Peripheral Neuropathy
December 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments.
Authors:Überall M, Bösl I, Hollanders E, Sabatschus I, Eerdekens M
Institution:Institute of Neurological Sciences, Nurnberg, Germany.; Grunenthal GmbH, Aachen, Germany
Journal:BMJ Open Diabetes Res Care. 2022 Nov;10(6):e003062. doi: 10.1136/bmjdrc-2022-003062.

2:Association of Taxane Type With Patient-Reported Chemotherapy-Induced Peripheral Neuropathy Among Patients With Breast Cancer.
Authors:Mo H, Yan X, Zhao F, Teng Y, Sun X, Lv Z, Cao M, Zhao J, Song G, Pan B, Li H, Zhai J, Xu B, Ma F
Institution:Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal:JAMA Netw Open. 2022 Nov 1;5(11):e2239788. doi: 10.1001/jamanetworkopen.2022.39788.

3:Preventing diabetes-related foot ulcers through early detection of peripheral neuropathy.
Authors:McMorrow R, Nube VL, Manski-Nankervis JA
Institution:MB, BCh BAO, CHIA, FRACGP, Graduate Researcher, Department of General Practice, University of Melbourne, Vic; General Practitioner, Parkville Precinct Medical, Vic.; BSc (Hons), MBBS (Hons), CHIA, PhD, FRACGP Associate Professor @ General Practice, Department of General Practice, University of Melbourne, Melbourne, Vic; Academic General Practitioner, ACADI Diabetes Centre, University of Melbourne, Melbourne, Vic.
Journal:Aust J Gen Pract. 2022 Nov;51(11):833-838. doi: 10.31128/AJGP-06-22-6456.

4:Calmangafodipir for Prevention of Oxaliplatin-Induced Peripheral Neuropathy: Two Placebo-Controlled, Randomized Phase 3 Studies (POLAR-A/POLAR-M).
Authors:Pfeiffer P, Lustberg M, Näsström J, Carlsson S, Persson A, Nagahama F, Cavaletti G, Glimelius B, Muro K
Institution:Department of Oncology, Odense University Hospital, Odense, Denmark.; Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
Journal:JNCI Cancer Spectr. 2022 Nov 1;6(6):pkac075. doi: 10.1093/jncics/pkac075.

5:Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT.
Authors:Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Young T, Rajbhandari S, Sharma S, Rayman G, Gouni R, Alam U, Julious SA, Cooper C, Loban A, Sutherland K, Glover R, Waterhouse S, Turton E, Horspool M, Gandhi R, Maguire D, Jude E, Ahmed SH, Vas P, Hariman C, McDougall C, Devers M, Tsatlidis V, Johnson M, Bouhassira D, Bennett DL, Selvarajah D
Institution:Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; Department of Oncology and Human Metabolism, Medical School, University of Sheffield, Sheffield, UK.
Journal:Health Technol Assess. 2022 Oct;26(39):1-100. doi: 10.3310/RXUO6757.

6:Therapies in Autoimmune Peripheral Neuropathies beyond Intravenous Immunoglobulin, Plasma Exchange and Corticosteroids: An Analytical Review.
Authors:Sivadasan A, Bril V
Institution:Ellen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:
Journal:Transfus Med Rev. 2022 Oct;36(4):220-229. doi: 10.1016/j.tmrv.2022.05.002. Epub 2022 Aug 28.

7:The efficacy of vitamin B(12) supplementation for treating vitamin B(12) deficiency and peripheral neuropathy in metformin-treated type 2 diabetes mellitus patients: A systematic review.
Authors:Pratama S, Lauren BC, Wisnu W
Institution:Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia. Electronic address:; Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Division of Endocrine, Metabolic and Diabetes, Internal Medicine Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia.
Journal:Diabetes Metab Syndr. 2022 Oct;16(10):102634. doi: 10.1016/j.dsx.2022.102634. Epub 2022 Oct 2.

