Meniere's Disease
May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Meniere's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Meniere's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Meniere's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Meniere's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Depression in Ménière's disease: a systematic review and meta-analysis.
Authors:Patel JJ, Levy DA, Nguyen SA, Rizk HG, Meyer TA
Institution:Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, USA.
Journal:J Laryngol Otol. 2020 Apr;134(4):293-301. doi: 10.1017/S002221512000081X.

2:Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre.
Authors:Pai I, Mendis S, Murdin L, Touska P, Connor S
Institution:Department of Otolaryngology, Guy's and St Thomas' Hospital, London, UK. Department of Radiology, Guy's and St Thomas' Hospital, London, UK.
Journal:J Laryngol Otol. 2020 Apr;134(4):302-310. doi: 10.1017/S0022215120000626. Epub 2020 Apr 3.

3:Ménière's disease clinical subtypes in a population from the USA.
Authors:Crossley J, Hussaini AS, Kim HJ, Hoa M
Institution:Georgetown University School of Medicine, Washington, DC, USA. Department of Otolaryngology - Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Journal:J Laryngol Otol. 2020 Jan;134(1):24-28. doi: 10.1017/S002221511900255X. Epub 2019 Dec 20.

4:Are viral-infections associated with Ménière's Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD.
Authors:Dean NJ, Pastras C, Brown D, Camp A
Institution:School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Journal:PLoS One. 2019 Nov 22;14(11):e0225650. doi: 10.1371/journal.pone.0225650. eCollection 2019.

5:Clinical application of cVEMPs and oVEMPs in patients affected by Ménière's disease, vestibular neuritis and benign paroxysmal positional vertigo: a systematic review.
Authors:Scarpa A, Gioacchini FM, Cassandro E, Tulli M, Ralli M, Re M, Cassandro C
Institution:Department of Medicine and Surgery, University of Salerno, Italy. Surgical Sciences Department, University of Turin, Italy.
Journal:Acta Otorhinolaryngol Ital. 2019 Oct;39(5):298-307. doi: 10.14639/0392-100X-2104.

6:Low-dose intratympanic gentamicin administration for unilateral Meniere's disease using a method based on clinical symptomatology: Preliminary results.
Authors:Scarpa A, Ralli M, Cassandro C, Gioacchini FM, Alicandri-Ciufelli M, Viola P, Chiarella G, de Vincentiis M, Cassandro E
Institution:Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
Journal:Am J Otolaryngol. 2019 Nov-Dec;40(6):102289. doi: 10.1016/j.amjoto.2019.102289. Epub 2019 Sep 9.

7:Are Meniere's disease patients with otolith organ impairment more likely to have balance dysfunction?
Authors:Zhou YJ, Li QZ, Gao YQ, Gao LX, Zhao ZX, Wu YZ, Wang J
Institution:Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , China.
Journal:Acta Otolaryngol. 2019 Nov;139(11):977-981. doi: 10.1080/00016489.2019.1663923. Epub 2019 Sep 19.

8:Current state of evidence for endolymphatic sac surgery in Menière's disease: a systematic review.
Authors:Devantier L, Schmidt JH, Djurhuus BD, Hougaard DD, Händel MN, Liviu-Adelin Guldfred F, Edemann-Callesen H
Institution:Department of Clinical Medicine, Aarhus University , Aarhus , Denmark. The Danish Health Authority , Copenhagen , Denmark.
Journal:Acta Otolaryngol. 2019 Nov;139(11):953-958. doi: 10.1080/00016489.2019.1657240. Epub 2019 Sep 9.

9:Intratympanically administered steroid for progressive sensorineural hearing loss in Ménière's disease.
Authors:Molnár A, Maihoub S, Tamás L, Szirmai Á
Institution:Department of Otolaryngology and Head and Neck Surgery, Semmelweis University , Budapest , Hungary.
Journal:Acta Otolaryngol. 2019 Nov;139(11):982-986. doi: 10.1080/00016489.2019.1658898. Epub 2019 Sep 9.

10:Association between Ménière's disease and vestibular migraine.
Authors:Pyykkö I, Manchaiah V, Färkkilä M, Kentala E, Zou J
Institution:Department of Otolaryngology, Hearing and Balance Research Unit, University of Tampere, Tampere, Finland. Electronic address: Department of Otolaryngology, Hearing and Balance Research Unit, University of Tampere, Tampere, Finland; Department of Otorhinolaryngology, University of Helsinki and Helsinki University Hospital, Hel
Journal:Auris Nasus Larynx. 2019 Oct;46(5):724-733. doi: 10.1016/j.anl.2019.02.002. Epub 2019 May 1.

11:Gadolinium-enhanced MRI reveals dynamic development of endolymphatic hydrops in Ménière's disease.
Authors:Li X, Wu Q, Sha Y, Dai C, Zhang R
Institution:National Health Commission Key Laboratory of Hearing Medicine (Fudan University), Department of Otology and Skull Base Surgery, Shanghai, China; Hospital of Xuzhou Medical University, Department of Oto Shanghai East Hospital, Department of Otorhinolaryngology Shanghai, Shanghai, China.
Journal:Braz J Otorhinolaryngol. 2020 Mar-Apr;86(2):165-173. doi: 10.1016/j.bjorl.2018.10.014. Epub 2018 Dec 20.

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