Atrial Fibrillation
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Left atrial appendage closure for stroke prevention in atrial fibrillation patients: A promise that came true.
Authors:Jiang X, Xiong Q, Yin Y, Ling Z
Institution:Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal:Pacing Clin Electrophysiol. 2023 Dec;46(12):1576-1585. doi: 10.1111/pace.14877. Epub 2023 Nov 21.

2:Direct oral anticoagulants vs vitamin K antagonist on dementia risk in atrial fibrillation: systematic review with meta-analysis.
Authors:Branco DR, Alves M, Severiano E Sousa C, Costa J, Ferreira JJ, Caldeira D
Institution:Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal.
Journal:J Thromb Thrombolysis. 2023 Oct;56(3):474-484. doi: 10.1007/s11239-023-02843-5. Epub 2023 Jul 5.

3:An Updated Meta-Analysis on the Clinical Outcomes of Percutaneous Left Atrial Appendage Closure Versus Direct Oral Anticoagulation in Patients With Atrial Fibrillation.
Authors:Jiang H, Koh TH, Vengkat V, Fei G, Ding ZP, Ewe SH, Jappar I, Lim ST, Yap J
Institution:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Cardiology, National Heart Center Singapore, Singapore.; Department of Cardiology, National Heart Center Singapore, Singapore; Duke-NUS Medical School, Singapore. Electronic address:
Journal:Am J Cardiol. 2023 Aug 1;200:135-143. doi: 10.1016/j.amjcard.2023.05.044. Epub 2023 Jun 13.

4:Sensitivity and Specificity of Wearables for Atrial Fibrillation in Elderly Populations: A Systematic Review.
Authors:Babar F, Cheema AM, Ahmad Z, Sarfraz A, Sarfraz Z, Ashraff H, Tayyab H, Bajwa AM, Ali H, Sarfraz M, Shahzad A, Sabzwari SRA
Institution:CMH Lahore Medical College, Lahore, Pakistan.; University of Colorado, Aurora, CO, USA.
Journal:Curr Cardiol Rep. 2023 Jul;25(7):761-779. doi: 10.1007/s11886-023-01898-3. Epub 2023 May 24.

5:Oral anticoagulant switching in patients with atrial fibrillation: a scoping review.
Authors:Adelakun AR, Turgeon RD, De Vera MA, McGrail K, Loewen PS
Institution:Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
Journal:BMJ Open. 2023 Apr 25;13(4):e071907. doi: 10.1136/bmjopen-2023-071907.

6:Efficacy and safety of non-vitamin K antagonist oral anticoagulants in patients (≥80 years of age) with atrial fibrillation: systematic review and meta-analysis.
Authors:Kang F, Su L, Fan S, Lv L, Luo B
Institution:Department of Cardiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
Journal:Intern Med J. 2023 Sep;53(9):1524-1532. doi: 10.1111/imj.16101. Epub 2023 Jun 20.

7:Electrocardiographic Predictors of Atrial Fibrillation.
Authors:Chousou PA, Chattopadhyay R, Tsampasian V, Vassiliou VS, Pugh PJ
Institution:Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.; Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Journal:Med Sci (Basel). 2023 Apr 7;11(2):30. doi: 10.3390/medsci11020030.

8:The bidirectional association between atrial fibrillation and myocardial infarction.
Authors:Frederiksen TC, Dahm CC, Preis SR, Lin H, Trinquart L, Benjamin EJ, Kornej J
Institution:Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Journal:Nat Rev Cardiol. 2023 Sep;20(9):631-644. doi: 10.1038/s41569-023-00857-3. Epub 2023 Apr 17.

9:Oral Anticoagulation in Patients With Advanced Chronic Kidney Disease and Atrial Fibrillation: Beyond Anticoagulation.
Authors:Dhaese SAM, De Vriese AS
Institution:Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Brugge, Belgium, and Department of Internal Medicine, Ghent University, Ghent, Belgium. Electronic address:
Journal:Mayo Clin Proc. 2023 May;98(5):750-770. doi: 10.1016/j.mayocp.2023.01.007. Epub 2023 Apr 5.