8:Evaluation of Calciferol, Cobalamin, and Stromelysin-1 in Patients with Diabetic Peripheral Neuropathy due to Type-2 Diabetes Mellitus.
Authors:Bilir B, Yilmaz I, Karaarsalan N, Bilir BE, Kaplan N, Ozbek H
Institution:Department of Internal Medicine, Namik Kemal University School of Medicine, Tekirdag, Turkey.; Department of Medical Pharmacology, Izmir Bakircay University School of Medicine, Izmir, Turkey.
Journal:J Coll Physicians Surg Pak. 2022 Oct;32(10):1255-1259. doi: 10.29271/jcpsp.2022.10.1255.

9:Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Authors:Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL
Institution:Department of Neurology, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Journal:Lancet Neurol. 2022 Oct;21(10):922-936. doi: 10.1016/S1474-4422(22)00188-0.

10:TENS and EMS Treatment for Diabetic Peripheral Neuropathy.
Authors:Prevost J, Lambert J
Journal:Altern Ther Health Med. 2022 Sep;28(6):57-59.

11:A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain.
Authors:Pickering E, Steels EL, Steadman KJ, Rao A, Vitetta L
Institution:School of Pharmacy, University of Queensland, PACE Precinct, 20 Cornwall Street, Wooloongabba, Brisbane, QLD, 4102, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Journal:Inflammopharmacology. 2022 Dec;30(6):2063-2077. doi: 10.1007/s10787-022-01033-8. Epub 2022 Sep 4.

12:Evaluation of Mindfulness Training Combined with Aerobic Exercise on Neurological Function and Quality of Life in Patients with Peripheral Neuropathy Type 2 Diabetes Mellitus.
Authors:Weng X, Liao S, Wang F, Wang H, Yang L
Institution:Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.
Journal:Contrast Media Mol Imaging. 2022 Aug 5;2022:7665483. doi: 10.1155/2022/7665483. eCollection 2022.

13:Effect of various exercise protocols on neuropathic pain in individuals with type 2 diabetes with peripheral neuropathy: A systematic review and meta-analysis.
Authors:Tatikola SP, Natarajan V, Desai VK, Asirvatham AR, Rajsekhar H
Institution:Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. Electronic address:; Apollo College of Physiotherapy, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India.
Journal:Diabetes Metab Syndr. 2022 Sep;16(9):102603. doi: 10.1016/j.dsx.2022.102603. Epub 2022 Aug 27.

14:Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes.
Authors:Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Institution:Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Journal:Eur J Neurol. 2022 Dec;29(12):3571-3579. doi: 10.1111/ene.15534. Epub 2022 Sep 14.

15:Peripheral neuropathy: A neglected cause of disability in COPD - A narrative review.
Authors:Odajiu I, Covantsev S, Sivapalan P, Mathioudakis AG, Jensen JS, Davidescu EI, Chatzimavridou-Grigoriadou V, Corlateanu A
Institution:Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania.; Department of Respiratory Medicine, State University of Medicine and Pharmacy 'Nicolae Testemitanu', Chisinau, Moldavia. Electronic address:
Journal:Respir Med. 2022 Sep;201:106952. doi: 10.1016/j.rmed.2022.106952. Epub 2022 Aug 11.

16:Peripheral neuropathies after BRAF and/or MEK inhibitor treatment: A pharmacovigilance study.
Authors:Picca A, Birzu C, Berzero G, Sanchez-Pena P, Gaboriau L, Vidil F, Lenglet T, Tafani C, Ricard D, Psimaras D, Bihan K
Institution:Sorbonne Universite, Inserm, CNRS, UMR S 1127, Institut du Cerveau, ICM, AP-HP, Hopitaux Universitaires La Pitie Salpetriere-Charles Foix, Paris, France.; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, GH Pitie-Salpetriere et Hopital Percy, Paris, France.
Journal:Br J Clin Pharmacol. 2022 Nov;88(11):4941-4949. doi: 10.1111/bcp.15513. Epub 2022 Sep 7.

17:Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.
Authors:Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R, Alam U, Cooper C, Loban A, Sutherland K, Glover R, Waterhouse S, Turton E, Horspool M, Gandhi R, Maguire D, Jude EB, Ahmed SH, Vas P, Hariman C, McDougall C, Devers M, Tsatlidis V, Johnson M, Rice ASC, Bouhassira D, Bennett DL, Selvarajah D
Institution:Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; School of Health and Related Research, and Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. Electronic address:
Journal:Lancet. 2022 Aug 27;400(10353):680-690. doi: 10.1016/S0140-6736(22)01472-6. Epub 2022 Aug 22.

