March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:The effect of preoperative degenerative spondylolisthesis on postoperative outcomes of degenerative lumbar spinal stenosis: A single-center cohort study protocol.
Authors:Chang Y, Zhou F, Fei L, Wang Z
Institution:Department of Spine Orthopaedic, Ningxia Medical University. Department of Spine Orthopaedic, General Hospital of Ningxia Medical University, Ningxia, China.
Journal:Medicine (Baltimore). 2020 Nov 6;99(45):e22355. doi: 10.1097/MD.0000000000022355.

2:Short-term comparison of preoperative and postoperative pain after indirect decompression surgery and direct decompression surgery in patients with degenerative spondylolisthesis.
Authors:Hiyama A, Katoh H, Sakai D, Tanaka M, Sato M, Watanabe M
Institution:Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. a.hiyama@tokai-u.jp.
Journal:Sci Rep. 2020 Nov 3;10(1):18887. doi: 10.1038/s41598-020-76028-y.

3:Health-Related Quality of Life Outcomes of Instrumented Circumferential Spinal Fusion for Pediatric Spondylolisthesis: A Comparison With Age and Sex Matched Healthy Controls.
Authors:Virkki EN, Oksanen H, Diarbakerli E, Helenius L, Pape B, Pajulo O, Gerdhem P, Helenius I
Institution:Department of Paediatric Orthopaedic Surgery, University of Turku and Turku University Hospital, Turku, Finland. Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Journal:Spine (Phila Pa 1976). 2020 Dec 1;45(23):E1572-E1579. doi: 10.1097/BRS.0000000000003681.

4:Comparative Effectiveness of Microdecompression Alone vs Decompression Plus Instrumented Fusion in Lumbar Degenerative Spondylolisthesis.
Authors:Austevoll IM, Gjestad R, Solberg T, Storheim K, Brox JI, Hermansen E, Rekeland F, Indrekvam K, Hellum C
Institution:Kysthospitalet in Hagevik, Orthopedic Clinic, Haukeland University Hospital, Bergen, Norway. The Norwegian Registry for Spine Surgery, University Hospital of Northern Norway, Tromso, Norway.
Journal:JAMA Netw Open. 2020 Sep 1;3(9):e2015015. doi: 10.1001/jamanetworkopen.2020.15015.

5:Complications rate of and risk factors for the unplanned reoperation of degenerative lumbar spondylolisthesis in elderly patients: a retrospective single-Centre cohort study of 33 patients.
Authors:Zhong W, Liang X, Luo X, Huang T, Quan Z
Institution:Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing, Medical University, Chongqing, China.
Journal:BMC Geriatr. 2020 Aug 24;20(1):301. doi: 10.1186/s12877-020-01717-2.

6:Epidural Steroid Injections for Management of Degenerative Spondylolisthesis: Little Effect on Clinical Outcomes in Operatively and Nonoperatively Treated Patients.
Authors:Gerling MC, Bortz C, Pierce KE, Lurie JD, Zhao W, Passias PG
Institution:Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY.
Journal:J Bone Joint Surg Am. 2020 Aug 5;102(15):1297-1304. doi: 10.2106/JBJS.19.00596.

7:Open Lumbar Microdiscectomy and Posterolateral Endoscopic Lumbar Discectomy for Antero- and Retrospondylolisthesis.
Authors:Yun DJ, Park SJ, Lee SH
Institution:Department of Neurosurgery, Busan Wooridul Spine Hospital (WSH), Busan, Korea. Daegu Wooridul Spine Hospital, Jung-Gu, Daegu, Republic of Korea.
Journal:Pain Physician. 2020 Jul;23(4):393-404.

8:The Effect of Surgical Decompression and Fusion on Functional Balance in Patients With Degenerative Lumbar Spondylolisthesis.
Authors:Haddas R, Lieberman I, Block A, Derman P
Institution:Texas Back Institute, Plano, TX.
Journal:Spine (Phila Pa 1976). 2020 Jul 15;45(14):E878-E884. doi: 10.1097/BRS.0000000000003436.

9:Prevalence of cervical anterior and posterior spondylolisthesis and its association with degenerative cervical myelopathy in a general population.
Authors:Murakami K, Nagata K, Hashizume H, Oka H, Muraki S, Ishimoto Y, Yoshida M, Tanaka S, Minamide A, Nakagawa Y, Yoshimura N, Yamada H
Institution:Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama, Japan.
Journal:Sci Rep. 2020 Jun 26;10(1):10455. doi: 10.1038/s41598-020-67239-4.

10:Deep Venous Thrombosis and Pulmonary Embolism After Minimally Invasive Transforaminal Lumbar Interbody Fusion: Report of 2 Cases in 315 Procedures.
Authors:Olinger CR, Gardocki RJ
Institution:Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee-Campbell Clinic, 1211 Union Avenue, Suite 510, Memphis, TN 38104, USA. Electronic address: colinger@campbellclinic.com.
Journal:Orthop Clin North Am. 2020 Jul;51(3):423-425. doi: 10.1016/j.ocl.2020.02.006. Epub 2020 Mar 19.

