Chronic Pancreatitis
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Pancreatitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Pancreatitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Pancreatitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Pancreatitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study.
Authors:Park SM, Kim KB, Han JH, Kim N, Kang TU, Swan H, Kim HJ
Institution:Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.; Department of Preventive Medicine, Korea University College of Medicine, 126-1, 5-ga, Inchon-ro, Seoul, 136-705, Republic of Korea.
Journal:Sci Rep. 2023 Nov 2;13(1):18930. doi: 10.1038/s41598-023-45382-y.

2:Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study.
Authors:Parhiala M, Nøjgaard C, Bartholdy A, Waage A, Ignatavičius P, Engjom T, Dimcevski G, Nordaas IK, Kalaitzakis E, Drewes AM, Hadi A, Olesen SS, Poulsen JL, Laukkarinen J
Institution:Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Journal:United European Gastroenterol J. 2023 Nov;11(9):884-893. doi: 10.1002/ueg2.12466. Epub 2023 Oct 9.

3:Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation-Single Center Experience With Large Cohort of Patients.
Authors:Coluzzi M, Takita M, Saracino G, Rub Hakim Mohammed A, Darden CM, Testa G, Beecherl E, Onaca N, Naziruddin B
Institution:Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, United States.
Journal:Transpl Int. 2023 Sep 4;36:11409. doi: 10.3389/ti.2023.11409. eCollection 2023.

4:Advances in the Management of Pain in Chronic Pancreatitis.
Authors:Maydeo A, Kamat N, Dalal A, Patil G
Institution:Institute of Gastrosciences, Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaon, Mumbai, Maharashtra, India, 400004.
Journal:Curr Gastroenterol Rep. 2023 Oct;25(10):260-266. doi: 10.1007/s11894-023-00898-1. Epub 2023 Sep 15.

5:Management of Benign Biliary Stricture in Chronic Pancreatitis.
Authors:Ramchandani M, Pal P, Costamagna G
Institution:Department of Medical Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, Telangana, India; Interventional Endoscopy, AIG Hospitals, Plot No 2/3/4/5 Survey, 1, Mindspace Road, Gachibowli, Hyderabad, Telangana 500032, India. Electronic address:; Department of Translational Medicine and Surgery, Catholic University, Rome.
Journal:Gastrointest Endosc Clin N Am. 2023 Oct;33(4):831-844. doi: 10.1016/j.giec.2023.04.002. Epub 2023 May 11.

6:Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study.
Authors:Cai QY, Tan K, Zhang XL, Han X, Pan JP, Huang ZY, Tang CW, Li J
Institution:Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Journal:World J Gastroenterol. 2023 Aug 14;29(30):4671-4684. doi: 10.3748/wjg.v29.i30.4671.

7:The hidden dangers of chronic pancreatitis in pregnancy: Evidence from a large-scale population study.
Authors:Niu C, Zhang J, Zhu K, Liu H, Okolo PI 3rd
Institution:Internal Medicine Residency Program, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA. Electronic address:; Division of Gastroenterology, Rochester General Hospital, Rochester, NY 14621, USA.
Journal:Dig Liver Dis. 2023 Dec;55(12):1712-1718. doi: 10.1016/j.dld.2023.07.001. Epub 2023 Jul 18.

8:Chronic Pancreatitis and Risk of Atherosclerotic Cardiovascular Disease: A US Cohort Propensity-Matched Study.
Authors:Desai A, Chandan S, Ramai D, Kaul V, Kochhar GS
Institution:From the Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH.; Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, PA.
Journal:Pancreas. 2023 Jan 1;52(1):e21-e28. doi: 10.1097/MPA.0000000000002204.

9:Changing trends in the minimally invasive surgery for chronic pancreatitis.
Authors:Kalayarasan R, Shukla A
Institution:Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
Journal:World J Gastroenterol. 2023 Apr 14;29(14):2101-2113. doi: 10.3748/wjg.v29.i14.2101.

10:Chronic pancreatitis and nutritional support.
Authors:Campagnola P, de Pretis N, Zorzi A, Caldart F, Frulloni L
Institution:Department of Medicine, University of Verona, Verona, Italy. Electronic address:
Journal:Best Pract Res Clin Gastroenterol. 2023 Feb-Mar;62-63:101823. doi: 10.1016/j.bpg.2023.101823. Epub 2023 Feb 3.