18:Are herbal medicines alone or in combination for diabetic peripheral neuropathy more effective than methylcobalamin alone? A systematic review and meta-analysis.
Authors:Lee CW, Jin JS, Kwon S, Jin C, Cho SY, Park SU, Jung WS, Moon SK, Park JM, Ko CN, Cho KH
Institution:Department of Korean Medicine Cardiology and Neurology, Graduate School, Kyung Hee University, Seoul, Republic of Korea.; Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Journal:Complement Ther Clin Pract. 2022 Nov;49:101657. doi: 10.1016/j.ctcp.2022.101657. Epub 2022 Aug 18.

19:Impact of acupuncture and integrative therapies on chemotherapy-induced peripheral neuropathy: A multicentered, randomized controlled trial.
Authors:Ben-Arye E, Hausner D, Samuels N, Gamus D, Lavie O, Tadmor T, Gressel O, Agbarya A, Attias S, David A, Schiff E
Institution:Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Journal:Cancer. 2022 Oct;128(20):3641-3652. doi: 10.1002/cncr.34422. Epub 2022 Aug 12.

20:A randomised, pragmatic clinical trial of ACUpuncture plus standard care versus standard care alone FOr Chemotherapy Induced peripheral Neuropathy (ACUFOCIN).
Authors:Stringer J, Ryder WD, Mackereth PA, Misra V, Wardley AM
Institution:The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, UK; School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK. Electronic address:; School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK; Outreach Research & Innovation Group, Adamson House, Ground Floor, Towers Business Park, Wilmslow Road, Didsbury, M20 2YY, UK. Electronic address:
Journal:Eur J Oncol Nurs. 2022 Oct;60:102171. doi: 10.1016/j.ejon.2022.102171. Epub 2022 Jul 11.

21:Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study.
Authors:Engvall K, Gréen H, Fredrikson M, Lagerlund M, Lewin F, Åvall-Lundqvist E
Institution:Department of Oncology, Region Jonkoping County, SE-551 11, Jonkoping, Sweden.; Department of Oncology and Department of Biomedical and Clinical Sciences, Linkoping University, SE-581 85, Linkoping, Sweden.
Journal:Breast Cancer Res Treat. 2022 Oct;195(3):379-391. doi: 10.1007/s10549-022-06670-9. Epub 2022 Aug 9.

22:Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy.
Authors:Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J
Institution:Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Vestermarksvej 9, 4000, Roskilde, Denmark.
Journal:Support Care Cancer. 2022 Nov;30(11):9441-9451. doi: 10.1007/s00520-022-07312-y. Epub 2022 Aug 6.

23:Cancer Survivors' Perspectives of Virtual Yoga for Chronic Chemotherapy-Induced Peripheral Neuropathy Pain During the COVID-19 Pandemic.
Authors:Knoerl R, Bockhoff J, Fox E, Giobbie-Hurder A, Berry DL, Berfield J, Meyerhardt J, Wright A, Ligibel J
Institution:Author Affiliations: Phyllis F. Cantor Center for Research in Nursing and Patient Care Services (Dr Knoerl and Mss Bockhoff and Fox), Division of Biostatistics, Department of Data Science (Ms Giobbie-Hurder), The Leonard P. Zakim Center for Integrative Therapies and Healthy Living (Dr Berfield), and Medical Oncology (Drs Meyerhardt, Wright, and Ligibel), Dana-Farber Cancer Institute, Boston, MA; and Biobehavioral Nursing and Health Informatics (Dr Berry), University of Washington, Seattle.
Journal:Comput Inform Nurs. 2022 Sep 1;40(9):641-647. doi: 10.1097/CIN.0000000000000937.

24:Sleep impairment: Is it an overlooked burden in painful diabetic peripheral neuropathy? A single-centre, cross-sectional study from south India.
Authors:Lawrence A, Khataniar H, Joseph S, Nagarajan T, Umesh S, Michael Raj A J
Institution:Department of Biostatistics, St. Johns Medical College and Hospital, Bengaluru, Karnataka, India.
Journal:Diabetes Metab Syndr. 2022 Aug;16(8):102568. doi: 10.1016/j.dsx.2022.102568. Epub 2022 Jul 19.