10:Clinical Phenotypes and Atrial Fibrillation Recurrences After Catheter Ablation: An Unsupervised Cluster Analysis.
Authors:Bisson A, Fawzy AM, El-Bouri W, Angoulvant D, Lip GYH, Fauchier L, Clementy N
Institution:Service de Cardiologie, Centre Hospitalier Regional Universitaire et Faculte de Medecine de Tours, Tours, France; Service de Cardiologie, Centre Hospitalier Regional Universitaire d'Orleans, Orleans, France; EA4245, Transplantation Immunite Inflammation, Universite de Tours, Tours, France; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK. Electronic address:; Service de Cardiologie, Clinique du Millenaire, Montpellier, France.
Journal:Curr Probl Cardiol. 2023 Aug;48(8):101732. doi: 10.1016/j.cpcardiol.2023.101732. Epub 2023 Mar 31.

11:Clinical and Structural Factors Affecting Ablation Outcomes in Atrial Fibrillation Patients - A Review.
Authors:Brilliant J, Yadav R, Akhtar T, Calkins H, Trayanova N, Spragg D
Institution:Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, United States.
Journal:Curr Cardiol Rev. 2023;19(5):83-96. doi: 10.2174/1573403X19666230331103153.

12:Is There a Role for Vitamin K Antagonist in the Management of Atrial Fibrillation in 2023?
Authors:Burg MR, Ha ACT
Institution:Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, M5G 2C4, Canada.
Journal:Curr Cardiol Rep. 2023 May;25(5):391-399. doi: 10.1007/s11886-023-01863-0. Epub 2023 Mar 30.

13:The neurocognitive effects of atrial fibrillation: benefits of the ABC pathway.
Authors:Calvert P, Gupta D, Lip GYH
Institution:Department of Cardiology, Liverpool Centre for Cardiovascular Science and Liverpool Heart & Chest Hospital NHS Foundation Trust, Thomas Drive, Liverpool, L14 3PE, UK.
Journal:Eur Heart J Cardiovasc Pharmacother. 2023 Jul 29;9(5):413-420. doi: 10.1093/ehjcvp/pvad021.

14:Association of type 1 diabetes mellitus and risk of atrial fibrillation: Systematic review and meta-analysis.
Authors:Guo S, Huang Y, Liu X, Ma J, Zhu W
Institution:Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China. Electronic address:
Journal:Diabetes Res Clin Pract. 2023 May;199:110629. doi: 10.1016/j.diabres.2023.110629. Epub 2023 Mar 21.

15:Postoperative atrial fibrillation: from mechanisms to treatment.
Authors:Gaudino M, Di Franco A, Rong LQ, Piccini J, Mack M
Institution:Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 E 68th St, New York City, NY 10065, USA.; Department of Cardiac Surgery, Baylor Scott & White Health, 621 North Hall Street, Dallas, TX 75226, USA.
Journal:Eur Heart J. 2023 Mar 21;44(12):1020-1039. doi: 10.1093/eurheartj/ehad019.

16:Blood pressure, hypertension and the risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies.
Authors:Aune D, Mahamat-Saleh Y, Kobeissi E, Feng T, Heath AK, Janszky I
Institution:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2 1PG, UK.; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Journal:Eur J Epidemiol. 2023 Feb;38(2):145-178. doi: 10.1007/s10654-022-00914-0. Epub 2023 Jan 10.

17:Epidemiology and modifiable risk factors for atrial fibrillation.
Authors:Elliott AD, Middeldorp ME, Van Gelder IC, Albert CM, Sanders P
Institution:Centre for Heart Rhythm Disorders, University of Adelaide, Adelaide, South Australia, Australia.
Journal:Nat Rev Cardiol. 2023 Jun;20(6):404-417. doi: 10.1038/s41569-022-00820-8. Epub 2023 Jan 4.

18:Alcohol Consumption and Atrial Arrhythmia Recurrence After Atrial Fibrillation Ablation: A Systematic Review and Meta-analysis.
Authors:Grindal AW, Sparrow RT, McIntyre WF, Conen D, Healey JS, Wong JA
Institution:Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada. Electronic address:
Journal:Can J Cardiol. 2023 Mar;39(3):266-273. doi: 10.1016/j.cjca.2022.12.010. Epub 2022 Dec 19.