11:Etiology, Diagnosis, and Modern Management of Chronic Pancreatitis: A Systematic Review.
Authors:Cohen SM, Kent TS
Institution:Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Journal:JAMA Surg. 2023 Jun 1;158(6):652-661. doi: 10.1001/jamasurg.2023.0367.

12:Quality of Life in Patients With Definite Chronic Pancreatitis: A Nationwide Longitudinal Cohort Study.
Authors:de Rijk FEM, van Veldhuisen CL, Kempeneers MA, Issa Y, Boermeester MA, Besselink MG, Kelder JC, van Santvoort HC, de Jonge PJF, Verdonk RC, Bruno MJ
Institution:Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Journal:Am J Gastroenterol. 2023 Aug 1;118(8):1428-1438. doi: 10.14309/ajg.0000000000002266. Epub 2023 Mar 30.

13:Prevalence of depression among patients with chronic pancreatitis: A systematic review and meta-analysis.
Authors:Beas R, Riva-Moscoso A, Ribaudo I, Chambergo-Michilot D, Norwood DA, Karkash A, Izquierdo-Veraza D, Montrose J, Ramirez-Rojas M, Montalvan-Sanchez E
Institution:Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
Journal:Clin Res Hepatol Gastroenterol. 2023 May;47(5):102115. doi: 10.1016/j.clinre.2023.102115. Epub 2023 Mar 26.

14:Advances in acute and chronic pancreatitis.
Authors:Strum WB, Boland CR
Institution:Department of Gastroenterology, Scripps Clinic, La Jolla, CA 92037, United States.; Department of Medicine, University of California San Diego, La Jolla, CA 92037, United States.
Journal:World J Gastroenterol. 2023 Feb 21;29(7):1194-1201. doi: 10.3748/wjg.v29.i7.1194.

15:Surgical outcomes of the Frey procedure for chronic pancreatitis: correlation between preoperative characteristics and the histological severity of pancreatic fibrosis.
Authors:Tanemura A, Hayashi A, Maeda K, Shinkai T, Ito T, Hayasaki A, Gyoten K, Fujii T, Iizawa Y, Murata Y, Kuriyama N, Kishiwada M, Mizuno S
Institution:Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-0001, Japan.
Journal:Surg Today. 2023 Aug;53(8):930-939. doi: 10.1007/s00595-023-02653-5. Epub 2023 Feb 9.

16:Position statement on the definition, incidence, diagnosis and outcome of acute on chronic pancreatitis.
Authors:Bouça-Machado T, Bouwense SAW, Brand M, Demir IE, Frøkjær JB, Garg P, Hegyi P, Löhr JM, de-Madaria E, Olesen SS, Pandanaboyana S, Pedersen JB, Rebours V, Sheel A, Singh V, Smith M, Windsor JA, Yadav D, Drewes AM
Institution:Department of Surgery, Aalborg University Hospital, Aalborg, Denmark.; Mech-Sense & Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark. Electronic address:
Journal:Pancreatology. 2023 Mar;23(2):143-150. doi: 10.1016/j.pan.2023.01.010. Epub 2023 Jan 25.

17:Smoking Is Associated with Worse Clinical Outcomes in Chronic Pancreatitis.
Authors:Liyen Cartelle A, Bocchino RL, Shah I, Yakah W, Ahmed A, Freedman SD, Kothari DJ, Sheth SG
Institution:Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA.
Journal:Dig Dis Sci. 2023 Jun;68(6):2667-2673. doi: 10.1007/s10620-023-07841-4. Epub 2023 Jan 30.

18:Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health.
Authors:Yadav D, Askew RL, Palermo T, Li L, Andersen DK, Chen M, Fisher WE, Fogel EL, Forsmark CE, Hart PA, Othman MO, Pandol SJ, Park WG, Topazian MD, Van Den Eeden SK, Vege SS, Yang Y, Serrano J, Conwell DL
Institution:Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Journal:Clin Gastroenterol Hepatol. 2023 Jul;21(7):1781-1791.e4. doi: 10.1016/j.cgh.2022.09.026. Epub 2022 Oct 1.

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