25:Chemotherapy-induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors.
Authors:McNeish BL, Richardson JK, Whitney DG
Institution:Department of Physical Medicine and Rehabilitation, Michigan Medicine, Ann Arbor, Michigan, USA.
Journal:Eur J Cancer Care (Engl). 2022 Nov;31(6):e13648. doi: 10.1111/ecc.13648. Epub 2022 Jul 13.

26:Capsaicin 8% for Peripheral Neuropathic Pain Treatment: A Retrospective Cohort Study.
Authors:Vieira IF, de Castro AM, Loureiro MDC, Pinto J, Cardoso C, Assuncao JP
Institution:Anesthesiology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.
Journal:Pain Physician. 2022 Jul;25(4):E641-E647.

27:A cross-sectional study describing peripheral neuropathy in patients with symptoms of gastroparesis: associations with etiology, gastrointestinal symptoms, and gastric emptying.
Authors:Moors VJ, Graveran KD, Shahsavari D, Parkman HP
Institution:Lewis Katz School of Medicine at, Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.; Temple University Hospital, 3401 North Broad Street, Philadelphia, PA, 19140, USA.
Journal:BMC Gastroenterol. 2022 Jun 27;22(1):315. doi: 10.1186/s12876-022-02372-0.

28:Non-Pharmacological Self-Management Strategies for Chemotherapy-Induced Peripheral Neuropathy in People with Advanced Cancer: A Systematic Review and Meta-Analysis.
Authors:Crichton M, Yates PM, Agbejule OA, Spooner A, Chan RJ, Hart NH
Institution:Cancer and Palliative Care Outcomes Centre, School of Nursing, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Journal:Nutrients. 2022 Jun 9;14(12):2403. doi: 10.3390/nu14122403.

29:First-in-Human Single-Ascending-Dose, Multiple-Dose, and Food Interaction Studies of NRD.E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy.
Authors:Tiecke E, Rainisio M, Guentert T, Müller S, Hochman L, Kaplan E, Mangialaio S
Institution:Novaremed AG, Basel, Switzerland.
Journal:Clin Pharmacol Drug Dev. 2022 Sep;11(9):1012-1027. doi: 10.1002/cpdd.1103. Epub 2022 Jun 14.

30:NRD.E1, an innovative non-opioid therapy for painful diabetic peripheral neuropathy-A randomized proof of concept study.
Authors:Tiecke E, Rainisio M, Eisenberg E, Wainstein J, Kaplan E, Silverberg M, Hochman L, Mangialaio S
Institution:Novaremed AG, Basel, Switzerland.
Journal:Eur J Pain. 2022 Sep;26(8):1665-1678. doi: 10.1002/ejp.1989. Epub 2022 Jun 21.

31:Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Authors:Deng B, Jia LQ, Wan DG, Wang BY, Cheng ZQ, Deng C
Institution:Center of Science and Technology, China-Japan Friendship Hospital, Beijing, 100029, China.; Integrative Oncology Department of Chinese Medicine and Western Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.
Journal:Chin J Integr Med. 2022 Jul;28(7):579-585. doi: 10.1007/s11655-022-3575-y. Epub 2022 May 18.

32:An overview of painful diabetic peripheral neuropathy: Diagnosis and treatment advancements.
Authors:Hagedorn JM, Engle AM, George TK, Karri J, Abdullah N, Ovrom E, Bocanegra-Becerra JE, D'Souza RS
Institution:iSpine Pain Physicians, Maple Grove, MN, USA. Electronic address:; Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA.
Journal:Diabetes Res Clin Pract. 2022 Jun;188:109928. doi: 10.1016/j.diabres.2022.109928. Epub 2022 May 14.

33:Recent advances in managing chemotherapy-induced peripheral neuropathy: A systematic review.
Authors:Wang M, Pei Z, Molassiotis A
Institution:School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China. Electronic address:
Journal:Eur J Oncol Nurs. 2022 Jun;58:102134. doi: 10.1016/j.ejon.2022.102134. Epub 2022 Mar 26.