11:Outcomes of Minimally Invasive versus Open Surgery for Intermediate to High-grade Spondylolisthesis: A 10-Year Retrospective, Multicenter Experience.
Authors:Lak AM, Abunimer AM, Rahimi A, Tafel I, Chi J, Lu Y, Groff M, Zaidi HA
Institution:Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Journal:Spine (Phila Pa 1976). 2020 Oct 15;45(20):1451-1458. doi: 10.1097/BRS.0000000000003573.

12:A Comparison of Minimally Invasive and Open Transforaminal Lumbar Interbody Fusion for Grade 1 Degenerative Lumbar Spondylolisthesis: An Analysis of the Prospective Quality Outcomes Database.
Authors:Chan AK, Bisson EF, Bydon M, Foley KT, Glassman SD, Shaffrey CI, Wang MY, Park P, Potts EA, Shaffrey ME, Coric D, Knightly JJ, Fu KM, Slotkin JR, Asher AL, Virk MS, Kerezoudis P, Alvi MA, Guan J, Haid RW, Mummaneni PV
Institution:Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Journal:Neurosurgery. 2020 Sep 1;87(3):555-562. doi: 10.1093/neuros/nyaa097.

13:40% reoperation rate in adolescents with spondylolisthesis.
Authors:Nielsen E, Andras LM, Siddiqui AA, Michael N, Garg S, Paloski M, Brighton BK, Ferrero E, Mazda K, Ilharreborde B, Skaggs DL
Institution:Children's Orthopaedic Center, Children's Hospital Los Angeles, 4650 Sunset Blvd, Mailstop #69, Los Angeles, CA, 90027, USA. dskaggs@chla.usc.edu.
Journal:Spine Deform. 2020 Oct;8(5):1059-1067. doi: 10.1007/s43390-020-00121-5. Epub 2020 May 6.

14:Comparison of lumbar segmental stabilization and general exercises on clinical and radiologic criteria in grade-I spondylolisthesis patients: A double-blind randomized controlled trial.
Authors:Mohammadimajd E, Lotfinia I, Salahzadeh Z, Aghazadeh N, Noras P, Ghaderi F, Poureisa M, Sarbakhsh P, Choopani R
Institution:Department of Physiotherapy, Faculty of Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal:Physiother Res Int. 2020 Jul;25(3):e1843. doi: 10.1002/pri.1843. Epub 2020 Apr 28.

15:Systematic Review of Outcomes Following 10-Year Mark of Spine Patient Outcomes Research Trial (SPORT) for Degenerative Spondylolisthesis.
Authors:Oster BA, Kikanloo SR, Levine NL, Lian J, Cho W
Institution:Department of Orthopaedic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.
Journal:Spine (Phila Pa 1976). 2020 Jun 15;45(12):820-824. doi: 10.1097/BRS.0000000000003485.

16:Reduction versus In Situ Fusion for Adult High-Grade Spondylolisthesis: A Systematic Review and Meta-Analysis.
Authors:Lak AM, Abunimer AM, Devi S, Chawla S, Aydin L, Tafel I, Smith TR, Mekary RA, Zaidi HA
Institution:Computational Neurosciences Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Journal:World Neurosurg. 2020 Jun;138:512-520.e2. doi: 10.1016/j.wneu.2020.03.030. Epub 2020 Mar 14.

17:Adjacent segment disk degeneration three decades after fusion without attempted reduction for high-grade isthmic spondylolisthesis.
Authors:Joelson A, Danielson BI, Hedlund R, Wretenberg P, Frennered K
Institution:Department of Orthopaedics, Orebro University School of Medical Sciences, Orebro University Hospital, 701 85, Orebro, Sweden. anders@joelson.se. Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden.
Journal:Spine Deform. 2020 Aug;8(4):743-750. doi: 10.1007/s43390-020-00085-6. Epub 2020 Feb 17.

18:The Effect of Older Age on the Perioperative Outcomes of Spinal Fusion Surgery in Patients With Lumbar Degenerative Disc Disease With Spondylolisthesis: A Propensity Score-Matched Analysis.
Authors:Badhiwala JH, Karmur BS, Hachem LD, Wilson JRF, Jiang F, Jaja B, Nouri A, Witiw CD, Nassiri F, Fehlings MG, Wilson JR
Institution:Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada.
Journal:Neurosurgery. 2020 Sep 15;87(4):672-678. doi: 10.1093/neuros/nyz444.

19:Sexual Dysfunction: Prevalence and Prognosis in Patients Operated for Degenerative Lumbar Spondylolisthesis.
Authors:Chan AK, Bisson EF, Fu KM, Park P, Robinson LC, Bydon M, Glassman SD, Foley KT, Shaffrey CI, Potts EA, Shaffrey ME, Coric D, Knightly JJ, Wang MY, Slotkin JR, Asher AL, Virk MS, Kerezoudis P, Alvi MA, Guan J, Haid RW, Mummaneni PV
Institution:Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Journal:Neurosurgery. 2020 Aug 1;87(2):200-210. doi: 10.1093/neuros/nyz406.

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