Lymphedema
December 2022 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Current Concepts in Surgical Management of Lymphedema.
Authors:Knackstedt R, Chen WF
Institution:Department of Plastic Surgery, Center for Lymphedema Research and Reconstruction, Cleveland Clinic, 2049 East 100th Street, A60, Cleveland, OH 44195, USA. Electronic address: chenw6@ccf.org.
Journal:Phys Med Rehabil Clin N Am. 2022 Nov;33(4):885-899. doi: 10.1016/j.pmr.2022.06.003. Epub 2022 Sep 28.

2:Burden of lymphedema in long-term breast cancer survivors by race and age.
Authors:Ren Y, Kebede MA, Ogunleye AA, Emerson MA, Evenson KR, Carey LA, Hayes SC, Troester MA
Institution:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Journal:Cancer. 2022 Dec 1;128(23):4119-4128. doi: 10.1002/cncr.34489. Epub 2022 Oct 12.

3:Sleep disturbance in cancer survivors with lymphedema: a scoping review.
Authors:Bock K, Ludwig R, Vaduvathiriyan P, LeSuer L, Siengsukon C
Institution:Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA. kbock2@kumc.edu.
Journal:Support Care Cancer. 2022 Nov;30(11):9647-9657. doi: 10.1007/s00520-022-07378-8. Epub 2022 Oct 6.

4:Phase 1 Lymfactin® Study: 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema.
Authors:Leppäpuska IM, Hartiala P, Suominen S, Suominen E, Kaartinen I, Mäki M, Seppänen M, Kiiski J, Viitanen T, Lahdenperä O, Vuolanto A, Alitalo K, Saarikko AM
Institution:Department of Plastic and General Surgery, Turku University Hospital and University of Turku, Turku, Finland.; Department of Plastic Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. Electronic address: anne.saarikko@hus.fi.
Journal:J Plast Reconstr Aesthet Surg. 2022 Nov;75(11):3938-3945. doi: 10.1016/j.bjps.2022.08.011. Epub 2022 Aug 17.

5:Multidisciplinary preventive intervention for breast cancer-related lymphedema: An international consensus.
Authors:Martínez-Jaimez P, Fuster Linares P, Piller N, Masia J, Yamamoto T, López-Montoya L, Monforte-Royo C
Institution:Breast Reconstruction and Lymphedema Surgery Unit, Clinica Planas, Barcelona, Spain.; Nursing Department, Faculty of Medicine and Health Science, Universitat Internacional de Catalunya, Barcelona, Spain.
Journal:Eur J Cancer Care (Engl). 2022 Nov;31(6):e13704. doi: 10.1111/ecc.13704. Epub 2022 Sep 16.

6:The effect of the combined use of complex decongestive therapy with electrotherapy modalities for the treatment of breast cancer-related lymphedema: a randomized clinical trial.
Authors:Hemmati M, Rojhani-Shirazi Z, Zakeri ZS, Akrami M, Salehi Dehno N
Institution:Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Rehabilitation Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal:BMC Musculoskelet Disord. 2022 Sep 3;23(1):837. doi: 10.1186/s12891-022-05780-1.

7:Clinical application of low-level laser therapy (Photo-biomodulation therapy) in the management of breast cancer-related lymphedema: a systematic review.
Authors:Mahmood D, Ahmad A, Sharif F, Arslan SA
Institution:University Institute of Physical Therapy, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan. danyamehmud@gmail.com.
Journal:BMC Cancer. 2022 Aug 30;22(1):937. doi: 10.1186/s12885-022-10021-8.

8:A non-randomized, open-label study of the safety and effectiveness of a novel non-pneumatic compression device (NPCD) for lower limb lymphedema.
Authors:Rockson SG, Karaca-Mandic P, Nguyen M, Shadduck K, Gingerich P, Campione E, Hetrrick H
Institution:Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford, CA, 94305, USA. rockson@stanford.edu.; Department of Physical Therapy, Nova Southeastern University, Ft. Lauderdale, FL, USA.
Journal:Sci Rep. 2022 Aug 17;12(1):14005. doi: 10.1038/s41598-022-17225-9.