34:Severity, Risk Factors and Quality of Life of Patients associated with Chemotherapy-Induced Peripheral Neuropathy.
Authors:Srivastava SP, Sinha AP, Sharma KK, Malik PS
Institution:Vivekanand Polyclinic College of Nursing, Lucknow, Uttar Pradesh, India.; AIIMS, New Delhi, India.
Journal:Clin Nurs Res. 2022 Jul;31(6):1080-1090. doi: 10.1177/10547738221085613. Epub 2022 Apr 1.

35:The use of photobiomodulation therapy for the prevention of chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled pilot trial (NEUROLASER trial).
Authors:Joy L, Jolien R, Marithé C, Stijn E, Laura S, Hilde L, Sandra B, Wendy N, Ruth H, Liesbeth R, Sylvana S, Sylvia H, Jeroen M
Institution:Faculty of Medicine and Life Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Journal:Support Care Cancer. 2022 Jun;30(6):5509-5517. doi: 10.1007/s00520-022-06975-x. Epub 2022 Mar 21.

36:Efficacy and safety of botulinum A toxin for the treatment of chronic peripheral neuropathic pain: A systematic review of randomized controlled trials and meta-analysis.
Authors:Hary V, Schitter S, Martinez V
Institution:Faculty of medecine, Universite de Paris, Paris, France.; Pain Unit, Hopital?Raymond?Poincare, APHP, Garches, France.
Journal:Eur J Pain. 2022 May;26(5):980-990. doi: 10.1002/ejp.1941. Epub 2022 Mar 23.

37:Can Physical Exercise Prevent Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer? A Systematic Review and Meta-analysis.
Authors:Lopez-Garzon M, Cantarero-Villanueva I, Postigo-Martin P, González-Santos Á, Lozano-Lozano M, Galiano-Castillo N
Institution:Cuidate' from Biomedical Group (BIO277), University of Granada, Granada, Spain; Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs, Granada, Spain.; Cuidate' from Biomedical Group (BIO277), University of Granada, Granada, Spain; Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs, Granada, Spain; Sport and Health Joint University Institute (iMUDS), University of Granada, Granada, Spain; Unit of Excellence on Exercise and Health (UCEES), University of Granada, Granada, Spain.
Journal:Arch Phys Med Rehabil. 2022 Nov;103(11):2197-2208. doi: 10.1016/j.apmr.2022.02.008. Epub 2022 Mar 7.

38:Analgesic and neuroprotective effects of Baimai Ointment on diabetic peripheral neuropathy.
Authors:Li Z, Wang W, Meng F, Zhou Z, Zhao Z, Mei Z
Institution:School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China; Institute of Ethnomedicine, South-Central University for Nationalities, Wuhan, 430074, China. Electronic address:
Journal:J Ethnopharmacol. 2022 Jun 28;292:115122. doi: 10.1016/j.jep.2022.115122. Epub 2022 Feb 21.

39:The role of the capsaicin 8% patch in the treatment of painful diabetic peripheral neuropathy.
Authors:Leavell Y, Simpson DM
Institution:Department of Neurology, Oregon Health & Science University, Portland, OR97239, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA.
Journal:Pain Manag. 2022 Jul;12(5):595-609. doi: 10.2217/pmt-2021-0025. Epub 2022 Feb 14.

40:Efficacy of Siriraj, in-house-developed, frozen gloves for cold therapy reduction of chemotherapy-induced peripheral neuropathy in gynecological cancer patients: randomized controlled trial.
Authors:Chitkumarn P, Rahong T, Achariyapota V
Institution:Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Journal:Support Care Cancer. 2022 Jun;30(6):4835-4843. doi: 10.1007/s00520-022-06890-1. Epub 2022 Feb 11.

41:Pharmacological and Nonpharmacological Management of Chemotherapy-Induced Peripheral Neuropathy: A Scoping Review of Randomized Controlled Trials.
Authors:Jones KF, Wechsler S, Zulewski D, Wood L
Institution:William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA.
Journal:J Palliat Med. 2022 Jun;25(6):964-995. doi: 10.1089/jpm.2021.0512. Epub 2022 Feb 4.

42:Localized peripheral neuropathic pain: topical treatment with lidocaine 700 mg medicated plaster in routine clinical practice.
Authors:Überall MA, Bösl I, Hollanders E, Sabatschus I, Eerdekens M
Institution:Institute of Neurological Sciences, Nurnberg, Germany.; Grunenthal GmbH, Aachen, Germany.
Journal:Pain Manag. 2022 May;12(4):521-533. doi: 10.2217/pmt-2021-0117. Epub 2022 Jan 10.

