August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Outcomes of Posterolateral Fusion with and without Instrumentation and of Interbody Fusion for Isthmic Spondylolisthesis: A Prospective Study.
Authors:Endler P, Ekman P, Moller H, Gerdhem P
Institution:1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, and Department of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden 2Department of Clinical Sciences, Karolinska Institutet, Sodersjukhuset, and Department of Orthopaedics, Sodersjukhuset, Stockholm, Sweden.
Journal:J Bone Joint Surg Am. 2017 May 3;99(9):743-752. doi: 10.2106/JBJS.16.00679.

2:The Outcomes of Minimally Invasive versus Open Posterior Approach Spinal Fusion in Treatment of Lumbar Spondylolisthesis: The Current Evidence from Prospective Comparative Studies.
Authors:Wu AM, Chen CH, Shen ZH, Feng ZH, Weng WQ, Li SM, Chi YL, Yin LH, Ni WF
Institution:Department of Orthopedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Center, Wenzhou, Zhejiang, China.; Department of Orthopedics, Hainan Medical College, Haikou, Hainan, China.; Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Journal:Biomed Res Int. 2017;2017:8423638. doi: 10.1155/2017/8423638. Epub 2017 Jan 5.

3:Degenerative spondylolisthesis: contemporary review of the role of interbody fusion.
Authors:Baker JF, Errico TJ, Kim Y, Razi A
Institution:Department of Spine and Spinal Deformity Surgery, NYU Langone Medical Center Hospital for Joint Diseases, 301 East 17th Street, New York, NY, 10002, USA. joseph.f.baker@gmail.com.
Journal:Eur J Orthop Surg Traumatol. 2017 Feb;27(2):169-180. doi: 10.1007/s00590-016-1885-5. Epub 2016 Nov 25.

4:Extreme lateral interbody fusion relieves symptoms of spinal stenosis and low-grade spondylolisthesis by indirect decompression in complex patients.
Authors:Pereira EA, Farwana M, Lam KS
Institution:Spinal Unit, Department of Orthopaedic Surgery, Guy's and St Thomas' NHS Foundation Trust and Evelina London Children's Hospital, London, UK; Academic Neurosurgery Unit, St George's, University of London, University of London, London, UK; Atkinson Morley Neurosciences Centre, St George's University Hospital, Blackshaw Rd., London SW17 0QT, UK. Electronic address: eacp@eacp.co.uk. Foundation Trust and Evelina London Children's Hospital, London, UK. Foundation Trust and Evelina London Children's Hospital, London, UK.
Journal:J Clin Neurosci. 2017 Jan;35:56-61. doi: 10.1016/j.jocn.2016.09.010. Epub 2016 Oct 1.

5:Transforaminal lumbar interbody fusion versus instrumented posterolateral fusion In degenerative spondylolisthesis: An attempt to evaluate the superiority of one method over the other.
Authors:Ghasemi AA
Institution:Neurosurgery Department, Urmia Medical University, Ershad Blvd, Imam Khomeini Hospital, Urmia, Iran. Electronic address: dr.amirghasemi@ymail.com.
Journal:Clin Neurol Neurosurg. 2016 Nov;150:1-5. doi: 10.1016/j.clineuro.2016.08.017. Epub 2016 Aug 21.

6:Lumbar Degenerative Spondylolisthesis: Changes in Surgical Indications and Comparison of Instrumented Fusion With Two Surgical Decompression Procedures.
Authors:Inui T, Murakami M, Nagao N, Miyazaki K, Matsuda K, Tominaga Y, Kitano M, Hasegawa H, Tominaga S
Institution:Department of Neurosurgery, Tominaga Hospital, Naniwa-ku, Osaka-shi, Osaka, Japan.
Journal:Spine (Phila Pa 1976). 2017 Jan 1;42(1):E15-E24. doi: 10.1097/BRS.0000000000001688.

7:Two-year Comparative Outcomes of MIS Lateral and MIS Transforaminal Interbody Fusion in the Treatment of Degenerative Spondylolisthesis: Part I: Clinical Findings.
Authors:Sembrano JN, Tohmeh A, Isaacs R
Institution:*University of Minnesota, Minneapolis, Minnesota daggerMinneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota double daggerNorthwest Orthopedic Specialists, Spokane, Washington section signDepartment of Neurosurgery, Duke University, Durham, North Carolina.
Journal:Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S123-32. doi: 10.1097/BRS.0000000000001471.

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