Atrial Fibrillation
September 2021 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The role of atrial fibrillation catheter ablation in patients with heart failure.
Authors:Bernard ML, Benn F, Williams CM, Hiltbold AE, Rogers PA, Polin GM, Khatib S, Al-Khatib SM, Morin DP
Institution:Ochsner Medical Center, New Orleans, LA, USA. Electronic address: mbernard@ochsner.org.
Journal:Prog Cardiovasc Dis. 2021 May-Jun;66:80-85. doi: 10.1016/j.pcad.2021.06.002.

2:Anticoagulation in special patient populations with atrial fibrillation.
Authors:Ueberham L, Hindricks G
Institution:Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Strümpellstraße 39, 04289, Leipzig, Germany. laura.ueberham@helios-gesundheit.de. Strümpellstraße 39, 04289, Leipzig, Germany.
Journal:Herz. 2021 Aug;46(4):323-328. doi: 10.1007/s00059-021-05042-1. Epub 2021 Jul 5.

3:Update on the efficacy of statins in primary and secondary prevention of atrial fibrillation.
Authors:Oraii A, Vasheghani-Farahani A, Oraii S, Roayaei P, Balali P, Masoudkabir F
Institution:Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran. Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Cardiac Electrophysiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Medical Sciences, Tehran, Iran. Tehran, Iran. Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Cardiac Electrophysiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: fmasoudkabir@sina.tums.ac.ir.
Journal:Rev Port Cardiol. 2021 Jul;40(7):509-518. doi: 10.1016/j.repc.2020.11.010. Epub 2021 Jul 1.

4:Antiarrhythmic Drugs for Atrial Fibrillation in the Outpatient Setting: Common Clinical Scenarios and Pearls for the Primary Care Clinician.
Authors:Tseng AS, Kowlgi GN, DeSimone CV
Institution:Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN. MN. MN. Electronic address: desimone.christopher@mayo.edu.
Journal:Mayo Clin Proc. 2021 Aug;96(8):2230-2242. doi: 10.1016/j.mayocp.2021.01.010. Epub 2021 Jun 10.

5:Cryoablation versus antiarrhythmic therapy for initial treatment of atrial fibrillation: a systematic review and meta-analysis.
Authors:Patel M, Changal K, Patel N, Elzanaty A
Institution:Department of Internal Medicine, The University of Toledo, Toledo, OH, USA.
Journal:Expert Rev Cardiovasc Ther. 2021 Jul;19(7):667-671. doi: 10.1080/14779072.2021.1941875. Epub 2021 Jun 19.

6:Surgical Treatment of Atrial Fibrillation.
Authors:Wolf RK
Institution:Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
Journal:Methodist Debakey Cardiovasc J. 2021 Apr 5;17(1):56-64. doi: 10.14797/VNDG5944. Epub 2021 Mar 25.

7:Percutaneous Left Atrial Appendage Occlusion: An Emerging Option in Patients with Atrial Fibrillation at High Risk of Bleeding.
Authors:Cimmino G, Loffredo FS, Gallinoro E, Prozzo D, Fabiani D, Cante L, Salerno G, Cappelli Bigazzi M, Golino P
Institution:Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Journal:Medicina (Kaunas). 2021 May 3;57(5):444. doi: 10.3390/medicina57050444.

8:Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction: Two Chronic Troublemakers.
Authors:Kim IC
Institution:Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, 1035, Dalgubeol-daero, Dalseo-gu, Daegu 42601, Republic of Korea. Electronic address: kimic@dsmc.or.kr.
Journal:Heart Fail Clin. 2021 Jul;17(3):377-386. doi: 10.1016/j.hfc.2021.03.001.

9:Beyond cardioversion, ablation and pharmacotherapies: Risk factors, lifestyle change and behavioral counseling strategies in the prevention and treatment of atrial fibrillation.
Authors:Mehta NK, Strickling J, Mark E, Swinehart S, Puthumana J, Lavie CJ, Haines DE, Franklin BA
Institution:Department of Cardiovascular Medicine, Oakland University William Beaumont School of Medicine, Beaumont Hospital Royal Oak, Royal Oak, MI, United States of America; University of Virginia Medical Center, Charlottesville, VA, United States of America. Electronic address: Nishaki.Mehta@beaumont.org. America. America. America. America. of Queensland School of Medicine, New Orleans, LA, United States of America. Medicine, Beaumont Hospital Royal Oak, Royal Oak, MI, United States of America. Medicine, Beaumont Hospital Royal Oak, Royal Oak, MI, United States of America.
Journal:Prog Cardiovasc Dis. 2021 May-Jun;66:2-9. doi: 10.1016/j.pcad.2021.05.002. Epub 2021 May 21.