43:Self-Reported Severity, Characteristics, and Functional Limitations of Chemotherapy-Induced Peripheral Neuropathy.
Authors:Knoerl R, Mazzola E, Hong F, Salehi E, McCleary N, Ligibel J, Reyes K, Berry DL
Institution:Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address:; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Journal:Pain Manag Nurs. 2022 Aug;23(4):532-540. doi: 10.1016/j.pmn.2021.11.010. Epub 2021 Dec 28.

44:Yoga for chronic chemotherapy-induced peripheral neuropathy pain: a pilot, randomized controlled trial.
Authors:Knoerl R, Giobbie-Hurder A, Berfield J, Berry D, Meyerhardt JA, Wright AA, Ligibel JA
Institution:Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, 450 Brookline Ave, LW 518, Boston, MA, 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Journal:J Cancer Surviv. 2022 Aug;16(4):882-891. doi: 10.1007/s11764-021-01081-z. Epub 2021 Sep 15.

45:Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function.
Authors:Jain SM, Balamurugan R, Tandon M, Mozaffarian N, Gudi G, Salhi Y, Holland R, Freeman R, Baron R
Institution:TOTALL Diabetes Hormone Institute, Indore, India.; Division of Neurological Pain Research and Therapy, Universitatsklinikum Schleswig-Holstein, Campus-Kiel, Germany.
Journal:Pain. 2022 Jun 1;163(6):e738-e747. doi: 10.1097/j.pain.0000000000002470. Epub 2021 Sep 2.

46:The effect of salt-water bath in the management of treatment-related peripheral neuropathy in cancer patients receiving taxane and platinum-based treatment.
Authors:Emine KE, Gulbeyaz C
Institution:Department of Nursing Istanbul Medeniyet University Faculty of Health Sciences, Atalar, Sht. Hakan Kurban Cd. No. 44, Kartal, Istanbul 34862, Turkey. Electronic address:; Department of Internal Medicine Nursing, Istanbul University-Cerrahpasa Florence Nightingale Faculty of Nursing, Abide-i Hurriyet Cad, Caglayan, Istanbul, Turkey.
Journal:Explore (NY). 2022 May-Jun;18(3):347-356. doi: 10.1016/j.explore.2021.07.002. Epub 2021 Jul 18.

47:A Systematic Review of Peripheral Neuropathies in Breast Cancer-Related Lymphedema.
Authors:Forte AJ, Huayllani MT, Boczar D, Manrique OJ, Lu X, McLaughlin SA, Kung TA
Institution:Mayo Clinic, Jacksonville, FL, USA.; University of Michigan Health Systems, Ann Arbor, USA.
Journal:Hand (N Y). 2022 Jul;17(4):668-675. doi: 10.1177/1558944720963944. Epub 2020 Oct 19.

48:Nerve tubes for peripheral nerve repair.
Authors:de Ruiter GC, Spinner RJ, Yaszemski MJ, Windebank AJ, Malessy MJ
Institution:Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.
Journal:Neurosurg Clin N Am. 2009 Jan;20(1):91-105, vii.

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The Medifocus Guidebook on Peripheral Neuropathy is available in the following two convenient formats:


Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $37.45
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Available for immediate download as a PDF document.

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  • Discounted Price = $24.75

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What Our Customers Are Saying...

"This is the BEST informational and reference book pertaining to my long-time ailment 'Peripheral Neuropathy'. I have researched this relatively obscure subject for seven years. The MediFocus Guidebook on Peripheral Neuropathy is easy reading, concise, and contains great references."
Bellevue, Nebraska

"Your very informative Guidebook helped me understand my Peripheral Neuropathy much better than my doctor had time to explain. Thank you."
Midland, Texas

"I recently purchased your MediFocus Guidebook on Peripheral Neuropathy and found the information quite helpful in making decisions about the direction I wanted to take in dealing with my condition. Even after meeting with a Neurologist and being tested, I had many questions that he was unable to answer. We all have to take control of our own health care and the MediFocus Guidebook is a great tool for doing that."
Seattle, Washington

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