, Garcia-Aparicio A, Tomero E, Manrique-Arija S, Horcada L, Uriarte E, Gil S, Blanco R, Lopez-Gonzalez R, Boteanu A, Freire M, Galisteo C, Rodriguez-Gomez M, Diez-Alvarez E, Pego-Reigosa JM
Institution:Doctor Negrin Hospital of Gran Canaria, Spain. Vigo, Spain.
Journal:Arthritis Care Res (Hoboken). 2017 Jan;69(1):38-45. doi: 10.1002/acr.23015. Epub 2016 Nov 21.

14:Severe Health-Related Quality of Life Impairment in Active Primary Sjogren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial.
Authors:Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puechal X, Le Guern V, Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Yves Hatron P, Goeb V, Hayem G, Morel J, Zarnitsky C, Dubost JJ, Saliou P, Pers JO, Seror R, Saraux A
Institution:Centre Hospitalier Universitaire de la Cavale Blanche, and EA 2216, INSERM ESPRI, ERI29, Universite de Brest, LabEx IGO, Brest, France.; Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, INSERM U1184, Universite Paris-Sud, Le Kremlin Bicetre, France.; Hotel-Dieu, Centre Hospitalier Universitaire Nantes, Nantes, France.; Centre Hospitalier Universitaire, Hopital Sud, Rennes, France.; Hopital Cochin, Paris, France.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):528-535. doi: 10.1002/acr.22974.

15:Treatment Guidelines for Rheumatologic Manifestations of Sjogren's Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain.
Authors:Carsons SE, Vivino FB, Parke A, Carteron N, Sankar V, Brasington R, Brennan MT, Ehlers W, Fox R, Scofield H, Hammitt KM, Birnbaum J, Kassan S, Mandel S
Institution:Winthrop-University Hospital Campus, State University of New York, Stony Brook, Mineola. Foundation, and Oklahoma City Department of Veterans Affairs Medical Center, Oklahoma City. Hempstead, New York.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-527. doi: 10.1002/acr.22968. Epub 2017 Mar 3.

16:Pregnancy and primary Sjogren's syndrome: management and outcomes in a multicentre retrospective study of 54 pregnancies.
Authors:Ballester C, Grobost V, Roblot P, Pourrat O, Pierre F, Laurichesse-Delmas H, Gallot D, Aubard Y, Bezanahary H, Fauchais AL
Institution:a Department of Obstetrics , Limoges University Hospital , Limoges , France. Clermont-Ferrand , France. France. France. Clermont-Ferrand , France. Clermont-Ferrand , France. France. France.
Journal:Scand J Rheumatol. 2017 Jan;46(1):56-63. doi: 10.3109/03009742.2016.1158312. Epub 2016 May 18.

17:Anticentromere antibody-positive primary Sjogren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients.
Authors:Tanaka N, Muro Y, Suzuki Y, Nishiyama S, Takada K, Sekiguchi M, Hashimoto N, Ohmura K, Shimoyama K, Saito I, Kawano M, Akiyama M
Institution:a Department of Dermatology , Nagoya University Graduate School of Medicine , Nagoya , Aichi , Japan. Nagoya , Aichi , Japan. Japan. Japan. Institute , Saitama , Japan. Medicine , Nishinomiya , Hyogo , Japan. Medicine , Nishinomiya , Hyogo , Japan. School of Medicine , Kyoto , Japan. University School of Medicine , Hamamatsu , Shizuoka , Japan , and. Yokohama , Kanagawa , Japan. Japan. Nagoya , Aichi , Japan.
Journal:Mod Rheumatol. 2017 Jan;27(1):115-121. doi: 10.1080/14397595.2016.1176327. Epub 2016 May 10.

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