19:Atrial fibrillation and stroke.
Authors:Choi SE, Sagris D, Hill A, Lip GYH, Abdul-Rahim AH
Institution:Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Journal:Expert Rev Cardiovasc Ther. 2023 Jan;21(1):35-56. doi: 10.1080/14779072.2023.2160319. Epub 2023 Jan 8.

20:Atrial Fibrillation Detection and Management in Hypertension.
Authors:Gawałko M, Linz D
Institution:First Department of Cardiology, Medical University of Warsaw, Poland (M.G.).; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (D.L.).
Journal:Hypertension. 2023 Mar;80(3):523-533. doi: 10.1161/HYPERTENSIONAHA.122.19459. Epub 2022 Dec 15.

21:Efficacy of Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis.
Authors:Faraz F, Rehman MEU, Sabir B, Ghaffar A, Iftikhar A, Maqsood A, Ahmad Cheema H, Yasmin F, Aamir M, Ahmed MU, Asghar MS
Institution:Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.; Mayo Clinic, Rochester, MN. Electronic address:
Journal:Curr Probl Cardiol. 2023 Mar;48(3):101524. doi: 10.1016/j.cpcardiol.2022.101524. Epub 2022 Nov 28.

22:Atrial fibrillation: Epidemiology, pathophysiology, and clinical complications (literature review).
Authors:Bizhanov KA, Аbzaliyev KB, Baimbetov AK, Sarsenbayeva AB, Lyan E
Institution:Department of Health Policy and Organization, Al-Farabi Kazakh National University, Almaty, Republic of Kazakhstan.; Cardiovascular Center, University Clinic Schleswig-Holstein, Kiel, Germany.
Journal:J Cardiovasc Electrophysiol. 2023 Jan;34(1):153-165. doi: 10.1111/jce.15759. Epub 2022 Dec 9.

23:Direct Oral Anticoagulants: An Updated Systematic Review of Their Clinical Pharmacology and Clinical Effectiveness and Safety in Patients With Nonvalvular Atrial Fibrillation.
Authors:Bortman LV, Mitchell F, Naveiro S, Pérez Morales J, Gonzalez CD, Di Girolamo G, Giorgi MA
Institution:Department of Pharmacology, School of Medicine, Instituto Universitario CEMIC, Buenos Aires, Argentina.
Journal:J Clin Pharmacol. 2023 Apr;63(4):383-396. doi: 10.1002/jcph.2184. Epub 2023 Jan 29.

24:Racial, ethnic, and sex disparities in atrial fibrillation management: rate and rhythm control.
Authors:Gomez SE, Fazal M, Nunes JC, Shah S, Perino AC, Narayan SM, Tamirisa KP, Han JK, Rodriguez F, Baykaner T
Institution:Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, H2146, Stanford, CA, 94305, USA.
Journal:J Interv Card Electrophysiol. 2023 Aug;66(5):1279-1290. doi: 10.1007/s10840-022-01383-x. Epub 2022 Oct 13.

25:Atrial Fibrillation Ablation Success Rate - A Retrospective Multicenter Study.
Authors:Ayzenberg O, Swissa M, Shlezinger T, Bloch S, Katzir I, Chodick G, Caspi A, Vered Z
Institution:Maccabi Health Organization, Cardiology Section; Department of Cardiology, Kaplan Medical Center, Rehovot, Hebrew University.; Maccabi Health Organization, Cardiology Section; Sackler School of Medicine, Tel Aviv University.
Journal:Curr Probl Cardiol. 2023 Aug;48(8):101161. doi: 10.1016/j.cpcardiol.2022.101161. Epub 2022 Mar 1.

26:Atrial fibrillation and stroke: A review and new insights.
Authors:Escudero-Martínez I, Morales-Caba L, Segura T
Institution:Stroke Unit, Department of Neurology, Hospital Universitari i Politecnic La Fe, Valencia, Spain; Instituto de Investigacion Sanitaria La Fe - Universidad de Valencia, Valencia, Spain. Electronic address:; Department of Medical Sciences, Faculty of Medicine of Albacete, University of Castilla-La Mancha, Albacete, Spain; Stroke Unit, Department of Neurology, Hospital General Universitario de Albacete, Spain.
Journal:Trends Cardiovasc Med. 2023 Jan;33(1):23-29. doi: 10.1016/j.tcm.2021.12.001. Epub 2021 Dec 7.

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