Sjogren's Syndrome
April 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes.
Authors:Everett S, Vishwanath S, Cavero V, Shen L, Suresh L, Malyavantham K, Lincoff-Cohen N, Ambrus JL Jr
Institution:Department of Ophthalmology, SUNY at Buffalo School of Medicine, Buffalo, NY, USA. USA. jambrus@buffalo.edu. Medicine, Room C281, Buffalo General Hospital, 100 High Street, Buffalo, NY, 14203, USA. jambrus@buffalo.edu.
Journal:BMC Ophthalmol. 2017 Mar 7;17(1):20. doi: 10.1186/s12886-017-0412-8.

2:Acupuncture for Primary Sjogren Syndrome (pSS) on symptomatic improvements: study protocol for a randomized controlled trial.
Authors:Jiang Q, Zhang H, Pang R, Chen J, Liu Z, Zhou X
Institution:Rheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Sciences, Beijing, China. Sciences, Beijing, China. (BUCM), Beijing, China. Sciences, Beijing, China. Sciences, Beijing, China. xyz_1102@126.com.
Journal:BMC Complement Altern Med. 2017 Jan 19;17(1):61. doi: 10.1186/s12906-017-1559-9.

3:Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren's Syndrome.
Authors:Lee SJ, Oh HJ, Choi BY, Jang YJ, Lee JY, Park JK, Song YW
Institution:Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. University Hospital, Seoul, Republic of Korea. Seoul, Republic of Korea. of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
Journal:J Immunol Res. 2016;2016:5781070. doi: 10.1155/2016/5781070. Epub 2016 Dec 15.

4:Optic neuritis as an initial presentation of primary Sjogren syndrome: A case report and literature review.
Authors:Sun JY, Liu Z, Zhao P, Liu T
Institution:aDepartment of OphthalmologybDepartment of Pathology and Molecular MedicinecDepartment of Rheumatology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi Province, China.
Journal:Medicine (Baltimore). 2016 Nov;95(44):e5194.

5:Treating the Underlying Pathophysiology of Primary Sjogren Syndrome: Recent Advances and Future Prospects.
Authors:Brito-Zeron P, Retamozo S, Gheitasi H, Ramos-Casals M
Institution:Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Spain. Font, CELLEX-IDIBAPS, Barcelona, Spain. 08036, Barcelona, Spain. Font, CELLEX-IDIBAPS, Barcelona, Spain. Font, CELLEX-IDIBAPS, Barcelona, Spain. Font, CELLEX-IDIBAPS, Barcelona, Spain. mramos@clinic.ub.es. 08036, Barcelona, Spain. mramos@clinic.ub.es. mramos@clinic.ub.es.
Journal:Drugs. 2016 Nov;76(17):1601-1623.

6:Interstitial lung disease in primary Sjogren's syndrome.
Authors:Roca F, Dominique S, Schmidt J, Smail A, Duhaut P, Levesque H, Marie I
Institution:Department of Internal Medicine, Rouen University Hospital, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address: isabelle.marie@chu-rouen.fr.; Department of Pneumology, Rouen University Hospital, Rouen, France.; Department of Internal Medicine, Amiens University Hospital, Amiens, France.
Journal:Autoimmun Rev. 2017 Jan;16(1):48-54. doi: 10.1016/j.autrev.2016.09.017. Epub 2016 Sep 25.

7:Significance and Implications of Patient-reported Xerostomia in Sjogren's Syndrome: Findings From the National Institutes of Health Cohort.
Authors:Billings M, Dye BA, Iafolla T, Baer AN, Grisius M, Alevizos I
Institution:Molecular Physiology and Therapeutics Branch, National Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA. Institute of Dental and Craniofacial Research, Bethesda, MD, USA. Institute of Dental and Craniofacial Research, Bethesda, MD, USA. National Institute of Dental and Craniofacial Research, Bethesda, MD, USA; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. National Institute of Dental and Craniofacial Research, Bethesda, MD, USA. National Institute of Dental and Craniofacial Research, Bethesda, MD, USA. Electronic address: alevizosi@mail.nih.gov.
Journal:EBioMedicine. 2016 Oct;12:270-279. doi: 10.1016/j.ebiom.2016.09.005. Epub 2016 Sep 9.

8:Sjogren's syndrome: from pathogenesis to novel therapeutic targets.
Authors:Barone F, Colafrancesco S
Institution:Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, University of Birmingham, UK. f.barone@bham.ac.uk. Ageing, University of Birmingham, UK; and Department of Internal Medicine and Medical Specialties, Rheumatology Unit, Sapienza University of Rome, Italy.
Journal:Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):58-62. Epub 2016 Jul 21.

9:Chronic Pruritus in Primary Sjogren's Syndrome: Characteristics and Effect on Quality of Life.
Authors:Valdes-Rodriguez R, Rowe B, Lee HG, Moldovan T, Chan YH, Blum M, Yosipovitch G
Institution:Department of Dermatology and Itch Center, , Lewis Katz School of Medicine at Temple University, Philadelphia, , Pennsylvania, USA.
Journal:Acta Derm Venereol. 2017 Mar 10;97(3):385-386. doi: 10.2340/00015555-2524.

10:Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjogren's Syndrome: a Double-Blind Randomized Control Study.
Authors:Yoon CH, Lee HJ, Lee EY, Lee EB, Lee WW, Kim MK, Wee WR
Institution:Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.; Laboraory of Ocular Regenerative Medicine and Immunology, Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea. Seoul National University Hospital Biomedical Research Institute, Seoul, Korea . Seoul, Korea . Seoul, Korea . Medicine, Seoul, Korea . Laboraory of Ocular Regenerative Medicine and Immunology, Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea. Laboraory of Ocular Regenerative Medicine and Immunology, Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Journal:J Korean Med Sci. 2016 Jul;31(7):1127-35. doi: 10.3346/jkms.2016.31.7.1127. Epub 2016 Apr 20.

11:Predicting the risk for lymphoma development in Sjogren syndrome: An easy tool for clinical use.
Authors:Fragkioudaki S, Mavragani CP, Moutsopoulos HM
Institution:aDepartment of Physiology bDepartment of Pathophysiology cJoint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Journal:Medicine (Baltimore). 2016 Jun;95(25):e3766. doi: 10.1097/MD.0000000000003766.

12:Association between primary Sjogren's syndrome and pregnancy complications: a systematic review and meta-analysis.
Authors:Upala S, Yong WC, Sanguankeo A
Institution:Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, 1 Atwell Rd, Cooperstown, NY, 13326, USA. Hospital, Mahidol University, Bangkok, Thailand. College of Physicians and Surgeons, 1 Atwell Rd, Cooperstown, NY, 13326, USA. waichung.yong@bassett.org. College of Physicians and Surgeons, 1 Atwell Rd, Cooperstown, NY, 13326, USA. Hospital, Mahidol University, Bangkok, Thailand.
Journal:Clin Rheumatol. 2016 Aug;35(8):1949-55. doi: 10.1007/s10067-016-3323-9. Epub 2016 Jun 8.

13:Future treatments for Sjogren's syndrome.
Authors:Pers JO, Saraux A
Institution:CHRU Morvan, universite de Brest, Labex "immunotherapy, graft, oncology", laboratoire d'immunotherapies et pathologies lymphocytaires B, EA2216, Inserm ESPRI ERI29, BP 824, 29609 Brest cedex, France. Electronic address: pers@univ-brest.fr. laboratoire d'immunotherapies et pathologies lymphocytaires B, EA2216, Inserm ESPRI ERI29, BP 824, 29609 Brest cedex, France.
Journal:Presse Med. 2016 Jun;45(6 Pt 2):e193-200. doi: 10.1016/j.lpm.2016.05.005. Epub 2016 May 27.

14:Pregnancy and primary Sjogren's syndrome: management and outcomes in a multicentre retrospective study of 54 pregnancies.
Authors:Ballester C, Grobost V, Roblot P, Pourrat O, Pierre F, Laurichesse-Delmas H, Gallot D, Aubard Y, Bezanahary H, Fauchais AL
Institution:a Department of Obstetrics , Limoges University Hospital , Limoges , France. Clermont-Ferrand , France. France. France. Clermont-Ferrand , France. Clermont-Ferrand , France. France. France.
Journal:Scand J Rheumatol. 2017 Jan;46(1):56-63. doi: 10.3109/03009742.2016.1158312. Epub 2016 May 18.

15:The increase of aqueous tear volume by diquafosol sodium in dry-eye patients with Sjogren's syndrome: a pilot study.
Authors:Yokoi N, Kato H, Kinoshita S
Institution:Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. Japan. Japan.
Journal:Eye (Lond). 2016 Jun;30(6):857-64. doi: 10.1038/eye.2016.54. Epub 2016 Apr 8.

16:Primary Sjgren's syndrome: Clinical phenotypes, outcome and the development of biomarkers.
Authors:Goules AV, Tzioufas AG
Institution:Department of Pathophysiology, School of Medicine, University of Athens, Mikras Asias Str 75, Athens 115 27, Greece. Electronic address: agoules@med.uoa.gr. Asias Str 75, Athens 115 27, Greece. Electronic address: agtzi@med.uoa.gr.
Journal:Autoimmun Rev. 2016 Jul;15(7):695-703. doi: 10.1016/j.autrev.2016.03.004. Epub 2016 Mar 9.

17:Characterization and Comparison of Patient Subgroups Suspicious for IgG4-Related Disease and Malignant Lymphoma in Patients Followed-up for Sjogren's Syndrome.
Authors:Szanto A, Szabo K, Nagy G, Molnar C, Zeher M
Institution:Division of Clinical Immunology, Medical Faculty, University of Debrecen, 22 Moricz Zs. Krt, Debrecen, H-4032, Hungary. Nyiregyhaza, H-4400, Hungary. Moricz Zs. Krt, Debrecen, H-4032, Hungary. Krt., Debrecen, H-4032, Hungary. Moricz Zs. Krt, Debrecen, H-4032, Hungary. zeher@iiibel.dote.hu.
Journal:Pathol Oncol Res. 2016 Jul;22(3):579-85. doi: 10.1007/s12253-016-0041-1. Epub 2016 Jan 19.

18:Diffusion-weighted MRI findings in Sjogren's syndrome: a preliminary study.
Authors:Ding C, Xing X, Guo Q, Liu D, Guo Y, Cui H
Institution:Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Shenyang, Liaoning, PR China. Shenyang, Liaoning, PR China guo_qiyong@126.com. Chinese Medicine, Shenyang, Liaoning, PR China. University, Shenyang, Liaoning, PR China. University, Shenyang, Liaoning, PR China.
Journal:Acta Radiol. 2016 Jun;57(6):691-700. doi: 10.1177/0284185115603245. Epub 2015 Sep 2.

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