9:Breast cancer-related lymphedema correlated with incidence of cellulitis and mortality.
Authors:Cheng MH, Ho OA, Tsai TJ, Lin YL, Kuo CF
Institution:Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Journal:J Surg Oncol. 2022 Dec;126(7):1162-1168. doi: 10.1002/jso.27054. Epub 2022 Aug 12.

10:Surgical Treatment and Rehabilitation Strategies for Upper and Lower Extremity Lymphedema: A Comprehensive Review.
Authors:de Sire A, Losco L, Lippi L, Spadoni D, Kaciulyte J, Sert G, Ciamarra P, Marcasciano M, Cuomo R, Bolletta A, Invernizzi M, Cigna E
Institution:Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', 88100 Catanzaro, Italy.; Plastic Surgery and Microsurgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56122 Pisa, Italy.
Journal:Medicina (Kaunas). 2022 Jul 19;58(7):954. doi: 10.3390/medicina58070954.

11:Pediatric Lymphedema: Study of 180 Patients Referred to a Tertiary Lymphedema Clinic.
Authors:Colmant C, Turpin S, Lambert R, Wong N, Ondrejchak S, Lapointe C, Powell J, Dubois J, McCuaig C
Institution:25461 Dermatology Division, Department of Pediatrics, Sainte-Justine University Hospital Center University of Montreal, Montreal, Quebec, Canada.
Journal:J Cutan Med Surg. 2022 Sep-Oct;26(5):502-511. doi: 10.1177/12034754221112002. Epub 2022 Jul 18.

12:Risk factors for breast cancer-related lymphedema in patients undergoing 3 years of prospective surveillance with intervention.
Authors:Koelmeyer LA, Gaitatzis K, Dietrich MS, Shah CS, Boyages J, McLaughlin SA, Taback B, Stolldorf DP, Elder E, Hughes TM, French JR, Ngui N, Hsu JM, Moore A, Ridner SH
Institution:Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Faculty Medicine, Health & Human Sciences, Macquarie University, Sydney, New South Wales, Australia.; Vanderbilt University School of Nursing, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Journal:Cancer. 2022 Sep 15;128(18):3408-3415. doi: 10.1002/cncr.34377. Epub 2022 Jul 7.

13:Vascularized Lymph Node Transfer Improved Outcomes of Elderly Patients with Secondary Upper Extremity Lymphedema.
Authors:Francis EC, Kim BS, Lin MC, Cheng MH
Institution:Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. minghueicheng@gmail.com.
Journal:Ann Surg Oncol. 2022 Nov;29(12):7868-7878. doi: 10.1245/s10434-022-12035-9. Epub 2022 Jul 2.

14:Risk Factors and Racial and Ethnic Disparities in Patients With Breast Cancer-Related Lymphedema.
Authors:Montagna G, Zhang J, Sevilimedu V, Charyn J, Abbate K, Gomez EA, Mehrara B, Morrow M, Barrio AV
Institution:Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Journal:JAMA Oncol. 2022 Aug 1;8(8):1195-1200. doi: 10.1001/jamaoncol.2022.1628.

15:Early intervention with compression garments prevents progression in mild breast cancer-related arm lymphedema: a randomized controlled trial.
Authors:Blom KY, Johansson KI, Nilsson-Wikmar LB, Brogårdh CB
Institution:Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Journal:Acta Oncol. 2022 Jul;61(7):897-905. doi: 10.1080/0284186X.2022.2081932. Epub 2022 Jun 3.

