January 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis.
Authors:Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG 2nd, Benzel EC
Institution:From the Alan L. and Jacqueline B. Stuart Spine Research Center, the Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington (Z.G., S.N.M.), and the Department of Neurosurgery, Massachusetts General Hospital (W.E.B., J.-V.C.E.C., F.G.B.), and Tufts Clinical and Translational Science Institute, Tufts University School of Medicine (N.T.), Boston - all in Massachusetts; Wallace Trials Center, Greenwich Hospital, Greenwich (Z.G.), and Yale Center for Analytical Sciences, Yale School of Public Health, New Haven (J.D., F.D.) - both in Connecticut; the Department of Neurosurgery, University of New Mexico, Albuquerque (J.F.H.); the Department of Neurosurgery, University of Illinois at Chicago, Chicago (S.A.-H.); Perelman School of Medicine (J.S.S.), Wharton School of Business (J.S.S), and the Leonard Davis Institute (J.S.S.), University of Pennsylvania, Philadelphia; Barrow Neurosurgical Associates, Barrow Neurological Institute, Phoenix, AZ (V.K.H.S.); and the Center for Spine Health and the Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland (E.C.B.).
Journal:N Engl J Med. 2016 Apr 14;374(15):1424-34. doi: 10.1056/NEJMoa1508788.

2:Mini-invasive Transforaminal Lumbar Interbody Fusion through Wiltse Approach to Treating Lumbar Spondylolytic Spondylolisthesis.
Authors:Zhou C, Tian YH, Zheng YP, Liu XY, Wang HH
Institution:Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China.
Journal:Orthop Surg. 2016 Feb;8(1):44-50. doi: 10.1111/os.12224.

3:Surgical Versus Nonsurgical Treatment for High-Grade Spondylolisthesis in Children and Adolescents: A Systematic Review and Meta-Analysis.
Authors:Xue X, Wei X, Li L
Institution:From the Department of Orthopedics (XXH, WXC), The Second Hospital, Shanxi Medical University, Taiyuan; and The First People's Hospital of Jinzhong (LL), Shanxi Medical University, Jinzhong, Shanxi, P.R. China.
Journal:Medicine (Baltimore). 2016 Mar;95(11):e3070. doi: 10.1097/MD.0000000000003070.

4:Anterior lumbar inter-body fusion with instrumentation compared with posterolateral fusion for low grade isthmic-spondylolisthesis.
Authors:Chandra V, Singh RK
Journal:Acta Orthop Belg. 2016 Mar;82(1):23-30.

5:National Trends in the Surgical Management of Adult Lumbar Isthmic Spondylolisthesis: 1998 to 2011.
Authors:Thirukumaran CP, Raudenbush B, Li Y, Molinari R, Rubery P, Mesfin A
Institution:*Department of Public Health Science, University of Rochester School of Medicine and Dentistry, Rochester, New York daggerDepartment of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Journal:Spine (Phila Pa 1976). 2016 Mar;41(6):490-501. doi: 10.1097/BRS.0000000000001238.

6:Reduction and fusion in high-grade L5-S1 spondylolisthesis by a single posterior approach. Results in 50 patients.
Authors:Moreau S, Lonjon G, Guigui P, Lenoir T, Garreau de Loubresse C, Chopin D
Institution:Service d'orthopedie, hopital europeen Georges-Pompidou, 20-40, rue Leblanc, 75908 Paris, France. Electronic address: seba.moreau@yahoo.fr.; Service d'orthopedie, institut Calot, rue du Docteur-Calot, 62608 Berck, France.
Journal:Orthop Traumatol Surg Res. 2016 Apr;102(2):233-7. doi: 10.1016/j.otsr.2015.12.016. Epub 2016 Feb 26.

7:Effects of the Pilates method on variables related to functionality of a patient with traumatic spondylolisthesis at L4-L5: A case study.
Authors:Oliveira LC, Guedes CA, Jassi FJ, Martini FA, Oliveira RG
Institution:Health Sciences Center, State University of North Parana, Jacarezinho, Parana, Brazil. Electronic address: oliveiralc@uenp.edu.br. Brazil. Brazil. Brazil. Brazil.
Journal:J Bodyw Mov Ther. 2016 Jan;20(1):123-31. doi: 10.1016/j.jbmt.2015.07.038. Epub 2015 Jul 26.

8:Radiographic Restoration of Sagittal Spinopelvic Alignment After Posterior Lumbar Interbody Fusion in Degenerative Spondylolisthesis.
Authors:Kong LD, Zhang YZ, Wang F, Kong FL, Ding WY, Shen Y
Institution:Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Journal:Clin Spine Surg. 2016 Mar;29(2):E87-92. doi: 10.1097/BSD.0000000000000104.

9:Long-term Outcome After Monosegmental L4/5 Stabilization for Degenerative Spondylolisthesis With the Dynesys Device.
Authors:Hoppe S, Schwarzenbach O, Aghayev E, Bonel H, Berlemann U
Institution:*Das Ruckenzentrum, Spinal Surgery, ThundaggerDepartment of Orthopaedic Surgery, University of Bern, Inselspitaldouble daggerMEM Research Center, Bern section signDepartment of Radiology, University of Bern, Inselspital, Bern, Switzerland.
Journal:Clin Spine Surg. 2016 Mar;29(2):72-7. doi: 10.1097/BSD.0b013e318277ca7a.

