Sjogren's Syndrome
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Different perception of dry eye symptoms between patients with and without primary Sjogren's syndrome.
Authors:Kim M, Chun YS, Kim KW
Institution:Department of Ophthalmology, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.
Journal:Sci Rep. 2022 Feb 9;12(1):2172. doi: 10.1038/s41598-022-06191-x.

2:Disease mechanisms in Sjögren's syndrome: What do we know?
Authors:Jonsson R
Institution:Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Journal:Scand J Immunol. 2022 Mar;95(3):e13145. doi: 10.1111/sji.13145. Epub 2022 Feb 1.

3:The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients.
Authors:Assy Z, Brand HS, Bots CP, Bikker FJ
Institution:Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan, 3004, 1081 LA, Amsterdam, The Netherlands.
Journal:Clin Oral Investig. 2022 Mar;26(3):3097-3108. doi: 10.1007/s00784-021-04292-x. Epub 2022 Jan 10.

4:New developments in Sjogren's syndrome.
Authors:Thalayasingam N, Baldwin K, Judd C, Ng WF
Institution:Department of Rheumatology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust.
Journal:Rheumatology (Oxford). 2021 Dec 24;60(Suppl 6):vi53-vi61. doi: 10.1093/rheumatology/keab466.

5:Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial.
Authors:Bowman SJ, Fox R, Dörner T, Mariette X, Papas A, Grader-Beck T, Fisher BA, Barcelos F, De Vita S, Schulze-Koops H, Moots RJ, Junge G, Woznicki JN, Sopala MA, Luo WL, Hueber W
Institution:Rheumatology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, UK; National Institute for Health Research Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK; Rheumatology Department, Milton Keynes University Hospital, Milton Keynes, UK. Electronic address: Novartis Pharma, Basel, Switzerland.
Journal:Lancet. 2022 Jan 8;399(10320):161-171. doi: 10.1016/S0140-6736(21)02251-0. Epub 2021 Nov 30.

6:Cancer incidence in primary Sjögren's syndrome: Data from the French hospitalization database.
Authors:Goulabchand R, Malafaye N, Jacot W, Witkowski Durand Viel P, Morel J, Lukas C, Rozier P, Lamure S, Noel D, Molinari N, Mura T, Guilpain P
Institution:Internal Medicine Department, CHU Nimes, Univ Montpellier, Nimes, France; University of Montpellier, Montpellier, France; IRMB, University of Montpellier, INSERM, Montpellier, France. University of Montpellier, Montpellier, France; IRMB, University of Montpellier, INSERM, Montpellier, France; Department of Internal Medicine and Multi-Organic Diseases, Local Referral Center for Systemic and Autoimmune Diseases, St Eloi Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier, France. Electronic address:
Journal:Autoimmun Rev. 2021 Dec;20(12):102987. doi: 10.1016/j.autrev.2021.102987. Epub 2021 Oct 28.

7:Asymptomatic myocardial dysfunction was revealed by feature tracking cardiac magnetic resonance imaging in patients with primary Sjögren's syndrome.
Authors:Yokoe I, Kobayashi H, Nishiwaki A, Nagasawa Y, Kitamura N, Haraoka M, Kobayashi Y, Takei M, Nakamura H
Institution:Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Journal:Int J Rheum Dis. 2021 Dec;24(12):1482-1490. doi: 10.1111/1756-185X.14227. Epub 2021 Oct 25.

8:Pulmonary involvement in Sjögren's syndrome.
Authors:Mestre-Torres J, Solans-Laque R
Institution:Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital Vall d'Hebron, Barcelona, Espana; Departamento de Medicina, Facultad de Medicina, Universidad Autonoma de Barcelona, Barcelona, Espana. Electronic address:
Journal:Med Clin (Barc). 2022 Feb 25;158(4):181-185. doi: 10.1016/j.medcli.2021.06.016. Epub 2021 Aug 13.

9:Cardiac involvement in primary Sjӧgren's syndrome.
Authors:Qin L, Zhang Y, Yang X, Luo Q, Wang H
Institution:Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, No.82, Qinglong Street, Chengdu, Sichuan, China.
Journal:Rheumatol Int. 2022 Feb;42(2):179-189. doi: 10.1007/s00296-021-04970-9. Epub 2021 Aug 13.

10:The role of minor salivary glands' biopsy in the diagnosis of Sjögren's syndrome and other systemic diseases.
Authors:Lopes AI, Machado-Neves R, Honavar M, Pereira PR
Institution:Department of Internal Medicine, Pedro Hispano Hospital, Matosinhos Local Health Unit. Matosinhos, Portugal. Electronic address: Matosinhos, Portugal. Matosinhos, Portugal. Unit. Matosinhos, Portugal.
Journal:Eur J Intern Med. 2021 Dec;94:69-72. doi: 10.1016/j.ejim.2021.07.012. Epub 2021 Aug 9.