16:Intensive complex physical therapy combined with intermittent pneumatic compression versus Kinesio taping for treating breast cancer-related lymphedema of the upper limb: A randomised cross-over clinical trial.
Authors:Pajero Otero V, García Delgado E, Martín Cortijo C, Rodríguez Ramos ML, De Carlos Iriarte E, Gil García A, Romay-Barrero H, Avendaño-Coy J
Institution:University Hospital Infanta Sofia, San Sebastian de los Reyes, Spain.; Faculty of Physical Therapy and Nursing, Castilla-La Mancha University, Toledo, Spain.
Journal:Eur J Cancer Care (Engl). 2022 Sep;31(5):e13625. doi: 10.1111/ecc.13625. Epub 2022 May 31.

17:A Meta-analysis of 37 Studies on the Effectiveness of Microsurgical Techniques for Lymphedema.
Authors:Kong X, Du J, Du X, Cong X, Zhao Q
Institution:Division of Lymphatic Surgery, Department of Vascular Surgery, Key Laboratory of Lymphatic Surgery Jilin Province, Engineering Laboratory of Lymphatic Surgery Jilin Province, China?Japan Union Hospital of Jilin University, Jilin University, Changchun, PR China.; Division of Lymphatic Surgery, Department of Vascular Surgery, Engineering Laboratory of Memory and Cognitive Impairment Disease Jilin Province, China?Japan Union Hospital of Jilin University, Jilin University, Changchun, PR China.
Journal:Ann Vasc Surg. 2022 Oct;86:440-451.e6. doi: 10.1016/j.avsg.2022.04.038. Epub 2022 May 16.

18:Physical and Functional Outcomes of Simultaneous Vascularized Lymph Node Transplant and Lymphovenous Bypass in the Treatment of Lymphedema.
Authors:Garza RM, Beederman M, Chang DW
Institution:From the Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine & Biological Sciences.
Journal:Plast Reconstr Surg. 2022 Jul 1;150(1):169-180. doi: 10.1097/PRS.0000000000009247. Epub 2022 May 19.

19:Risk Factors Associated With Postmastectomy Breast Cancer Lymphedema: A Multicenter Retrospective Analysis.
Authors:Kuruvilla AS, Krajewski A, Li X, Yang J, Mulay SR, Agha SM, Kohli HK, Bellis RM, Tannous HJ, Shroyer ALW
Institution:From the Department of Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.
Journal:Ann Plast Surg. 2022 May 1;88(3 Suppl 3):S239-S245. doi: 10.1097/SAP.0000000000003107.

20:How to Care and Minimize the Sequelae of Lower Extremity Lymphedema.
Authors:Bobrek K, Nabavizadeh R, Nabavizadeh B, Master V
Institution:Department of Urology, Emory University School of Medicine, Atlanta, GA.; Department of Urology, Emory University School of Medicine, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA.
Journal:Semin Oncol Nurs. 2022 Jun;38(3):151270. doi: 10.1016/j.soncn.2022.151270. Epub 2022 Apr 15.

21:How we approach lymphedema in the pediatric population.
Authors:Pateva I, Greene AK, Snyder KM
Institution:Pediatric Hematology/Oncology, Rainbow Babies and Children's Hospital, Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Comprehensive Vascular Anomalies Program, Solid Tumor Program, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Journal:Pediatr Blood Cancer. 2022 Aug;69(8):e29611. doi: 10.1002/pbc.29611. Epub 2022 Apr 11.

22:Manual Lymphatic Drainage for Breast Cancer-related Lymphedema: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Authors:Lin Y, Yang Y, Zhang X, Li W, Li H, Mu D
Institution:Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address: doctormudali@hotmail.com.
Journal:Clin Breast Cancer. 2022 Jul;22(5):e664-e673. doi: 10.1016/j.clbc.2022.01.013. Epub 2022 Feb 24.

23:A review of American insurance coverage and criteria for conservative management of lymphedema.
Authors:Finkelstein ER, Ha M, Hanwright P, Ngaage LM, Yoon JS, Liang F, Nam AJ, Rasko YM
Institution:Ross University School of Medicine, Bridgetown, Barbados.; Division of Plastic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD. Electronic address: yrasko@som.umaryland.edu.
Journal:J Vasc Surg Venous Lymphat Disord. 2022 Jul;10(4):929-936. doi: 10.1016/j.jvsv.2022.03.008. Epub 2022 Mar 29.