10:Patient-Based Surgical Outcomes of Posterior Lumbar Interbody Fusion: Patient Satisfaction Analysis.
Authors:Okuda S, Fujimori T, Oda T, Yamasaki R, Maeno T, Yamashita T, Matsumoto T, Iwasaki M
Institution:*Department of Orthopaedic Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai, Osaka, JapandaggerDepartment of Orthopaedic Surgery, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, Japan.
Journal:Spine (Phila Pa 1976). 2016 Feb;41(3):E148-54. doi: 10.1097/BRS.0000000000001188.

11:Predictive Factors for Subjective Improvement in Lumbar Spinal Stenosis Patients with Nonsurgical Treatment: A 3-Year Prospective Cohort Study.
Authors:Matsudaira K, Hara N, Oka H, Kunogi J, Yamazaki T, Takeshita K, Atsushi S, Tanaka S
Institution:Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan. Century Medical & Research Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan. Tokyo, Japan.
Journal:PLoS One. 2016 Feb 10;11(2):e0148584. doi: 10.1371/journal.pone.0148584. eCollection 2016.

12:Two-Year Comparative Outcomes of MIS Lateral and MIS Transforaminal Interbody Fusion in the Treatment of Degenerative Spondylolisthesis: Part II: Radiographic Findings.
Authors:Isaacs RE, Sembrano JN, Tohmeh AG
Institution:*Department of Neurosurgery, Duke University Medical Centere, Durham, NC daggerUniversity of Minnesota, Minneapolis, MN double daggerMinneapolis Veterans Affairs Health Care Systems, Minneapolis, MN section signNorthwest Orthopaedic Specialists, Spokane, WA.
Journal:Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S133-44. doi: 10.1097/BRS.0000000000001472.

13:Distraction Laminoplasty With Interlaminar Lumbar Instrumented Fusion (ILIF) for Lumbar Stenosis With or Without Grade 1 Spondylolisthesis: Technique and 2-Year Outcomes.
Authors:Cuellar JM, Field JS, Bae HW
Institution:*The Spine Center, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA daggerDesert Institute for Spine Care (DISC), Phoeniz, AZ.
Journal:Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S97-S105. doi: 10.1097/BRS.0000000000001484.

14:Two-year Comparative Outcomes of MIS Lateral and MIS Transforaminal Interbody Fusion in the Treatment of Degenerative Spondylolisthesis: Part I: Clinical Findings.
Authors:Sembrano JN, Tohmeh A, Isaacs R
Institution:*University of Minnesota, Minneapolis, Minnesota daggerMinneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota double daggerNorthwest Orthopedic Specialists, Spokane, Washington section signDepartment of Neurosurgery, Duke University, Durham, North Carolina.
Journal:Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S123-32. doi: 10.1097/BRS.0000000000001471.

15:L5S1 spondylolisthesis in children and adolescents.
Authors:Violas P, Lucas G
Institution:Service de chirurgie pediatrique, CHU de Rennes, 35033 Rennes, France; Faculte de medecine, universite Rennes 1, 35043 Rennes, France. Electronic address: philippe.violas@chu-rennes.fr.
Journal:Orthop Traumatol Surg Res. 2016 Feb;102(1 Suppl):S141-7. doi: 10.1016/j.otsr.2015.03.021. Epub 2016 Jan 7.

16:Risk factors of radiological adjacent disc degeneration with lumbar interbody fusion for degenerative spondylolisthesis.
Authors:Tsuji T, Watanabe K, Hosogane N, Fujita N, Ishii K, Chiba K, Toyama Y, Nakamura M, Matsumoto M
Institution:Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan. Electronic address: morio@a5.keio.jp.; Department of Advanced Treatment for Spine and Spinal Cord Disorders, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.; Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitame, 359-8513, Japan.
Journal:J Orthop Sci. 2016 Mar;21(2):133-7. doi: 10.1016/j.jos.2015.12.007. Epub 2015 Dec 22.

17:Dynamic stabilization for L4-5 spondylolisthesis: comparison with minimally invasive transforaminal lumbar interbody fusion with more than 2 years of follow-up.
Authors:Kuo CH, Chang PY, Wu JC, Chang HK, Fay LY, Tu TH, Cheng H, Huang WC
Institution:Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital; Hospital; Hospital; Hospital; Hospital; Hospital; Sinica, Taipei, Taiwan. Hospital; Hospital;
Journal:Neurosurg Focus. 2016 Jan;40(1):E3. doi: 10.3171/2015.10.FOCUS15441.

18:Workers' Compensation, Return to Work, and Lumbar Fusion for Spondylolisthesis.
Authors:Anderson JT, Haas AR, Percy R, Woods ST, Ahn UM, Ahn NU
Journal:Orthopedics. 2016 Jan-Feb;39(1):e1-8. doi: 10.3928/01477447-20151218-01. Epub 2015 Dec 23.