11:The association between oral dryness and use of dry-mouth interventions in Sjögren's syndrome patients.
Authors:Assy Z, Bikker FJ, Picauly O, Brand HS
Institution:Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan, 3004, Amsterdam, 1081 LA, the Netherlands.
Journal:Clin Oral Investig. 2022 Feb;26(2):1465-1475. doi: 10.1007/s00784-021-04120-2. Epub 2021 Aug 10.

12:An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development.
Authors:Retamozo S, Sisó-Almirall A, Flores-Chávez A, Ramos-Casals M, Brito-Zerón P
Institution:Sjogren Syndrome Research Group (AGAUR), Department of Autoinmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain.
Journal:Expert Opin Pharmacother. 2021 Dec;22(17):2359-2371. doi: 10.1080/14656566.2021.1951224. Epub 2021 Jul 29.

13:Treatment strategies for Sjögren's syndrome with childhood onset: a systematic review of the literature.
Authors:Doolan G, Faizal NM, Foley C, Al-Obaidi M, Jury EC, Price E, Ramanan AV, Lieberman SM, Ciurtin C
Institution:Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London.
Journal:Rheumatology (Oxford). 2022 Mar 2;61(3):892-912. doi: 10.1093/rheumatology/keab579.

14:Preliminary Screening Questionnaire for Sjögren's Syndrome in the Rheumatology Setting.
Authors:Yu K, Ying GS, Vivino FB, Gonzales JA, Massaro-Giordano M, Bunya VY
Institution:From the Perelman School of Medicine at the University of Pennsylvania. Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania.
Journal:J Clin Rheumatol. 2022 Mar 1;28(2):e456-e461. doi: 10.1097/RHU.0000000000001760.

15:Sjögren's syndrome: a systemic autoimmune disease.
Authors:Negrini S, Emmi G, Greco M, Borro M, Sardanelli F, Murdaca G, Indiveri F, Puppo F
Institution:Department of Internal Medicine, Clinical Immunology and Translational Medicine Unit, University of Genoa and IRCCS Ospedale Policlinico San Martino, Viale Benedetto XV, 6, 16132, Genoa, Italy. Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Journal:Clin Exp Med. 2022 Feb;22(1):9-25. doi: 10.1007/s10238-021-00728-6. Epub 2021 Jun 7.

16:Patients with early-onset primary Sjögren's syndrome have distinctive clinical manifestations and circulating lymphocyte profiles.
Authors:Wei L, Zhifei X, Xiaoran N, Meilu L, Yang L, Yixuan L, Xiuying R, Yashuang S, Jingjing C, Shaoying G, Liu Y, Lijun S, Fengxiao Z, Wen Z
Institution:Department of Rheumatology and Immunology. Department of Rheumatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.
Journal:Rheumatology (Oxford). 2022 Feb 2;61(2):597-605. doi: 10.1093/rheumatology/keab367.

17:Evaluation of the effect of topical tacrolimus 0.03% versus cyclosporine 0.05% in the treatment of dry eye secondary to Sjogren syndrome.
Authors:Moawad P, Shamma R, Hassanein D, Ragab G, El Zawahry O
Institution:Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt.
Journal:Eur J Ophthalmol. 2022 Jan;32(1):673-679. doi: 10.1177/1120672121992680. Epub 2021 Feb 2.

18:Ultrasonographic features of arthritis in patients with primary Sjögren's syndrome and its clinical significance.
Authors:Wang S, Shao Q
Institution:Department of Rheumatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China. Chongqing 400021, China. Electronic address:
Journal:Med Clin (Barc). 2021 Dec 10;157(11):507-512. doi: 10.1016/j.medcli.2020.08.017. Epub 2021 Jan 9.

19:Novel insights on lymphoma and lymphomagenesis in primary Sjögren's Syndrome.
Authors:Alunno A, Leone MC, Bartoloni E, Gerli R, Carubbi F
Institution:Unit of Rheumatology, University of Perugia, Perugia, Italy. L'Aquila, Italy -
Journal:Panminerva Med. 2021 Dec;63(4):491-498. doi: 10.23736/S0031-0808.20.04079-3. Epub 2020 Dec 4.

20:Frequency of Polyautoimmunity in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus.
Authors:Ordoñez-Cañizares MC, Mena-Vázquez N, Redondo-Rodriguez R, Manrique-Arija S, Jimenez-Núñez FG, Ureña-Garnica I, Fernández-Nebro A
Journal:J Clin Rheumatol. 2022 Jan 1;28(1):e38-e43. doi: 10.1097/RHU.0000000000001574.

21:Can We Expect Any Effect of Rituximab on Fatigue in Primary Sjögren Syndrome?: A Systematic Review and Critical Appraisal.
Authors:Hermans AM, Vulsteke JB, Lenaerts J, De Langhe E
Institution:From the Division of Rheumatology, University Hospitals Leuven.
Journal:J Clin Rheumatol. 2021 Dec 1;27(8):e510-e515. doi: 10.1097/RHU.0000000000001217.

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