10:Oral Anticoagulant Treatment in Patients with Atrial Fibrillation and Chronic Kidney Disease.
Authors:Stoica MC, Gáll Z, Gliga ML, Căldăraru CD, Székely O
Institution:Department of Nephrology/Internal Medicine, Mures County Clinical Hospital, 540103 Targu Mure?, Romania.
Journal:Medicina (Kaunas). 2021 Apr 27;57(5):422. doi: 10.3390/medicina57050422.

11:Cancer and atrial fibrillation: Epidemiology, mechanisms, and anticoagulation treatment.
Authors:Menichelli D, Vicario T, Ameri P, Toma M, Violi F, Pignatelli P, Pastori D
Institution:Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. University of Rome, Rome, Italy; Emergency Department, Policlinico Tor Vergata Hospital, Rome, Italy. Department of Internal Medicine, University of Genova, Genova, Italy. Department of Internal Medicine, University of Genova, Genova, Italy. Sapienza University of Rome, Rome, Italy; Mediterranea Cardiocentro, Naples, Italy. Sapienza University of Rome, Rome, Italy; Mediterranea Cardiocentro, Naples, Italy. Sapienza University of Rome, Rome, Italy. Electronic address: daniele.pastori@uniroma1.it.
Journal:Prog Cardiovasc Dis. 2021 May-Jun;66:28-36. doi: 10.1016/j.pcad.2021.04.004. Epub 2021 Apr 26.

12:Risk factor management and atrial fibrillation.
Authors:Hendriks JM, Gallagher C, Middeldorp ME, Lau DH, Sanders P
Institution:Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. University, GPO Box 2100, Adelaide 5001, Australia. Hospital, Adelaide, Australia. Hospital, Adelaide, Australia. Hospital, Adelaide, Australia. Hospital, Adelaide, Australia.
Journal:Europace. 2021 Apr 10;23(23 Suppl 2):ii52-ii60. doi: 10.1093/europace/euaa346.

13:Early atrial fibrillation detection and the transition to comprehensive management.
Authors:Linz D, Hermans A, Tieleman RG
Institution:Department of Cardiology, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, 6202 AZ Maastricht, The Netherlands. Netherlands. Adelaide, SA, Australia. University of Copenhagen, Copenhagen, Denmark. Research Institute Maastricht, 6202 AZ Maastricht, The Netherlands. The Netherlands.
Journal:Europace. 2021 Apr 10;23(23 Suppl 2):ii46-ii51. doi: 10.1093/europace/euaa424.

14:Diagnostic Accuracy of Ambulatory Devices in Detecting Atrial Fibrillation: Systematic Review and Meta-analysis.
Authors:Yang TY, Huang L, Malwade S, Hsu CY, Chen YC
Institution:School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Department of Family Medicine, Taipei Medical University Hospital, Taipei City, Taiwan.
Journal:JMIR Mhealth Uhealth. 2021 Apr 9;9(4):e26167. doi: 10.2196/26167.

15:Atrial fibrillation during pregnancy: a 9-month period with limited options.
Authors:Iliodromitis K, Kociszewski J, Bogossian H
Institution:Klinik fur Kardiologie und Rhythmologie, Evangelisches Krankenhaus Hagen, Brusebrinkstrae20, 58135, Hagen, Germany. bogossian@evk-haspe.de.
Journal:Herzschrittmacherther Elektrophysiol. 2021 Jun;32(2):158-163. doi: 10.1007/s00399-021-00751-w. Epub 2021 Apr 6.

16:Meta-analysis of Safety and Efficacy of Anticoagulation versus no Anticoagulation in Octogenarians and Nonagenarians with Atrial Fibrillation.
Authors:Barssoum K, Kumar A, Thakkar S, Sheth AR, Kharsa A, Ibrahim M, Rai D, Idemudia O, Akula N, Patel HP, Mowafy A, Elkaryoni A, Ibrahim F, Mubasher M, Ghattas KN, Rao M
Institution:Department of Internal Medicine, Rochester Regional Health, Unity Hospital, Rochester, NY, USA. kiro11090@hotmail.com. kiro11090@hotmail.com. Center, Bergen, NJ, USA. Rochester, NY, USA. Rochester, NY, USA. USA. University Medical Cemter, Maywood, IL, USA. Rochester, NY, USA. Health, Rochester, NY, USA.
Journal:High Blood Press Cardiovasc Prev. 2021 May;28(3):271-282. doi: 10.1007/s40292-021-00442-0. Epub 2021 Mar 19.