19:Guideline summary review: An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spondylolisthesis.
Authors:Matz PG, Meagher RJ, Lamer T, Tontz WL Jr, Annaswamy TM, Cassidy RC, Cho CH, Dougherty P, Easa JE, Enix DE, Gunnoe BA, Jallo J, Julien TD, Maserati MB, Nucci RC, O'Toole JE, Rosolowski K, Sembrano JN, Villavicencio AT, Witt JP
Institution:Brain and Spine Center, 232 S. Woods Mill Rd., Ste. 400E, Chesterfield, MO 63017-3417, USA. Electronic address: matzpg@yahoo.com. 75418, USA. USA. USA. 55455, USA.
Journal:Spine J. 2016 Mar;16(3):439-48. doi: 10.1016/j.spinee.2015.11.055. Epub 2015 Dec 8.

20:Outcomes in cases of lumbar degenerative spondylolisthesis more than 5 years after treatment with minimally invasive decompression: examination of pre- and postoperative slippage, intervertebral disc changes, and clinical results.
Authors:Mori G, Mikami Y, Arai Y, Ikeda T, Nagae M, Tonomura H, Takatori R, Sawada K, Fujiwara H, Kubo T
Institution:Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Journal:J Neurosurg Spine. 2016 Mar;24(3):367-74. doi: 10.3171/2015.6.SPINE141298. Epub 2015 Nov 27.

21:Use of Recombinant Human Bone Morphogenetic Protein-2 in the Treatment of Degenerative Spondylolisthesis.
Authors:Schroeder GD, Hsu WK, Kepler CK, Kurd MF, Vaccaro AR, Patel AA, Savage JW
Institution:*The Rothman Institute, Thomas Jefferson University, Philadelphia, PA daggerDepartment of Orthopedic Surgery, Northwestern University, Chicago, IL.
Journal:Spine (Phila Pa 1976). 2016 Mar;41(5):445-9. doi: 10.1097/BRS.0000000000001228.

22:Intraoperative reduction does not result in better outcomes in low-grade lumbar spondylolisthesis with neurogenic symptoms after minimally invasive transforaminal lumbar interbody fusion-a 5-year follow-up study.
Authors:Tay KS, Bassi A, Yeo W, Yue WM
Institution:Department of Orthopaedic Surgery, Singapore General Hospital, 20 College Rd, Academia, Level 4, Singapore 169865. Electronic address: yuewm@singnet.com.sg.
Journal:Spine J. 2016 Feb;16(2):182-90. doi: 10.1016/j.spinee.2015.10.026. Epub 2015 Oct 26.

23:Cervical degenerative spondylolisthesis: analysis of facet orientation and the severity of cervical spondylolisthesis.
Authors:Xu C, Lin B, Ding Z, Xu Y
Institution:Department of Orthopaedics, The Fourth Affiliated Hospital of Nanchang University, No. 133 square south road, Xihu District, Nanchang 330003, China. No. 1838 Guangzhou Ave North, Baiyun District, Guangzhou 510515, China. Ave North, Baiyun District, Guangzhou 510515, China. Electronic address: Ding_zihai@163.com. No. 1838 Guangzhou Ave North, Baiyun District, Guangzhou 510515, China.
Journal:Spine J. 2016 Jan 1;16(1):10-5. doi: 10.1016/j.spinee.2015.09.035. Epub 2015 Sep 26.

24:One-stage posterior spinal shortening by L5 partial spondylectomy for spondyloptosis or L5-S1 high-grade spondylolisthesis management.
Authors:Obeid I, Laouissat F, Bourghli A, Boissiere L, Vital JM
Institution:Spine Unit 1, Orthopedic Surgery Department, Bordeaux University Hospital, Place Amelie Raba-Leon, 33076, Bordeaux, France.; CMCR Massues, Croix Rouge Francaise, 92, rue Edmond Locard, 69005, Lyon, France. flaouissat@gmail.com.
Journal:Eur Spine J. 2016 Feb;25(2):664-70. doi: 10.1007/s00586-015-4174-9. Epub 2015 Aug 14.

25:Influence of gender on patient-oriented outcomes in spine surgery.
Authors:Pochon L, Kleinstuck FS, Porchet F, Mannion AF
Institution:Spine Center Division, Department of Research and Development, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland. Lengghalde 2, 8008, Zurich, Switzerland. anne.mannion@yahoo.com.
Journal:Eur Spine J. 2016 Jan;25(1):235-46. doi: 10.1007/s00586-015-4062-3. Epub 2015 Jul 5.

26:The Correlation Between Restoration of Lumbar Lordosis and Surgical Outcome in the Treatment of Low-grade Lumbar Degenerative Spondylolisthesis With Spinal Fusion.
Authors:Hsu HT, Yang SS, Chen TY
Institution:*Division of NeurosurgerydaggerDepartment of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Taipeidouble daggerSchool of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan.
Journal:Clin Spine Surg. 2016 Feb;29(1):E16-20. doi: 10.1097/BSD.0000000000000061.

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