24:The Effect of Exercise for the Prevention and Treatment of Cancer-Related Lymphedema: A Systematic Review with Meta-analysis.
Authors:Hayes SC, Singh B, Reul-Hirche H, Bloomquist K, Johansson K, Jönsson C, Plinsinga ML
Institution:Menzies Health Institute Queensland, Griffith University, Nathan, Queensland, AUSTRALIA.
Journal:Med Sci Sports Exerc. 2022 Aug 1;54(8):1389-1399. doi: 10.1249/MSS.0000000000002918. Epub 2022 Mar 22.

25:The American Venous Forum, American Vein and Lymphatic Society and the Society for Vascular Medicine expert opinion consensus on lymphedema diagnosis and treatment.
Authors:Lurie F, Malgor RD, Carman T, Dean SM, Iafrati MD, Khilnani NM, Labropoulos N, Maldonado TS, Mortimer P, O'Donnell TF Jr, Raffetto JD, Rockson SG, Gasparis AP
Institution:92661Jobst Vascular Institute of Promedica, Toledo, OH, USA.; 480303Stony Brook Medicine, Stony Brook, NY, USA.
Journal:Phlebology. 2022 May;37(4):252-266. doi: 10.1177/02683555211053532. Epub 2022 Mar 8.

26:Prophylactic Use of Compression Sleeves Reduces the Incidence of Arm Swelling in Women at High Risk of Breast Cancer-Related Lymphedema: A Randomized Controlled Trial.
Authors:Paramanandam VS, Dylke E, Clark GM, Daptardar AA, Kulkarni AM, Nair NS, Badwe RA, Kilbreath SL
Institution:Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Journal:J Clin Oncol. 2022 Jun 20;40(18):2004-2012. doi: 10.1200/JCO.21.02567. Epub 2022 Feb 2.

27:Lymphedema and Obesity.
Authors:Sudduth CL, Greene AK
Institution:Department of Plastic and Oral Surgery, Lymphedema Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Journal:Cold Spring Harb Perspect Med. 2022 May 27;12(5):a041176. doi: 10.1101/cshperspect.a041176.

28:Acceptance of disability, coping style, perceived social support and quality of life among patients with chronic lymphedema: a cross-sectional study.
Authors:Huang Z, Wu S
Institution:The Nethersol School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Horse Material Water, Shatin, New Territories, Hong Kong, Hong Kong SAR, China. huangzh@link.cuhk.edu.hk.; Foshan Hospital of Traditional Chinese Medicine, Foshan, China.
Journal:Support Care Cancer. 2022 May;30(5):4099-4108. doi: 10.1007/s00520-022-06855-4. Epub 2022 Jan 24.

29:Body image and sexuality concerns in women with breast cancer-related lymphedema: a cross-sectional study.
Authors:Hoyle E, Kilbreath S, Dylke E
Institution:Discipline of Physiotherapy, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia. Elizabeth.dylke@sydney.edu.au.
Journal:Support Care Cancer. 2022 May;30(5):3917-3924. doi: 10.1007/s00520-021-06751-3. Epub 2022 Jan 18.

30:Weight Gain and Lymphedema After Breast Cancer Treatment: Avoiding the Catch-22?
Authors:Boyages J, Cave AE, Naidoo D, Ee CCL
Institution:ICON Cancer Centre, Sydney Adventist Hospital, Wahroonga, Australia.; NICM Health Research Institute, Western Sydney University, Penrith, Australia.
Journal:Lymphat Res Biol. 2022 Aug;20(4):409-416. doi: 10.1089/lrb.2020.0048. Epub 2021 Nov 8.