17:Cryoballoon ablation vs. antiarrhythmic drugs: first-line therapy for patients with paroxysmal atrial fibrillation.
Authors:Kuniss M, Pavlovic N, Velagic V, Hermida JS, Healey S, Arena G, Badenco N, Meyer C, Chen J, Iacopino S, Anselme F, Packer DL, Pitschner HF, Asmundis C, Willems S, Di Piazza F, Becker D, Chierchia GB
Institution:Kerckhoff Heart Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany. Consortium, EVK Düsseldorf, Düsseldorf, Germany. program in Cardiac Electrophysiology and Pacing, European Reference Networks Guard-Heart, Vrije Universiteit Brussel, Brussels, Belgium. program in Cardiac Electrophysiology and Pacing, European Reference Networks Guard-Heart, Vrije Universiteit Brussel, Brussels, Belgium.
Journal:Europace. 2021 Jul 18;23(7):1033-1041. doi: 10.1093/europace/euab029.

18:Clinical outcomes following rhythm control for atrial fibrillation: is early better?
Authors:Kotalczyk A, Ding WY, Gupta D, Wright DJ, Lip GYH
Institution:Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.
Journal:Expert Rev Cardiovasc Ther. 2021 Apr;19(4):277-287. doi: 10.1080/14779072.2021.1902307. Epub 2021 Apr 13.

19:Rivaroxaban monotherapy versus combination therapy according to patient risk of stroke and bleeding in atrial fibrillation and stable coronary disease: AFIRE trial subanalysis.
Authors:Akao M, Yasuda S, Kaikita K, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H
Institution:Department of Cardiology, National Hospital Organization Kyoto Medical Center, Fushimi-ku, Kyoto, Japan. Electronic address: akao@kuhp.kyoto-u.ac.jp. Medicine, Sendai, Miyagi, Japan; National Cerebral and Cardiovascular Center, Suita, Osaka, Japan. University, Chuo-ku, Kumamoto, Japan. Sagamihara, Kanagawa, Japan. University, Fukuoka, Japan. Meguro-ku, Tokyo, Japan. Japan. Japan. Japan. Kumamoto, Kumamoto, Japan.
Journal:Am Heart J. 2021 Jun;236:59-68. doi: 10.1016/j.ahj.2021.02.021. Epub 2021 Feb 28.

20:High-power short duration vs. conventional radiofrequency ablation of atrial fibrillation: a systematic review and meta-analysis.
Authors:Ravi V, Poudyal A, Abid QU, Larsen T, Krishnan K, Sharma PS, Trohman RG, Huang HD
Institution:Section of Electrophysiology, Division of Cardiology, Department of Medicine, Rush University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. County, Chicago, IL, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA. University Medical Center, 1717 W Congress Pkwy Suite 317 Kellogg, Chicago, IL 60612, USA.
Journal:Europace. 2021 May 21;23(5):710-721. doi: 10.1093/europace/euaa327.

21:Edoxaban versus warfarin in patients with atrial fibrillation in relation to the risk of stroke: A secondary analysis of the ENGAGE AF-TIMI 48 study.
Authors:de Groot JR, Ruff CT, Murphy SA, Hamershock RA, Vehmeijer JT, Oude Ophuis AJM, Grip L, Lanz H, Mercuri MF, Antman EM, Giugliano RP
Institution:Amsterdam UMC, University of Amsterdam, Heart Center, Department of Cardiology, Amsterdam, the Netherlands. Amsterdam, the Netherlands. Electronic address: rgiugliano@bwh.harvard.edu.
Journal:Am Heart J. 2021 May;235:132-139. doi: 10.1016/j.ahj.2021.01.013. Epub 2021 Jan 22.

22:Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation with warfarin or edoxaban: An in-depth analysis from the ENGAGE AF-TIMI 48 randomized trial.
Authors:Nelson SE, Giugliano RP, Antman EM, Park JG, Norden AD, Rost NS, Silverman S, Singhal AB, Lanz HJ, Braunwald E, Ruff CT
Institution:Department of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA. Electronic address: snelso43@jhmi.edu. Harvard Medical School, Boston, MA, USA. Electronic address: rgiugliano@bwh.harvard.edu. Harvard Medical School, Boston, MA, USA. Electronic address: eantman@rics.bwh.harvard.edu. Harvard Medical School, Boston, MA, USA. Electronic address: jpark58@bwh.harvard.edu. of Neurology, Brigham and Women's Hospital, Boston, MA, USA. address: nrost@partners.org. address: sbsilverman@partners.org. address: asinghal@partners.org. Hans-Joachim.Lanz@daiichi-sankyo.eu. Harvard Medical School, Boston, MA, USA. Electronic address: ebraunwald@partners.org. Harvard Medical School, Boston, MA, USA. Electronic address: cruff@bwh.harvard.edu.
Journal:J Clin Neurosci. 2021 Apr;86:294-300. doi: 10.1016/j.jocn.2020.10.036. Epub 2021 Jan 12.

23:Long-term observation of catheter ablation vs. pharmacotherapy in the management of persistent and long-standing persistent atrial fibrillation (CAPA study).
Authors:Wu G, Huang H, Cai L, Yang Y, Liu X, Yu B, Tang Y, Jiang H, Huang C
Institution:Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China. Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China. China. University, Dalian, Liaoning, China. Shanghai, China. Harbin, China. Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China. Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China. Research Institute, Wuhan university, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China.
Journal:Europace. 2021 May 21;23(5):731-739. doi: 10.1093/europace/euaa356.

24:Atrial fibrillation and cardiac arrhythmia associated with acute dental infection: A systematic literature review and case report.
Authors:Hassan A, Lip GYH, Harris RV
Institution:Department of Public Health, Policy and Systems, Institute of Population Health, The University of Liverpool, Liverpool, UK. Heart & Chest Hospital, Liverpool, UK. University of Liverpool, Liverpool, UK.
Journal:Int J Clin Pract. 2021 May;75(5):e13875. doi: 10.1111/ijcp.13875. Epub 2020 Dec 16.

25:Pulmonary vein isolation alone vs. more extensive ablation with defragmentation and linear ablation of persistent atrial fibrillation: the EARNEST-PVI trial.
Authors:Inoue K, Hikoso S, Masuda M, Furukawa Y, Hirata A, Egami Y, Watanabe T, Minamiguchi H, Miyoshi M, Tanaka N, Oka T, Okada M, Kanda T, Matsuda Y, Kawasaki M, Hayashi K, Kitamura T, Dohi T, Sunaga A, Mizuno H, Nakatani D, Sakata Y
Institution:Cardiovascular Center, Sakurabashi-Watanabe Hospital, 2-4-32 Umeda, Kita-ku, Osaka 530-0001, Japan. 530-0001, Japan. Suita, Japan. 530-0001, Japan. 530-0001, Japan. 530-0001, Japan. 530-0001, Japan. Suita, Japan. Suita, Japan. Osaka, Japan. Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Japan. 530-0001, Japan. 530-0001, Japan. 530-0001, Japan. 530-0001, Japan. 530-0001, Japan.
Journal:Europace. 2021 Apr 6;23(4):565-574. doi: 10.1093/europace/euaa293.

26:Stroke prevention strategies in high-risk patients with atrial fibrillation.
Authors:Kotalczyk A, Mazurek M, Kalarus Z, Potpara TS, Lip GYH
Institution:Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK. University of Silesia, Silesian Centre for Heart Diseases, Zabrze, Poland. University of Silesia, Silesian Centre for Heart Diseases, Zabrze, Poland. University of Silesia, Silesian Centre for Heart Diseases, Zabrze, Poland. Heart and Chest Hospital, Liverpool, UK. gregory.lip@liverpool.ac.uk. University of Silesia, Silesian Centre for Heart Diseases, Zabrze, Poland. gregory.lip@liverpool.ac.uk. gregory.lip@liverpool.ac.uk. gregory.lip@liverpool.ac.uk.
Journal:Nat Rev Cardiol. 2021 Apr;18(4):276-290. doi: 10.1038/s41569-020-00459-3. Epub 2020 Oct 27.

27:External versus internal cardioversion for atrial fibrillation: a meta-analysis of randomized controlled trials.
Authors:Aggarwal G, Anantha-Narayanan M, Robles J, Bandyopadhyay D, Abed M, Henry BM, Aggarwal S, Alla V
Institution:Jersey City Medical Center, Jersey City, NJ, USA. Medicine, 7500 Mercy Road, Omaha, NE, USA. venkataalla@creighton.edu.
Journal:J Interv Card Electrophysiol. 2021 Sep;61(3):445-451. doi: 10.1007/s10840-020-00836-5. Epub 2020 Jul 31.

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