31:Immediate Lymphatic Reconstruction to Prevent Breast Cancer-Related Lymphedema: A Systematic Review.
Authors:Cook JA, Sinha M, Lester M, Fisher CS, Sen CK, Hassanein AH
Institution:Division of Plastic Surgery; Indianapolis, Indiana, USA.
Journal:Adv Wound Care (New Rochelle). 2022 Jul;11(7):382-391. doi: 10.1089/wound.2021.0056. Epub 2022 Feb 23.

32:Current Status and Progress in the Treatment of Lower Limb Lymphedema After Treatment of Gynecological Oncology.
Authors:Zhang H, Kong W, Han C, Liu T, Li J, Song D
Institution:Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Journal:Lymphat Res Biol. 2022 Jun;20(3):308-314. doi: 10.1089/lrb.2021.0035. Epub 2021 Oct 25.

33:Adding Pneumatic Compression Therapy in Lower Extremity Lymphedema Increases Compliance of Treatment, While Decreasing the Infection Rate.
Authors:Soran A, Toktas O, Grassi A, Sezgin E
Institution:Comprehensive Lymphedema Program, UPMC, Pittsburgh, Pennsylvania, USA.; Department of Food and Engineering, Faculty of Engineering, Izmir Institute of Technology, Izmir, Turkey.
Journal:Lymphat Res Biol. 2022 Jun;20(3):315-318. doi: 10.1089/lrb.2020.0086. Epub 2021 Oct 14.

34:A systematic review of pharmacologic and cell-based therapies for treatment of lymphedema (2010-2021).
Authors:Walker J, Tanna S, Roake J, Lyons O
Institution:Academic Department of Vascular Surgery, King's College London, St Thomas' Hospital, London, UK. Electronic address: james.walker35@nhs.net.; Academic Department of Vascular Surgery, King's College London, St Thomas' Hospital, London, UK; Department of Surgery, University of Otago, Christchurch, New Zealand; Department of Vascular Endovascular and Transplant Surgery, Christchurch Hospital, Canterbury District Health Board, Christchurch, New Zealand.
Journal:J Vasc Surg Venous Lymphat Disord. 2022 Jul;10(4):966-975.e1. doi: 10.1016/j.jvsv.2021.09.004. Epub 2021 Sep 26.

35:A systematic review and meta-analysis of vascularized lymph node transfer for breast cancer-related lymphedema.
Authors:Winters H, Tielemans HJP, Paulus V, Hummelink S, Slater NJ, Ulrich DJO
Institution:Department of Plastic and Reconstructive Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: harm.winters@radboudumc.nl.
Journal:J Vasc Surg Venous Lymphat Disord. 2022 May;10(3):786-795.e1. doi: 10.1016/j.jvsv.2021.08.023. Epub 2021 Sep 8.

36:Preliminary outcomes of combined surgical approach for lower extremity lymphedema: supraclavicular lymph node transfer and lymphaticovenular anastomosis.
Authors:Chung JH, Hwang YJ, Park SH, Yoon ES
Institution:Department of Plastic and Reconstructive Surgery, Korea University Hospital, Seoul, Republic of Korea.
Journal:J Plast Surg Hand Surg. 2022 Oct;56(5):261-269. doi: 10.1080/2000656X.2021.1964980. Epub 2021 Aug 21.

37:Current Overview of Obesity-Induced Lymphedema.
Authors:Sudduth CL, Greene AK
Institution:Lymphedema Program, Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Journal:Adv Wound Care (New Rochelle). 2022 Jul;11(7):392-398. doi: 10.1089/wound.2020.1337. Epub 2021 Jan 27.

38:A Single Institution Multi-disciplinary Approach to Power-assisted Liposuction for the Management of Lymphedema.
Authors:Granoff MD, Johnson AR, Shillue K, Fleishman A, Tsai L, Carroll B, Donohoe K, Lee BT, Singhal D
Institution:Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Journal:Ann Surg. 2022 Nov 1;276(5):e613-e621. doi: 10.1097/SLA.0000000000004588. Epub 2020 Nov 4.

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